Article
Oncology
Takaya Yamamoto, Yu Katagiri, Yoko Tsukita, Haruo Matsushita, Rei Umezawa, Yoshiyuki Katsuta, Noriyuki Kadoya, Noriyoshi Takahashi, Yu Suzuki, Kazuya Takeda, Keita Kishida, So Omata, Eisaku Miyauchi, Ryota Saito, Keiichi Jingu
Summary: This study evaluated the efficacy of a risk-adapted strategy of SRS for lung cancer, and the results showed a low rate of 3-year local recurrence and tolerable toxicity.
Article
Oncology
Nalee Kim, Jee Suk Chang, Chirag Shah, Hyejung Shin, Ki Chang Keum, Chang-Ok Suh, Yong Bae Kim
Summary: The study showed that for breast cancer patients undergoing adjuvant radiotherapy, HF-VMAT had significant advantages in reducing acute and late toxicities compared to CF-3D or HF-3D, especially in patients receiving regional node irradiation.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Chemistry, Physical
Yucel Saglam, Ugur Selek, Yasemin Bolukbasi
Summary: This study assessed the feasibility of using dynamic conformal arc (DCA) therapy as an alternative to volumetric-modulated arc therapy (VMAT) for the treatment of lung cancer. The results showed that WO-DCA plans can reduce treatment time and dose, protect organs, and improve treatment efficiency and quality.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Oncology
F. Deodato, D. Pezzulla, S. Cilla, M. Ferro, R. Giannini, C. Romano, M. Boccardi, M. Buwenge, V. Valentini, A. G. Morganti, G. Macchia
Summary: This study reports the final results of a dose-escalation study of VMAT-SRS boost in patients with spine metastases. The study found that a 12 Gy dose of SRS boost after 25 Gy to the affected and adjacent vertebrae resulted in excellent local control and survival rates without significant toxicity.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhigong Wei, Xingchen Peng, Ling He, Jingjing Wang, Zheran Liu, Jianghong Xiao
Summary: In this study, VMAT-based plans were found to significantly reduce the dose to organs at risk (OARs) and steepen the dose fall-off curves compared to IMRT-based plans in lung SBRT. Plans using 6-MV energy level performed better in terms of OARs dose and dose fall-off than those using 10-MV. The differences between VMAT and IMRT techniques were more obvious than those between different energy levels.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Na-Hyun Hwang, Myungsoo Kim, Nam Kwon Lee, Suk Lee, Jinho Hwang
Summary: This study compares the dosimetric effects of traditional metallic ports and RFID ports in post-mastectomy VMAT planning for left-sided breast cancer. The results demonstrate that RFID ports significantly reduce distortions on CT images and result in lower doses to the heart and lungs.
APPLIED SCIENCES-BASEL
(2022)
Article
Oncology
Gulsen Pinar Soydemir, Nazli Bilici, Elif Eda Tiken, Ayben Yentek Balkanay, Ali Firat Sisman, Didem Karacetin
Summary: By comparing dosimetric parameters for sparing the contralateral hippocampus in radiotherapy for brain tumors using IMRT and VMAT techniques, it was found that VMAT planning showed the best protection for the hippocampus, preserving cognitive functions. Patients undergoing radiotherapy may have a lower risk of hippocampal damage during treatment.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Article
Oncology
Fady Samir, Talaat M. Meaz, Fathi AEl Hussiny, Ahmed A. Ahmed, Amr A. Mahmoud, Tamer Refaat, Ahmed Gawish, Mohamed Abouegylah
Summary: The study compared four techniques in prostate treatment to find the preferred technique. Plans were created for 30 prostate cancer patients using different techniques, and the quality of the plans was assessed by comparing target coverage, organs at risk, monitor units, homogeneity, and conformity among the techniques.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Shengpeng Jiang, Yi Xue, Ming Li, Chengwen Yang, Daguang Zhang, Qingxin Wang, Jing Wang, Jie Chen, Jinqiang You, Zhiyong Yuan, Xiaochun Wang, Xiaodong Zhang, Wei Wang
Summary: This study investigated the use of artificial intelligence-based automated treatment planning to generate high-quality postmastectomy VMAT plans. The automated plans showed significant improvements in target volume uniformity and conformity, as well as dose to the heart and lungs compared to manual clinical plans.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Takuya Uehara, Hajime Monzen, Mikoto Tamura, Masahiro Inada, Masakazu Otsuka, Hiroshi Doi, Kenji Matsumoto, Yasumasa Nishimura
Summary: The study evaluated the clinical use of VMAT with Halcyon (TM) linac for TBI, showing promising results in terms of dosimetry and treatment efficiency. This new approach provides a potential alternative for TBI treatment, demonstrating feasibility and effectiveness in clinical application.
RADIATION ONCOLOGY
(2021)
Article
Otorhinolaryngology
Nikolett Buciuman, Loredana G. Marcu
Summary: A planning study compared dosimetric differences between IMRT and VMAT for head and neck cancer treatment, showing advantages in target coverage and organ protection for both techniques with distinct characteristics.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Oncology
Tsuyoshi Katsuta, Yuji Murakami, Daisuke Kawahara, Shota Miyoshi, Nobuki Imano, Junichi Hirokawa, Ikuno Nishibuchi, Yasushi Nagata
Summary: This study aimed to evaluate the impact of different respiratory motion patterns on the dose distribution in patients with lower esophageal cancer by creating virtual 4DCT images. The results showed that the proposed method could control the dose distribution within 3% in cases with diaphragm motion <= 15 mm.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Medicine, General & Internal
Fabrizio Tonetto, Alessandro Magli, Eugenia Moretti, Andrea Emanuele Guerini, Annarita Tullio, Chiara Reverberi, Tino Ceschia, Luigi Spiazzi, Francesca Titone, Agnese Prisco, Marco Andrea Signor, Michela Buglione, Gioacchino De Giorgi, Marco Trovo, Luca Triggiani
Summary: This study compares gastrointestinal (GI) and genitourinary (GU) toxicity rates among prostate cancer patients treated with image-guided volumetric modulated arc therapy (IG-VMAT) and IG-3D conformal radiation therapy (IG-3DCRT). Results show lower late GI and GU toxicity rates in the VMAT group, with overall low rates of G >= 2 toxicities. VMAT allowed for dose reduction to organs at risk, showing promising results in terms of organ sparing and reduced toxicity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pei-Chieh Yu, Ching-Jung Wu, Hsin-Hua Nien, Louis Tak Lui, Suzun Shaw, Yu-Lun Tsai
Summary: HVMAT is an innovative treatment planning technique that shows promising potential in reducing dose to organs at risk during adjuvant radiotherapy for gynecological cancers. It is recommended for pelvic irradiation, especially in the treatment of gynecological cancers, as it can reduce dose to multiple OARs simultaneously.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Multidisciplinary Sciences
Jongmoo Park, Jaehyeon Park, Sean Oh, Ji Woon Yea, Jeong Eun Lee, Jae Won Park
Summary: The study compared the efficacy of VMAT plans with and without multi-criteria optimization (MCO), finding that the MCO plan improved gross treatment volume coverage, reduced maximal dose, and improved dose distribution quality. In terms of OAR sparing, the MCO plan performed better by sacrificing tolerable dose to bilateral femoral heads for better protection of the rectum and bladder.
Article
Oncology
Luca Cozzi, Reynald Vanderstraeten, Antonella Fogliata, Feng-Ling Chang, Po-Ming Wang
Summary: The study demonstrates that a knowledge-based RapidPlan model was successfully trained and validated for IMPT in HCC patients, showing similar or superior results compared to manual planning. RapidPlan has the potential to optimize proton therapy outcomes and lessen the impact of operator planning skills on patient results.
STRAHLENTHERAPIE UND ONKOLOGIE
(2021)
Article
Oncology
Mauro Loi, Davide Franceschini, Luca Dominici, Ilaria Chiola, Ciro Franzese, Giuseppe Roberto D'Agostino, Piera Navarria, Marco Marzo, Lucia Paganini, Tiziana Comito, Pietro Mancosu, Stefano Tomatis, Luca Cozzi, Marco Alifano, Marta Scorsetti
Summary: The study assessed the determinants of efficacy and toxicity in oligometastatic patients with ultra-central lung tumors treated with SBRT. It found that V95% PTV > 85% and GTV < 90cm(3) were independent predictors of local control. It also highlighted the importance of carefully evaluating the dose to the esophagus, lung, and heart to minimize treatment-related toxicities.
STRAHLENTHERAPIE UND ONKOLOGIE
(2021)
Article
Oncology
Gerardo Rosati, Sara Lonardi, Fabio Galli, Maria Di Bartolomeo, Monica Ronzoni, Maria G. Zampino, Maria Banzi, Alberto Zaniboni, Felice Pasini, Silvia Bozzarelli, Silvio K. Garattini, Daris Ferrari, Vincenzo Montesarchio, Andrea Mambrini, Libero Ciuffreda, Francesca Galli, Valeria Pusceddu, Chiara Carlomagno, Paolo Bidoli, Domenico Amoroso, Anna M. Bochicchio, Luca Frassineti, Domenico Corsi, Domenico Bilancia, Alessandro Pastorino, Alfonso De Stefano, Roberto Labianca
Summary: Older patients receiving oxaliplatin-based adjuvant therapy have worse prognostic factors and reduced treatment compliance, leading to decreased efficacy.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Luca Cozzi, Sushil Beriwal, Esa Kuusela, Supriya Chopra, Hester Burger, Nanette Joubert, Antonella Fogliata, Jai Prakash Agarwal, Pat Kupelian
Summary: The study investigates a novel spatially fractionated radiation therapy (SFRT) method in the treatment of cervical cancer. The results show that this method can boost the cervix uteri while protecting organs at risk, and effectively increase dose inhomogeneity.
RADIATION ONCOLOGY
(2021)
Article
Oncology
D. Franceschini, A. Fogliata, R. Spoto, L. Dominici, L. Lo Faro, C. Franzese, T. Comito, F. Lobefalo, G. Reggiori, L. Cozzi, A. Sagona, D. Gentile, M. Scorsetti
Summary: This study reported the toxicity and cosmetic outcome of hypofractionated radiotherapy with VMAT and SIB for early-stage breast cancer after conservative surgery. After a median follow-up of 6 years, it was found that the treatment was effective with minimal toxicity, good cosmetic outcome, and improvement in cosmesis and breast pain.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Johannes Rosenbrock, Christian Baues, Andres Vasquez-Torres, Alessandro Clivio, Antonella Fogliata, Peter Borchmann, Simone Marnitz, Luca Cozzi
Summary: The study found that infra diaphragmatic intensity-modulated proton therapy (IMPT) and volumetric modulated arc therapy (VMAT) were equivalent in target coverage, but IMPT had a significant reduction in dose to organs at risk. IMPT demonstrated greater advantages in preventing secondary cancer and ovarian failure compared to VMAT.
Article
Oncology
Ciro Franzese, Luca Cozzi, Marco Badalamenti, Davide Baldaccini, Giuseppe D'Agostino, Antonella Fogliata, Pierina Navarria, Davide Franceschini, Tiziana Comito, Elena Clerici, Giacomo Reggiori, Stefano Tomatis, Marta Scorsetti
Summary: The study demonstrated the predictive capability of radiomics features in determining the risk of metastatic progression in high-risk prostate cancer patients. Combining radiomics features with clinical characteristics allowed for the stratification of high-risk patients into favorable and unfavorable prognostic groups.
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)
Article
Oncology
Pierina Navarria, Davide Baldaccini, Elena Clerici, Beatrice Marini, Luca Cozzi, Davide Franceschini, Alexia Francesca Bertuzzi, Vittorio Quagliuolo, Valter Torri, Piergiuseppe Colombo, Ciro Franzese, Luisa Bellu, Marta Scorsetti
Summary: This study aimed to assess the role of SBRT in patients with lung metastases. The results showed that SBRT can effectively control lung metastases with minimal toxicity, and the overall survival rate was satisfactory.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Tanweer Shahid, Sourav Mandal, Subhra Snigdha Biswal, Arundhati De, Mukti Mukherjee, Sandipan Roy Chowdhury, Anupam Chakrapani, Kirubha George, Jibak Bhattacharya, Prosenjit Soren, Tanmoy Ghosh, Biplab Sarkar, Luca Cozzi
Summary: This study aims to validate and provide the first clinical treatment of total bone marrow irradiation (TMI) and total bone marrow and lymph nodal irradiation (TMLI) using the Halcyon-E ring gantry linear accelerator. Only one patient received the TMLI treatment, while the other three patients dropped out due to clinical complications. The results showed that the dose distribution was within acceptable limits for the PTV and important organs.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Davide Franceschini, Luca Cozzi, Antonella Fogliata, Beatrice Marini, Luciana Di Cristina, Luca Dominici, Ruggero Spoto, Ciro Franzese, Pierina Navarria, Tiziana Comito, Giacomo Reggiori, Stefano Tomatis, Marta Scorsetti
Summary: The study investigated the performance of a narrow-scope knowledge-based RapidPlan model for intensity-modulated proton therapy and volumetric modulated arc therapy plans applied to pleural mesothelioma patients. The results showed that IMPT plans outperformed VMAT plans for all organs at risk (OARs). RP-based planning enables the automation of part of the optimization process and harmonization of dose-volume results. Using an RP-based approach can simplify the optimization workflow without impacting the plan quality for these complex treatment indications.
RADIATION ONCOLOGY
(2022)
Article
Oncology
D. Franceschini, L. Cozzi, V. Vernier, A. M. Marzo, B. Marini, S. Stefanini, P. Navarria, M. Scorsetti
Summary: The purpose of this study was to identify factors associated with poly-progression in patients receiving SRT for OMD. The study found four independent factors associated with poly-progression in these patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Otorhinolaryngology
Ciro Franzese, Sara Lillo, Luca Cozzi, Maria Ausilia Teriaca, Marco Badalamenti, Luciana Di Cristina, Veronica Vernier, Sara Stefanini, Damiano Dei, Stefano Pergolizzi, Armando De Virgilio, Giuseppe Mercante, Giuseppe Spriano, Pietro Mancosu, Stefano Tomatis, Marta Scorsetti
Summary: In this study, novel radiomics- and clinical-based predictive models were developed to predict survival and radiation therapy response in head and neck cancer with metastatic lymph nodes. The results showed that radiomic and clinical features were independent predictive factors with significant predictive value for locoregional failure, progression-free survival, and overall survival.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Meeting Abstract
Oncology
D. Franceschini, L. Cozzi, L. Lo Faro, A. Marzo, L. Di Cristina, B. Marini, C. Franzese, C. Galdieri, M. Scorsetti
RADIOTHERAPY AND ONCOLOGY
(2022)
Meeting Abstract
Oncology
A. Fogliata, S. Parabicoli, G. Reggiori, L. Paganini, F. Lobefalo, L. Cozzi, S. Tomatis, M. Scorsetti
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Ciro Franzese, Antonella Fogliata, Mauro Loi, Marco Badalamenti, Davide Franceschini, Tiziana Comito, Luca Cozzi, Giacomo Reggiori, Stefano Tomatis, Marta Scorsetti
Summary: The study evaluated the toxicity and outcomes of nasopharyngeal carcinoma patients treated with 3DCRT or VMAT technique, showing that VMAT had significant benefits in terms of side effects compared to 3DCRT, with higher dosimetric correlations.
REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY
(2021)