Article
Oncology
R. Kinj, J. Doyen, J. M. Hannoun-Levi, A. O. Naghavi, M. E. Chand, G. Baudin, J. M. Ferrero, E. Francois, L. Evesque, D. Borchiellini, K. Benezery, P. Y. Bondiau
Summary: This study evaluated the outcomes of SBRT reirradiation for extraosseous recurrences in the pelvis, showing it to be a safe and effective treatment modality. Improved local control was associated with smaller tumour volume and primary prostate location.
Article
Oncology
Salvatore Cozzi, Sebastiano Finocchi Ghersi, Lilia Bardoscia, Masoumeh Najafi, Gladys Blandino, Emanuele Ali, Matteo Augugliaro, Federica Vigo, Maria Paola Ruggieri, Raffaele Cardano, Lucia Giaccherini, Federico Iori, Andrea Botti, Valeria Trojani, Patrizia Ciammella, Cinzia Iotti
Summary: This study retrospectively evaluated the toxicities and outcomes of twenty patients treated with salvage stereotactic reirradiation for intraprostatic recurrence of prostate cancer. The results showed that prostate reirradiation is feasible, safe, and can delay the initiation of androgen deprivation therapy.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Review
Oncology
Jim Zhong, Finbar Slevin, Andrew F. Scarsbrook, Maria Serra, Ananya Choudhury, Peter J. Hoskin, Sarah Brown, Ann M. Henry
Summary: Salvage reirradiation of locally radiorecurrent prostate cancer using HDR-BT or SBRT provides similar biochemical control and acceptable late toxicity. Salvage LDR-BT is associated with higher late GU/GI toxicity. Challenges exist in comparing BT and SBRT, and prospective randomised trials are needed to provide more definitive conclusions.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Francois Lucia, Ruben Touati, Nicolae Crainic, Gurvan Dissaux, Olivier Pradier, Vincent Bourbonne, Ulrike Schick
Summary: Approximately 30% of cancer patients will develop brain metastases, leading to local recurrence post intracranial stereotactic radiotherapy. Advances in cancer treatments have increased overall survival, but also local failures (LF) after SRS/SRT. Second courses of SRS or SRT may be used to treat LF, with factors affecting efficacy including histology, tumor size, and prior treatments. Prospective studies with more patients are needed to determine the best management of brain metastases recurrence.
Article
Oncology
Bin Huo, Zhe Ji, Chuang He, Wanying Yang, Yanli Ma, Xiaodong Huo, Zhe Wang, Xinxin Zhao, Jinchao Dai, Haitao Wang, Guanglie Chen, Ruoyu Wang, Yuqing Song, Kaixian Zhang, Xuequan Huang, Shude Chai, Junjie Wang
Summary: This study evaluated the safety and efficacy of stereotactic ablative brachytherapy (SABT) as a salvage therapy for patients with recurrent chest wall cancer. The results showed that SABT had good local control and survival rates for recurrent chest wall cancer, and it alleviated pain symptoms. This study provides support for the clinical application of SABT.
FRONTIERS IN ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Giulio Francolini, Maria Grazia Carnevale, Vanessa Di Cataldo, Mauro Loi, Beatrice Detti, Carolina Orsatti, Luisa Caprara, Niccolo Bertini, Victoria Lorenzetti, Emanuela Olmetto, Carlotta Becherini, Luca Visani, Viola Salvestrini, Gabriele Simontacchi, Daniela Greto, Pierluigi Bonomo, Raffaela Doro, Laura Masi, Isacco Desideri, Icro Meattini, Sergio Serni, Lorenzo Livi
Summary: This study retrospectively collected data from 101 patients with locally recurrent prostate cancer who underwent re-irradiation. The results showed that CyberknifeR rSBRT had promising oncological outcomes and low toxicity in this patient cohort.
Review
Oncology
Xiao-Yao Feng, Jing Li, Ao-Mei Li, Sheng-Hua Jing, Xi-Xu Zhu, Zhen Wang
Summary: This study retrospectively analyzed the safety and efficacy of SBRT for recurrent and oligometastatic STS. The results showed that SBRT is a safe and effective treatment, and histological grade influences local control and survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Sofiane Allali, Pierre Loap, Jean-Emmanuel Bibault, Sarah Krepps, Aurelien Deforge, Damien Moreau, Catherine Durdux, Philippe Giraud
Summary: This study evaluated the clinical outcome of prostatic reirradiation with stereotactic body radiation therapy (SBRT) in patients with intraprostatic recurrence initially treated by radiotherapy. The results showed that SBRT had good biochemical relapse-free survival and local recurrence-free survival rates, suggesting that it is an effective and well-tolerated treatment for local recurrence of prostate cancer.
Article
Oncology
Laure Kuntz, Clara Le Fevre, Delphine Jarnet, Audrey Keller, Philippe Meyer, Christophe Mazzara, Helene Cebula, Georges Noel, Delphine Antoni
Summary: This retrospective study analyzed the data of patients who received at least two courses of SRT between 2010 and 2020. The results showed that NDFS and OS after SRT were influenced by various factors, including the number of treatments, patient condition, salvage WBRT, and metastasis velocity.
Article
Oncology
Shigeru Yamada, Hirotoshi Takiyama, Yuka Isozaki, Makoto Shinoto, Daniel K. Ebner, Masashi Koto, Hiroshi Tsuji, Hideaki Miyauchi, Mitsugu Sekimoto, Hideki Ueno, Michio Itabashi, Masataka Ikeda, Hisahiro Matsubara
Summary: The study demonstrates that carbon-ion re-irradiation for previously X-ray-irradiated locally recurrent rectal cancer is safe and effective, providing good local control and survival advantage without unacceptable morbidity.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yaoru Huang, Po-Yung Chen, Tzu-Yen Cheng, Jeng-Fong Chiou
Summary: This study investigated the outcomes of reirradiation for recurrent HCC and found that better local control could prolong survival. The results suggest that reirradiation may be a viable treatment option for recurrent HCC.
APPLIED SCIENCES-BASEL
(2021)
Article
Oncology
Luca Boldrini, Angela Romano, Giuditta Chiloiro, Stefanie Corradini, Viola De Luca, Valeria Verusio, Andrea D'Aviero, Alessandra Castelluccia, Anna Rita Alitto, Francesco Catucci, Gianmarco Grimaldi, Christian Trapp, Juliane Hoerner-Rieber, Domenico Marchesano, Vincenzo Frascino, Gian Carlo Mattiucci, Vincenzo Valentini, Piercarlo Gentile, Maria Antonietta Gambacorta
Summary: This multicentric retrospective analysis evaluates the feasibility and efficacy of prostate cancer reirradiation using a 0.35 T hybrid MR delivery unit. The results show that MRgSBRT treatment achieves low rates of acute toxicity and efficiently spares organs at risk.
RADIATION ONCOLOGY
(2023)
Article
Oncology
John A. Vargo, Vitali Moiseenko, Jimm Grimm, Jimmy Caudell, David A. Clump, Ellen Yorke, Jinyu Xue, Yevgeniy Vinogradskiy, Eduardo G. Moros, Panayiotis Mavroidis, Sheena Jain, Issam El Naqa, Lawrence B. Marks, Dwight E. Heron
Summary: This study systematically reviewed the available literature on tumor control probability with SBRT in head and neck cancer patients, finding a dose-response relationship suggesting better local control and possibly improved overall survival with doses of 35 to 45 Gy (in 5 fractions) compared with <30 Gy. It is suggested that SBRT doses equivalent to 5-fraction doses of 40 to 50 Gy are used for retreatment.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Multidisciplinary Sciences
Caroline John, Riccardo Dal Bello, Nicolaus Andratschke, Matthias Guckenberger, Judit Boda-Heggemann, Eleni Gkika, Frederick Mantel, Hanno M. Specht, Carmen Stromberger, Franz Zehentmayr, Oliver Blanck, Panagiotis Balermpas
Summary: The study investigated the feasibility and safety of a second course of thoracic SBRT with PTV overlap, and found it to be safe and achieve reasonable local control. Factors correlating with tumor control were identified as peripheral location and dose.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Stefi Nordkamp, Eva L. K. Voogt, Desley M. G. van Zoggel, Anna Martling, Torbjorn Holm, Gabriella Jansson Palmer, Chikako Suzuki, Joost Nederend, Miranda Kusters, Jacobus W. A. Burger, Harm J. T. Rutten, Henrik Iversen
Summary: No standard of care has been defined in the treatment of locally recurrent rectal cancer due to its heterogeneous nature, low incidence, and varied treatment options. This study compared data from two tertiary hospitals and found that aiming for wide resection margins increased the R0 resection rate and local re-recurrence-free survival. Neoadjuvant full-course chemoradiotherapy improved survival, while reirradiation showed no benefit.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Oncology
Caglayan Selenge Beduk Esen, Gozde Yazici, Pervin Hurmuz, Gokhan Ozyigit, Faruk Zorlu
Summary: Video-based education significantly reduces patient anxiety before SRS/SBRT and increases their compliance with the treatment.
JOURNAL OF CANCER EDUCATION
(2023)
Article
Biology
Mert Cananoglu, Pervin Hurmuz, Mete Yeginer, Gokhan Ozyigit
Summary: This study compared the dosimetric effects of three total body irradiation (TBI) techniques delivered by a standard linear accelerator and concluded that the Standard SSD VMAT technique is superior in sparing the lung tissue. All three techniques were found to be feasible in clinical practice with acceptable dose homogeneity.
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2023)
Article
Biology
Yagiz Yedekci, Pervin Hurmuz, Gokhan Ozyigit
Summary: The study investigated the impact of tumour motion on imaging strategies and treatment plan accuracy for lung SBRT. It found that MIP had advantages in defining the internal target volume, and recommended the use of 4D CBCT and 3D EPID dosimetry for lung SBRT treatments.
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2023)
Article
Oncology
Cem Onal, Ezgi Oymak, Ozan Cem Guler, Burak Tilki, Guler Yavas, Pervin Hurmuz, Cagdas Yavas, Gokhan Ozyigit
Summary: This study demonstrates that the combination of SBRT and TKIs is an effective and safe treatment option for RCC patients with <= 5 metastases. However, there is still room for improvement in distant disease control.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Urology & Nephrology
Ozan Cem Guler, Ezgi Oymak, Pervin Hurmuz, Guler Yavas, Burak Tilki, Cagdas Yavas, Gokhan Ozyigit, Cem Onal
Summary: This study aimed to investigate the clinical outcomes of SBRT in the treatment of oligometastatic RCC. The results showed that SBRT had excellent local control and minimal toxicity, and there were no significant differences in survival between patients with synchronous and metachronous oligometastasis. Patients with solitary oligometastasis had better overall survival.
UROLOGIA INTERNATIONALIS
(2023)
Article
Oncology
Gokhan Ozyigit, Cem Onal, Caglayan Selenge Beduk Esen, Burak Tilki, Pervin Hurmuz
Summary: This retrospective study evaluated the safety and efficacy of postoperative ultra-hypofractionated stereotactic body radiation therapy (SBRT) for prostate bed. A total of 66 prostate cancer patients received 35 Gy in 5 fractions. The biochemical complete response (BCR) rate was 86.4% and the 2-year freedom from biochemical failure (FFBF) rate was 88.4%. Pre- and post-SBRT PSA levels were found to be prognostic factors for FFBF. Acute and late toxicities were manageable, with no severe complications observed.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Letter
Oncology
Aysenur Elmali, Sepideh Mohammadipour, Gozde Yazici
Letter
Oncology
Alper Kahvecioglu, Sezin Yuce Sari, Gozde Yazici
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Enes Erul, Deniz C. Guven, Yakup Ozbay, Ahmet Y. Altunbulak, Alper Kahvecioglu, Fatih Ercan, Muhammed F. Yesil, Mete T. Ucdal, Mustafa Cengiz, Gozde Yazici, Oguz Kuscu, Nilda Suslu, Ibrahim Gullu, Mehmet R. Onur, Sercan Aksoy
Summary: The study evaluated the effect of sarcopenia on survival in head and neck squamous cell carcinoma patients treated with chemoradiotherapy. The results showed that pretreatment sarcopenia was associated with lower disease-free survival and overall survival in locally advanced head and neck squamous cell carcinoma patients treated with chemoradiotherapy. Sarcopenic patients also experienced more frequent radiotherapy-related toxicities and platinum-related side effects than non-sarcopenic patients.
BIOMARKERS IN MEDICINE
(2023)
Meeting Abstract
Oncology
E. Yigit, S. Yuce Sari, M. Cengiz, I. H. Gullu, S. Aksoy, G. Ozyigit, G. Yazici
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Meeting Abstract
Oncology
P. Sutera, M. P. Deek, O. C. Guler, P. Hurmuz, M. Reyhan, S. Rowe, W. T. Hrinivich, L. Ren, D. Song, A. P. Kiess, E. Oymak, K. Pienta, M. G. Pomper, F. Y. Feng, G. Ozyigit, P. T. Tran, R. Phillips, C. Onal
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Meeting Abstract
Oncology
O. C. Guler, P. Hurmuz, B. Atalar, Y. Yukselen Guney, E. K. Saglam, S. Akyurek, Y. Bolukbasi, Z. Gural, F. Tugrul, A. F. Korcum, C. A. Sen, B. Akkus Yildirim, D. C. Oksuz, O. Karakoyun Celik, M. Kurt, Z. Guzeloz, G. Yavas, G. Ozyigit, M. G. Aksu, C. Onal
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Meeting Abstract
Oncology
O. C. Guler, P. Hurmuz, G. Ozyigit, C. Onal
RADIOTHERAPY AND ONCOLOGY
(2022)