Article
Oncology
Walburga Yvonne Joko-Fru, Mirko Griesel, Nikolaus Christian Simon Mezger, Lucia Haemmerl, Tobias Paul Seraphin, Jana Feuchtner, Henry Wabinga, Guy N'da, Assefa Mathewos, Bakarou Kamate, Judith Nsonde Malanda, Freddy Houehanou Rodrigue Gnangnon, Gladys Chebet Chesumbai, Anne Korir, Cesaltina Lorenzoni, Annelle Zietsman, Margaret Ziona Borok, Biying Liu, Christoph Thomssen, Paul McGale, Ahmedin Jemal, Donald Maxwell Parkin, Eva Johanna Kantelhardt
Summary: This study aims to describe the cancer-directed therapy received by patients with breast cancer in sub-Saharan Africa, compare these results with the NCCN Harmonized Guidelines, and evaluate the impact on survival. The study found that access to adequate therapy and early-stage diagnosis were the most important determinants of survival for breast cancer patients in sub-Saharan Africa.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)
Article
Oncology
Shuofeng Li, Ran Wei, Guanhua Yu, Hengchang Liu, Tianli Chen, Xu Guan, Xishan Wang, Zheng Jiang
Summary: This study aimed to investigate the effect of pelvic radiation therapy on the development of secondary bladder cancer. The results showed that patients who received radiation therapy had a higher risk of developing secondary bladder cancer compared to those who did not receive radiation therapy. Different treatment modalities of pelvic radiation therapy had different effects on the risk of secondary bladder cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Huijiang Gao, Yuanyong Wang, Zhihui Jiang, Guodong Shi, Shiyu Hu, Jiangshan Ai, Zhaofeng Wang, Yucheng Wei
Summary: This study explores the link between adjuvant radiotherapy and survival in pN0 esophageal cancer patients. It suggests that adjuvant radiotherapy following upfront esophagectomy can improve the overall survival of high-risk patients. This finding has significant implications for the use of adjuvant radiotherapy in pN0 esophageal cancer.
Article
Oncology
Melvin J. Silverstein, Brian Kim, Kevin Lin, Shane Lloyd, Lincoln Snyder, Sadia Khan, Katherine Kramme, Peter Chen
Summary: Randomized trials have shown that risk-adapted intraoperative radiation therapy (IORT) is a safe alternative to whole-breast radiation therapy (WBRT) for low-risk breast cancer patients. Additional WBRT is given to patients with high-risk pathologic characteristics. However, the more WBRT is given, the less we understand the contribution of IORT as a stand-alone treatment.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Jing-Ying Xu, Jun-Ni Chen, Jian Lei, Min Hu, San-Gang Wu, Juan Zhou
Summary: This study evaluated the value of local treatment in stage IVB cervical cancer patients and found that the addition of local surgery or radiotherapy to chemotherapy can improve survival outcomes.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Fuchao Liang, Fei Zhou, Xiaoyuan Qian, Linghui Qin, Jiange Wang, Chen Ding, Yasen Kuniduzi, Xuejun Zhang, Lianming Fan
Summary: This study suggests that radiotherapy improves the survival benefits for patients with small cell carcinoma of the bladder who undergo bladder-sparing surgery. Furthermore, radiotherapy combined with chemotherapy demonstrates a greater survival benefit compared with chemotherapy alone.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Hans H. B. Wenzel, Ruud L. M. Bekkers, Valery E. P. P. Lemmens, Maaike A. Van der Aa, Hans W. Nijman
Summary: Surgery remains the preferred treatment for early-stage cervical cancer patients aged 15-74, with higher application rates seen in younger patients. The use of chemoradiation has increased over time in locally advanced cervical cancer patients, while radiotherapy remains common in older patients aged 75 and above.
EUROPEAN JOURNAL OF CANCER
(2021)
Review
Oncology
Thomas Bardol, Lorenzo Ferre, Safa Aouinti, Marie Dupuy, Eric Assenat, Jean-Michel Fabre, Marie-Christine Picot, Regis Souche
Summary: This systematic review assesses the survival outcome of surgically treated metastatic esophageal cancer patients and finds that multimodality treatment, including surgery in curative intent, is associated with a significant improvement in three-year overall survival.
Review
Oncology
Adham Hijab, Boris Tocco, Ian Hanson, Hanneke Meijer, Christina Junker Nyborg, Anders Smedegaard Bertelsen, Robert Jan Smeenk, Gillian Smith, Jeff Michalski, Brian C. Baumann, Shaista Hafeez
Summary: Radiotherapy plays a significant role in both curative and palliative treatment of bladder cancer, but faces technical challenges such as poor tumor visualization and bladder size variability. Magnetic resonance imaging (MRI) is favored for tumor visualization and staging, and the integration of MRI scanning with linear accelerator in MR-Linac systems allows for real-time plan adaptation during treatment, potentially improving outcomes for bladder cancer patients. However, robust evidence is needed to determine if MR-guided radiotherapy translates into better patient outcomes before widespread clinical implementation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Noortje Verschoor, Wilma D. Heemsbergen, Joost L. Boormans, Martine Franckena
Summary: This study found that organ-sparing treatment for muscle-invasive bladder cancer by maximal transurethral removal of the tumor (TURB) followed by chemoradiation (CRT) is feasible and acceptable. The outcomes in terms of local control (LC) and overall survival (OS) were satisfactory compared to radical cystectomy (RC).
Article
Otorhinolaryngology
Liang Peng, Xue-Lan Zeng, Rui-Hua Fang, Ren-Qiang Ma, Wei-Ping Wen, Wei Sun
Summary: This retrospective study compared the survival outcomes of early-stage oropharyngeal cancer patients who received upfront surgery or definitive radiotherapy. The results showed that upfront surgery was associated with lower cancer-specific and noncancer mortality in HPV-negative patients, while both treatments had similar efficacy in HPV-positive patients.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Oncology
Xiaopei Chao, Xiaochen Song, Huanwen Wu, Yan You, Ming Wu, Lei Li
Summary: In patients with recurrent cervical cancer, radiotherapy can improve PFS and OS for those with recurrence within the pelvic cavity and no prior radiotherapy. Combination or individualized therapy may provide potential survival benefits for recurrence beyond the pelvic cavity or cases with a history of radiotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yoon Young Jo, Ji Woon Yea, Jaehyeon Park, Se An Oh, Jae Won Park
Summary: Bladder filling variation presents a challenge for radiotherapy delivery. Adaptive radiotherapy using individualized plan libraries has shown good survival outcomes and high local control rates.
Article
Oncology
Dorian Culie, Renaud Schiappa, Anouchka Modesto, Julien Viotti, Emmanuel Chamorey, Olivier Dassonville, Gilles Poissonnet, Alain Bizeau, Sebastien Vergez, Agnes Dupret-Bories, Nicolas Fakhry, Laure Santini, Benjamin Lallemant, Guillaume Chambon, Anne Sudaka, Frederic Peyrade, Esma Saada-Bouzid, Karen Benezery, Florence Jourdan-Soulier, Francoise Chapel, Anne Sophie Ramay, Pascal Roger, Thibault Galissier, Valerie Coste, Aicha Ben Lakdar, Joanne Guerlain, Haitham Mirghani, Phillipe Gorphe, Bruno Guelfucci, Renaud Garrel, Stephane Temam, Alexandre Bozec
Summary: This study aimed to evaluate the impact of initial therapeutic strategy on oncologic outcomes in patients with HPV-positive oropharyngeal squamous cell carcinoma. The results showed that surgical strategy demonstrated significant differences in disease-specific and recurrence-free survival compared to non-surgical strategy, especially after multivariate analysis.
Article
Oncology
Naif Fnais, Francisco Laxague, Faisal Alzahrani, Kevin Fung, Eric Di Gravio, Danielle MacNeil, Adrian Mendez, John Yoo, Pencilla Lang, Joe S. Mymryk, John W. Barrett, Keng Yow Tay, Andrew Leung, Anthony C. Nichols, David A. Palma
Summary: This study compared the outcomes of patients with early-stage OPSCC who were potential candidates for transoral surgery (TOS) to those who were not. The results showed that patients with TOS-favorable primary site had better overall survival, disease-specific survival, and recurrence-free survival compared to TOS-unfavorable patients. This provides valuable prognostic information and highlights the importance of considering confounding by indication in nonrandomized treatment comparisons.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Caroline L. Furness, Lesley Smith, Eva Morris, Caroline Brocklehurst, Sasha Daly, Rachael E. Hough
JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY
(2017)
Article
Hematology
Lesley Smith, Adam W. Glaser, Sally E. Kinsey, Darren C. Greenwood, Lucy Chilton, Anthony V. Moorman, Richard G. Feltbower
BRITISH JOURNAL OF HAEMATOLOGY
(2018)
Article
Oncology
Lesley Smith, Simon Pini, Andrea Ferrari, Daniel Yeomanson, Rachael Hough, Pia Riis Olsen, Leila Gofti-Laroche, Thomas Fleming, Martin Elliott, Richard Feltbower, Gabriella Kertesz, Dan Stark
JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY
(2018)
Article
Oncology
Lesley Smith, Adam W. Glaser, Daniel Peckham, Darren C. Greenwood, Richard G. Feltbower
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Respiratory System
L. Caley, L. Smith, H. White, D. G. Peckham
Summary: This study aimed to determine the national rate of decline in percent predicted Forced Expiratory Volume in 1 second (ppFEV(1)) in adults with cystic fibrosis in the UK, taking into account age, sex, and pancreatic status. The results showed that pancreatic status had a significant impact on the average rate of decline in lung function, with younger adults, especially females, exhibiting a faster rate of decline.
JOURNAL OF CYSTIC FIBROSIS
(2021)
Article
Oncology
Lesley Smith, Adam W. Glaser, Darren C. Greenwood, Richard G. Feltbower
CANCER EPIDEMIOLOGY
(2020)
Article
Oncology
Christopher Clements, Kirsten J. Cromie, Lesley Smith, Richard G. Feltbower, Nicola Hughes, Adam W. Glaser
Summary: Risk-stratified levels of aftercare based on the NCSI approach can effectively predict long-term morbidity in young adult cancer survivors aged 18-29, indicating the potential for improved quality of care and resource utilization in this population.
JOURNAL OF CANCER SURVIVORSHIP
(2021)
Article
Oncology
Lesley Smith, Amy Downing, Paul Norman, Penny Wright, Luke Hounsome, Eila Watson, Richard Wagland, Peter Selby, Paul Kind, David W. Donnelly, Hugh Butcher, Dyfed Huws, Emma McNair, Anna Gavin, Adam W. Glaser
CANCER EPIDEMIOLOGY
(2020)
Editorial Material
Primary Health Care
Richard D. Neal, Lesley Smith
BRITISH JOURNAL OF GENERAL PRACTICE
(2021)
Article
Oncology
Lesley Smith, Charles A. Stiller, Joanne F. Aitken, Lisa L. Hjalgrim, Tom Johannesen, Paivi Lahteenmaki, Martin G. McCabe, Robert Phillips, Kathy Pritchard-Jones, Eva Steliarova-Foucher, Jeanette F. Winther, Ryan R. Woods, Adam W. Glaser, Richard G. Feltbower
Summary: Despite significant temporal reductions in cancer mortality rates for all cancers and age groups in the six ICBP countries, the greatest improvements were seen in children aged 0-14 compared to adolescents and adults. This may be attributed to better care and treatment protocols for children.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Editorial Material
Primary Health Care
Lesley Smith, Nigel Sansom, Scott Hemphill, Stephen H. Bradley, Bethany Shinkins, Pete Wheatstone, Willie Hamilton, Richard D. Neal
BRITISH JOURNAL OF GENERAL PRACTICE
(2022)
Editorial Material
Primary Health Care
Lesley Smith, Jonathan Carmichael, Gordon Cook, Bethany Shinkins, Richard D. Neal
BRITISH JOURNAL OF GENERAL PRACTICE
(2022)
Article
Oncology
Lesley Smith, Jonathan Carmichael, Gordon Cook, Bethany Shinkins, Richard D. Neal
Summary: This study developed an algorithm to identify individuals at high-risk of undiagnosed myeloma based on routine blood test results. Further testing can then be conducted to specifically diagnose myeloma. This method has the potential to significantly impact the diagnosis of myeloma on a large scale and at a low cost.
Article
Oncology
Charlotte Summerfield, Lesley Smith, Oliver Todd, Cristina Renzi, Georgios Lyratzopoulos, Richard D. Neal, Daniel Jones
Summary: Over 60% of cancer diagnoses in the UK are in patients aged 65 and over. Cancer diagnosis and treatment in older adults is complicated by the presence of frailty, and delays in diagnosis and treatment can lead to poorer patient outcomes.
Article
Endocrinology & Metabolism
Jane West, Gillian Santorelli, Peter H. Whincup, Lesley Smith, Naveed A. Sattar, Noel Cameron, Diane Farrar, Paul Collings, John Wright, Debbie A. Lawlor