Review
Clinical Neurology
Diogo Alpuim Costa, Mafalda Sampaio-Alves, Eduardo Netto, Goncalo Fernandez, Edson Oliveira, Andreia Teixeira, Pedro Modas Daniel, Guilherme Silva Bernardo, Carla Amaro
Summary: Glioblastoma (GBM) is a common and aggressive brain tumor with poor treatment outcomes. Recent studies suggest that hyperbaric oxygen therapy (HBOT) may enhance the sensitivity of anticancer therapies by increasing oxygen tension within the tumor tissue, potentially improving the treatment outcomes for GBM.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nasser K. Yaghi, Mark R. Gilbert
Summary: This review examines the challenges faced by immunotherapies in treating glioblastoma, explores current treatment options, and proposes future directions for GBM immunotherapy.
Review
Oncology
AmirAhmad Arabzadeh, Tohid Mortezazadeh, Tayebeh Aryafar, Esmaeil Gharepapagh, Mehrsa Majdaeen, Bagher Farhood
Summary: Glioblastoma is an aggressive type of brain tumor with resistance to conventional therapies. Resveratrol, a natural polyphenolic compound, has shown to have anti-tumoral effects by regulating various cellular pathways such as cell cycle progression, autophagy, and apoptosis. Studies have also explored the potential of using resveratrol in combination with radiation therapy and chemotherapy for glioblastoma treatment.
CANCER CELL INTERNATIONAL
(2021)
Review
Oncology
Li Yanchu, Pu Rong, Cao Rong, Zhang Li, Yang Xiaoyan, Wang Feng
Summary: High-grade gliomas are aggressive brain tumors that are difficult to treat. Ozone therapy has shown promising results in preclinical studies and clinical trials for various cancers, but there have been limited studies on gliomas. Optimizing the dosage and timing of ozone therapy remains a challenge. This study provides an overview of ozone therapy in high-grade gliomas, including its mechanisms of action and clinical evidence.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chun-Man Yuen, Hung-Pei Tsai, Tzu-Ting Tseng, Yu-Lung Tseng, Ann-Shung Lieu, Aij-Lie Kwan, Alice Y. W. Chang
Summary: This study evaluated the effects of hyperbaric oxygen (HBO) therapy on glioblastoma multiforme (GBM). The results showed that HBO therapy reduced GBM's ability to form cancer stem cells and increased its sensitivity to chemotherapy and radiotherapy. This suggests that HBO therapy may serve as an adjuvant treatment for GBM.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Zhiguo Li, Xiaotong Fan, Zheng Luo, Xian Jun Loh, Yedong Ma, Enyi Ye, Yun-Long Wu, Chaobin He, Zibiao Li
Summary: The authors developed a multifunctional nanoenzyme-chitosan hydrogel complex to improve the microenvironment of diabetic wounds and provide continuous oxygen delivery. By reducing glucose and reactive oxygen species concentrations and promoting cell proliferation, migration, and angiogenesis, the complex significantly accelerated diabetic wound healing.
Article
Cardiac & Cardiovascular Systems
Romain Guenneugues, Anne Henckes, Vincent Mansourati, Jacques Mansourati
Summary: This study evaluated the effects of hyperbaric oxygen therapy on implantable cardioverter-defibrillators (ICD) and found no mechanical or electronic damage. These findings may lead to a reconsideration of the contraindication of emergency hyperbaric oxygen therapy for ICD recipients.
Article
Oncology
Antonio Moreira Monteiro, Diogo Alpuim Costa, Virginia Mareco, Carla Espiney Amaro
Summary: This study evaluated the effectiveness and safety of hyperbaric oxygen therapy (HBOT) for radiation-induced proctitis (RIP). The results showed that HBOT had a significant therapeutic effect on RIP, relieving symptoms and improving patients' quality of life.
FRONTIERS IN ONCOLOGY
(2023)
Review
Gastroenterology & Hepatology
Diogo Alpuim Costa, Carla Espiney Amaro, Ana Nunes, Joana Santos Cardoso, Pedro Modas Daniel, Isabel Rosa, Joao Vieira Branco
Summary: Radiotherapy is a common treatment for cancer, but it may lead to late complications such as radiation proctitis (RP). Management of RP is challenging and may include hyperbaric oxygen therapy (HBOT), although the effectiveness of HBOT remains uncertain. More prospective and randomized studies are needed to determine the true impact of HBOT on RP treatment.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
F. J. Dieleman, G. J. Meijer, M. A. W. Merkx
Summary: An online survey conducted among Dutch oral and maxillofacial surgery units revealed controversy over the use and efficacy of HBO in treating ORN. The study showed a trend towards experienced units using HBOT to cure ORN, indicating a possible centralization of ORN care to these units.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Oncology
Clara Gaio-Lima, Joao Castedo, Mafalda Cruz, Margarida Candeias, Oscar Camacho
Summary: Cancer remains a leading cause of death worldwide, with a significant number of patients experiencing late radiation injuries. Hyperbaric oxygen therapy has been shown to be an effective complementary treatment for refractory radiation lesions.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Clinical Neurology
Pierina Navarria, Federico Pessina, Elena Clerici, Zefferino Rossini, Davide Franceschini, Giuseppe D'Agostino, Ciro Franzese, Tiziana Comito, Mauro Loi, Matteo Simonelli, Elena Lorenzi, Pasquale Persico, Letterio Salvatore, Marco Grimaldi, Lorenzo Bello, Armando Santoro, Maurizio Fornari, Franco Servadei, Marta Scorsetti
Summary: In addition to IDH status, the extent of resection and residual tumor volume have been shown to significantly impact survival. Sequential radio-chemotherapy was found to be the more effective treatment option.
JOURNAL OF NEUROSURGERY
(2021)
Article
Biochemistry & Molecular Biology
Clement Leveque, Simona Mrakic Sposta, Sigrid Theunissen, Peter Germonpre, Kate Lambrechts, Alessandra Vezzoli, Gerardo Bosco, Morgan Levenez, Pierre Lafere, Francois Guerrero, Costantino Balestra
Summary: Hyperbaric oxygen therapy (HBOT) is a treatment method that exposes the body to pure oxygen at increased atmospheric pressure. This study investigated the metabolic responses to hyperbaric hyperoxia exposures at 1.4 and 2.5 ATA for 1 hour. The results showed that both mild and high hyperbaric hyperoxia led to a significant increase in the production of reactive oxygen species (ROS) and antioxidant reactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Justyna Podgorska-Bednarz, Lidia Perenc
Summary: The review found that hyperbaric oxygen therapy (HBOT) is not significantly effective in treating autism spectrum disorder (ASD). Most literature reviews and intervention study results do not recommend the use of this therapy in children with ASD.
Article
Biochemistry & Molecular Biology
Tania Cemeli, Marta Guasch-Valles, Marina Ribes-Santolaria, Eva Ibars, Raul Navaridas, Xavier Dolcet, Neus Pedraza, Neus Colomina, Jordi Torres-Rosell, Francisco Ferrezuelo, Judit Herreros, Eloi Gari
Summary: This study found that the downregulation of Ral GTPases, especially RalB, can inhibit the proliferation of primary GBM cells and trigger a senescence-like response. Additionally, downregulation of RalA and RalB reduces the viability of GBM cells growing as tumorspheres, suggesting a possible role of these GTPases in the survival of GBM stem cells. Mouse xenograft experiments confirmed the role of RalB in GBM growth. Furthermore, the knockdown of RalB also inhibits cell growth in temozolomide-resistant GBM cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Shinji Yamashita, Hideo Takeshima, Yoshihito Kadota, Minako Azuma, Tsuyoshi Fukushima, Natsuki Ogasawara, Tomoki Kawano, Mitsuru Tamura, Jyunichiro Muta, Kiyotaka Saito, Go Takeishi, Asako Mizuguchi, Takashi Watanabe, Hajime Ohta, Kiyotaka Yokogami
Summary: The T2-FLAIR mismatch sign is a promising method for detecting IDH mut-Noncodel LGGs but has low sensitivity, possibly associated with enlarged intercellular space and overexpression of mTOR-related genes.
BRAIN TUMOR PATHOLOGY
(2022)
Article
Clinical Neurology
Tomohisa Ishida, Takashi Inoue, Tomoo Inoue, Atsushi Saito, Shinsuke Suzuki, Hiroshi Uenohara, Teiji Tominaga
Summary: This study aimed to evaluate the prognosis of surgery for chronic subdural hematoma (CSDH) and identify factors affecting the outcome. The study found that older age, poorer pre-hospital functional score, and preoperative consciousness disturbance were significant predictors of poor recovery after CSDH. The choice of operative procedure did not have a significant impact on functional outcome or recurrence, but irrigation was associated with an increased risk of postoperative delirium and longer hospital stay.
NEUROLOGIA MEDICO-CHIRURGICA
(2022)
Article
Respiratory System
Hiroyuki Sugawara, Atsushi Saito, Saori Yokoyama, Kazunori Tsunematsu, Hirofumi Chiba
Summary: This study investigated the factors associated with annual decline in forced expiratory volume in one second (FEV1) in patients with chronic obstructive pulmonary disease (COPD). The study found that smoking, pneumonia, and asthma were risk factors for the progression of COPD.
BMC PULMONARY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Toshiya Morozumi, Yohei Nakayama, Satoshi Shirakawa, Kentaro Imamura, Kaname Nohno, Takatoshi Nagano, Haruna Miyazawa, Takahiro Hokari, Ryo Takuma, Shuntaro Sugihara, Kazuhiro Gomi, Atsushi Saito, Yorimasa Ogata, Motohiro Komaki
Summary: This prospective pilot study aimed to evaluate the effect of minocycline-HCl ointment (MO) as an adjunct to scaling and root planing (SRP) on subgingival microflora. The results showed that the combination therapy of SRP and local MO significantly reduced the subgingival microbial counts, especially Veillonella species.
Article
Oncology
Hiroji Uemura, Kazuki Kobayashi, Akira Yokomizo, Shiro Hinotsu, Shigeo Horie, Yoshiyuki Kakehi, Norio Nonomura, Osamu Ogawa, Mototsugu Oya, Kazuhiro Suzuki, Atsushi Saito, Keiko Asakawa, Satoshi Uno, Seiji Naito
Summary: This study compared the HRQoL benefit of enzalutamide plus ADT and flutamide plus ADT in the treatment of patients with CRPC. The results showed no significant difference in HRQoL between the two groups during first-line treatment.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Psychiatry
Sun -Hong Kim, Kyongman An, Ho Namkung, Atsushi Saito, Matthew D. Rannals, James R. Moore, Marina Mihaljevic, Sneha Saha, Seyun Oh, Mari A. Kondo, Koko Ishizuka, Kun Yang, Brady J. Maher, Minae Niwa, Akira Sawa
Summary: This study aims to fill the gap in the neurobiological mechanisms of the anterior insula for social cognition. The results show that the anterior insula plays a crucial role in the recognition of social novelty mediated by a local retinoic acid cascade and a remote oxytocin mechanism.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Oncology
Mitsuru Tamura, Kiyotaka Yokogami, Takashi Watanabe, Tomoki Kawano, Junichiro Muta, Shinji Yamashita, Nobuyuki Oguri, Yuichiro Sato, Hideo Takeshima
Summary: Malignant craniopharyngioma is a rare condition, and the molecular genetic characteristics of malignant transformation in this type of tumor have not been well explained. This study investigated the genetic mutations associated with malignant transformation in a case of recurrent craniopharyngioma. The findings suggest that genetic mutations in PBRM1 and BAP1 may play a role in the malignant transformation of adamantinomatous craniopharyngioma.
BRAIN TUMOR PATHOLOGY
(2023)
Article
Neurosciences
Ho Namkung, Hiroshi Yukitake, Daisuke Fukudome, Brian J. Lee, Mengnan Tian, Gianluca Ursini, Atsushi Saito, Shravika Lam, Suvarnambiga Kannan, Rupali Srivastava, Minae Niwa, Kamal Sharma, Peter Zandi, Hanna Jaaro-Peled, Koko Ishizuka, Nilanjan Chatterjee, Richard L. Huganir, Akira Sawa
Summary: This study identifies the miR-124-3p-AMPAR pathway as a key neurobiological mediator that connects the shared polygenic risks and behavioral changes between schizophrenia and bipolar disorder. Upregulation of miR-124-3p is found in neuronal cells and the prefrontal cortex of both schizophrenia and bipolar disorder patients, and this upregulation is associated with the shared polygenic risks between the two disorders. Experimental findings in mice demonstrate that upregulation of miR-124-3p increases GRIA2-lacking calcium-permeable AMPARs, leading to deficits in shared behavioral dimensions.
Article
Clinical Neurology
Takashi Watanabe, Hisao Uehara, Go Takeishi, Hideki Chuman, Minako Azuma, Kiyotaka Yokogami, Hideo Takeshima
Summary: This study proposes a system based on the optic recess displacement pattern to select surgical approaches for craniopharyngiomas. The involvement type showed better visual and endocrinologic outcomes compared to the other types. Therefore, the authors suggest using the translamina terminalis approach for craniopharyngiomas with the involvement type for the best surgical outcome.
WORLD NEUROSURGERY
(2023)
Article
Oncology
Natsuki Ogasawara, Shinji Yamashita, Koji Yamasaki, Tomoki Kawano, Tomohiro Kawano, Junichiro Muta, Fumitaka Matsumoto, Takashi Watanabe, Hajime Ohta, Kiyotaka Yokogami, Tsuyoshi Fukushima, Yuichiro Sato, Hideo Takeshima
Summary: This article reports a case of malignant peripheral nerve sheath tumors (MPNSTs) of the trigeminal nerve caused by the malignant transformation of a trigeminal schwannoma. Genetic considerations revealed that only the recurrent MPNST sample had genetic mutations, while the initial diagnosis of schwannoma did not. Additionally, the fusion of SH3PXD2A and HTRA1, a common genetic aberration of schwannoma, was detected in the recurrent tumor. The study provides insights into the accumulation of gene abnormalities in the development of MPNSTs from schwannomas.
BRAIN TUMOR PATHOLOGY
(2023)
Article
Engineering, Biomedical
Atsushi Saito, Kanji Hirashima, Rie Ikeda, Kiyomi Ogawa, Sumie Sato, Ken-ichiro Kikuchi
Summary: Epithelial-mesenchymal interactions mediate the development of the submandibular gland. The postnatal development involves changes in the expression and localization of Jmjd3, an epigenetic modifier. The study demonstrates the development and differentiation of the mouse submandibular gland tissue, accompanied by significant changes in Jmjd3 expression and localization during the early postnatal period.
JOURNAL OF HARD TISSUE BIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Tasuku Murakami, Kentaro Imamura, Naoko Watanabe-Egawa, Sachiyo Tomita, Atsushi Saito
Summary: This report presents a case of generalized chronic periodontitis that was successfully treated with regenerative therapy. The patient showed significant improvement after undergoing a combination of periodontal treatments.
BULLETIN OF TOKYO DENTAL COLLEGE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yurie Kitamura, Hideto Aoki, Atsushi Saito
Summary: This report describes a case of generalized chronic periodontitis requiring periodontal treatment, including surgery. The patient underwent initial periodontal therapy and open flap debridement, resulting in significant improvement.
BULLETIN OF TOKYO DENTAL COLLEGE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Saki Nakane-Koyachi, Kentaro Imamura, Atsushi Saito
Summary: This report describes a case of generalized chronic periodontitis that required periodontal regeneration therapy. By implementing periodontal and surgical treatment, the patient's periodontal condition significantly improved and remained stable after two years.
BULLETIN OF TOKYO DENTAL COLLEGE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Juri Iwaki, Kentaro Imamura, Kobun Tanaka, Hiroki Sugito, Atsushi Saito
Summary: This report presents a case of generalized chronic periodontitis treated with periodontal regenerative therapy using GTR and rhFGF-2, resulting in stable periodontal conditions.
BULLETIN OF TOKYO DENTAL COLLEGE
(2022)
