Article
Medicine, General & Internal
Irini Youssef, Jennifer Yoon, Nader Mohamed, Kaveh Zakeri, Robert H. Press, Linda Chen, Daphna Y. Gelblum, Sean M. McBride, Chiaojung Jillian Tsai, Nadeem Riaz, Yao Yu, Marc A. Cohen, Lara Ann Dunn, Alan L. Ho, Richard J. Wong, Loren S. Michel, Jay O. Boyle, Bhuvanesh Singh, Anuja Kriplani, Ian Ganly, Eric J. Sherman, David G. Pfister, James Fetten, Nancy Y. Lee
Summary: This study compared the toxic effects and oncologic outcomes of patients with newly diagnosed nonmetastatic oropharyngeal carcinoma (OPC) treated with intensity-modulated proton therapy (IMPT) or intensity-modulated radiation therapy (IMRT). The results showed that IMPT treatment was associated with reduced acute toxicity and favorable oncologic outcomes compared to IMRT.
Article
Engineering, Biomedical
Ehsan Salari, Thomas Mazur, Gregory Sharp
Summary: The goal of this research is to manage intrafraction motion by feedback control of delivered dose in order to achieve dosimetry comparable to respiratory gating without compromising delivery efficiency. A stochastic control approach is developed for step-and-shoot intensity-modulated radiotherapy (IMRT) to estimate the delivered dose and future motion trajectory in real time. Results show that the proposed method reduces treatment time compared to traditional respiratory-gated treatment without compromising dose quality.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Xin Lian, Zhuoran Xu, Shuai Sun, Weiping Wang, Huijuan Zhu, Lin Lu, Xiaorong Hou, Fuquan Zhang
Summary: The study aimed to investigate the efficacy and toxicity of intensity-modulated radiotherapy (IMRT) in treating Cushing's Disease (CD). The results showed that IMRT was a highly effective therapy with low side effects for CD patients, with comparable rates of endocrine remission, tumor control, and recurrence to previous reports.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Kunzhi Chen, Zhuangzhuang Zheng, Lijuan Ding, Na Tao, Libo Wang, Wenming Xia, Huidong Wang, Xin Jiang
Summary: A systematic quantitative evaluation of IMRT quality change in modified radical mastectomy using Plan-IQ feasibility tool was conducted. Results showed that the RP group had significantly better OAR dose limits compared to the NP group, with a decrease in total scores. PTV scores decreased in the RP group, while OAR scores improved.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Xingzhe Li, Sarin Kitpanit, Anna Lee, Dennis Mah, Kevin Sine, Eric J. Sherman, Lara A. Dunn, Loren S. Michel, James Fetten, Kaveh Zakeri, Yao Yu, Linda Chen, Jung Julie Kang, Daphna Y. Gelblum, Sean M. McBride, Chiaojung J. Tsai, Nadeem Riaz, Nancy Y. Lee
Summary: This study compared the toxic effects and oncologic outcomes of patients with nonmetastatic NPC treated with IMPT vs IMRT with or without chemotherapy. The results showed that IMPT was associated with lower acute toxicity burden compared with IMRT, rare late complications, and excellent oncologic outcomes, including 100% locoregional control at 2 years.
Review
Oncology
Won Il Jang, Sunmi Jo, Ji Eun Moon, Sun Hyun Bae, Hee Chul Park
Summary: This study is the first systematic review and meta-analysis on the advantages of IMRT for hepatocellular carcinoma. Despite most patients being in advanced stages and using combined treatment, IMRT for HCC showed similar survival rates to existing radiotherapy modalities and relatively low toxicity.
Article
Multidisciplinary Sciences
Along Chen, Zhenghuan Li, Yadi He, Fei Chen, Li Chen
Summary: This study investigated the impact of control point numbers on IMRT plans for nasopharyngeal carcinoma patients. Results showed that using 20 control points per field led to the best plan quality, delivery efficiency, and accuracy.
JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
(2021)
Article
Neurosciences
Bing Li, Junying Chen, Wei Guo, Ronghu Mao, Xiaoli Zheng, Xiuyan Cheng, Tiantian Cui, Zhaoyang Lou, Ting Wang, Dingjie Li, Hongyan Tao, Hongchang Lei, Hong Ge
Summary: This study evaluated the utility of planomics features in predicting and classifying GPR results in head and neck VMAT plans. The results showed that planomics features have potential in GPR prediction and classification, and combining them with conventional features can improve model performance.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Oncology
Pan Ma, Yuan Tian, Minghui Li, Chuanmeng Niu, Yuchun Song, Jianrong Dai
Summary: This study introduces a scanning algorithm for intensity-modulated electron therapy (IMET) and validates it using clinical data from patients with pancreatic cancer. The optimized scanning path can reduce the delivery time, and methods to further reduce the delivery time are proposed.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Shan-Shan Yang, Pu-Yun OuYang, Jian-Gui Guo, Jia-Jun Cai, Jun Zhang, Qing-He Peng, Yun He, Bao-Yu Zhang, Zhi-Qiao Liu, Xue-Feng Hu, Yan-Feng Chen, Chun-Yan Chen, Fang-Yun Xie
Summary: The study aimed to evaluate the value of dose distribution-based dosiomics and planning computed tomography-based radiomics in predicting radiation-induced temporal lobe injury (TLI) and guiding individualized intensity modulated radiation therapy. The results showed that the dosiomics risk model outperformed traditional models in predicting TLI risk, offering potential for precise prediction of radiation-induced toxicities and guiding individualized intensity modulated radiation therapy.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Siddhartha Laskar, Sangeeta Kakoti, Nehal Khanna, Jifmi Jose Manjali, Akshay Mangaj, Ajay Puri, Ashish Gulia, Prakash Nayak, Prathamesh Pai, Deepa Nair, Sajid Qureshi, Girish Chinnaswamy, Jyoti Bajpai, Kumar Prabhash, Bharat Rekhi, Mukta Ramadwar, Nirmala Jambhekar, Amit Janu, Sashikant Juvekar, Nilendu Purandare, Venkatesh Rangarajan
Summary: The study evaluated the efficacy and toxicity of dose-escalated image guided-intensity modulated radiation therapy in osteosarcoma, chondrosarcoma, and chordoma of head and neck and pelvis. The results showed good local control and functional improvement with minimal toxicity in these patients, with significant improvement in Musculoskeletal Tumour Society score and reduction in pain score.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Engineering, Biomedical
Jiayuan Peng, Yuanhua Chen, Jun Zhao, Jiazhou Wang, Xiang Xia, Bin Cai, Thomas R. Mazur, Ji Zhu, Zhen Zhang, Weigang Hu
Summary: The study developed an efficient and automatic approach, AGAP, that fully automated the IMRT planning process in rectal cancer radiotherapy. It reduced the dependence on planner experience and maintained comparable plan quality with P-auto plans.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Oncology
Sota Nakahara, Takayuki Ohguri, Sho Kakinouchi, Hirohide Itamura, Takahiro Morisaki, Subaru Tani, Katuya Yahara, Naohiro Fujimoto
Summary: This study retrospectively analyzed the efficacy and toxicity of adding regional hyperthermia to intensity-modulated radiotherapy (IMRT) plus neoadjuvant androgen deprivation therapy (ADT) for high-risk localized prostate carcinoma. The results showed that adding hyperthermia improved clinical relapse-free survival and higher thermal dose predicted improved biochemical disease-free survival.
Article
Oncology
Shun Tasaka, Keiichi Jingu, Noriyoshi Takahashi, Rei Umezawa, Takaya Yamamoto, Yojiro Ishikawa, Kazuya Takeda, Yu Suzuki, Noriyuki Kadoya
Summary: This study evaluated the long-term change of parotid gland volume after IMRT in nasopharyngeal carcinoma patients, finding a gradual recovery in volume even three years post-radiotherapy, especially in parotids receiving less than 40 Gy as the mean dose. Additionally, the mean irradiated dose for bilateral parotids was negatively correlated with oral QOL score and oral moisture after a long period.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jianzhong Cao, Xiaodong Zhang, Bo Jiang, Jiayun Chen, Xiaochun Wang, Li Wang, Narayan Sahoo, X. Ronald Zhu, Rong Ye, Pierre Blanchard, Adam S. Garden, C. David Fuller, G. Brandon Gunn, Steven J. Frank
Summary: The study showed that in patients with oropharyngeal cancer, IMPT treatment was associated with less late xerostomia compared to IMRT treatment. Dosimetric variables related to the oral cavity were associated with late xerostomia.
RADIOTHERAPY AND ONCOLOGY
(2021)