Article
Oncology
Masanori Yoshida, Kazuhiko Nakabayashi, Wentao Yang, Aiko Sato-Otsubo, Shin-ichi Tsujimoto, Hiroko Ogata-Kawata, Tomoko Kawai, Keisuke Ishiwata, Mika Sakamoto, Kohji Okamura, Kaoru Yoshida, Ryota Shirai, Tomoo Osumi, Chikako Kiyotani, Yoko Shioda, Keita Terashima, Sae Ishimaru, Yuki Yuza, Masatoshi Takagi, Yuki Arakawa, Toshihiko Imamura, Daisuke Hasegawa, Akiko Inoue, Takako Yoshioka, Shuichi Ito, Daisuke Tomizawa, Katsuyoshi Koh, Kimikazu Matsumoto, Nobutaka Kiyokawa, Seishi Ogawa, Atsushi Manabe, Akira Niwa, Kenichiro Hata, Jun J. Yang, Motohiro Kato
Summary: This study revealed that 35.7% of pediatric patients with SMNs had pathogenic germline variants in cancer-predisposing genes (CPGs), suggesting the association between genetic variation and the development of SMNs after treatment of pediatric solid tumors.
Article
Oncology
Nan Song, Qi Liu, Carmen L. Wilson, Yadav Sapkota, Matthew J. Ehrhardt, Todd M. Gibson, Lindsay M. Morton, Stephen J. Chanock, Joseph P. Neglia, Michael A. Arnold, J. Robert Michael, Alexander M. Gout, Heather L. Mulder, John Easton, Smita Bhatia, Gregory T. Armstrong, Jinghui Zhang, Angela Delaney, Melissa M. Hudson, Leslie L. Robison, Yutaka Yasui, Zhaoming Wang
Summary: The study evaluated the polygenic contributions to subsequent thyroid cancer (STC) risk and found that integrating the polygenic risk score with clinical factors significantly improved the risk prediction of STC. This suggests the potential utility of polygenic risk score for optimizing screening strategies in survivorship care.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Gastroenterology & Hepatology
Sandra Baile-Maxia, Carolina Mangas-Sanjuan, Uri Ladabaum, Cesare Hassan, Matthew D. Rutter, Michael Bretthauer, Licia Medina-Prado, Noelia Sala-Miquel, Oscar Murcia Pomares, Pedro Zapater, Rodrigo Jover
Summary: This study aimed to assess the association between HRA characteristics and the outcomes of CRC or AAs surveillance. The study found that adenomas larger than 20mm, high-grade dysplasia (HGD), and adenomas with villous component were associated with higher risk of metachronous CRC. However, multiplicity of adenomas did not seem to be significantly associated with higher CRC risk in the near term.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Multidisciplinary Sciences
Meihua Jin, Ahreum Jang, Won Gu Kim, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Min Ji Jeon
Summary: Graves' disease can occur after lobectomy for thyroid cancer, although it is rare. It is important to properly evaluate and manage this condition during postoperative follow-up.
Article
Veterinary Sciences
Kate Burbery, Olivier Simon, Lucy Woolford, Gustavo Ferlini Agne
Summary: This is a case report of bilateral thyroid adenomas in an alpaca, which was treated with chemical ablation with effective results and no apparent adverse effects. It is the first known report of this condition in alpacas.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Jun Park, Hyunju Park, Tae Hyuk Kim, Sun Wook Kim, Hye Won Jang, Jae Hoon Chung
Summary: This study analyzed the trends of childhood thyroid cancer in Korean between 1999 and 2017, finding an increase in incidence rate, especially in the 14-18 age group. Factors such as seaweed intake, medical examinations, obesity prevalence, and lifestyle choices were identified as potential contributors to the rising rates of thyroid cancer in Korean children.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Armida Sodo, Martina Verri, Andrea Palermo, Anda Mihaela Naciu, Marialuisa Sponziello, Cosimo Durante, Michael Di Gioacchino, Alessio Paolucci, Alessandra di Masi, Filippo Longo, Pierfilippo Crucitti, Chiara Taffon, Maria Antonietta Ricci, Anna Crescenzi
Summary: This study analyzed molecular differences between follicular thyroid adenomas with malignant spectroscopic profiles and those with benign Raman spectra. Results showed expression of malignancy-associated proteins in malignant clustered adenomas, with one example exhibiting a TSHR mutation. This suggests the potential predictive value of spectroscopic assessment in recognizing characteristics associated with tumor progression in follicular thyroid neoplasms.
Article
Oncology
Trausti Oskarsson, Anne Katrine Duun-Henriksen, Andrea Bautz, Scott Montgomery, Arja Harila-Saari, Cecilia Petersen, Riitta Niinimaki, Laura Madanat-Harjuoja, Laufey Tryggvadottir, Anna Sallfors Holmqvist, Henrik Hasle, Mats Heyman, Jeanette Falck Winther
Summary: The study identified 26,334 childhood cancer survivors diagnosed before the age of 20, and found a higher risk of hospital admissions for skeletal adverse events in these survivors. The risks of osteonecrosis, osteoporosis, fractures, osteochondropathies, and osteoarthrosis were all increased among the survivors. Understanding the different lifetime patterns of skeletal adverse events and identifying high-risk groups is crucial for optimizing skeletal health in childhood cancer survivors.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Laura K. Seppaelae, Laura-Maria Madanat-Harjuoja, Maarit K. Leinonen, Mitja Laeaeperi, Kim Vettenranta
Summary: Maternal hypothyroidism may increase the risk of childhood lymphoma in offspring, and this association persists even after excluding possible familial cancers.
Article
Surgery
Christopher Webb, Patricia Cronin, Nikita Gupta, Jens Verhey, Esteban Calderon, Adyr Moss, Amit K. Mathur, Barbara Pockaj, Nabil Wasif, Chee-Chee Stucky
Summary: The study found that solid organ transplantation does not significantly impact the survival outcomes and recurrence rates of patients with thyroid cancer. Discovery of thyroid disease during transplant screening should not be a contraindication for transplant listing.
Review
Endocrinology & Metabolism
Mariacarla Moleti, Tommaso Aversa, Salvatore Crisafulli, Gianluca Trifiro, Domenico Corica, Giorgia Pepe, Laura Cannavo, Maria Di Mauro, Giuseppe Paola, Andrea Fontana, Fabrizio Calapai, Salvatore Cannavo, Malgorzata Wasniewska
Summary: Differentiated thyroid cancer (DTC) is rare in childhood and adolescence but represents the most frequent endocrine malignancy in this population. This systematic review and meta-analysis aimed to estimate the overall incidence and prevalence of DTCs in patients aged 0-19 years. The study found that PTC is the most common histological type of DTC in children, and the implementation of a prospective international registry on pediatric DTC is proposed.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Alan C. C. Geller, Adina Coroiu, Robyn R. R. Keske, Sebastien Haneuse, Jessica A. A. Davine, Karen M. M. Emmons, Casey L. L. Daniel, Todd M. M. Gibson, Aaron J. J. McDonald, Leslie L. L. Robison, Ann C. C. Mertens, Elena B. B. Elkin, Ashfaq Marghoob, Gregory T. T. Armstrong
Summary: A comparative effectiveness trial was conducted to improve skin cancer screening among childhood cancer survivors treated with radiotherapy. The results showed that all three intervention groups had significant increases in skin cancer screening rates, but there were no differences between the groups. Any of these interventions could improve skin cancer prevention behaviors among childhood cancer survivors.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Medicine, General & Internal
Debbie W. Chen, Brian H. H. Lang, Donald S. A. McLeod, Kate Newbold, Megan R. Haymart
Summary: The past 5-10 years have seen significant advancements in the diagnosis and management of thyroid cancer, including ultrasound-based risk stratification systems, less invasive alternatives to surgery, and the availability of new systemic therapies for advanced cases. However, disparities in thyroid cancer care still exist, highlighting the importance of population-based studies and inclusive research to address barriers to equitable care.
Article
Endocrinology & Metabolism
Jun Choul Lee, Byong-Sop Song, Young Mi Kang, Yu-Ri Kim, Yea Eun Kang, Ju Hee Lee, Minho Shong, Hyon-Seung Yi
Summary: The study found a correlation between TSH concentration and muscle mass, muscle function related parameters in DTC patients undergoing TSH suppression therapy. Particularly, low TSH concentration was associated with decreased grip strength, especially in male patients under 70 years old.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Yifei Ma, Bocen Chen, Yanqi Wang, Pengfei Zhu, Nianqi Liu, Zhiying Zhang, Guanqing Zhong, Guangzhen Fu, Dao Wang, Lu Cao, Shenrui Bai, Youlong Wang, Shuqin Chen, Xiaolong Wei, Jun Lv, Ao Zhang, Xinjia Wang
Summary: This study investigated the immune response and safety of SARS-CoV-2 vaccines in childhood cancer patients (CCP). The results showed that CCP had a weaker immune response to the variants of concern (VOCs) compared to adult cancer patients (ACP) and healthy children. Age and chemotherapy time were identified as the main factors contributing to the poor response in CCP. The vaccine was generally safe with mild adverse events that were well-managed.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Ceren Sunguc, Michael M. Hawkins, David L. Winter, Isabelle M. Dudley, Emma J. Heymer, Jop C. Teepen, Rodrigue S. Allodji, Fabien N. Belle, Francesca Bagnasco, Julianne Byrne, Edit Bardi, Cecile M. Ronckers, Nadia Haddy, Thorgerdur Gudmundsdottir, Stanislaw Garwicz, Momcilo Jankovic, Helena J. H. van der Pal, Maja Cesen Mazic, Christina Schindera, Desiree Grabow, Milena M. Maule, Peter Kaatsch, Melanie Kaiser, Brice Fresneau, Gisela Michel, Roderick Skinner, Thomas Wiebe, Carlotta Sacerdote, Zsuzsanna Jakab, Maria Winther Gunnes, Monica Terenziani, Jeanette F. Winther, Paivi M. Lahteenmaki, Lorna Zadravec Zaletel, Claudia E. Kuehni, Leontien C. Kremer, Riccardo Haupt, Florent de Vathaire, Lars Hjorth, Raoul C. Reulen
Summary: Childhood cancer survivors are at higher risk of developing salivary gland and tongue cancers, particularly those who have received radiotherapy or chemotherapy.
BRITISH JOURNAL OF CANCER
(2023)
Review
Oncology
Thi-Van-Trinh Tran, Cari Meinhold Kitahara, Laurence Leenhardt, Florent de Vathaire, Marie-Christine Boutron-Ruault, Neige Journy
Summary: In this updated meta-analysis, an association between hyperthyroidism and increased breast cancer risk, as well as no association between hypothyroidism and breast cancer risk, was found. Menopausal status and blood levels of thyroid-stimulating hormone (TSH) and thyroid hormones were found to modify this association.
ENDOCRINE-RELATED CANCER
(2023)
Article
Oncology
Esmee C. de Baat, Elizabeth A. M. Feijen, Raoul C. Reulen, Rodrigue S. Allodji, Francesca Bagnasco, Edit Bardi, Fabien N. Belle, Julianne Byrne, Elvira C. van Dalen, Ghazi Debiche, Ibrahima Diallo, Desiree Grabow, Lars Hjorth, Momcilo Jankovic, Claudia E. Kuehni, Gill Levitt, Damien Llanas, Jacqueline Loonen, Lorna Z. Zaletel, Milena M. Maule, Lucia Miligi, Helena J. H. van der Pal, Cecile M. Ronckers, Carlotta Sacerdote, Roderick Skinner, Zsuzsanna Jakab, Cristina Veres, Nadia Haddy, David L. Winter, Florent de Vathaire, Michael M. Hawkins, Leontien C. M. Kremer
Summary: This study evaluated the risk and risk factors for heart failure in childhood cancer survivors and highlighted the impact of radiation therapy and anthracycline dose on the risk. These findings may have important implications for improving current treatment protocols and surveillance guidelines.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Isabelle M. Dudley, Ceren Sunguc, Emma J. Heymer, David L. Winter, Jop C. Teepen, Fabien N. Belle, Edit Bardi, Francesca Bagnasco, Thorgerdur Gudmundsdottir, Roderick Skinner, Gisela Michel, Julianne Byrne, Hilde Ofstaas, Momcilo Jankovic, Maja Cesen Mazic, Luzius Mader, Jaqueline Loonen, Stanislaw Garwicz, Thomas Wiebe, Daniela Alessi, Rodrigue S. Allodji, Nadia Haddy, Desiree Grabow, Peter Kaatsch, Melanie Kaiser, Milena M. Maule, Zsuzsanna Jakab, Maria Winther Gunnes, Monica Terenziani, Lorna Zadravec Zaletel, Claudia E. Kuehni, Riccardo Haupt, Florent de Vathaire, Leontien C. Kremer, Paivi M. Lahteenmaki, Jeanette F. Winther, Lars Hjorth, Michael M. Hawkins, Raoul C. Reulen
Summary: This study found that survivors of Hodgkin lymphoma (HL) are at an increased risk of developing non-Hodgkin lymphoma (NHL) after treatment. The researchers also identified other types of childhood cancer survivors who are at risk of developing NHL, including survivors of Wilms tumor, leukemia, and bone sarcoma. Treatment with chemotherapy increased the risk of NHL, while treatment with radiotherapy did not.
Article
Oncology
Thomas Sarrade, Rodrigue Allodji, Youssef Ghannam, Guillaume Auzac, Sibille Everhard, Youlia Kirova, Karine Peignaux, Philippe Guilbert, David Pasquier, Severine Racadot, Celine Bourgier, Sandrine Ducornet, Fabrice Andre, Florent De Vathaire, Sofia Rivera
Summary: The manuscript describes the methodology and the characterization of the study population and radiation therapy (RT) data in CANTO-RT (Cancer Toxicities RadioTherapy). This study is the largest available multicenter cohort of early breast cancer with full DICOM RT data, aiming to identify predictors of long-term toxicities in breast cancer patients.
Article
Medicine, General & Internal
Philip C. Haycock, Maria Carolina Borges, Kimberley Burrows, Rozenn N. Lemaitre, Stephen Burgess, Nikhil K. Khankari, Konstantinos K. Tsilidis, Tom R. Gaunt, Gibran Hemani, Jie Zheng, Therese Truong, Brenda M. Birmann, Tracy OMara, Amanda B. Spurdle, Mark M. Iles, Matthew H. Law, Susan L. Slager, Fatemeh Saberi Hosnijeh, Daniela Mariosa, Michelle Cotterchio, James R. Cerhan, Ulrike Peters, Stefan Enroth, Puya Gharahkhani, Loic Le Marchand, Ann C. Williams, Robert C. Block, Christopher I. Amos, Rayjean J. Hung, Wei Zheng, Marc J. Gunter, George Davey Smith, Caroline Relton, Richard M. Martin
Summary: Using Mendelian randomization, this study found that polyunsaturated fatty acids (PUFAs) may be causally related to colorectal cancer and esophageal squamous cell carcinoma, but they also increase the risk of inflammatory bowel disease.
Article
Oncology
Stefania Chounta, Rodrigue Allodji, Maria Vakalopoulou, Mahmoud Bentriou, Duyen Thi Do, Florent De Vathaire, Ibrahima Diallo, Brice Fresneau, Thibaud Charrier, Vincent Zossou, Stergios Christodoulidis, Sarah Lemler, Veronique Letort Le Chevalier
Summary: Childhood cancer survivors are at risk of experiencing late effects due to treatment complications, including Valvular Heart Disease (VHD) caused by radiation leakage during radiotherapy. This study explores the use of machine learning algorithms to accurately predict the risk of late VHD in survivors. The results show that the use of dosiomics features significantly improves the predictive capability of the models, especially in the sub-population with spatially heterogeneous dose distribution.
Article
Oncology
Afi Mawulawoe Sylvie Henyoh, Rodrigue S. S. Allodji, Florent de Vathaire, Marie-Christine Boutron-Ruault, Neige M. Y. Journy, Thi-Van-Trinh Tran
Review
Oncology
Nathan Benzazon, Julie Colnot, Francois de Kermenguy, Samir Achkar, Florent de Vathaire, Eric Deutsch, Charlotte Robert, Ibrahima Diallo
Summary: A growing body of scientific evidence suggests that low doses of ionizing radiation (< 2 Gy) can increase the risk of radiation-induced cancer and have significant impacts on immune responses. This has led to a renewed interest in evaluating the out-of-field dose in photon radiotherapy, with a focus on analytical models for calculation purposes. However, there is a lack of consensus and standardization in practices and metrics, making quantitative comparisons difficult. The use of neural networks shows promise in overcoming these limitations, but the lack of sufficient data sets is a major obstacle.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Florent de Vathaire, Monia Zidane, Constance Xhaard, Vincent Souchard, Sylvie Chevillard, Catherine Ory, Frederique Rachedi, Sebastien Nunez, Axelle Leufroy, Laurent Noel, Thierry Guerin, Larys Shan, Frederique Bost-Bezeaud, Patrice Petitdier, Gilles Soubiran, Rodrigue Allodji, Yan Ren, Francoise Doyon, Marc Taquet, Jacques Gardon, Andre Bouville, Vladimir Drozdovitch
Summary: This study examines the association between radiation exposure from French nuclear tests and the risk of thyroid cancer. The results suggest that there is an increase in the risk of thyroid cancer, although the credibility of the findings is reduced due to inconsistencies with the initial study. The lifetime risk of thyroid cancer in the population of French Polynesia is estimated to be 2.3%.
Article
Economics
Daniel Bejarano-Quisoboni, Henri Panjo, Brice Fresneau, Chiraz El-Fayech, Francois Doz, Aurore Surun, Florent de Vathaire, Nathalie Pelletier-Fleury
Summary: This study aimed to estimate the excess healthcare expenditure for long-term childhood cancer survivors (CCS) in France compared to the general population and investigate the associated factors. The study found that CCS had higher healthcare expenditure, mainly due to hospitalization and pharmacy expenses. The type of treatment administered was a key factor influencing healthcare expenditure.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2023)
Article
Medicine, Research & Experimental
Monia Zidane, Marc Haber, Therese Truong, Frederique Rachedi, Catherine Ory, Sylvie Chevillard, Helene Blanche, Robert Olaso, Anne Boland, Eric Conte, Mojgan Karimi, Yan Ren, Constance Xhaard, Vincent Souchard, Jacques Gardon, Marc Taquet, Andre Bouville, Jean-Francois Deleuze, Vladimir Drozdovitch, Florent de Vathaire, Jean-Baptiste Cazier
Summary: This study aimed to analyze the genetic factors associated with differentiated thyroid cancer (DTC) risk among the native populations of French Polynesia (FP). The research identified three genetic loci associated with increased DTC risk and suggested the need for whole genome sequencing to characterize these factors and validate their functional impact.
PRECISION CLINICAL MEDICINE
(2023)
Article
Oncology
Agnes Dumas, Karen Milcent, Nicolas Bougas, Daniel Bejarano-Quisoboni, Chiraz El Fayech, Helene Charreire, Odile Oberlin, Catherine Patte, Julie Allard, Eric Thebault, Amel Boumaraf, Amel Belhout, Vu-Bezin Giao, Vincent Souchard, Angela Jackson, Rodrigue Allodji, Dominique Valteau-Couanet, Christelle Dufour, Gilles Vassal, Nadia Haddy, Florent De Vathaire, Brice Fresneau
Summary: The study found that patients who received combined chemotherapy and radiotherapy, had bone sarcoma, central nervous system primitive tumor, or underwent autologous hematopoietic cell transplant were more likely to attend long-term follow-up visits. Additionally, factors such as health status, medical expenses, social status, and distance from the follow-up center also influenced attendance.
Article
Cardiac & Cardiovascular Systems
Manoj Kumar Honaryar, Rodrigue Allodji, Gaelle Jimenez, Mathieu Lapeyre, Loic Panh, Jeremy Camilleri, David Broggio, Jean Ferrieres, Florent De Vathaire, Sophie Jacob
Summary: This study aimed to evaluate the development of atherosclerotic plaques over 2 years after breast cancer radiotherapy (RT) and their associations with cardiac exposure. The results showed that the risk of overall plaque development was significantly associated with doses to the coronary arteries.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)