Article
Radiology, Nuclear Medicine & Medical Imaging
Dragos Grama, Max Dahele, Ward van Rooij, Ben Slotman, Deepak K. Gupta, Wilko F. A. R. Verbakel
Summary: Radiotherapy (RT) is an important treatment for cancer patients, with external beam RT being the most common type. Volumetric modulated arc therapy (VMAT) is a novel delivery method that allows real-time tracking of tumor location. In this study, a patient-specific deep Siamese network was trained and evaluated on synthetic and clinical data, showing superior performance compared to the conventional template matching-based method.
Review
Oncology
Felix Ehret, David Kaul, Volker Budach, Laura-Nanna Lohkamp
Summary: This systematic review summarizes the current experience and evidence for robotic radiosurgery (RRS) and robotic stereotactic radiotherapy (RSRT) in pediatric neuro-oncology. The results indicate that both treatment modalities are infrequently used and primarily employed in specific situations, with encouraging treatment outcomes but a lack of high-quality studies. Prospective studies are needed to determine the actual utility of RRS and RSRT in pediatric neuro-oncology.
Article
Oncology
Yukinori Matsuo, Masahiro Hiraoka, Katsuyuki Karasawa, Masaki Kokubo, Takashi Sakamoto, Nobutaka Mukumoto, Mitsuhiro Nakamura, Satoshi Morita, Takashi Mizowaki
Summary: This study evaluated the safety and efficacy of dynamic tumor tracking-stereotactic body radiotherapy (DTT-SBRT) for lung tumors and found that DTT-SBRT achieved excellent local control with low incidences of severe toxicities in lung tumors with respiratory motion.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Clinical Neurology
Leila Maria Da Roz, Geovanne Pedro Mauro, Vinicius de Carvalho Gico, Eduardo Weltman, Evandro Cesar de Souza, Eberval Gadelha Figueiredo, Manoel Jacobsen Teixeira
Summary: This study retrospectively reviewed AVM patients treated with radiation or a combination of radiation and embolization. The results showed that stereotactic radiosurgery plays an important role in AVM treatment and should be preferred whenever possible.
WORLD NEUROSURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Suhong Yu, Huijun Xu, Yin Zhang, Xin Zhang, Michael Dyer, Ariel Hirsch, Minh Tam Truong, Heming Zhen
Summary: The study developed a knowledge-based planning (KBP) model for predicting dosimetric indices and facilitating planning in CyberKnife intracranial stereotactic radiosurgery/radiotherapy (SRS/SRT). The KBP model showed desirable predictability in terms of dose prediction and planning efficiency, demonstrating its ability to improve plan quality and efficiency.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2021)
Article
Oncology
Percy Lee, Billy W. Loo Jr, Tithi Biswas, George X. Ding, Issam M. El Naqa, Andrew Jackson, Feng-Ming Kong, Tamara LaCouture, Moyed Miften, Timothy Solberg, Wolfgang A. Tome, An Tai, Ellen Yorke, X. Allen Li
Summary: Based on the evaluation of published experiences with SBRT, a steep dose-response relationship exists with high rates of durable local control for early-stage non-small cell lung cancer when physical doses of 43-50 Gy are delivered.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Pawel Polanowski, Aleksandra Nasiek, Aleksandra Grzadziel, Ewa Chmielik, Agnieszka Pietruszka, Krzysztof Skladowski, Katarzyna Polanowska
Summary: This paper presents a case study on the use of radiotherapy and stereotactic boost in the radical treatment of sebaceous carcinoma. The individualized approach showed positive results in the treatment of this rare malignancy.
Article
Oncology
Melina Kord, Anne Kluge, Markus Kufeld, Goda Kalinauskaite, Franziska Loebel, Carmen Stromberger, Volker Budach, Bernhard Gebauer, Gueliz Acker, Carolin Senger
Summary: Fiducial markers (FM) inserted into tumors increase the precision of irradiation during robotic radiosurgery (RRS). This retrospective study evaluated the clinical complications, marker migration, and motion amplitude of FM implantations by analyzing 288 cancer patients who underwent 357 FM implantations prior to RRS with CyberKnife between 2011 and 2019. Complications were most common in lesions affected by respiratory motion, particularly in pulmonary lesions, and were associated with concurrent biopsy sampling. FM migration was observed after CT-guided and clinical implantations, with the largest motion amplitudes seen in hepatic and lower lung lobe lesions. This study emphasizes the importance of FM placement, especially in lesions with significant motion amplitude.
Review
Oncology
Danielle Golub, Joshua D. Mcbriar, Hayley Donaldson, Taylor Wong, Prashin Unadkat, Timothy G. White, Eric T. Quach, Sara Haddock, Bhargava Chitti, Yonah Ziemba, Anuj Goenka, Samuel Singer, Michael Schulder, Amir R. Dehdashti
Summary: Stereotactic radiosurgery (SRS) is a safe and effective treatment for intracranial solitary fibrous tumors (SFTs). Increasing the SRS margin dose may improve local tumor control (LTC). Understanding the aggressive biology of SFTs and the tolerated adjuvant SRS parameters supports potentially earlier use of SRS in the postoperative treatment paradigm for intracranial SFTs.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Geovanne Pedro Mauro, Leila Maria Da Roz, Vinicius de Carvalho Gico, Eduardo Weltman, Evandro Cesar de Souza, Eberval Gadelha Figueiredo, Manoel Jacobsen Teixeira
Summary: This study aimed to evaluate whether fractionated radiotherapy (FRT) is more effective than single-dose radiosurgery (SRS) in the treatment of vestibulocochlear schwannomas in patients with type 2 neurofibromatosis (NF2). The results showed that in the NF2 population, FRT may yield worse control rates than SRS. Therefore, it is preferable to avoid fractionated treatment for these patients whenever possible.
WORLD NEUROSURGERY
(2023)
Article
Oncology
I. F. Remmerts de Vries, Max Dahele, Hassan Mostafavi, Ben Slotman, Wilko Verbakel
Summary: The study evaluated the use of kV imaging for tumor tracking during lung SBRT treatment and found that 3D positional verification during single fraction lung SBRT is feasible but improvements are needed. The results showed that the treatment time with this method was fast, but there was a significant amount of time where the tumor position could not be determined.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Paolo Sogono, Mathias Bressel, Steven David, Mark Shaw, Sarat Chander, Julie Chu, Nikki Plumridge, Keelan Byrne, Nicholas Hardcastle, Tomas Kron, Greg Wheeler, Gerard G. Hanna, Michael MacManus, David Ball, Shankar Siva
Summary: The study showed that single-fraction stereotactic body radiation therapy is safe and effective for patients with oligometastatic disease, reducing the number of attendances and improving efficiency. Patients had high overall survival rates and a significant proportion remained treatment-free for several years after therapy.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Clinical Neurology
Varun M. Bhave, Nayan Lamba, Ayal A. Aizer, Wenya Linda Bi
Summary: This retrospective study analyzed 716 patients diagnosed with single or solitary brain metastases and found that surgical resection combined with postoperative cavity radiotherapy or stereotactic radiosurgery (SRS) was associated with decreased all-cause mortality and reduced risks of neurological death and radiation necrosis compared to SRT alone. Among surgical patients, gross total resection was associated with extended overall survival and lower risks of neurological death and local failure.
Article
Oncology
Ahmed Gawish, Nurlan Abdulayev, Souhir El-Arayed, Burkard Roellich, Hans-Joachim Ochel, Thomas B. Brunner
Summary: This study retrospectively analyzed 48 patients with intracranial meningiomas treated with radiation surgery, and found that SFRT had better local control effects in the treatment of Grade I meningiomas compared to SRS. This may be due to the reduced risk of brain necrosis in large PTVs with SFRT. Therefore, SFRT is a better choice for typical meningioma PTVs.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Oncology
Hamoun Rozati, Jiarong Chen, Matt Williams
Summary: This study conducted a systematic review and meta-analysis to assess the overall survival of patients with ten or more brain metastases treated with stereotactic radiosurgery. The results showed that patients with ten or more metastases had statistically worse overall survival compared to the control group. However, there was insufficient information to draw conclusions on toxicity.