Article
Oncology
Michelle L. Mierzwa, Madhava Aryal, Choonik Lee, Matthew Schipper, Monica VanTil, Krystal Morales, Paul L. Swiecicki, Keith A. Casper, Kelly M. Malloy, Matthew E. Spector, Andrew G. Shuman, Steven B. Chinn, Mark E. P. Prince, Chaz L. Stucken, Andrew J. Rosko, Theodore S. Lawrence, J. Chad Brenner, Benjamin Rosen, Caitlin A. Schonewolf, Jennifer Shah, Avraham Eisbruch, Francis P. Worden, Yue Cao
Summary: In this study, a randomized clinical trial was conducted to evaluate the efficacy of physiologic MRI-based radiotherapy (RT) dose escalation in patients with poor prognosis head and neck cancer. The results showed that RT dose escalation decreased locoregional failure, but did not significantly improve disease-free survival or overall survival. Additional improvements in systemic therapy may be necessary to enhance patient outcomes.
CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Thorsteinn Astradsson, Felix Sellberg, Ylva Tiblom Ehrsson, Karl Sandstrom, Goran Laurell
Summary: This real-world study aimed to evaluate the expression of inflammatory proteins in head and neck cancer patients before and after treatment, and to compare the expression differences associated with different treatment modalities. The results showed that the expression levels of certain proteins significantly decreased at 7 weeks after the start of treatment, with the largest decrease observed in the group receiving cisplatin-based chemoradiation. Most of the inflammatory proteins returned to their pretreatment levels after 12 months.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jonas Habrich, Simon Boeke, Marcel Nachbar, Konstantin Nikolaou, Fritz Schick, Cihan Gani, Daniel Zips, Daniela Thorwarth
Summary: This study assessed the repeatability of ADC derived from EPI DW-MRI in HNC using a 1.5T MR-Linac. The results demonstrated good repeatability of ADC values, suggesting its potential use in future biologically adapted MR-guided radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Francois Cherifi, Maud Villemin, Frederique Bisiaux, Alison Johnson, Heidi Solem Laviec, Audrey Rambeau
Summary: This study assessed the impact of a global pretherapeutic comprehensive supportive care assessment and early interventions on treatment choice for head and neck cancer patients who require chemoradiation. The results showed that the assessment led to treatment changes in 13.7% of patients, with cognitive function being the most frequently altered domain. Altered functional ability was significantly associated with treatment de-escalation, and de-escalation was associated with poorer progression-free survival.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Omar Freihat, Toth Zoltan, Tamas Pinter, Andras Kedves, David Sipos, Imre Repa, Arpad Kovacs, Cselik Zsolt
Summary: This study aimed to assess the association between 18F-FDG PET and DWI imaging parameters and their correlations with clinicopathological factors in primary tumors of head and neck cancer. The results showed a non-significant correlation between the DWI and FDG parameters. FDG-PET-based glucose metabolic and DWI-MR-derived cellularity data may represent different biological aspects of HNC.
Review
Oncology
Emer Fahy, Rachel C. C. Brooker, Jason C. C. Fleming, Joanne M. M. Patterson
Summary: Non-surgical treatment for head and neck cancer often leads to unplanned hospital admissions, with patients undergoing chemoradiotherapy being the most vulnerable. The common reasons for admission are nausea and vomiting, and decreased oral intake/dehydration.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lars Bielak, Nils Henrik Nicolay, Ute Ludwig, Thomas Lottner, Alexander Ruehle, Anca-Ligia Grosu, Michael Bock
Summary: The use of water bags during MRI measurements helps to reduce artifacts and improve image quality for head and neck cancer patients in radiation therapy.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qiao-Yuan Lu, Zhen Guan, Xiao-Yan Zhang, Xiao-Ting Li, Rui-Jia Sun, Qing-Yang Li, Ying-Shi Sun
Summary: Contrast-enhanced MRI has been found to provide accurate differentiation of ypT0-1 from ypT2-4 tumors after neoadjuvant chemotherapy and radiation therapy. The diagnostic performance of contrast-enhanced MRI is better than that of T2-weighted imaging and DWI. yT stage on contrast-enhanced MRI is an independent predictor of ypT0-1 tumors.
Review
Health Care Sciences & Services
Francesca De Felice, Daniela Musio, Vincenzo Tombolini
Summary: Tailored approaches are needed in head and neck cancer management to optimize clinical outcomes. Recent studies focus on the combination of immune check-point inhibitors and (chemo)radiotherapy, aiming to improve survival rates and reduce toxicity for patients. These strategies provide a useful clinical tool for further research in the field.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
James C. Korte, Carlos Cardenas, Nicholas Hardcastle, Tomas Kron, Jihong Wang, Houda Bahig, Baher Elgohari, Rachel Ger, Laurence Court, Clifton D. Fuller, Sweet Ping Ng
Summary: This study investigates the reproducibility of radiomics features calculated with two widely used software packages (IBEX, MaZda) in comparison to an IBSI compliant software package (PyRadiomics). Only a subset of highly correlated features are considered reproducible, and including non-reproducible radiomics features in a HNC radiotherapy response model impacts the model's performance. Using radiomic features from different software packages can classify equivalent patient groups, but only when restricting the model to reliable features.
SCIENTIFIC REPORTS
(2021)
Article
Otorhinolaryngology
Craig A. Bollig, Brian P. Kinealy, David R. Gilley, Andrew D. Clark, Tabitha L. I. Galloway, Robert P. Zitsch, Jeffrey B. Jorgensen, Gregory B. Biedermann
Summary: The study found a significant proportion of head and neck cancer patients using opioids long-term, with those receiving primary chemoradiation at highest risk. Other risk factors for chronic opioid use include pretreatment opioid use, tobacco use, and psychiatric disorder.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Multidisciplinary Sciences
Yingying Fan, Meining Chen, Hongyun Huang, Mi Zhou
Summary: This study aimed to compare the diagnostic performance of the traditional single-parameter evaluation (diffusion-weighted imaging, DWI) with the dual-parameter approach (time-resolved angiography with stochastic trajectories, TWIST or golden-angle radial sparse parallel, GRASP) in predicting pathological lymphovascular invasion (pLVI) in rectal cancer. Results showed that the combined analysis of ADC and perfusion parameters (Ktrans) acquired with GRASP had a higher diagnostic performance compared to DWI alone. However, combining GRASP-acquired Kep and TWIST-acquired perfusion parameters (Ktrans or Kep) did not provide any additional benefit. The Ktrans acquired with the GRASP technique improved the diagnostic performance of multiparametric MRI in predicting rectal cancers with pLVI-positive, while TWIST did not achieve the same effect.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Francesca De Felice, Carlo Guglielmo Cattaneo, Pierfrancesco Franco
Summary: This review explores the current radio(chemo)therapy strategy for head and neck squamous cell carcinoma (HNSCC) in order to improve understanding of the disease and potentially enhance patient care. The best practice for managing HNSCC should involve discussion within a multidisciplinary team. Currently, radiation therapy (RT) with or without chemotherapy is the standard treatment for locally advanced disease, and intensity-modulated photon therapy (IMRT) is the recommended RT technique.
Article
Oncology
R. Mesia, L. Iglesias, J. Lambea, J. Martinez-Trufero, A. Soria, M. Taberna, J. Trigo, M. Chaves, A. Garcia-Castano, J. Cruz
Summary: The updated guidelines from the Spanish Society of Medical Oncology for the diagnosis and treatment of squamous cell head and neck cancers include new approaches such as sentinel node biopsy, concurrent radiotherapy with weekly cisplatin in the adjuvant setting, new methods for HPV-related oropharyngeal cancer, and treatment with immune checkpoint inhibitors for recurrent/metastatic disease.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
S. E. J. Connor, C. Burd, N. Sivarasan, V Goh
Summary: This study aimed to investigate the optimal timing for post-chemoradiotherapy reference MRI in head and neck cancer patients, finding that the 6-week post-treatment MRI demonstrates maximal treatment response. The nodal necrosis score at 6 weeks and nodal volume at 6 and 12 weeks were predictive of 2-year progression-free survival.
EUROPEAN RADIOLOGY
(2021)
Review
Otorhinolaryngology
Carlos M. Chiesa-Estomba, Jose A. Gonzalez-Garcia, Eric M. Genden, Cesare Piazza, Orlando Guntinas-Lichius, Vincent Vander-Poorten, Luiz P. Kowalski, Fernando Lopez, Miquel Quer, Juan P. Rodrigo, Alvaro Sanabria, Veronica Fernandez-Alvarez, Carlos Suarez, Oded Cohen, Remco de Bree, Ashok R. Shaha, Antti A. Makitie, Alfio Ferlito
Summary: This study systematically reviewed and qualitatively analyzed methods for vascular perfusion assessment in Head and Neck microsurgical reconstruction. The results indicated that Cook-Swartz IDP is a safe and effective device. Further detailed prospective registration is needed to accurately evaluate results and complications.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Margot Baudelet, Frederic Duprez, Leen Van den Steen, Sandra Nuyts, Daan Nevens, Ann Goeleven, Caroline Vandenbruaene, Hanne Massonet, Alice Vergauwen, Heleen Bollen, Sarah Deschuymer, Kristien Wouters, Marc Peeters, Carl Van Laer, Steven Marien, Michiel Van den Brekel, Lisette van der Molen, Tom Vauterin, Joost van Dinther, Hilde Verstraete, Isabel Hutsebaut, Sabine Meersschout, Olivier Vanderveken, Marc De Bodt, Gwen Van Nuffelen
Summary: This multicenter RCT investigated the effect of three different service-delivery modes on patients' adherence to prophylactic swallowing exercises during radiotherapy. The study found that adherence decreased over time in all groups, but the therapist-supported group achieved the highest adherence rates. Increasing face-to-face contact with a speech-language therapist can overcome the problem of low adherence in this population.
Article
Oncology
Philipp Heumann, Miguel E. Aguado-Barrera, Barbara Avuzzi, David Azria, Erik Briers, Renee Bultijnck, Ananya Choudhury, Dirk De Ruysscher, Marie-Pierre Farcy-Jacquet, Valerie Fonteyne, Antonio Gomez Caamano, Irmgard Helmbold, Kerstie Johnson, Sarah L. Kerns, Maarten Lambrecht, Zoe Lingard, Tiziana Rancati, Barry S. Rosenstein, Elena Sperk, R. Paul Symonds, Christopher Talbot, Riccardo Valdagni, Ana Vega, Liv Veldeman, Tim Ward, Adam Webb, Catharine M. West, Jenny Chang-Claude, Petra Seibold
Summary: Previous studies have shown low to moderate agreement between healthcare professionals and patients in assessing treatment-related symptoms. This study aimed to determine the levels of agreement in a large cohort of prostate cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Charlotte Kerstens, Hans P. M. W. Wildiers, Gwen Schroyen, Mercedes Almela, Ruth E. Mark, Maarten Lambrecht, Sabine Deprez, Charlotte Sleurs
Summary: As more cancer patients survive into older age, the focus has shifted to the potential cognitive effects, which may result from accelerated brain aging. A systematic review was conducted to examine the risks of cognitive decline, neurotoxicity as shown by neuroimaging, and neurodegenerative disease development in older cancer survivors. The evidence suggests both structural and functional brain changes, with cognitive decline mainly affecting memory function. Various factors contribute to the risk, including cancer type, treatment methods, genetic predisposition, age, comorbidities, and psychological and social factors. Further research is needed to gain a more comprehensive understanding of accelerated neurocognitive aging in specific older subpopulations and to develop targeted interventions.
Review
Biochemistry & Molecular Biology
Carlos M. Chiesa-Estomba, Miguel Mayo-Yanez, Orlando Guntinas-Lichius, Vincent Vander-Poorten, Robert P. Takes, Remco de Bree, Gyorgy B. Halmos, Nabil F. Saba, Sandra Nuyts, Alfio Ferlito
Summary: Radiomics is a promising tool for the diagnosis, treatment, and follow-up of patients with hypopharyngeal squamous cell carcinoma (HPSCC). Further large-scale prospective studies are needed to validate its effectiveness in this patient population.
Article
Health Care Sciences & Services
Katherine J. Taylor, Cecilie D. Amdal, Kristin Bjordal, Guro L. Astrup, Bente B. Herlofson, Frederic Duprez, Ricardo R. Gama, Alexandre Jacinto, Eva Hammerlid, Melissa Scricciolo, Femke Jansen, Irma M. Verdonck-de Leeuw, Giuseppe Fanetti, Orlando Guntinas-Lichius, Johanna Inhestern, Tatiana Dragan, Alexander Fabian, Andreas Boehm, Ulrike Woehner, Naomi Kiyota, Maximilian Krueger, Pierluigi Bonomo, Monica Pinto, Sandra Nuyts, Joaquim C. Silva, Carmen Stromberger, Francesco Tramacere, Ayman Bushnak, Pietro Perotti, Michaela Plath, Alberto Paderno, Noa Stempler, Maria Kouri, Susanne Singer
Summary: This study investigated the long-term problems of head and neck cancer survivors. The most frequent problems reported were dry mouth, difficulty swallowing/eating, hoarseness/difficulty speaking, and pain in the head and neck. The use of chemo-radiotherapy compared to surgery alone increased the odds of reporting dry mouth and difficulty swallowing/eating, but decreased the odds of hoarseness/difficulty speaking and pain in the head and neck. Patients diagnosed with UICC stage IV had increased odds of reporting hoarseness/difficulty speaking. Laryngeal cancer survivors had lower odds of reporting dry mouth compared to oropharynx cancer survivors, but higher odds of hoarseness/difficulty speaking.
Article
Otorhinolaryngology
Meulemans Jeroen, Van Boven Alexander, Debacker Jens, Laenen Annouschka, Delaere Pierre, Van Lierde Charlotte, Huvenne Wouter, Vander Poorten Vincent
Summary: This study designed and validated prognostic nomograms to predict oncological outcomes in patients who undergo STL. It was found that the nomograms based on postoperative variables performed better than those based on preoperative variables, with the nomogram predicting DSS based on postoperative variables performing the best.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Review
Otorhinolaryngology
Kevin T. Robbins, Ohad Ronen, Nabil F. Saba, Primoz Strojan, Vincent Vander Poorten, Antti Makitie, Fernando Lopez, Juan P. Rodrigo, Akihiro Homma, Ehab Hanna, Alfio Ferlito
Summary: This article reviews the current evidence supporting functional preservation in sinonasal cancer treatment. Primary surgery with adjuvant modalities remains the standard of care, but often leads to functional compromise. However, with advances in therapeutic techniques, treatments aimed at preserving function and cosmesis are emerging.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Review
Oncology
Karthik Nagaraja Rao, Ripudaman Arora, Prajwal Dange, Nitin Nagarkar, Antti A. Makitie, Luiz P. Kowalski, Avraham Eisbruch, Marc Hamoir, Francisco J. Civantos, Vincent Vander Poorten, Sweet Ping Ng, Sandra Nuyts, Mark Zafereo, Ameya A. Asarkar, Pawel Golusinski, Ohad Ronen, Alfio Ferlito
Summary: The overall surgical outcomes of infranotch T4b oral cancers were examined and compared with T4a oral cancers. The meta-analysis results suggest that IN-T4b oral cancers have similar outcomes to T4a oral cancers, supporting the down-staging of IN-T4b cancers to T4a cancers.
ONCOLOGY AND THERAPY
(2023)
Article
Oncology
Elnaz Naderi, Miguel E. Aguado-Barrera, Line M. H. Schack, Leila Dorling, Tim Rattay, Laura Fachal, Holly Summersgill, Laura Martinez-Calvo, Ceilidh Welsh, Tom Dudding, Yasmin Odding, Ana Varela-Pazos, Rajesh Jena, David J. Thomson, Roel J. H. M. Steenbakkers, Joe Dennis, Ramon Lobato-Busto, Jan Alsner, Andy Ness, Chris Nutting, Antonio Gomez-Caamano, Jesper G. Eriksen, Steve J. Thomas, Amy M. Bates, Adam J. Webb, Ananya Choudhury, Barry S. Rosenstein, Begona Taboada-Valladares, Carsten Herskind, David Azria, David P. Dearnaley, Dirk de Ruysscher, Elena Sperk, Emma Hall, Hilary Stobart, Jenny Chang-Claude, Kim De Ruyck, Liv Veldeman, Manuel Altabas, Maria Carmen De Santis, Marie-Pierre Farcy-Jacquet, Marlon R. Veldwijk, Matthew R. Sydes, Matthew Parliament, Nawaid Usmani, Neil G. Burnet, Petra Seibold, R. Paul Symonds, Rebecca M. Elliott, Renee Bultijnck, Sara Gutierrez-Enriquez, Meritxell Molla, Sarah L. Gulliford, Sheryl Green, Tiziana Rancati, Victoria Reyes, Ana Carballo, Paula Peleteiro, Paloma Sosa-Fajardo, Chris Parker, Valerie Fonteyne, Kerstie Johnson, Maarten Lambrecht, Ben Vanneste, Riccardo Valdagni, Alexandra Giraldo, Monica Ramos, Brenda Diergaarde, Geoffrey Liu, Suzanne M. Leal, Melvin L. K. Chua, Miranda Pring, Jens Overgaard, Luis M. Cascallar-Caneda, Frederic Duprez, Christopher J. Talbot, Gillian C. Barnett, Alison M. Dunning, Ana Vega, Christian Nicolaj Andreassen, Johannes A. Langendijk, Catharine M. L. West, Behrooz Z. Alizadeh, Sarah L. Kerns
Summary: This study identified shared genetic susceptibility for acute radiation-induced toxicity across different cancer types, with a shared SNV-based heritability estimated at around 10%. Higher heritability rates were found for prostate, head and neck, and breast cancers. Additionally, several potentially associated SNVs and gene sets related to acute toxicity were discovered.
JNCI CANCER SPECTRUM
(2023)
Article
Oncology
Celie Cokelaere, Ruveyda Dok, Emanuela E. Cortesi, Peihua Zhao, Anna Sablina, Sandra Nuyts, Rita Derua, Veerle Janssens
Summary: Our study revealed that increased expression of TIPRL1 in tumor tissues is associated with poor locoregional control and decreased survival in RT-treated HNSCC patients. Deletion of TIPRL1 in HNSCC cells resulted in increased sensitivity to RT, prolonged cell cycle arrest, increased micronuclei formation, and altered proteome-wide DNA Damage Response. Additionally, we found that ATM-dependent phosphorylation of TIPRL1 plays a crucial role in radiotherapy resistance by modulating DDR, suggesting TIPRL1 as a potential predictive marker and therapeutic target in HNSCC.
Review
Oncology
Heleen Bollen, Akos Gulyban, Sandra Nuyts
Summary: The aim of this study was to evaluate the impact of international expert consensus guidelines (CG) on the delineation quality and consistency of clinical target volume of the primary tumor (CTVp). The results showed that the implementation of CG significantly improved delineation uniformity in Belgian radiation therapy centers. However, there is a need for clarification of the existing guidelines, especially for oropharyngeal and hypopharyngeal carcinoma.
RADIOTHERAPY AND ONCOLOGY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Ester Aguado-Flor, Petra Seibold, Miguel E. Aguado-Barrera, Manuel Altabas, Ananya Choudhury, Orland Diez, Noelia Docampo Azuaga, Sandrine Ducornet, David Gibon, Alexandra Giraldo, Renan Gomes, Antonio Gomez-Caamano, Maarten Lambrecht, Sarah Libert, Susana Magrina, Giovanna Muggiolu, Tiziana Rancati, Tim Rattay, Victoria Reyes, Sylvie Sauvaigo, Paloma Sosa-Fajardo, Christopher Talbot, Ana Vega, Liv Veldeman, Paolo Zunino, Jordi Giralt, Jenny Chang-Claude, Sara Gutierrez-Enriquez
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Oncology
Ursula Nestle, Sonja Adebahr, Coen Hurkmans, Merina Ahmed, Shahreen Ahmad, Matthias Guckenberger, Xavier Geets, Yolande Lievens, Maarten Lambrecht, Nicolas Pourel, Victor Lewitzki, Krzysztof Konopa, Kevin Franks, Rafal Dziadziuszko, Fiona Mcdonald, Enrico Clementel, Beatrice Fournier, Catherine Fortpied, Kin Jip Cheung, Eleni Gkika, Tanja Schimeck-Jasch, Christian Fink, Oliver Riesterer, Heike Peulen, Corinne Faivre-Finn, Anca-Ligia Grosu, Cecile Le Pechoux
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)