Article
Biochemistry & Molecular Biology
Hong-Hsiang Guan, Yen-Hua Huang, En-Shyh Lin, Chun-Jung Chen, Cheng-Yang Huang
Summary: This study reported the crystal structures of Saccharomyces cerevisiae DHOase in complex with malate, 5-fluorouracil, and 5-aminouracil. The findings revealed the binding characteristics of 5-FU and 5-AU to DHOase, providing structural insights for the development of new inhibitors targeting DHOase.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Chemistry, Medicinal
Deepa R. Parmar, Jigar Y. Soni, Ramakrishna Guduru, Rahul H. Rayani, Rakesh V. Kusurkar, Anand G. Vala
Summary: Azetidines have been relatively unexplored due to difficulties in synthesis, but recent efforts by scientists have shown their diverse pharmacological activities and potential as valuable scaffolds in medicinal research.
ARCHIV DER PHARMAZIE
(2021)
Article
Chemistry, Multidisciplinary
Anil Kumar Soda, Srinivas Kurva, Kamini Singh, Dileepkumar Veeragoni, Sunil Misra, Manikanta Murahari, Sridhar Madabhushi
Summary: This study synthesized a series of functionalized quinoline-3-carboxylate derivatives and found that one compound exhibited potent antimicrobial and antibiofilm activity against Staphylococcus aureus. Additionally, this compound displayed significant cytotoxicity towards cancer cells without any toxic effects towards normal cells.
Article
Multidisciplinary Sciences
Jun Byeon, Jung Yeon Moon, Se Ryoung Je, So Hyun Park, Jun Won Kim
Summary: This study investigated the effectiveness of a qEEG biomarker in predicting the response to pharmacological treatment in patients with anxiety disorder. The results showed that patients with a lower TBR and higher beta and high-beta waves in T3 and T4 were more likely to respond to medication.
SCIENTIFIC REPORTS
(2023)
Article
Materials Science, Biomaterials
Balaji Gowrivel Vijayakumar, Deepthi Ramesh, K. Santhosh Manikandan, Mary Theresa, Aiswarya Sethumadhavan, V. Brindha Priyadarisini, E. K. Radhakrishnan, Maheswaran Mani, Tharanikkarasu Kannan
Summary: Chitosan biopolymer with pendant (E)-5-((4-acetylphenyl)diazenyl)-6-aminouracil (APAU) groups exhibited improved thermal stability and antimicrobial activity. The novel chitosan samples showed higher activity against S. aureus, K. pneumoniae, and E. coli compared to plain chitosan, and the antimicrobial effect was enhanced at higher concentrations.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Chemistry, Organic
Ghodsi Mohammadi Ziarani, Marzieh Rad, Fatemeh Mohajer, Hitesh Sehrawat, Ravi Tomar
Summary: The analogs of 6-Amino uracil play a crucial role in biological activities and are utilized as important components in the synthesis of various heterocyclic compounds. This compound has been extensively used as a precursor in the synthesis of diverse heterocyclic cores from 2016 to 2020.
CURRENT ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Fuying Li, Theresa A. Kopajtic, Jonathan L. Katz, Dan Luo, Thomas E. Prisinzano, Gregory H. Imler, Jeffrey R. Deschamps, Arthur E. Jacobson, Kenner C. Rice
Summary: This study focuses on the design and synthesis of enantiopure stereoisomers of N-2-phenylcyclopropylmethyl-substituted ortho-c oxide-bridged phenylmorphans as potential opioid receptor ligands. The compounds were synthesized and evaluated for their affinity and functional activity.
Article
Chemistry, Multidisciplinary
Taylor A. Watts, Louise S. Price, Sarah L. Price, Sara M. Niederberger, Jeffery A. Bertke, Jennifer A. Swift
Summary: This study reported the first single-crystal structure of the nucleobase derivative 5-aminouracil, which had previously only been studied as aggregates of microcrystalline particles. Crystal structure prediction efforts revealed that a good match to the experimental powder pattern required using the experimental cell parameters.
ISRAEL JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Bingnan Du, Chun-Ming Chan, Yuxin Ouyang, Kalok Chan, Zhenyang Lin, Wing-Yiu Yu
Summary: This study presents a novel method for the synthesis of high-value amides through NiH-catalyzed anti-Markovnikov intermolecular hydroamidation of unactivated alkenes. The protocol allows for the direct synthesis of structurally diverse N-alkyl amides using abundant carboxylic acid feedstocks and has shown success with both unactivated alkenes and natural products. Mechanistic studies suggest that the observed regioselectivities are controlled by the sterical environment of the coupling reaction.
COMMUNICATIONS CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Nishithendu Bikash Nandi, Nishan Das, Susanta Ghanta, Krishti Rekha Puzari, Pranab Dutta, Julia Klak, Leslaw Sieron, Waldemar Maniukiewicz, Tarun Kumar Misra
Summary: In this study, a uracil-azo derivative and its atropisomers were synthesized, along with a copper(II) complex. The stereochemistry of the compounds was determined using single crystal analysis. The compounds exhibited significant efficacy against bacterial and fungal plant pathogens.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
Nishithendu Bikash Nandi, Atanu Purkayastha, Julia Klak, Rakesh Ganguly, Susanta Ghanta, Tarun Kumar Misra
Summary: Two monomeric copper(II) complexes based on 1,3-dimethyl-5-(4'/3'-pyridylazo)-6-aminouracil were synthesized and characterized, showing high redox stability and weak antiferromagnetic interaction. These complexes interact with Bovine Serum Albumin through specific binding sites, indicating their potential as multi-functional materials.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Organic
Rulin Zhao, Zhenqiu Hong, Bei Wang, James Kempson, Lyndon Cornelius, Jianqing Li, Yi-Xin Li, Arvind Mathur
Summary: A simple and efficient method for the synthesis of N1-substituted-4-nitropyrazole-5-carboxylates has been developed, with excellent regioselectivity and good yields.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Huda Sharbini Kamaluddin, Xuan Gong, Pandong Ma, Katabathini Narasimharao, Abhishek Dutta Chowdhury, Mohamed Mokhtar
Summary: The study focuses on the methanol-to-olefin process catalyzed by ZSM-5 zeolite for producing essential chemical building blocks from renewable feedstocks. It highlights the importance of tuning the physicochemical properties of ZSM-5 zeolite for reaction performance and the potential of using hierarchical hybrid/composite zeolite materials.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Rosa Sparaco, Ewa Kedzierska, Agnieszka A. Kaczor, Anna Bielenica, Elisa Magli, Beatrice Severino, Angela Corvino, Ewa Gibula-Tarlowska, Jolanta H. Kotlinska, Giorgia Andreozzi, Paolo Luciano, Elisa Perissutti, Francesco Frecentese, Marcello Casertano, Anna Lesniak, Magdalena Bujalska-Zadrozny, Malgorzata Ozieblo, Raffaele Capasso, Vincenzo Santagada, Giuseppe Caliendo, Ferdinando Fiorino
Summary: A series of new derivatives were prepared and evaluated to identify selective ligands for serotonin receptors. The most active compounds, Norbo-4 and Norbo-18, showed high specificity and affinity towards the receptors.
Article
Chemistry, Organic
Lukas V. Hoff, Joana M. Hauser, Karl Gademann
Summary: An efficient method utilizing Pd catalysis for cross-coupling of 5-bromo-1,2,3-triazine is described. Optimization of reaction conditions enables the preparation of a diverse range of (hetero)aryl-1,2,3-triazines in high yields (up to 97%). Assessment of the reaction scope using data science techniques and subsequent diversification of products allows for the efficient synthesis of pyrimidines and pyridines.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
