Review
Dentistry, Oral Surgery & Medicine
Carlos Arturo Cespedes-Ajun, Sara Amghar-Maach, Cosme Gay-Escoda
Summary: This study analyzed and compared the incidence and success rates of MORN after head and neck radiotherapy using two novel irradiation techniques, 3DCRT and IMRT. The results showed that IMRT had a lower risk of MORN development and better treatment outcomes compared to 3D-CRT.
MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gokcen Inan, Osman Vefa Gul
Summary: IMRT offers better protection for kidneys, liver, heart, and spinal cord in treating stomach cancer. When considering dose to OARs, IMRT appears to be the superior technique.
JOURNAL OF RADIOTHERAPY IN PRACTICE
(2022)
Article
Oncology
Ryan Urban, Justin Wong, Peter Lim, Susan Zhang, Ingrid Spadinger, Robert Olson, Francois Bachand, Clement Ho, Anna Tinker, Lovedeep Gondara, Sarah Nicole Hamilton
Summary: This study evaluated gastrointestinal patient reported outcomes in cervical cancer patients treated with different types of radiation therapy. The results showed that 3D conformal RT was associated with significantly greater worsening of gastrointestinal symptoms compared to intensity modulated/volumetric modulated arc therapy in the subacute and late phase. These findings support the ongoing use of the latter therapy in routine practice.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
Article
Medicine, General & Internal
Aftab Ahmad, Saikat Das, Vipin Kharade, Manish Gupta, V. P. Pandey, K. V. Anju, Ilamparithi Balasubramanian, Rajesh K. Pasricha
Summary: This study compared IMRT, VMAT, and 3D-CRT for a one-week hypofractionated radiotherapy regimen for adjuvant breast radiotherapy. IMRT and VMAT techniques were found to be feasible and achieved better dosimetric goals for target and OARs, although concerns remain regarding minimizing the area achieving low dose for VMAT.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Oncology
Gage Redler, Erik Pearson, Xinmin Liu, Inna Gertsenshteyn, Boris Epel, Charles Pelizzari, Bulent Aydogan, Ralph Weichselbaum, Howard J. Halpern, Rodney D. Wiersma
Summary: The study demonstrates the efficacy of using 3D-printed compensators for small-animal IMRT treatment plans and shows that the preclinical data provided can be translated into clinical practice. Compensators of varied thickness provide the desired attenuation, with spatial resolution capabilities investigated using 3D printing. The methodology was ultimately validated for accuracy and precision.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Minsi Zhang, Aimee Crago, Sam S. Yoon, Samuel Singer, Kaled Alektiar
Summary: In patients with borderline-resectable primary nonmetastatic retroperitoneal sarcoma, preoperative dose-painting IMRT rendered 67% of patients resectable, provided a 5-year local control rate of 57%, which is similar to those with resectable disease, and had an acceptable morbidity profile.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Fady Samir, Talaat M. Meaz, Fathi AEl Hussiny, Ahmed A. Ahmed, Amr A. Mahmoud, Tamer Refaat, Ahmed Gawish, Mohamed Abouegylah
Summary: The study compared four techniques in prostate treatment to find the preferred technique. Plans were created for 30 prostate cancer patients using different techniques, and the quality of the plans was assessed by comparing target coverage, organs at risk, monitor units, homogeneity, and conformity among the techniques.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Cem Onal, Sezin Yuce Sari, Guler Yavas, Ezgi Oymak, Sumerya Duru Birgi, Ecem Yigit, Ozan Cem Guler, Melis Gultekin, Serap Akyurek, Ferah Yildiz
Summary: In this study, EC patients treated with IMRT showed comparable clinical outcomes but lower incidence of GI toxicities compared to those treated with 3DCRT.
Article
Oncology
Reshma Jagsi, Kent A. Griffith, Jean M. Moran, Martha M. Matuszak, Robin Marsh, Margaret Grubb, Eyad Abu-Isa, Joshua T. Dilworth, Michael M. Dominello, David Heimburger, Danielle Lack, Eleanor M. Walker, James A. Hayman, Frank Vicini, Lori J. Pierce
Summary: Inverse-planned intensity modulated radiation therapy (IMRT) offers an advantage over forward-planned, 3-dimensional conformal radiation therapy (3DCRT) in reducing acute toxicity of breast radiation therapy.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Daniela Alterio, Simona Marani, Valeria Zurlo, Stefano Filippo Zorzi, Annamaria Ferrari, Stefania Volpe, Francesco Bandi, Sabrina Vigorito, Maria Giulia Vincini, Sara Gandini, Aurora Gaeta, Cristiana Iuliana Fodor, Alessia Casbarra, Mattia Zaffaroni, Anna Starzynska, Liliana Belgioia, Mohssen Ansarin, Cynthia Aristei, Barbara Alicja Jereczek-Fossa
Summary: The study compared the toxicity profiles of patients treated with intensity-modulated radiotherapy (IMRT) and 3D conformal radiotherapy (3D-CRT) for tumors of the supraglottic regions, finding that IMRT had lower toxicity rates and better treatment outcomes, especially in preserving long-term laryngeal and swallowing functions for patients.
Article
Oncology
Jessica Prunaretty, Celine Bourgier, Sophie Gourgou, Claire Lemanski, David Azria, Pascal Fenoglietto
Summary: This study compared IMRT and 3D conformal radiotherapy and found that 3D MHD is not representative of heart exposure after IMRT. In cases of high dose exposure, 3D MHD cannot represent similar heart substructure exposure as IMRT.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Michela Buglione, Andrea Emanuele Guerini, Andrea Riccardo Filippi, Luigi Spiazzi, Nadia Pasinetti, Alessandro Magli, Cristian Toraci, Paolo Borghetti, Luca Triggiani, Alessandro Alghisi, Gianluca Costantino, Francesco Bertagna, Niccolo Giaj Levra, Ludovica Pegurri, Stefano Maria Magrini
Summary: IMRT is effective in reducing the dose to OARs in mediastinal lymphoma treatment, which decreases the risk of long-term toxicity. However, there is a trade-off as it may increase the risk of SMNs due to increased low dose volumes, highlighting the importance of personalized treatment planning and selecting appropriate techniques for individual patients and disease characteristics.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Medicine, General & Internal
Austin J. Iovoli, Lauren Turecki, Michelle L. Qiu, Michael Khan, Kelsey Smith, Han Yu, Sung Jun Ma, Mark K. Farrugia, Anurag K. Singh
Summary: Oral mucositis is a common adverse effect in head and neck cancer patients receiving radiation therapy. This study aimed to investigate the associations between the severity of oral mucositis and clinical outcomes and quality of life. The results showed that severe oral mucositis was associated with feeding tube placement, hospitalization, opiate use, and weight loss.
Article
Oncology
Mehdi Varmaghani, Malihe Amiri, Hossein Ebrahimpour, Roham Salek, Javad Javan-Noughabi
Summary: This study compared the cost-effectiveness of intensity-modulated radiation therapy and three-dimensional conformal radiotherapy for head and neck cancer treatment in east of Iran. The results showed that three-dimensional conformal radiotherapy was more cost-effective and saved more quality-adjusted life years than intensity-modulated radiotherapy.
RADIATION ONCOLOGY
(2023)
Article
Oncology
Tobias Forster, Adriane Hommertgen, Matthias Felix Haefner, Nathalie Arians, Laila Koenig, Semi Ben Harrabi, Ingmar Schlampp, Clara Koehler, Eva Meixner, Vanessa Heinrich, Nicola Weidner, Johannes Huesing, Christof Sohn, Joerg Heil, Michael Golatta, Holger Hof, David Krug, Juergen Debus, Juliane Hoerner-Rieber
Summary: The study showed that IMRT-SIB was associated with slightly better quality of life in breast cancer treatment, particularly in terms of pain and arm symptoms. However, there was significant improvement in global score after 2 years, but slight deterioration in role functioning, social functioning, and future perspectives.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Lynn Million, Andrea Hayes-Jordan, Yueh-Yun Chi, Sarah S. Donaldson, Suzanne Wolden, Carol Morris, Stephanie Terezakis, Fran Laurie, Karen Morano, T. J. Fitzgerald, Torunn I. Yock, David A. Rodeberg, James R. Anderson, Rose Anne Speights, Jennifer O. Black, Cheryl Coffin, Mary Beth McCarville, Simon C. Kao, Douglas S. Hawkins, Sheri L. Spunt, R. Lor Randall
Summary: The ARST0332 trial for pediatric and young adults with NRSTS utilized risk-based treatment to achieve high local control rates, particularly after R0 resection. Most patients were able to undergo delayed R0/R1 resection after neoadjuvant therapy, leading to improved survival outcomes.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Caressa Hui, Danielle H. Shin, Adrienne Wakeling, Sarah S. Donaldson, Florette K. Hazard, Arun Rangaswami, Susan M. Hiniker
Summary: Limited data on radiation therapy in pediatric pleuropulmonary blastoma (PPB) are available. A case of a 3-year-old girl with type II PPB successfully treated with trimodality therapy has been reported, with no recurrent disease or observable toxicity after 3.5 years. Due to the rarity of the disease, prospective randomized controlled trials are not feasible, and the goal of this report is to contribute our experience to the literature on PPB and its treatment.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
Monika L. Metzger, Michael P. Link, Amy L. Billett, Jamie Flerlage, John T. Lucas, Belinda N. Mandrell, Matthew J. Ehrhardt, Nickhill Bhakta, Torunn Yock, Alison M. Friedmann, Pedro de Alarcon, Sandra Luna-Fineman, Eric Larsen, Sue C. Kaste, Barry Shulkin, Zhaohua Lu, Chen Li, Susan M. Hiniker, Sarah S. Donaldson, Melissa M. Hudson, Matthew J. Krasin
Summary: The study demonstrated the effectiveness and safety of brentuximab vedotin in the treatment of pediatric high-risk HL, significantly reducing radiation exposure and achieving excellent treatment outcomes.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Editorial Material
Environmental Sciences
Aurora B. Le, Christopher K. Brown, Shawn G. Gibbs, Alexander Uhrig, Andrew D. Green, Arne Broch Brantsaeter, Jocelyn J. Herstein, Angela Vasa, Jill Shugart, Wanda Wilson Egbe, John J. Lowe
Summary: With the increasing number of highly infectious disease incidents, the need for consensus and best practices on highly infectious decedent management is critical. This commentary presents consensus recommendations on best practices in highly infectious decedent management, aiming to address the lack of guidance in this area. It also emphasizes the importance of discussions and highlights overlooked topics.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE
(2022)
Review
Oncology
Josephine H. Haduong, Christine M. Heske, Wendy Allen-Rhoades, Wei Xue, Lisa A. Teot, David A. Rodeberg, Sarah S. Donaldson, Aaron Weiss, Douglas S. Hawkins, Rajkumar Venkatramani
Summary: This review discusses the evolution of risk-based therapy and the current risk stratification for children and adolescents with rhabdomyosarcoma (RMS), as well as the rationale for incorporating novel biomarkers into the risk stratification.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Oncology
Paulina M. Gutkin, Rie von Eyben, Alexander Chin, Sarah S. Donaldson, Justin Oh, Alice Jiang, Kristen N. Ganjoo, Raffi S. Avedian, Matias Bruzoni, Robert J. Steffner, Everett J. Moding, Susan M. Hiniker
Summary: This study analyzed patients with metastatic sarcoma and found that those treated with SBRT had excellent local control and lower local recurrence rates compared to surgical management.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Review
Oncology
Jacquelyn N. Crane, Wei Xue, Amira Qumseya, Zhengya Gao, Carola A. S. Arndt, Sarah S. Donaldson, Douglas J. Harrison, Douglas S. Hawkins, Corinne M. Linardic, Leo Mascarenhas, William H. Meyer, David A. Rodeberg, Erin R. Rudzinski, Barry L. Shulkin, David O. Walterhouse, Rajkumar Venkatramani, Aaron R. Weiss
Summary: The Children's Oncology Group (COG) uses Clinical Group (CG) and modified Tumor Node Metastasis (TNM) stage to classify rhabdomyosarcoma (RMS). These classification systems have evolved over several decades and remain relevant and useful for predicting prognosis in RMS. This review analyzes data from recent COG trials and proposes updates based on the findings. The article also discusses factors warranting future study to optimize these classification systems.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Justin Oh, Paulina Gutkin, Yi Peng Wang, Navjot Sandhu, Robbie G. Majzner, Helen Nadel, Hiroyuki Shimada, Olivia Lansinger, Rie von Eyben, Sarah Donaldson, Matias Bruzoni, Quaovi H. Sodji, Susan M. Hiniker
Summary: This study aimed to determine the resolution time of I-123-MIBG avidity after radiation therapy (RT) in neuroblastoma (NB) and the rate of local failure (LF). The median time to resolution of I-123-MIBG activity after RT was found to be 78 days. Primary lesions without residual disease showed excellent local control, while the LF rate was higher after RT for residual disease and there was no benefit observed for boost RT.
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2023)
Letter
Oncology
Jacquelyn N. Crane, Sarah S. Donaldson, Sheri L. Spunt, Susan M. Hiniker
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Claire Baniel, Christopher H. Yoo, Alice Jiang, Rie von Eyben, David G. Mohler, Kristen Ganjoo, Nam Bui, Sarah S. Donaldson, Lynn Million, Matt van de Rijn, Justin Moon Oh, Susan M. Hiniker
Summary: This study retrospectively reviewed the clinical data of 30 patients with TGCT and found that postsurgical radiation therapy can effectively control disease recurrence and improve patients' quality of life.
PRACTICAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Erik S. Blomain, Alice Jiang, Sarah S. Donaldson, Rajni Agarwal, Alice Bertaina, David Shyr, Michael L. Eisenberg, Richard T. Hoppe, Susan M. Hiniker, Justin Oh
Summary: This study compared the effects of testicular boost irradiation in children with leukemia undergoing hematopoietic stem cell transplant. The results showed that testicular boost did not reduce the risk of relapse, but resulted in a higher rate of gonadal dysfunction.
ADVANCES IN RADIATION ONCOLOGY
(2023)
Article
Oncology
Paulina M. Gutkin, Lawrie Skinner, Alice Jiang, Sarah S. Donaldson, Billy W. Loo Jr, Justin Oh, Yi Peng Wang, Rie von Eyben, John Snyder, Jeremy S. Bredfeldt, John C. Breneman, Louis S. Constine, Austin M. Faught, Daphne Haas-Kogan, Jordan A. Holmes, Matthew Krasin, Charlene Larkin, Karen J. Marcus, Peter G. Maxim, Shearwood McClelland III, Blair Murphy, Joshua D. Palmer, Stephanie M. Perkins, Colette J. Shen, Stephanie Terezakis, Karl Bush, Susan M. Hiniker
Summary: This study evaluated the feasibility and effects of the Audio-Visual Assisted Therapeutic Ambience in Radiotherapy (AVATAR) system in a multicenter pediatric trial. The results showed that AVATAR was successful in reducing anesthesia use and improving quality of life and anxiety in pediatric patients undergoing radiation therapy. AVATAR implementation is feasible and should be further studied and made available to patients who may benefit from video-based distraction.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Review
Oncology
Sidharth Totadri, Deepak Bansal, Sarah S. Donaldson, Odion Binitie, Lisa Teot, Abha A. Gupta, Sapna Oberoi
Summary: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma among children and adolescents. Treatment involves risk stratification based on clinicopathological characteristics and requires collaboration between multiple disciplines. Clinicians in low- and middle-income countries face challenges such as disease heterogeneity, molecular testing, evolving treatment regimens, and limited resources. This review aims to bring together experts from various fields to address common questions in managing RMS in these settings.
PEDIATRIC BLOOD & CANCER
(2023)
Meeting Abstract
Oncology
Wendy A. Allen-Rhoades, Leo Mascarenhas, Wei Xue, Sarah S. Donaldson, Dana Casey, John Frederick Shern, Erin R. Rudzinski, Stephen Skapek, David A. Rodeberg, Timothy Lautz, Archana Shenoy, Irit Maianski, Sireesha Yedururi, Kim Maxa, Brian D. Crompton, Lindsey Fricke, Zhong Su, Douglas James Harrison, Rajkumar Venkatramani
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Justin Oh, Paulina Gutkin, Sarah Donaldson, Robert Steffner, Matias Bruzoni, Raffi Avedian, Sheri Spunt, Allison Pribnow, Susan Hiniker
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2022)