Article
Environmental Sciences
Hao Bai, Jufang Wang, Qiaojuan Wang, Yaxiong Chen, Guoying Miao, Tongshan Zhang, Junrui Hua, Yanan Zhang, Jinpeng He, Nan Ding, Heng Zhou, Li Sui, Wenjun Wei
Summary: The study suggests that circulating IGFBP-3 may serve as a promising universal biomarker for complex environmental radiation exposure, and its upregulation is influenced by MKC in a P53-dependent manner. Circulating IGFBP-3 assays could provide rapid, convenient and effective dose and toxicity assessment methods in occupational exposure or radiation disaster management.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Michal Marczyk, Joanna Polanska, Andrzej Wojcik, Lovisa Lundholm
Summary: This study aimed to test miRNA biomarkers in leukocytes of breast cancer patients undergoing external beam radiotherapy. The results showed that while miR-744-5p showed promise as a stable miRNA marker, most tested miRNAs displayed individual signal variability and temporal patterns, potentially excluding them as sensitive biomarkers of radiation response in this setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Environmental Sciences
Antonio J. Signes-Pastor, Enrique Gutierrez-Gonzalez, Miguel Garcia-Villarino, Francisco D. Rodriguez-Cabrera, Jorge J. Lopez-Moreno, Elena Varea-Jimenez, Roberto Pastor-Barriuso, Marina Pollan, Ana Navas-Acien, Beatriz Perez-Gomez, Margaret R. Karagas
Summary: This systematic review highlights the reliability of toenail arsenic concentrations as biomarkers of long-term exposure, showing influences from geographic locations and sources of arsenic contamination. Notably, toenail arsenic levels correlate with concentrations in hair, fingernails, and urine, suggesting its potential as an indicator of long-term internal dose-exposure.
ENVIRONMENTAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Mary Sproull, Uma Shankavaram, Kevin Camphausen
Summary: A novel high-throughput proteomics screening approach was used to identify proteomic markers of radiation exposure in the plasma of total body irradiated mice. A subset panel of significantly altered proteins was selected to build predictive models of radiation exposure and radiation dose. The new predictive models showed high accuracy in differentiating between radiation exposure levels and doses.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Environmental Sciences
Inmaculada Salcedo-Bellido, Enrique Gutierrez-Gonzalez, Esther Garcia-Esquinas, Nerea Fernandez de Larrea-Baz, Ana Navas-Acien, Maria Tellez-Plaza, Roberto Pastor-Barriuso, Virginia Lope, Jose Luis Gomez-Ariza, Tamara Garcia-Barrera, Marina Pollan, Jose Juan Jimenez Moleon, Beatriz Perez-Gomez
Summary: Toenails have been used as biomarkers of exposure to toxic metals, but their validity is still unclear and needs further research. Different toxic metals may have varying levels of validity as biomarkers in toenails. Lack of standardization and conflicting results among studies make it difficult to conclude whether toenails are a reliable biomarker of exposure to toxic metals.
ENVIRONMENTAL RESEARCH
(2021)
Article
Oncology
Yue Shen, Ming Li, Li Liao, Suyue Gao, Yongzhen Wang
Summary: This study found that the levels of plasma exosome-derived Cx43 were significantly downregulated in patients with melanoma, and it was negatively correlated with overall survival and disease-free survival. Specifically, patients with tumor located in the skin, tumor size < 10 cm, Clark level I-III, TNM stages IIb-IV, and no lymph node metastasis had higher levels of plasma exosome-derived Cx43. Plasma exosome-derived Cx43 could be a potential prognostic indicator for 5-year overall survival and 5-year disease-free survival in patients with melanoma.
Review
Biochemistry & Molecular Biology
Leyla A. Akh, Mohammad O. Ishak, Jennifer F. Harris, Trevor G. Glaros, Zachary J. Sasiene, Phillip M. Mach, Laura M. Lilley, Ethan M. McBride
Summary: This article discusses the advancements in in vitro 3D skin models and MS-based -omics techniques used in low-dose ionizing radiation research, as well as tracks their application in the search for biomarkers.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Cell Biology
Meng Jia, Zhidong Wang
Summary: In this article, the distribution of microRNAs, the progress in researching microRNAs as markers of ionizing radiation (IR), and a hypothesis about their origin and destination after IR are summarized.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ikhwan Rinaldi, Melva Louisa, Resti Mulya Sari, Elly Arwanih
Summary: The one-year survival of AML patients in Indonesia is not affected by FLT3-ITD mutation and FLT3 ligand plasma level. However, the glomerular filtration rate (GFR) showed an association with one-year survival in this cohort study.
ONCOTARGETS AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Lexin He, Shixiang Zhou, Weihong Li, Qi Wang, Zhenhua Qi, Pingkun Zhou, Zhidong Wang, Jing Chen, Yaqiong Li, Zhongwu Lin
Summary: The study demonstrates that serum BPIFA2 can serve as a biomarker for predicting fatal radiation injury in the early stage post nuclear accident, accurately identifying radiation exposure and injury severity. This plays a vital role in rational use of medical resources, and greater efficiency of medical treatment to minimize casualties.
Article
Oncology
Peng-Fei Tian, Yu-Chen Ma, Dong-Sheng Yue, Fan Liang, Chen-Guang Li, Chen Chen, Hua Zhang, Xiao-Yan Sun, Wu-Hao Huang, Zhen-Fa Zhang, Guang-Biao Zhou, Gui-Zhen Wang, Bin Zhang, Chang-Li Wang
Summary: The study suggests that CXCL14 could serve as a potential diagnostic and prognostic biomarker in patients with lung cancer, as its expression is significantly associated with advanced disease stage, recurrence, and metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yan Zhuang, Jin Wang, Huihui Li, Yanghui Chen, Chen Chen, Dao Wen Wang
Summary: The study identified plasma Siglec-5 and CD163 as valuable novel biomarkers for the early diagnosis of fulminant myocarditis (FM).
Article
Medicine, General & Internal
Palaniswamy Ramaswamy, Rita Christopher, Pramod Kumar Pal, Monojit Debnath, Ravi Yadav
Summary: This study found that plasma miRNA expression was altered in patients with progressive supranuclear palsy (PSP) compared to controls. Five miRNAs (miR-19b-3p, miR-33a-5p, miR-130b-3p, miR-136-3p, and miR-210-3p) were identified as potential biomarkers for PSP. Further validation studies are needed to confirm these findings.
Article
Multidisciplinary Sciences
Malin Larsson, Nils-Petter Rudqvist, Johan Spetz, Toshima Z. Parris, Britta Langen, Khalil Helou, Eva Forssell-Aronsson
Summary: This study aimed to compare the differences in RNA and protein expression in the thyroid and plasma of young and adult rats exposed to I-131 irradiation, and identify potential age-dependent biomarkers for I-131 exposure. The results showed distinct age-dependent differences in gene and protein expression, and novel biomarkers for thyroid I-131 exposure were identified.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Peter Hermann, Sezgi Canaslan, Anna Villar-Pique, Timothy Bunck, Stefan Goebel, Franc Llorens, Matthias Schmitz, Inga Zerr
Summary: Plasma neurofilament light chain may be a valuable diagnostic and prognostic biomarker for fatal familial insomnia.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
