Article
Oncology
Han Gyul Yoon, Yong Chan Ahn, Dongryul Oh, Jae Myoung Noh, Seung Gyu Park, Heerim Nam, Sang Gyu Ju, Dongyeol Kwon, Seyjoon Park
Summary: In treating oropharynx cancer patients, the combination of IMRT and IMPT achieved more favorable acute toxicity profiles compared to IMRT alone, while maintaining comparable oncologic outcomes.
Article
Oncology
James R. Janopaul-Naylor, Yichun Cao, Neal S. McCall, Jeffrey M. Switchenko, Sibo Tian, Haijian Chen, William A. Stokes, Aparna H. Kesarwala, Mark W. McDonald, Joseph W. Shelton, Jeffrey D. Bradley, Kristin A. Higgins
Summary: Definitive IMPT re-irradiation for lung cancer can prolong disease control with limited toxicity, particularly in the immunotherapy era.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Nathan Y. Yu, Todd A. DeWees, Molly M. Voss, William G. Breen, Jennifer S. Chiang, Julia X. Ding, Thomas B. Daniels, Dawn Owen, Kenneth R. Olivier, Yolanda I. Garces, Sean S. Park, Jann N. Sarkaria, Ping Yang, Panayiotis S. Savvides, Vinicius Ernani, Wei Liu, Steven E. Schild, Kenneth W. Merrell, Terence T. Sio
Summary: This study reports the outcomes of 163 Stage III NSCLC patients treated with chemoradiation, comparing the effects of intensity-modulated proton therapy (IMPT) and intensity-modulated radiation therapy (IMRT). The findings indicate that IMPT can reduce the risk of pneumonitis and cardiac events without compromising tumor control.
CLINICAL LUNG CANCER
(2022)
Article
Oncology
Darren M. Zuro, Gabriel Vidal, James Nathan Cantrell, Yong Chen, Chunhui Han, Christina Henson, Salahuddin Ahmad, Susanta Hui, Imad Ali
Summary: The purpose of this study is to investigate the treatment planning of TMI using IMPT. The dosimetric parameters of IMPT plans were evaluated and compared with VMAT plans. The results showed significant reduction in organ-at-risk dose in IMPT plans compared to VMAT plans.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Pavel Vitek, Jiri Kubes, Vladimir Vondracek, Michal Andrlik, Matej Navratil, Radek Zapletal, Alexandra Haas, Katerina Dedeckova, Barbora Ondrova, Alexander Grebenyuk, Jozef Rosina
Summary: This single-institution study demonstrated the high efficacy of PBS IMPT in the definitive chemoradiotherapy of anal cancer, achieving a high rate of complete regression with low haematological acute toxicity. The acute toxicities completely resolved in all patients without lethal outcomes. Longer follow-up is needed to assess the impact of PBT on chronic toxicity.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jingjing M. Dougherty, Edward Castillo, Richard Castillo, Austin M. Faught, Mark Pepin, Sean S. Park, Chris J. Beltran, Thomas Guerrero, Inga Grills, Yevgeniy Vinogradskiy
Summary: The study evaluated the dosimetric gains of functional avoidance-based proton treatment planning compared to conventional treatment planning, showing significant dose reduction to lung structures without increasing dose to Organ at Risk (OAR) structures. Functional proton plans did not exhibit significant dose degradation to OARs or clinical target volumes when considering interplay effect. Additionally, NTCP calculation indicated a further reduction in the risk of pulmonary complications with functional based IMPT.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2021)
Article
Oncology
Paul B. Romesser, Eric J. Sherman, Karissa Whiting, Margaret L. Ho, Ashok R. Shaha, Mona M. Sabra, Nadeem Riaz, Todd E. Waldenberg, Christopher R. Sabol, Ian Ganly, Sean M. McBride, James A. Fagin, Zhigang Zhang, R. Michael Tuttle, Richard J. Wong, Nancy Y. Lee
Summary: The study found that concurrent chemotherapy with intensity-modulated radiation therapy can significantly reduce locoregional failure rates, with acceptable toxicity and positive patient-reported outcomes.
Article
Oncology
Thomas Berger, Jeremy Godart, Thyrza Jagt, Anders Schwartz Vittrup, Lars Ulrik Fokdal, Jacob Christian Lindegaard, Nina Boje Kibsgaard Jensen, Andras Zolnay, Dominique Reijtenbagh, Petra Trnkova, Kari Tanderup, Mischa Hoogeman
Summary: This study evaluated the dosimetric effect of intrafraction motion on target coverage in patients with cervical cancer treated with online-adaptive IMPT. Results showed that a 5 mm planning target volume margin was effective in compensating for intrafraction motion due to bladder filling for prefraction times of 5 to 10 minutes.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Health Care Sciences & Services
Dorota Maria Borowicz, Konstantin N. Shipulin, Gennady V. Mytsin, Agnieszka Skrobala, Piotr Milecki, Victor N. Gayevsky
Summary: Comparison between passive scattering (PS) and intensity-modulated proton therapy (IMPT) for ultra-hypofractionated proton therapy in localized prostate cancer (PCa) showed that IMPT provided better target coverage and lower mean doses to the rectum and bladder compared to PS. However, PS had a slightly better performance in high dose distribution to the rectum. There were no significant differences in mean conformity index values and gamma index between the two treatment methods.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Jianzhong Cao, Xiaodong Zhang, Bo Jiang, Jiayun Chen, Xiaochun Wang, Li Wang, Narayan Sahoo, X. Ronald Zhu, Rong Ye, Pierre Blanchard, Adam S. Garden, C. David Fuller, G. Brandon Gunn, Steven J. Frank
Summary: The study showed that in patients with oropharyngeal cancer, IMPT treatment was associated with less late xerostomia compared to IMRT treatment. Dosimetric variables related to the oral cavity were associated with late xerostomia.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Kate Haslett, Neil Bayman, Kevin Franks, Nicki Groom, Susan Harden, Catherine Harris, Gerard Hanna, Stephen Harrow, Matthew Hatton, Paula McCloskey, Fiona McDonald, W. David Ryder, Corinne Faivre-Finn
Summary: The study demonstrates that using isotoxic intensity modulated radiation therapy (IMRT) for treatment intensification in stage III non-small cell lung cancer patients is feasible and well-tolerated.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Christopher Nutting, Laura Finneran, Justin Roe, Mark A. Sydenham, Matthew Beasley, Shree Bhide, Cheng Boon, Audrey Cook, Emma De Winton, Marie Emson, Bernadette Foran, Robert Frogley, Imran Petkar, Laura Pettit, Keith Rooney, Tom Roques, Devraj Srinivasan, Justine Tyler, DARS Trialist Grp
Summary: The study found that dysphagia-optimised intensity-modulated radiotherapy (DO-IMRT) improved swallowing function and reduced radiation dose-related damage in patients with oropharyngeal and hypopharyngeal cancers. Therefore, DO-IMRT should be considered as a new standard treatment for patients receiving radiotherapy for pharyngeal cancers.
Article
Oncology
Paul D. Brown, Caroline Chung, Diane D. Liu, Sarah McAvoy, David Grosshans, Karine Al Feghali, Anita Mahajan, Jing Li, Susan L. McGovern, Mary-Fran Mcaleer, Amol J. Ghia, Erik P. Sulman, Marta Penas-Prado, John F. de Groot, Amy B. Heimberger, Jihong Wang, Terri S. Armstrong, Mark R. Gilbert, Nandita Guha-Thakurta, Jeffrey S. Wefel
Summary: The study found that proton radiotherapy (PT) did not delay time to cognitive failure in patients with newly diagnosed gliobiastoma (GBM) compared to intensity-modulated radiotherapy (IMRT), but it reduced toxicity and patient-reported fatigue. PT significantly reduced the radiation dose for almost all structures analyzed. Larger randomized trials are needed to further explore the potential benefits of PT in GBM and cognitive preservation in patients with lower-grade gliomas.
Article
Oncology
Michelle Oud, Sebastiaan Breedveld, Marta Gizynska, Michiel Kroesen, Stefan Hutschemaekers, Steven Habraken, Steven Petit, Zoltan Perko, Ben Heijmen, Mischa Hoogeman
Summary: This study proposes and evaluates a new approach in intensity modulated proton therapy, which involves the daily selection of plans from patient-specific pre-treatment established plan libraries for treatment. Compared to daily online re-planning, this approach is simpler and reduces the risk of xerostomia and dysphagia, while improving adherence to target coverage constraints.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Otorhinolaryngology
Ariel E. Pollock, Danielle Arons, Gregory S. Alexander, David Alicia, Kayla M. Birkman, Jason K. Molitoris, Ranee Mehra, Kevin J. Cullen, Kyle M. Hatten, Rodney J. Taylor, Jeffrey S. Wolf, William F. Regine, Matthew E. Witek
Summary: A retrospective analysis showed that the extent of high-dose gross tumor volume (GTV) to clinical target volume (CTV) expansion is associated with local control in patients with p16-positive oropharynx cancer (p16+ OPC) treated with intensity modulated proton therapy (IMPT). Excellent local control was achieved using IMPT for p16+ OPC independent of GTV expansion.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)