Non-canonical Stat3 signaling in cancer

The IL-6/JAK/Stat3 Feed-Forward Loop Drives Tumorigenesis and Metastasis

(2015) Qing Chang et al.   NEOPLASIA

STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation

(2014) D. J. Gough et al.   BLOOD

Prohibitin 1 modulates mitochondrial function of Stat3

(2014) Jie Han et al.   CELLULAR SIGNALLING

Critical Role for Lysine 685 in Gene Expression Mediated by Transcription Factor Unphosphorylated STAT3

(2014) Maupali Dasgupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stat3 Binds to mtDNA and Regulates Mitochondrial Gene Expression in Keratinocytes

(2014) Everardo Macias et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mitochondrial-Targeted Curcuminoids: A Strategy to Enhance Bioavailability and Anticancer Efficacy of Curcumin

(2014) Cheruku Apoorva Reddy et al.   PLoS One

Toward a new STATe: The role of STATs in mitochondrial function

(2014) Jeremy A. Meier et al.   SEMINARS IN IMMUNOLOGY

JAB1 regulates unphosphorylated STAT3 DNA-binding activity through protein–protein interaction in human colon cancer cells

(2013) Arata Nishimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The STAT3 Inhibitor Stattic Impairs Cardiomyocyte Mitochondrial Function Through Increased Reactive Oxygen Species Formation

(2013) Kerstin Boengler et al.   CURRENT PHARMACEUTICAL DESIGN

Observation of unphosphorylated STAT3 core protein binding to targetdsDNA by PEMSA and X-ray crystallography

(2013) Edwin Nkansah et al.   FEBS LETTERS

Constitutive Activation of Signal Transducer and Activator of Transcription 3 (STAT3) and Nuclear Factor κB Signaling in Glioblastoma Cancer Stem Cells Regulates the Notch Pathway

(2013) Jo Meagan Garner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Localized Stat3 Promotes Breast Cancer Growth via Phosphorylation of Serine 727

(2013) Qifang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Mitochondrial STAT3 with the Novel Phospho-Valproic Acid (MDC-1112) Inhibits Pancreatic Cancer Growth in Mice

(2013) Gerardo G. Mackenzie et al.   PLoS One

The MEK-ERK Pathway Is Necessary for Serine Phosphorylation of Mitochondrial STAT3 and Ras-Mediated Transformation

(2013) Daniel J. Gough et al.   PLoS One

Mitochondrial Dysfunction in Cancer

(2013) Michelle L. Boland et al.   Frontiers in Oncology

Reduction of STAT3 expression induces mitochondrial dysfunction and autophagy in cardiac HL-1 cells

(2012) Myriam Elschami et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

High Mitochondrial DNA Copy Number and Bioenergetic Function Are Associated with Tumor Invasion of Esophageal Squamous Cell Carcinoma Cell Lines

(2012) Chen-Sung Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of Unphosphorylated STAT3 Transcription Factor Binding to DNA

(2012) Olga A. Timofeeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Import of the Transcription Factor STAT3 into Mitochondria Depends on GRIM-19, a Component of the Electron Transport Chain

(2012) Prasad Tammineni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GRIM-19-mediated translocation of STAT3 to mitochondria is necessary for TNF-induced necroptosis

(2012) Nataly Shulga et al.   JOURNAL OF CELL SCIENCE

STAT3 negatively regulates thyroid tumorigenesis

(2012) J. P. Couto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multi-tasking: nuclear transcription factors with novel roles in the mitochondria

(2012) Karol Szczepanek et al.   TRENDS IN CELL BIOLOGY

p53-Dependent Regulation of Mitochondrial Energy Production by the RelA Subunit of NF- B

(2011) R. F. Johnson et al.   CANCER RESEARCH

Transgenic overexpression of PKCε in the mouse prostate induces preneoplastic lesions

(2011) Fernando Benavides et al.   CELL CYCLE

Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein

(2011) Michel Bernier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytoprotection by the modulation of mitochondrial electron transport chain: The emerging role of mitochondrial STAT3

(2011) Karol Szczepanek et al.   MITOCHONDRION

Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion

(2010) Kerstin Boengler et al.   BASIC RESEARCH IN CARDIOLOGY

Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells

(2010) Fu-Yu Chueh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stoichiometry of STAT3 and Mitochondrial Proteins

(2010) Darci Phillips et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis

(2010) Okkyung Rho et al.   MOLECULAR CARCINOGENESIS

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

(2010) Robert B. Hamanaka et al.   TRENDS IN BIOCHEMICAL SCIENCES

Targeted Disruption of Stat3 Reveals a Major Role for Follicular Stem Cells in Skin Tumor Initiation

(2009) D. J. Kim et al.   CANCER RESEARCH

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Roles of unphosphorylated STATs in signaling

(2008) Jinbo Yang et al.   CELL RESEARCH

Impact of Stat3 activation upon skin biology: A dichotomy of its role between homeostasis and diseases

(2007) Shigetoshi Sano et al.   JOURNAL OF DERMATOLOGICAL SCIENCE