Article
Oncology
Qun Liu, Qiang Yin, Yang Dong, Fengtong Li, Wenliang Li, Xiaoguang Wang
Summary: There is no general consensus on the optimal treatment for multiple brain metastases. Radiotherapy is commonly used, while the role of surgical resection is unclear. This study compared the outcomes of surgery and stereotactic radiosurgery (SRS) in patients with multiple brain metastases and found that they have similar overall survival and local tumor control rates.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yongye Chen, Qizheng Wang, Guangjin Zhou, Ke Liu, Siyuan Qin, Weili Zhao, Peijin Xin, Huishu Yuan, Hongqing Zhuang, Ning Lang
Summary: This study aimed to establish a prediction model for pain response after stereotactic body radiotherapy (SBRT) in patients with spinal metastases by analyzing conventional MRI, DCE-MRI, and clinical features. The results showed that the number of treated lesions, pretreatment pain score, Karnofsky performance status score, Bilsky grade, and DCE-MRI quantitative parameter K-trans were independent predictors of post-SBRT pain response in patients with spinal metastases. The predictive model had good discrimination performance with a C-index of 0.806.
EUROPEAN RADIOLOGY
(2023)
Review
Oncology
Giorgio Fiore, Leonardo Tariciotti, Giulio Andrea Bertani, Dario Gagliano, Antonio D'Ammando, Antonella Maria Ampollini, Luigi Schisano, Stefano Borsa, Mauro Pluderi, Marco Locatelli, Manuela Caroli
Summary: Brain metastases (BMs) are the most common malignant intracranial lesions, occurring in up to 40% of patients with solid tumors. There is a lack of evidence supporting the superiority of surgery or stereotactic radiosurgery (RS) as first-line treatment for solitary and oligometastatic brain disease. This systematic review with meta-analysis aims to provide a quantitative synthesis of the results of studies comparing the efficacy and safety of surgery and RS for localized metastatic brain disease. Evaluation: 7/10.
Article
Oncology
Binwei Lin, Dan Huang, Huan Du, Jinjia Fan, Yu Zhang, Gang Feng, Feng Gao, Xiao Bo Du
Summary: This study compared the efficacy of whole-brain radiation therapy (WBRT) with simultaneous integrated boost (SIB) to WBRT followed by stereotactic radiosurgery (SRS) in lung cancer patients with brain metastasis. The results showed that WBRT + SIB provided a longer intracranial progression-free survival and lower incidence of progression outside the radiation field compared to WBRT + SRS, indicating better local control for brain metastasis. However, there was no significant difference in overall survival and toxicity between the two treatment groups.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Ji Li, Wang Jing, Xiaoyang Zhai, Wenxiao Jia, Hui Zhu, Jinming Yu
Summary: This study validates the feasibility of the Lung-molGPA tool in predicting survival of patients with non-small-cell lung cancer, providing evidence for its usefulness in determining treatment strategies and prognosis. Patients in the adenocarcinoma group with higher Lung-molGPA scores had longer median survival times, while a similar trend was observed in the non-adenocarcinoma group.
ONCOTARGETS AND THERAPY
(2021)
Article
Clinical Neurology
Joonho Byun, Sang Woo Song, Young-Hoon Kim, Chang Ki Hong, Jeong Hoon Kim, Jong Hyun Kim
Summary: This study investigated the treatment outcomes of Gamma Knife radiosurgery for patients with brain metastasis from thyroid cancer. The results showed that Gamma Knife treatment was effective in achieving local control, but the rate of distant brain metastasis was high and the median survival was only 15 months.
WORLD NEUROSURGERY
(2023)
Article
Medicine, General & Internal
Wenxia Li, Tongsheng Wang, Yubing Zhu, Haijiao Yu, Ling Ma, Yuhan Ding, Gao Hong, Ding Lei
Summary: This study investigated the clinical characteristics, survival, prognostic factors, and treatment of brain metastasis from colorectal cancer. The researchers found that Karnofsky performance status and treatment modalities were independent prognostic factors, and patients with high Karnofsky performance status and multimodal treatment had improved survival.
Article
Oncology
Yen-Ling Lai, Jun-Hyeok Kang, Che-Yu Hsu, Jung-Il Lee, Wen-Fang Cheng, Yu-Li Chen, Yoo-Young Lee
Summary: This study found that for EOC patients with CNS metastases, factors such as serous histological type, disease progression, CNS involvement in first disease recurrence, and GKS-based combination treatment significantly impact survival. Patients with CNS involvement not in first tumor recurrence who underwent GKS-based combination treatment showed superior survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Niels J. van Ruitenbeek, Vincent K. Y. Ho, Hans M. Westgeest, Laurens V. Beerepoot, Patrick E. J. Hanssens
Summary: This study validated the updated Renal Graded Prognostic Assessment (GPA) as a valuable tool for predicting survival in patients with brain metastasis from renal cell carcinoma treated with Gamma Knife radiosurgery (GKRS). Karnofsky performance status, serum hemoglobin level, age, and time from primary diagnosis to brain metastasis were significantly associated with shorter survival, while other factors had no significant impact on overall survival.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Oncology
Alejandro Bugarini, Evan Meekins, Joshua Salazar, Andrea L. Berger, Michel Lacroix, Edward A. Monaco III, Andrew R. Conger, Anand Mahadevan
Summary: Neoadjuvant stereotactic radiosurgery (SRS) may reduce the incidence of radionecrosis (RN) and decrease radiation to normal tissue in patients with cerebral metastatic disease. A retrospective analysis of 47 brain metastases patients showed that neoadjuvant SRS was associated with reduced radiotherapy doses, improved conformality profile, and decreased radiation to normal tissue, supporting its use in the treatment of brain metastases.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Biology
Yi-Han Huang, Huai-Che Yang, Chi-Lu Chiang, Hsiu-Mei Wu, Yung-Hung Luo, Yong-Sin Hu, Chung-Jung Lin, Wen-Yuh Chung, Cheng-Ying Shiau, Wan-Yuo Guo, Cheng-Chia Lee
Summary: Administering stereotactic radiosurgery to the surgical cavity after surgery can improve local tumor control, but it does not have a significant effect on overall survival.
Article
Oncology
Mohammed Abdulhaleem, Hannah Johnston, Ralph D'Agostino, Claire Lanier, Michael LeCompte, Christina K. Cramer, Jimmy Ruiz, Thomas Lycan, Hui-Wen Lo, Kuonosuke Watabe, Stacey O'Neill, Christopher Whitlow, Jaclyn J. White, Stephen B. Tatter, Adrian W. Laxton, Jing Su, Michael D. Chan
Summary: This retrospective study compared the clinical outcomes of lung cancer patients receiving immune checkpoint inhibitors and stereotactic radiosurgery with a historical control group. The results showed that patients receiving immunotherapy had improved overall survival and local control compared to the control group.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Oncology
Naoyuki Kanayama, Toshiki Ikawa, Shingo Ohira, Takero Hirata, Masahiro Morimoto, Kazuhiko Ogawa, Teruki Teshima, Koji Konishi
Summary: This study demonstrates that a significant reduction in brain metastases volume at 6 months post-SRT can predict local control. The dose of 80% of the gross tumor volume (GTV) D80 in the LQ model: alpha/beta = 20 may be a predictive factor for volume reduction.
Article
Clinical Neurology
Josh Neman, Meredith Franklin, Zachary Madaj, Krutika Deshpande, Timothy J. Triche, Gal Sadlik, John D. Carmichael, Eric Chang, Cheng Yu, Ben A. Strickland, Gabriel Zada
Summary: This study reveals nonuniform spatial distribution patterns of brain metastasis, with different cancer subtypes exhibiting preferential colonization in specific brain regions. These findings provide insights into the abilities of different cancers to adapt to regional neural microenvironments and establish metastasis. They could serve as predictive diagnostic tools and guide future translational and therapeutic research.
JOURNAL OF NEUROSURGERY
(2022)
Review
Oncology
Susanne J. Rogers, Nicoletta Lomax, Sara Alonso, Tessa Lazeroms, Oliver Riesterer
Summary: This study evaluated the clinical outcomes of patients with 5 or more brain metastases, showing that SRS achieved high rates of local control and low rates of distant brain failure for these patients. Overall survival was prolonged in patients with good prognostic factors.
FRONTIERS IN ONCOLOGY
(2022)