Article
Oncology
Zhuolin Li, Yao Lin, Bizhen Cheng, Qiaoxin Zhang, Yingmu Cai
Summary: This study evaluated prognostic factors for cervical squamous cell carcinoma (CSCC) and developed personalized risk assessment nomograms to predict overall survival (OS) and cancer-specific survival (CSS) in CSCC patients. The nomograms showed good performance in prognostic prediction and could be used as an effective tool for evaluating the prognosis of CSCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Nicholas R. Lenze, Douglas R. Farquhar, Siddharth Sheth, Jose P. Zevallos, Catherine Lumley, Jeffrey Blumberg, Samip Patel, Trevor Hackman, Mark C. Weissler, Wendell G. Yarbrough, Andrew F. Olshan, Adam M. Zanation
Summary: In this study, it was found that socioeconomic status (SES) may have a prognostic ability similar to overall stage for HPV-negative head and neck squamous cell carcinoma (HNSCC) patients. Low SES was associated with significantly increased risk of mortality and this association persisted even after adjusting for other factors.
Article
Cell Biology
Satoshi Kawaguchi, Bruno Moukette, Marisa N. Sepulveda, Taiki Hayasaka, Tatsuya Aonuma, Angela K. Haskell, Jessica Mah, Suthat Liangpunsakul, Yaoliang Tang, Simon J. Conway, Il-man Kim
Summary: miR-150 is downregulated during heart failure and correlates with patient outcomes. It protects against myocardial infarction by reducing cardiomyocyte apoptosis and targets small proline-rich protein 1a. Knockdown of SPrr1a improves cardiac dysfunction and fibrosis post-MI.
CELL DEATH & DISEASE
(2023)
Article
Biotechnology & Applied Microbiology
Victoriano Mendieta-Carmona, Guadalupe Delgado-Lopez, Julio Reyes-Leyva, Claudia Teresita Gutierrez-Quiroz, Victor Javier Vazquez-Zamora, Denisse Alejandra Picazo-Mendoza, Alvaro Jose Montiel-Jarquin, Laura Patricia Martinez-Morales, Veronica Vallejo-Ruiz
Summary: The aim of this study was to investigate the correlation between the expression of galectin-9 gene (LGALS9) and cervical cancer progression, clinicopathological characteristics, and overall survival. The results showed that higher expression levels of LGALS9 were associated with better prognosis and early clinical stages, and were also positively correlated with immune pathways enrichment and abundance of tumor infiltrating immune cells.
ONCOTARGETS AND THERAPY
(2023)
Article
Oncology
Muyuan Liu, Litian Tong, Bin Liang, Xuhong Song, Lingzhu Xie, Hanwei Peng, Dongyang Huang
Summary: Our study successfully established a novel 15-mRNA prognostic model for predicting overall survival of non-distant metastatic OTSCC. The prediction ability of this 15-gene signature was independent of other clinicopathological factors and demonstrated excellent prediction accuracy. Additionally, an external validation using the GEO dataset confirmed the good prediction ability of the 15-gene model. The prognostic nomogram integrating the 15-gene signature and clinicopathological factors has the potential to be developed as a prognostic tool.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Christin Friedrich, Renske L. R. E. Taggenbrock, Remi Doucet-Ladeveze, Gosia Golda, Rebekka Moenius, Panagiota Arampatzi, Natasja A. M. Kragten, Katharina Kreymborg, Mercedes Gomez de Agueero, Wolfgang Kastenmueller, Antoine-Emmanuel Saliba, Dominic Gruen, Klaas P. J. M. van Gisbergen, Georg Gasteiger
Summary: ILC1 cells exhibit similar differentiation pathways in different organs, with a gradual loss of TCF-1 resulting in loss of proliferative potential and increased expression of effector molecules.
Article
Cell Biology
Bao-Biao Zhuo, Lun-Qing Zhu, Chen Yao, Xi-Hua Wang, Shi-Xian Li, Rong Wang, Yuan Li, Zhuo-Yan Ling
Summary: We have shown that ADCK1, a mitochondrial protein, is upregulated in human osteosarcoma tissues and cells. ADCK1 plays a crucial role in cell viability, proliferation, migration, apoptosis, and mitochondrial functions. Inhibition of ADCK1 enhances doxorubicin-induced apoptosis and decreases cell growth. The mTOR pathway is important for ADCK1 expression. ADCK1 is a novel therapeutic target for osteosarcoma.
CELL DEATH & DISEASE
(2022)
Article
Medicine, General & Internal
Lang Qin, Xiangtian Yu, Chuang Xu, Yangchen Liu
Summary: This study investigated the impact of different metastasis patterns on overall survival (OS) in patients with organ metastatic lung squamous cell carcinoma (LUSC). The study analyzed a large database of 36,025 LUSC cases and found that the site and number of metastases significantly affected OS. Chemotherapy was beneficial for patients with single and multiple-organ metastases, while surgery only improved prognosis in patients with single and dual-organ metastases. The study highlights the importance of understanding metastasis patterns in guiding treatment decisions for LUSC patients.
Article
Medicine, General & Internal
Ruilin Ding, Zhou Su, Mi Chen, Longxia Chen
Summary: This study aimed to develop prognostic nomograms for better predictions of overall survival (OS) and cancer-specific survival (CSS) in patients with advanced cervical squamous cell carcinoma (mCSCC). Data from the SEER database between 2004 and 2015 were used to construct the nomograms based on Cox regression analysis. The nomograms showed satisfactory predictive performance with good consistency between prediction and actual survival, and they were useful in survival prediction for mCSCC patients.
Article
Oncology
Tomoki Abe, Taro Oshikiri, Hironobu Goto, Takashi Kato, Manabu Horikawa, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Tetsu Nakamura, Yoshihiro Kakeji
Summary: This study established a novel nutritional and inflammatory index, Delta Alb-dNLR, and evaluated its association with prognosis in patients with esophageal squamous cell carcinoma (ESCC) receiving neoadjuvant chemotherapy (nCT). The results showed that Delta Alb-dNLR is a useful prognostic factor for overall survival (OS) in these patients.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Pathology
Peter Jung, David Horst, Thomas Kirchner, Frederick Klauschen, Jens Neumann
Summary: This study analyzed the prognostic value of AURKA in stage II colorectal cancer patients and examined the association of AURKA expression with patient survival and molecular markers. The results showed that AURKA H-Score is correlated with good overall survival and wild-type KRAS status.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Alexandre Tendron, Marion Classe, Odile Casiraghi, Helene Pere, Caroline Even, Philippe Gorphe, Antoine Moya-Plana
Summary: This study investigated the incidence and impact of human papilloma virus (HPV) infection on the prognosis of patients with sinonasal squamous cell carcinoma (SNSCC). The results showed that patients with HPV-positive SNSCC were younger, had a primary tumor originating mainly in the nasal fossa, and had better oncologic outcomes. P16 expression was not a good surrogate of HPV status in SNSCC.
Article
Dentistry, Oral Surgery & Medicine
Jia Kang, Ming Su, Qiaoshi Xu, Chong Wang, Xiaohong Yuan, Zhengxue Han
Summary: The objective of this study was to evaluate the prognostic value of TSR and TB in OTSCC and establish a predictive model for the outcome of OTSCC patients. The results indicated that TSR was an independent risk factor for the prognosis of OTSCC patients and patients with stroma-rich had a worse long-term prognosis. The risk model combining TSR and TB showed valuable predictive power for the outcome of OTSCC patients.
Article
Surgery
Deliang Zeng, Xiao Wang, Shuning Zhang, Ao Zheng, Qingfeng Huang, Lingyan Cao
Summary: This study explored and identified potential biomarkers for cell pyroptosis in oral squamous cell carcinoma (OSCC) and constructed a pyroptosis-related prognostic signature. The results showed that the prognostic signature may have a potential role in predicting the prognosis of OSCC, and pyroptosis-related regulators could be novel biomarkers for tumor diagnosis and treatment in OSCC.
FRONTIERS IN SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Maria Cecilia Ramiro Talarico, Rafaella Almeida Lima Nunes, Gabriela Avila Fernandes Silva, Larissa Bastos Eloy da Costa, Marcella Regina Cardoso, Sergio Carlos Barros Esteves, Luis Otavio Zanatta Sarian, Luiz Carlos Zeferino, Lara Termini
Summary: High SOD2 expression is strongly associated with recurrence, distant recurrence, and death in patients with stage IIIB squamous cell cervical carcinoma. Multivariate analysis revealed a threefold increased risk of recurrence and death in patients with high SOD2 expression compared to those with low expression. Patients with high SOD2 expression had shorter disease-free and overall survival times.
Correction
Biochemistry & Molecular Biology
M. Burgess, Y. C. E. Chen, S. Mapp, A. Blumenthal, P. Mollee, D. Gill, N. A. Saunders
Summary: Correction to the paper has been published.
Review
Biochemistry & Molecular Biology
James Nightingale, Benedict Lum, Rahul Ladwa, Fiona Simpson, Benedict Panizza
Summary: The natural history of adenoid cystic carcinoma (ACC) is characterized by treatment failure due to locoregional recurrence and distant metastases. Recent research indicates that ACC is resistant to immune checkpoint inhibition. Targeting PSMA and receptor manipulation may be potential directions for future therapeutic approaches in ACC.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Medicine, General & Internal
Naomi Watson, Anita Cox, Jasotha Sanmugarajah, Marcin Dzienis, Ian Hughes
Summary: Telephone clinics have been utilized to reduce the risk of transmission during the COVID-19 pandemic. Evidence shows that most patients and clinicians view telephone clinics favorably, but there is still a significant portion of patients who prefer face-to-face clinics. Tailored services that accommodate individual preferences are recommended.
INTERNAL MEDICINE JOURNAL
(2021)
Article
Dermatology
Rehan Villani, Valentine Murigneux, Josue Alexis, Seen-Ling Sim, Michael Wagels, Nicholas Saunders, H. Peter Soyer, Laurent Parmentier, Sergey Nikolaev, J. Lynn Fink, Edwige Roy, Kiarash Khosrotehrani
Summary: Infiltrative BCCs do not differ significantly in terms of genomic alterations, but show a specific type of interaction with the extracellular matrix environment regulating Wnt signaling.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Review
Cell Biology
Emma-Anne Karlsen, Sam Kahler, Joan Tefay, Shannon R. Joseph, Fiona Simpson
Summary: This review critically analyzes the mechanisms of EGFR expression in NSCLC, its relevance to currently approved targeted treatment options, and the complex nature of secondary mutations and intrinsic and acquired resistance patterns in NSCLC.
Article
Biochemistry & Molecular Biology
Aideen M. McInerney-Leo, Hui Yi Chew, Po-Ling Inglis, Paul J. Leo, Shannon R. Joseph, Caroline L. Cooper, Satomi Okano, Tim Hassall, Lisa K. Anderson, Rayleen Bowman, Michael Gattas, Jessica E. Harris, Mhairi S. Marshall, Janet G. Shaw, Lawrie Wheeler, Ian A. Yang, Matthew A. Brown, Kwun M. Fong, Fiona Simpson, Emma L. Duncan
Summary: This study identified a germline variant in the ERBB3 gene in a family with heritable non-small-cell lung cancer, providing further insights into the role of the ErbB family pathway in oncogenesis. The mutation was found to be tumorogenic, leading to increased cellular proliferation and altered signaling pathway activation.
HUMAN MOLECULAR GENETICS
(2021)
Review
Immunology
Ban Qi Tay, Quentin Wright, Rahul Ladwa, Christopher Perry, Graham Leggatt, Fiona Simpson, James W. Wells, Benedict J. Panizza, Ian H. Frazer, Jazmina L. G. Cruz
Summary: Advances in genetics, molecular biology, biochemistry, and immunology have led to promising developments in cancer vaccine research, with novel delivery methods and combination therapies offering new hope for the future of cancer vaccines.
Article
Microbiology
Thao Thanh Tran, Carmen D. Mathmann, Marcela Gatica-Andrades, Rachel F. Rollo, Melanie Oelker, Johanna K. Ljungberg, Tam T. K. Nguyen, Alina Zamoshnikova, Lalith K. Kummari, Orry J. K. Wyer, Katharine M. Irvine, Javier Melo-Bolivar, Annette Gross, Darren Brown, Jeffrey Y. W. Mak, David P. Fairlie, Karl A. Hansford, Matthew A. Cooper, Rabina Giri, Veronika Schreiber, Shannon R. Joseph, Fiona Simpson, Timothy C. Barnett, Joergen Johansson, Wendy Dankers, James Harris, Timothy J. Wells, Ronan Kapetanovic, Matthew J. Sweet, Eleanor A. Latomanski, Hayley J. Newton, Romain J. R. Guerillot, Abderrahman Hachani, Timothy P. Stinear, Sze Ying Ong, Yogeswari Chandran, Elizabeth L. Hartland, Bostjan Kobe, Jennifer L. Stow, A. Elisabeth Sauer-Eriksson, Jakob Begun, Jessica C. Kling, Antje Blumenthal
Summary: Listeria monocytogenes is a pathogen that escapes from its entry vacuole to replicate and spread in host cells. In this study, the inhibition of a key regulator of Listeria virulence resulted in the trapping of bacteria inside their entry vacuoles and extensive replication in spacious vacuoles. However, the majority of infected host immune cells were able to clear the bacteria, indicating that intra-vacuolar existence is not necessarily tied to bacterial persistence.
Article
Oncology
Shivanshan Pathmanathan, Hari Babu, Marcin Dzienis, Mary Azer, Melissa Eastgate
Summary: Combination immunotherapy with nivolumab and ipilimumab is an effective therapy for metastatic melanoma, and it is equally beneficial for patients aged 65 and above, with similar toxicity.
PIGMENT CELL & MELANOMA RESEARCH
(2022)
Review
Cell Biology
Blerida Banushi, Fiona Simpson
Summary: Lysosome-related organelles (LROs) are a group of functionally diverse cell organelles that are closely associated with various genetic disorders. These disorders affect the formation and function of LROs, resulting in compromised clinical features across multiple systems. By analyzing the expression of affected proteins in different cell types, we propose that transcriptional regulation may play a role in regulating the pleiotropic functions of LROs.
Review
Oncology
Sam Dowthwaite, James Jackson, Marcin Dzienis, Eric Khoo, Mathew Cronin, Emily Guazzo
Summary: The impact of contemporary treatment strategies on salvage outcomes in patients with recurrent human papilloma virus-positive oropharyngeal squamous cell carcinoma (HPV + OPSCC) is reviewed in this article. Changes in disease biology due to HPV have influenced primary treatments and subsequent approaches to patients with recurrence. Upfront surgery and less invasive endoscopic surgical approaches, such as transoral robotic surgery (TORS), and improved conformal radiotherapy techniques, have improved treatment options. Expansion in systemic treatment options, including immune-based therapies, has also been observed. Effective surveillance with systemic and oral biomarkers offers hope for early detection of recurrence. Management of patients with recurrent OPSCC remains difficult, but modest improvements in salvage treatment have been observed within the HPV + OPSCC cohort largely reflecting disease biology and improved treatment techniques.
CURRENT ONCOLOGY REPORTS
(2023)
Review
Oncology
Blerida Banushi, Shannon R. Joseph, Benedict Lum, Jason J. Lee, Fiona Simpson
Summary: This Review discusses the impact of endocytotic pathways on various cancer processes and how understanding these pathways can be used to improve cancer therapy. It also highlights the role of endocytosis in nutrient scavenging, metastasis, and drug delivery.
NATURE REVIEWS CANCER
(2023)
Meeting Abstract
Cell Biology
C. L. Cooper, E. Karlson, S. Leftwich, B. Banushi, C. Snell, F. Simpson
Article
Otorhinolaryngology
Emily Guazzo, Caroline Cooper, Lisa Wilkinson, Sophie Feng, Brigid King, Fiona Simpson, Sandro Porceddu, Benedict Panizza, Jermaine I. G. Coward
Summary: This retrospective analysis investigated the efficacy of immune checkpoint inhibitors (ICI) in salivary gland carcinomas (SGC) by examining recognized biomarkers of response, finding that PD-L1 positivity was associated with certain pathological features but did not impact overall survival. Additionally, the high rates of EGFR expression in SGC could potentially enhance the response to immune checkpoint therapy.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Peter Gorayski, Marcin Dzienis
Summary: The treatment of advanced melanoma has evolved significantly in the past decade, with a shift towards more effective MAP kinase and immune checkpoint inhibitors. A multidisciplinary approach is essential due to the increasing complexity of therapeutic decision-making.
JOURNAL OF MEDICAL RADIATION SCIENCES
(2021)