Article
Biochemistry & Molecular Biology
Markus V. Heppt, Anja Wessely, Eva Hornig, Claudia Kammerbauer, Saskia A. Graf, Robert Besch, Lars E. French, Alexander Matthies, Silke Kuphal, Melanie Kappelmann-Fenzl, Anja K. Bosserhoff, Carola Berking
Summary: The neural crest transcription factor BRN3A is essential for melanoma cell proliferation and survival. The mechanism underlying its aberrant expression is unknown. This study revealed that the epigenetic regulator HDAC2 plays a key role in the expression of BRN3A in melanocytes and melanoma cells. Inhibition of HDAC2 increased BRN3A expression, highlighting the importance of epigenetic mechanisms in regulating melanoma oncogenes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Chen Chen, Hongrui Chu, Anyang Wang, Huanhuan Yin, Yanqiao Gao, Shuhua Liu, Wei Li, Leiqiang Han
Summary: Incorporating a DNA-binding fragment in HDAC inhibitors has been proven effective in treating hematologic malignancies. However, these inhibitors have poor effects on solid tumors. In this study, a series of 2,5-diphenyl-1,3,4-thiadiazole hydroxamate derivatives were designed and synthesized as HDAC inhibitors with DNA binding affinity. Among them, compound 4j showed the strongest inhibitory activity against HDAC1 and demonstrated potent antiproliferative activity in tumor cell lines. Additionally, compound 4j enhanced the acetylation of histone H3 and alpha-tubulin, as well as activated caspase 3 in HCT116 and MC38 cell lines, leading to significant suppression of tumor growth in the MC38 tumor model. This work validates compound 4j as a promising lead compound for further optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yenan Fu, Xi Zhang, Xiao Liu, Peng Wang, Wenhui Chu, Wei Zhao, Yunling Wang, Guangbiao Zhou, Yu Yu, Hongquan Zhang
Summary: The DNMT1-PAS1-PH20 axis plays an important role in controlling breast cancer growth and metastasis. PAS1 suppresses PH20 expression by recruiting SUV39H1 for methylation, leading to its silencing. Targeting this axis could be a potential therapeutic strategy for breast cancer.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Review
Genetics & Heredity
Subramaniam Jayanthi, Michael T. McCoy, Jean Lud Cadet
Summary: Methamphetamine-use disorder is a serious condition that can lead to long-term changes in the brain and gene expression, highlighting the importance of researching the underlying mechanisms.
Article
Pharmacology & Pharmacy
Lauren A. Bertocci, Jeffrey R. Rovatti, Alex Wu, Amber Morey, Diptiman D. Bose, Shannon R. M. Kinney
Summary: Calcium signaling and DNA methylation are connected in tumor development, potentially regulating apoptosis in cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Psychiatry
Jiaqi Song, Yan Chen, Qing Zhao, Hongna Li, Wei Li, Ke Chen, Jianjin Yu, Weihong Fu, Dachun Chen
Summary: The study aimed to explore the regulation of DNA methylation of leptin promoters and mRNA expression in patients with schizophrenia. The results suggest that leptin methylation and mRNA expression may contribute to the pathogenesis of schizophrenia, and LEP-CpG7 methylation may be negatively associated with positive symptoms in patients.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Yu-Hsin Chu, Yi-Chen Huang, Pei-Yun Chiu, Wen-Hung Kuo, Yan-Ru Pan, Yuan-Ting Kuo, Rong-Hsuan Wang, Yu-Chin Kao, Yi-Hsiang Wang, Yi-Fan Lin, Kai-Ti Lin
Summary: Breast cancer is a leading cause of cancer-related death in women, and triple-negative breast cancer (TNBC) is a particularly aggressive subtype. Using bioinformatic approaches, researchers found that the microRNA-708 promoter is highly methylated in breast carcinomas, which is associated with a poor prognosis. By combining the hypomethylating agent decitabine with a synthetic glucocorticoid, they were able to increase the expression of microRNA-708 and suppress breast cancer cell proliferation, migration, and invasion in TNBC patients.
Article
Multidisciplinary Sciences
Deivid C. Rodrigues, Marat Mufteev, Kyoko E. Yuki, Ashrut Narula, Wei Wei, Alina Piekna, Jiajie Liu, Peter Pasceri, Olivia S. Rissland, Michael D. Wilson, James Ellis
Summary: This study measured transcription rate and mRNA half-life changes in RTT patient-derived neurons and reinterpreted nuclear and whole-cell RNAseq from Mecp2 mice. The results showed that dysregulation of genes in RTT is caused by changes in transcription rate or half-life, but genes are buffered when both change. In addition, three dinucleotide frequencies were found to be better predictors of transcription rate changes than CA and CG. MicroRNA and RNA-binding Protein (RBP) motifs were enriched in the 3'UTRs of genes with half-life changes, while nuclear RBP motifs were enriched in buffered genes with increased transcription rate. The study revealed post-transcriptional mechanisms in neurodevelopmental disorders caused by mutations in transcriptional modulator genes.
NATURE COMMUNICATIONS
(2023)
Article
Biochemical Research Methods
Isabelle Bichindaritz, Guanghui Liu, Christopher Bartlett
Summary: The study proposes an adaptive multi-task learning method for survival prediction of breast cancer patients using multi-modal learning, achieving more effective results compared to existing approaches. By combining different gene features, reducing dimensions, and introducing auxiliary loss, an ordinal Cox hazards model is built to predict patients' survival risk.
Article
Multidisciplinary Sciences
Paula Metselaar, Lucero Mendoza-Maldonado, Andrew Yung Fong Li Yim, Ilias Abarkan, Peter Henneman, Anje A. te Velde, Alexander Schoenhuth, Jos A. Bosch, Aletta D. Kraneveld, Alejandro Lopez-Rincon
Summary: The study combined mRNA expression and DNA methylation data to identify a gene signature that distinguishes ME/CFS patients from healthy controls. The results suggest that these genes are related to the dysregulated immune system in ME/CFS patients.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Bi Lian, Xiaosong Chen, Kunwei Shen
Summary: Breast cancer is a common malignancy with poor prognosis globally. Immunotherapy has shown promise in improving survival rates for breast cancer patients, but resistance to treatment remains a challenge. Histone deacetylases (HDACs) play a role in tumorigenesis and can be targeted by HDAC inhibitors, which have demonstrated anticancer activity in various cancers including breast cancer. HDAC inhibitors have also been found to enhance the efficacy of immunotherapy in breast cancer. This review explores the anti-tumor activity of different HDAC inhibitors in breast cancer and discusses their mechanisms in improving immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jasmin Hertler, Kaouthar Slama, Benedikt Schober, Zeynep Ozrendeci, Virginie Marchand, Yuri Motorin, Mark Helm
Summary: Techniques have been developed to isolate long, translatable, and internally point-modified mRNA, enabling functional analysis of these modified mRNAs.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Ying Wu, Zhe Wang, Lu Han, Zhihao Guo, Bohua Yan, Lili Guo, Huadong Zhao, Mengying Wei, Niuniu Hou, Jing Ye, Zhe Wang, Changhong Shi, Suling Liu, Ceshi Chen, Suning Chen, Ting Wang, Jun Yi, JianPing Zhou, Libo Yao, Wenxia Zhou, Rui Ling, Jian Zhang
Summary: Cancer cells regulate their response to the chemotherapeutic drug doxorubicin through RNA m6A modification. They do this by inhibiting RNA m6A modification through PRMT5 and enhancing the nuclear translocation of the demethylase ALKBH5. This leads to increased DNA repair ability and decreased efficacy of doxorubicin. The approved drug tadalafil was identified as a PRMT5 inhibitor that could enhance doxorubicin sensitivity in breast cancer cells by decreasing RNA m6A methylation.
Article
Environmental Sciences
Manoswini Chakrabarti, Anita Mukherjee
Summary: This study evaluated the Cd-induced adaptive response in plants to mitigate the genotoxicity of EMS. Priming plants with Cd decreased the genotoxicity of EMS and the adaptive response was evident in cytotoxicity, genotoxicity, and biochemical parameters. The involvement of metabolic pathways and epigenetic modifications in AR was investigated, showing the contribution of DNA hypermethylation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Ferda Ari, Rudolf Napieralski, Oguzhan Akgun, Viktor Magdolen, Engin Ulukaya
Summary: The study compared the effects of standard chemotherapy regimens and epigenetic modulators on gene methylation levels, expression status, and differentiation of tumour biomarkers in breast cancer cell models. The results suggest potential therapeutic benefits in reducing tumour malignancy.
CELL BIOCHEMISTRY AND FUNCTION
(2021)
Article
Zoology
Fabiola Carolina Espinosa-Gomez, Juan Carlos Serio-Silva, Juan Diego Santiago-Garcia, Carlos Alfredo Sandoval-Castro, Laura Teresa Hernandez-Salazar, Fernando Mejia-Varas, Javier Ojeda-Chavez, Colin Austin Chapman
AMERICAN JOURNAL OF PRIMATOLOGY
(2018)
Article
Oncology
Fabiola Hernandez-Rosas, Andres Hernandez-Oliveras, Lucia Flores-Peredo, Gabriela Rodriguez, Angel Zarain-Herzberg, Mario Caba, Juan Santiago-Garcia
Article
Biochemistry & Molecular Biology
Ivan Meneses-Morales, Eduardo Izquierdo-Torres, Lucia Flores-Peredo, Gabriela Rodriguez, Andres Hernandez-Oliveras, Angel Zarain-Herzberg
MOLECULAR CARCINOGENESIS
(2019)
Article
Biochemistry & Molecular Biology
Andres Hernandez-Oliverasa, Eduardo Izquierdo-Torres, Ivan Meneses-Morales, Gabriela Rodriguez, Angel Zarain-Herzberg, Juan Santiago-Garcia
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Eduardo Izquierdo-Torres, Andres Hernandez-Oliveras, Ivan Menses-Morales, Gabriela Rodriguez, Gabriela Fuentes-Garcia, Angel Zarain-Herzberg
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2019)
Article
Psychology, Biological
Araceli Vazquez, Andres Hernandez-Oliveras, Juan Santiago-Garcia, Mario Caba, Francisco Gonzalez-Lima, Diana Olivo, Aleph A. Corona-Morales
PHYSIOLOGY & BEHAVIOR
(2020)
Article
Cell Biology
Andres Hernandez-Oliveras, Eduardo Izquierdo-Torres, Guadalupe Hernandez-Martinez, Angel Zarain-Herzberg, Juan Santiago-Garcia
Summary: Ca2+ signaling plays a crucial role in regulating various cellular mechanisms, with some related genes showing altered expression in HCC and correlation with patients' survival. DNA methylation and histone posttranslational modifications are potential targets for regulating their expression in the future.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2021)
Article
Behavioral Sciences
Mauricio A. Nunez-Murrieta, Paula Noguez, Genaro A. Coria-Avila, Fabio Garcia-Garcia, Juan Santiago-Garcia, Victoria E. Bolado-Garcia, Aleph A. Corona-Morales
Summary: The study found that exposure to different environmental conditions during gestation can impact postpartum maternal behavior and the activity of brain regions related to social behavior, leading to differences in nurturing and defensive behavior in postpartum rats. This suggests that the environment has an influence on brain activity and behavior.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mariana G. Lecourtois-Amezquita, Betzaida Cuevas-Cordoba, Juan Santiago-Garcia
Summary: The study found that homozygous null genotypes of GSTT1 and GSTM1 in mothers and infants were associated with a higher risk of non-syndromic cleft lip, and that maternal GSTT1-null/null genotype interacted with frequent passive smoking to further increase the risk.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Developmental Biology
Ana Monserrat Vela-Alcantara, Ariadna Rios-Ramirez, Juan Santiago-Garcia, Juan Carlos Rodriguez-Alba, Elisa Tamariz Dominguez
Summary: The present study evaluated the impact of substrate stiffness on the response of DRG neurons to Sema3a, showing that stiffness can regulate cell morphology, Sema3a receptor expression, and cytoskeleton distribution, affecting the collapse response of growth cones.
CELLS & DEVELOPMENT
(2022)
Review
Cell Biology
Eduardo Izquierdo-Torres, Andres Hernandez-Oliveras, Gabriela Fuentes-Garcia, Angel Zarain-Herzberg