Article
Multidisciplinary Sciences
Sergey P. Primakov, Abdalla Ibrahim, Janita E. van Timmeren, Guangyao Wu, Simon A. Keek, Manon Beuque, Renee W. Y. Granzier, Elizaveta Lavrova, Madeleine Scrivener, Sebastian Sanduleanu, Esma Kayan, Iva Halilaj, Anouk Lenaers, Jianlin Wu, Rene Monshouwer, Xavier Geets, Hester A. Gietema, Lizza E. L. Hendriks, Olivier Morin, Arthur Jochems, Henry C. Woodruff, Philippe Lambin
Summary: Accurate interpretation of CT scans is crucial for assessing a patient's disease. This study presents a system that automatically segments non-small cell lung cancer on CT images, demonstrating faster and more reproducible results compared to clinicians.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Martijn H. van der Ree, Phillip S. Cuculich, Marcel van Herk, Geoffrey D. Hugo, Jippe C. Balt, Matthew Bates, Gordon Ho, Etienne Pruvot, Claudia Herrera-Siklody, Wiert F. Hoeksema, Justin Lee, Michael S. Lloyd, Michiel J. B. Kemme, Frederic Sacher, Romain Tixier, Joost J. C. Verhoeff, Brian V. Balgobind, Clifford G. Robinson, Coen R. N. Rasch, Pieter G. Postema
Summary: The study shows high interobserver variability in the manual delineation of the VT-target and ventricular segments. There is a need for methods and tools to improve variability and allow for future comparison of interventions aiming to reduce observer variation, for STAR but possibly also for catheter ablation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Oncology
Wonjoong Cheon, Seonghoon Jeong, Jong Hwi Jeong, Young Kyung Lim, Dongho Shin, Se Byeong Lee, Doo Yeul Lee, Sung Uk Lee, Yang Gun Suh, Sung Ho Moon, Tae Hyun Kim, Haksoo Kim
Summary: This research introduces a novel IOV prediction network (IOV-Net) that utilizes deep learning to produce high-quality IOV maps, aiming to reduce interobserver variability in oncologists' manual delineation of tumor contours. Experimental results demonstrate that IOV prediction accuracy is high, and clinical feasibility tests show that guidance from IOV maps can significantly reduce IOV and improve radiation therapy efficacy.
Review
Medicine, General & Internal
Shou-Feng Wang, Nai-Quan Mao, Wen-Hua Zhao, Xin-Bin Pan
Summary: This study evaluated the effect of postoperative radiotherapy on patients with non-small cell lung cancer. The results showed that radiotherapy decreased the incidence of local recurrence, but did not improve disease-free survival and overall survival.
Article
Multidisciplinary Sciences
Gargi Kothari, Beverley Woon, Cameron J. Patrick, James Korte, Leonard Wee, Gerard G. Hanna, Tomas Kron, Nicholas Hardcastle, Shankar Siva
Summary: This study investigates the robustness of radiomics features (RF) to inter-observer variation (IOV) in contouring in lung cancer. The majority of RF are robust to IOV, with first order, GLCM and shape features being the least robust.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Paul Van Houtte, Luigi Moretti, Florian Charlier, Martine Roelandts, Dirk Van Gestel
Summary: Preoperative and postoperative radiotherapy with or without chemotherapy has been used in NSCLC for decades, with many unanswered questions despite advancements in knowledge, technology, and surgery. This review summarizes current understanding and discusses unresolved issues in the field.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Marnix J. A. Rasing, Max Peters, Amy C. Moreno, Erik F. N. Hofman, Gerarda J. M. Herder, Pim W. N. Welvaart, Franz M. N. H. Schramel, Joyce E. Lodeweges, Steven H. Lin, Joost J. C. Verhoeff, Peter S. N. van Rossum
Summary: In this study, a prediction model was developed to estimate the chance of incomplete resection in non-small cell lung cancer patients based on preoperative factors. Independent predictors were identified through internal and external validation, and an internationally validated nomogram was presented.
ANNALS OF THORACIC SURGERY
(2021)
Review
Oncology
Ursula Nestle, Cecile Le Pechoux, Dirk De Ruysscher
Summary: In recent years, advancements in medical imaging and molecular imaging have allowed for improved target volume concepts in radiotherapy for locally advanced lung cancer. The use of 18F-FDG PET/CT as a standard diagnostic tool has shown superior accuracy compared to conventional imaging methods. The results from the PET-Plan trial may further refine standards and guidelines for treatment planning in lung cancer.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Medicine, General & Internal
Brian Yu, Sung Jun Ma, Olivia Waldman, Cynthia Dunne-Jaffe, Udit Chatterjee, Lauren Turecki, Jasmin Gill, Keerti Yendamuri, Austin Iovoli, Mark Farrugia, Anurag K. Singh
Summary: This retrospective cohort study found that the use of intensity-modulated radiation therapy (IMRT) for postoperative radiation therapy (PORT) among patients with incompletely resected non-small cell lung cancer (NSCLC) increased in the US from 2004 to 2019. Furthermore, IMRT was associated with improved survival compared with 3D conformal radiation therapy (3DCRT).
Article
Oncology
Yang Ni, Jinchao Peng, Xia Yang, Zhigang Wei, Bo Zhai, Jiachang Chi, Xiaoguang Li, Xin Ye
Summary: Microwave ablation (MWA) is an effective and safe treatment option for selected patients with pulmonary oligorecurrence after radical surgical resection of non-small-cell lung cancer (NSCLC). Local recurrence and intrathoracic oligorecurrence do not significantly affect overall survival (OS), but distant metastasis is a predictive factor for OS.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Alberto Cabanero Sanchez, Gemma Maria Munoz Molina, Sara Fra Fernandez, Alfonso Muriel Garcia, Angel Cilleruelo Ramos, Estor Martinez Hernandez, Florentino Hernando Trancho, Nicolas Moreno Mata
Summary: Neoadjuvant chemotherapy and chemoradiotherapy are associated with higher rates of cardiovascular complications, arrhythmias, and transfusions in patients with non-small-cell lung cancer undergoing anatomic lung resection.
Article
Oncology
Kristine N. Kim, Jonathan Heintz, Nikhil Yegya-Raman, Roger Cohen, Timothy Kegelman, Keith Cengel, Melina Marmarelis, Lova Sun, Corey Langer, Charu Aggarwal, Aditi Singh, Sunil Singhal, John Kucharczuk, Kyle Robinson, Steven Feigenberg
Summary: In this retrospective cohort study, the safety of modern postoperative radiotherapy for resected locally advanced non-small-cell lung cancer was evaluated. The results showed that radiotherapy was well tolerated with low rates of non-cancer-related deaths, including cardiopulmonary deaths. Proton therapy reduced heart and lung doses significantly, but did not improve the risk of non-cancer-related deaths.
CLINICAL LUNG CANCER
(2023)
Article
Oncology
Chen -Chen Zhang, Wen Yu, Qin Zhang, Xu-Wei Cai, Wen Feng, Xiao-Long Fu
Summary: Postoperative radiotherapy (PORT) is controversial in patients with pathological N2 non-small cell lung cancer. Recent studies have identified potential predictors of PORT. This study developed a decision support framework (DSF) combining risk factors and prognostic index to predict the outcomes of PORT. A specific pN2 subgroup with a high risk of loco-regional recurrence and without certain histological features may benefit from PORT.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Medicine, General & Internal
Mariano Provencio, Ernest Nadal, Jose L. Gonzalez-Larriba, Alex Martinez-Marti, Reyes Bernabe, Joaquim Bosch-Barrera, Joaquin Casal-Rubio, Virginia Calvo, Amelia Insa, Santiago Ponce, Noemi Reguart, Javier de Castro, Joaquin Mosquera, Manuel Cobo, Andres Aguilar, Guillermo Lopez Vivanco, Carlos Camps, Rafael Lopez-Castro, Teresa Moran, Isidoro Barneto, Delvys Rodriguez-Abreu, Roberto Serna-Blasco, Raquel Benitez, Carlos Aguado de la Rosa, Ramon Palmero, Florentino Hernando-Trancho, Javier Martin-Lopez, Alberto Cruz-Bermudez, Bartomeu Massuti, Atocha Romero
Summary: This study evaluated the efficacy of the neoadjuvant nivolumab plus chemotherapy regimen on operable stage III non-small-cell lung cancer (NSCLC) patients. The results showed that patients receiving the combination therapy had a higher rate of pathological complete response and longer survival, indicating the effectiveness of this treatment approach in this patient population.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Hyejo Ryu, Changhoon Song, Jae-Sung Kim, Jae Hyun Jeon, Sukki Cho, Kwhanmien Kim, Sanghoon Jheon, Se Hyun Kim, Yu Jung Kim, Jong Seok Lee
Summary: This study aimed to investigate the relationship between the prognostic nutritional index (PNI) and survival and recurrence in NSCLC patients who underwent postoperative radiotherapy (PORT). 97 NSCLC patients were included in the study, and higher post-RT PNI was significantly associated with better overall survival. This finding suggests that PNI can be used as a prognostic marker in this patient population.
Article
Oncology
Matthew Van Oirschot, Alanah Bergman, Wilko F. A. R. Verbakel, Lucy Ward, Isabelle Gagne, Vicky Huang, Nick Chng, Peter Houston, Kerry Symes, Christopher G. Thomas, Parminder Basran, David Bowes, Stephen Harrow, Robert Olson, Suresh Senan, Andrew Warner, David A. Palma, Stewart Gaede
Summary: This study assessed the association between target coverage compromise and patient outcomes in SABR treatment for oligometastases. The results showed that for some lesions, a reduction in dose or target coverage was necessary to meet organ at risk constraints. However, target coverage was not significantly associated with survival outcomes or lesional control.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
David R. Spigel, Corinne Faivre-Finn, Jhanelle E. Gray, David Vicente, David Planchard, Luis Paz-Ares, Johan F. Vansteenkiste, Marina C. Garassino, Rina Hui, Xavier Quantin, Andreas Rimner, Yi-Long Wu, Mustafa Ozguroglu, Ki H. Lee, Terufumi Kato, Maike de Wit, Takayasu Kurata, Martin Reck, Byoung C. Cho, Suresh Senan, Jarushka Naidoo, Helen Mann, Michael Newton, Piruntha Thiyagarajah, Scott J. Antonia
Summary: The study examined the efficacy of consolidation durvalumab in patients with non-small-cell lung cancer, showing significant improvements in overall survival and progression-free survival, with manageable safety. The 5-year follow-up data continued to demonstrate the positive effects of durvalumab on survival and disease progression.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Editorial Material
Oncology
Anand Swaminath, Timothy Ritter, Alexander V. Louie, David A. Palma, Matthias Guckenberger, Suresh Senan, Andrea Bezjak, Drew Moghanaki
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Claire van Vliet, Chris Dickhoff, Idris Bahce, Anton F. Engelsman, Sayed M. S. Hashemi, Cornelis J. A. Haasbeek, Anna M. E. Bruynzeel, Miguel A. Palacios, Annemarie Becker-Commissaris, Berend J. Slotman, Suresh Senan, Famke L. Schneiders
Summary: This study investigated treatment patterns for adrenal metastases using surgery or SABR at a single institution. The number of patients undergoing SABR doubled since 2016, while the numbers undergoing surgery remained unchanged. Both treatments showed low rates of acute toxicity and similar survival outcomes.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
S. Senan, M. Ozguroglu, D. Daniel, A. Villegas, D. Vicente, S. Murakami, R. Hui, C. Faivre-Finn, L. Paz-Ares, Y. L. Wu, H. Mann, P. A. Dennis, S. J. Antonia
Summary: Durvalumab improves progression-free survival and overall survival in patients with or without stage IIIA-N2 non-small-cell lung cancer (NSCLC). Further research is needed to determine the optimal treatment approach for patients who are deemed operable.
Editorial Material
Oncology
Andrew G. Shuman, Matti S. Aapro, Benjamin Anderson, Katherine Arbour, Pedro C. Barata, Aditya Bardia, Eduardo Bruera, Bruce A. Chabner, Herbert Chen, Edwin Choy, Pierfranco Conte, Giuseppe Curigliano, Don Dizon, Eileen O'Reilly, Antonio Tito Fojo, Hans Gelderblom, Timothy A. Graubert, Jayne S. Gurtler, Evan Hall, Fred R. Hirsch, Ahmed Idbaih, David H. Ilson, Michael Kelley, Carlo La Vecchia, Heinz Ludwig, Beverly Moy, Hyman Muss, Frans Opdam, Rebecca D. Pentz, Marshall R. Posner, Jeffrey S. Ross, Adrian Sacher, Suresh Senan, Enrique Soto Perez de Celis, Kenneth K. Tanabe, Jan B. Vermorken, Eric Wehrenberg-Klee, Susan E. Bates
Summary: In this editorial, the authors discuss the potential implications of the recent Supreme Court decision in Dobbs v. Jackson Women's Health Organization for patients with cancer, in the context of the difficult decision of whether or not to choose pregnancy termination.
Article
Radiology, Nuclear Medicine & Medical Imaging
Helen J. Ball, Lakshmi Santanam, Suresh Senan, James A. Tanyi, Marcel van Herk, Paul J. Keall
Summary: A survey was conducted to assess the clinical practice of respiratory motion management in radiation oncology. The results showed that 84% of respondents used deep inspiration breath hold for left-sided breast cancer. 83% of respondents considered respiratory motion management very important or required for thoracic and abdominal cancer patients. 95% of respondents used respiratory motion management for thoracic and abdominal sites.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Koen J. Nelissen, Eva Versteijne, Suresh Senan, Daan Hoffmans, Ben J. Slotman, Wilko F. A. R. Verbakel
Summary: A workflow involving preplanning on diagnostic CT imaging and online plan adaption using cone-beam CT scan was developed for single-visit radiotherapy. The study showed that this workflow can meet clinical goals and outperform initial treatment plans based on daily CT scan.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Moritz Rabe, Miguel A. Palacios, John van Sornsen R. de Koste, Chukwuka Eze, Martin Hillbrand, Claus Belka, Guillaume Landry, Suresh Senan, Christopher Kurz
Summary: This study compared the accumulated doses of MRgRT, non-adaptive IMPT, and online adaptive IMPT for central lung tumors, with a focus on the bronchial tree dose. The results showed that non-adaptive and online adaptive proton therapy achieved significant dose sparing for organs in close proximity to central lung tumors compared to MRgRT. Online adaptive IMPT achieved significantly lower doses to the bronchial tree compared to MRgRT.
Article
Oncology
Koen J. Nelissen, Eva Versteijne, Suresh Senan, Barbara Rijksen, Marjan Admiraal, Jorrit Visser, Sarah Barink, Amy L. de la Fuente, Daan Hoffmans, Ben J. Slotman, Wilko F. A. R. Verbakel
Summary: We developed a rapid palliative radiotherapy workflow using diagnostic imaging for pre-planning and on-couch target and plan adaptation based on a synthetic CT obtained from CBCT. The adapted treatment plans showed significant improvements in target coverage compared to the original plans. Most patients were satisfied with the workflow. The average treatment time, including consultation and on-couch adaptive treatment, was 85 minutes.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Puneeth Iyengar, Sean All, Mark F. Berry, Thomas P. Boike, Lisa Brad fi Eld, Anne -Marie C. Dingemans, Jill Feldman, Daniel R. Gomez, Paul J. Hesketh, Salma K. Jabbour, Melenda Jeter, Mirjana Josipovic, Yolande Lievens, Fiona Mcdonald, Bradford A. Perez, Umberto Ricardi, Enrico Ruffini, Dirk De Ruysscher, Hina Saeed, Bryan J. Schneider, Suresh Senan, Joachim Widder, Matthias Guckenberger
Summary: This guideline aims to review the use of local therapy in the management of extracranial oligometastatic non-small cell lung cancer (NSCLC) and provide recommendations. Currently, data is limited, but with increasing evidence supporting the use of local therapy in NSCLC, this guideline attempts to provide recommendations based on the quality of available data.
PRACTICAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Miguel A. Palacios, Georgi Gerganov, Paul Cobussen, Shyama U. Tetar, Tobias Finazzi, Berend J. Slotman, Suresh Senan, Cornelis J. A. Haasbeek, Iwan Kawrakow
Summary: This study evaluated the accuracy of automatic tumor segmentation in MR-guided radiotherapy (MRgRT) by comparing it to manual delineations performed by experienced observers. The results showed a high level of agreement between automatic segmentation and manual delineation.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2023)
Article
Oncology
Hilal Tekatli, Miguel A. Palacios, Famke L. Schneiders, Cornelis J. A. Haasbeek, Ben J. Slotman, Frank J. Lagerwaard, Suresh Senan
Summary: This study investigated the long-term clinical outcomes of MR-guided SF-SABR on a 0.35 T linac for lung tumors. The results showed that SF-SABR, using automatic beam gating during breath-holds, achieved good tumor control and low toxicity.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Famke L. Schneiders, Claire van Vliet, Nicolas Giraud, Anna M. E. Bruynzeel, Ben J. Slotman, Miguel A. Palacios, Suresh Senan
Summary: This study retrospectively reviewed the outcomes of MR-guided adrenal SABR and found that this approach is well tolerated and achieves high local control rates. Further research using deformable dose accumulation is needed to better understand the dose-response relationship.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Miguel A. Palacios, Sonja Verheijen, Famke L. Schneiders, Omar Bohoudi, Berend J. Slotman, Frank J. Lagerwaard, Suresh Senan
Summary: The study investigated the clinical feasibility, patient satisfaction, and delivery accuracy of single-fraction MR-guided SABR in a single day. All 10 patients completed the one-stop-shop procedure in a single day and reported satisfaction with the process. The accuracy of SABR delivery was high with little impact of system-latency.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2022)