Article
Biochemistry & Molecular Biology
Siqi Liang, Guangming Zhou, Wentao Hu
Summary: This article discusses the clinical progress of heavy ion radiotherapy in the treatment of non-small-cell lung cancer and explores the deficiencies and future research directions of heavy ion radiotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Shuri Aoki, Hiroshi Onishi, Masataka Karube, Naoyoshi Yamamoto, Hideomi Yamashita, Yoshiyuki Shioyama, Yasuo Matsumoto, Yukinori Matsuo, Akifumi Miyakawa, Haruo Matsushita, Hitoshi Ishikawa
Summary: This retrospective study aimed to assess the efficacy and safety of stereotactic body radiotherapy (SBRT) and carbon ion radiotherapy (CIRT) in elderly patients with non-small-cell lung cancer (NSCLC) using Japanese multicenter data. The study found that SBRT and CIRT showed similar survival and local control rates in elderly patients, but CIRT was associated with a lower incidence of radiation pneumonitis.
Article
Oncology
Elisabeth Schuetke, Sam Bayat, Stefan Bartzsch, Elke Brauer-Krisch, Valentin Djonov, Stefan Fiedler, Cristian Fernandez-Palomo, Felix Jaekel, Paolo Pellicioli, Verdiana Trappetti, Guido Hildebrandt
Summary: The mouse model study shows that microbeam irradiation in lung tissue has low acute adverse effects up to peak doses of 400 Gy. This model is well suited for exploring the potential of microbeam radiation therapy in the treatment of lung cancer.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Yuhei Miyasaka, Shuichiro Komatsu, Takanori Abe, Nobuteru Kubo, Naoko Okano, Kei Shibuya, Katsuyuki Shirai, Hidemasa Kawamura, Jun-ichi Saitoh, Takeshi Ebara, Tatsuya Ohno
Summary: The study compared oncologic outcomes after CIRT and SBRT for early-stage NSCLC and found that CIRT showed superior overall survival and local control compared to SBRT. These results were validated by propensity score-adjusted analyses, demonstrating a positive efficacy profile of CIRT in the management of early-stage NSCLC.
Article
Oncology
Daniel K. Ebner, Steven J. Frank, Taku Inaniwa, Shigeru Yamada, Toshiyuki Shirai
Summary: The research on high linear energy transfer (LET) radiotherapy has been ongoing for over half a century, with a focus now on carbon-ion beams due to their promising suitability in treating hypoxic and/or radioresistant cancers. Challenges remain in terms of technical development and limitations imposed by the physical properties of the beams.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yuhong Zhang, Xinglong Liu, Liang Zeng, Xinrui Zhao, Qianping Chen, Yan Pan, Yang Bai, Chunlin Shao, Jianghong Zhang
Summary: The study found that ANGPTL4 levels were significantly higher in hypoxic NSCLC cells and positively correlated with radioresistance. This protein affects radioresistance through two pathways: intracellular and exosomal, suggesting its potential as a therapeutic target to improve NSCLC treatment efficacy.
BRITISH JOURNAL OF CANCER
(2022)
Review
Oncology
Arnold Pompos, Robert L. Foote, Albert C. Koong, Quynh Thu Le, Radhe Mohan, Harald Paganetti, Hak Choy
Summary: This review advocates for the establishment of a limited number of heavy ion cancer research and treatment facilities in the United States. Based on research in physics, biology, and clinical trials, heavy ions have the potential to significantly enhance the therapeutic ratio for various types of cancer compared to conventional X-ray and proton radiotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ning-Yi Ma, Jian Chen, Xue Ming, Guo-Liang Jiang, Jiade J. Lu, Kai-Liang Wu, Jingfang Mao
Summary: The study found that proton plus carbon-ion radiotherapy combined with chemotherapy has good tolerability and promising survival rates in patients with limited-stage small cell lung cancer. Acute toxicities, both hematologically and non-hematologically related, were well managed, with some cases of late side effects observed.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Walter Tinganelli, Uli Weber, Anggraeini Puspitasari, Palma Simoniello, Amir Abdollahi, Julius Oppermann, Christoph Schuy, Felix Horst, Alexander Helm, Claudia Fournier, Marco Durante
Summary: This study presents the first in vivo results of the FLASH effect using high-energy carbon ions. The results demonstrate that carbon ion irradiation is effective in tumor control at both conventional and ultra-high dose rates, and it reduces normal tissue toxicity and lung metastasis compared to conventional dose-rate irradiation in an osteosarcoma mouse model.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Verity Ahern, Sebastian Adeberg, Piero Fossati, Richard Garrett, Bradford Hoppe, Anita Mahajan, Ester Orlandi, Roberto Orecchia, Dale Prokopovich, Jan Seuntjens, David Thwaites, Daniel Trifiletti, Richard Tsang, Hiroshi Tsuji
Summary: This study aims to establish the treatment indications and potential patient numbers for carbon ion radiation therapy (CIRT) at a proposed national carbon ion (and proton) therapy facility in New South Wales, Australia. An expert panel, including representatives from operational and proposed international carbon ion facilities, as well as local stakeholders, met virtually to discuss the available evidence and experience. The study concluded that CIRT can be justified in Australia for certain tumor types, including adenoid cystic carcinomas, mucosal melanomas, hepatocellular cancer, liver metastases, base of skull meningiomas, chordomas, and chondrosarcomas. Approximately 1400 Australian patients annually meet the consensus-derived indications.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Kei Shibuya, Hiroyuki Katoh, Yoshinori Koyama, Shintaro Shiba, Masahiko Okamoto, Shohei Okazaki, Kenichiro Araki, Satoru Kakizaki, Ken Shirabe, Tatsuya Ohno
Summary: This study evaluated the safety and efficacy of hypofractionated carbon-ion radiotherapy for hepatocellular carcinoma. Results showed promising local control and overall survival rates, with no serious adverse events observed, making it a safe and effective treatment modality for this type of malignancy.
Article
Oncology
Naoko Okano, Nobuteru Kubo, Koichi Yamaguchi, Shunichi Kouno, Yuhei Miyasaka, Tatsuji Mizukami, Katsuyuki Shirai, Jun-ichi Saitoh, Takeshi Ebara, Hidemasa Kawamura, Toshitaka Maeno, Tatsuya Ohno
Summary: Interstitial lung disease (ILD) is a risk factor for lung cancer and may impact the outcome of treatment, including carbon-ion radiotherapy (CIRT) for clinical stage I non-small cell lung cancer (NSCLC). Patients with ILD had lower overall and disease-specific survival rates compared to those without ILD, but there was no significant difference in treatment safety between the two groups. Coexisting ILD was identified as a poor prognostic factor for CIRT in clinical stage I lung cancer.
Article
Oncology
Nobuteru Kubo, Hiroaki Suefuji, Mio Nakajima, Sunao Tokumaru, Naoko Okano, Daisaku Yoshida, Osamu Suzuki, Hitoshi Ishikawa, Miyako Satouchi, Haruhiko Nakayama, Yoshiyuki Shioyama
Summary: This nationwide registry study in Japan provides real-world treatment outcomes of carbon-ion radiation therapy (CIRT) for inoperable stage I non-small cell lung cancer (NSCLC). The most common CIRT schedule was 60 Gy (relative biological effectiveness (RBE)) in four fractions, and the 3-year overall survival rate was 59.3%. Female sex and ECOG performance status of 0-1 were favorable prognostic factors for overall survival. Therefore, CIRT is an effective option for treating inoperable stage I NSCLC.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Shota Sora, Ariunbuyan Sukhbaatar, Shinichi Fukushige, Shiro Mori, Maya Sakamoto, Tetsuya Kodama
Summary: Chemotherapy using a lymphatic drug delivery system targeting lymph nodes has superior antitumor effect compared to systemic chemotherapy. Combination therapy with total body irradiation enhances immune response and improves the efficacy of LN metastases and distant metastases therapy, offering a promising new approach to treat cancer patients.
Article
Oncology
Teruaki Mizobuchi, Akihiro Nomoto, Hironobu Wada, Naoyoshi Yamamoto, Mio Nakajima, Takehiko Fujisawa, Hidemi Suzuki, Ichiro Yoshino
Summary: This study compares the outcomes of patients with GGO-dominant NSCLC treated with CIRT and segmentectomy. The results show that patients in the CIRT group are older, more likely to be male, and have lower forced vital capacity compared to the segmentectomy group. There is a significant difference in the 5-year overall survival rate, but not in the 5-year disease-specific survival rate.
RADIATION ONCOLOGY
(2023)