Role of Circulating Cell-Free DNA in Cancers

Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle

(2014) L. De Mattos-Arruda et al.   ANNALS OF ONCOLOGY

Plasma circulating tumor DNA as an alternative to metastatic biopsies for mutational analysis in breast cancer

(2014) F. Rothé et al.   ANNALS OF ONCOLOGY

Circulating cell-free methylated DNA and lactate dehydrogenase release in colorectal cancer

(2014) Alexander B Philipp et al.   BMC CANCER

Noninvasive Detection of Response and Resistance in EGFR-Mutant Lung Cancer Using Quantitative Next-Generation Genotyping of Cell-Free Plasma DNA

(2014) G. R. Oxnard et al.   CLINICAL CANCER RESEARCH

Detection of Cancer DNA in Plasma of Patients with Early-Stage Breast Cancer

(2014) J. A. Beaver et al.   CLINICAL CANCER RESEARCH

Transfer of malignant trait to immortalized human cells following exposure to human cancer serum

(2014) Mohamed Abdouh et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Detection of EGFR Mutations in the Plasma of Patients with Lung Adenocarcinoma for Real-Time Monitoring of Therapeutic Response to Tyrosine Kinase Inhibitors?

(2014) Marie Marcq et al.   Journal of Thoracic Oncology

An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage

(2014) Aaron M Newman et al.   NATURE MEDICINE

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

(2014) C. Bettegowda et al.   Science Translational Medicine

Angiogenic Alterations Associated with Circulating Neoplastic DNA in Ovarian Carcinoma

(2014) Tilley Jenkins Vogel et al.   Translational Oncology

Circulating Cell-Free DNA from Colorectal Cancer Patients May Reveal High KRAS or BRAF Mutation Load

(2014) Florent Mouliere et al.   Translational Oncology

Changes in Colorectal Carcinoma Genomes under Anti-EGFR Therapy Identified by Whole-Genome Plasma DNA Sequencing

(2014) Sumitra Mohan et al.   PLoS Genetics

Functions and Therapeutic Roles of Exosomes in Cancer

(2014) Jacob A. Tickner et al.   Frontiers in Oncology

Intragenic DNA Methylation Concomitant with Repression of ATP4B and ATP4A Gene Expression in Gastric Cancer is a Potential Serum Biomarker

(2013) Uthandaraman Mahalinga Raja et al.   Asian Pacific Journal of Cancer Prevention

First-line gefitinib in Caucasian EGFR mutation-positive NSCLC patients: a phase-IV, open-label, single-arm study

(2013) J-Y Douillard et al.   BRITISH JOURNAL OF CANCER

Noninvasive Detection of HER2 Amplification with Plasma DNA Digital PCR

(2013) H. Gevensleben et al.   CLINICAL CANCER RESEARCH

Multiplex Picodroplet Digital PCR to Detect KRAS Mutations in Circulating DNA from the Plasma of Colorectal Cancer Patients

(2013) V. Taly et al.   CLINICAL CHEMISTRY

Establishment of tumor-specific copy number alterations from plasma DNA of patients with cancer

(2013) Ellen Heitzer et al.   INTERNATIONAL JOURNAL OF CANCER

The Clinical Utilization of Circulating Cell Free DNA (CCFDNA) in Blood of Cancer Patients

(2013) Yahya Elshimali et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Detection of MGMT, RASSF1A, p15INK4B, and p14ARF promoter methylation in circulating tumor-derived DNA of central nervous system cancer patients

(2013) Aleksandra Majchrzak-Celińska et al.   JOURNAL OF APPLIED GENETICS

Detection of EGFR mutations in circulating free DNA by PNA-mediated PCR clamping

(2013) Hye-Ryoun Kim et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

(2013) Muhammed Murtaza et al.   NATURE

Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer

(2013) Sarah-Jane Dawson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Circulating Methylated XAF1 DNA Indicates Poor Prognosis for Gastric Cancer

(2013) Zhi-Qiang Ling et al.   PLoS One

Plasma Cell-Free DNA in Paediatric Lymphomas

(2013) Lara Mussolin et al.   Journal of Cancer

Detection of Tumor PIK3CA Status in Metastatic Breast Cancer Using Peripheral Blood

(2012) M. J. Higgins et al.   CLINICAL CANCER RESEARCH

Serum DNA methylation for monitoring response to neoadjuvant chemotherapy in breast cancer patients

(2012) Ayelet Avraham et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer Progression Mediated by Horizontal Gene Transfer in an In Vivo Model

(2012) Catalina Trejo-Becerril et al.   PLoS One

Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing

(2012) R. J. Leary et al.   Science Translational Medicine

Apoptosis-related deregulation of proteolytic activities and high serum levels of circulating nucleosomes and DNA in blood correlate with breast cancer progression

(2011) Carina Roth et al.   BMC CANCER

Circulating cell-free DNA in plasma of melanoma patients: Qualitative and quantitative considerations

(2011) Pamela Pinzani et al.   CLINICA CHIMICA ACTA

Origin, translocation and destination of extracellular occurring DNA — A new paradigm in genetic behaviour

(2011) Dimetrie L. Peters et al.   CLINICA CHIMICA ACTA

Quantitative Detection of EGFR Mutations in Circulating Tumor DNA Derived from Lung Adenocarcinomas

(2011) K. Taniguchi et al.   CLINICAL CANCER RESEARCH

Screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancer

(2011) Carina Roth et al.   Molecular Oncology

Serum DNA can define tumor-specific genetic and epigenetic markers in gliomas of various grades

(2011) I. Lavon et al.   NEURO-ONCOLOGY

High Fragmentation Characterizes Tumour-Derived Circulating DNA

(2011) Florent Mouliere et al.   PLoS One

Plasma cell-free DNA in ovarian cancer

(2010) Aparna A. Kamat et al.   CANCER

Cell-Free Nucleic Acids Circulating in the Plasma of Colorectal Cancer Patients Induce the Oncogenic Transformation of Susceptible Cultured Cells

(2010) D. C. Garcia-Olmo et al.   CANCER RESEARCH

The virtosome-a novel cytosolic informative entity and intercellular messenger

(2010) Peter B. Gahan et al.   CELL BIOCHEMISTRY AND FUNCTION

Molecular Analysis of Plasma DNA for the Early Detection of Lung Cancer by Quantitative Methylation-Specific PCR

(2010) K. L. Ostrow et al.   CLINICAL CANCER RESEARCH

Development of Personalized Tumor Biomarkers Using Massively Parallel Sequencing

(2010) R. J. Leary et al.   Science Translational Medicine

Quantification of free total plasma DNA and minimal residual disease detection in the plasma of children with acute lymphoblastic leukemia

(2009) Arne Kristian Schwarz et al.   ANNALS OF HEMATOLOGY

Cell-free circulating DNA in Hodgkin's and non-Hodgkin's lymphomas

(2009) S. Hohaus et al.   ANNALS OF ONCOLOGY

The presence of circulating total DNA and methylated genes is associated with circulating tumour cells in blood from breast cancer patients

(2009) I Van der Auwera et al.   BRITISH JOURNAL OF CANCER

Single-Molecule Detection of Epidermal Growth Factor Receptor Mutations in Plasma by Microfluidics Digital PCR in Non-Small Cell Lung Cancer Patients

(2009) T. K.F. Yung et al.   CLINICAL CANCER RESEARCH

Multimarker Circulating DNA Assay for Assessing Blood of Prostate Cancer Patients

(2009) E. Sunami et al.   CLINICAL CHEMISTRY

Comparison of Circulating Plasma DNA Levels between Lung Cancer Patients and Healthy Controls

(2009) Kyong-Ah Yoon et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Analysis of Circulating Tumor DNA to Confirm Somatic KRAS Mutations

(2009) Matthias Holdhoff et al.   JNCI-Journal of the National Cancer Institute

Quantitative Analysis of Circulating Methylated DNA as a Biomarker for Hepatocellular Carcinoma

(2008) K. C. A. Chan et al.   CLINICAL CHEMISTRY

Circulating mutant DNA to assess tumor dynamics

(2008) Frank Diehl et al.   NATURE MEDICINE