Article
Oncology
Jessica Prunaretty, Celine Bourgier, Sophie Gourgou, Claire Lemanski, David Azria, Pascal Fenoglietto
Summary: This study compared IMRT and 3D conformal radiotherapy and found that 3D MHD is not representative of heart exposure after IMRT. In cases of high dose exposure, 3D MHD cannot represent similar heart substructure exposure as IMRT.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Tadashi Matsumoto, Ryo Toya, Yoshinobu Shimohigashi, Takahiro Watakabe, Tomohiko Matsuyama, Tetsuo Saito, Yoshiyuki Fukugawa, Yudai Kai, Natsuo Oya
Summary: In this study comparing 3D-CRT, IMRT, and VMAT for gastric MALT lymphoma using 4D-CT images, it was found that the IMRT plan yielded the best plan quality with significantly better homogeneity and conformity indices. The D95 did not show significant differences among the three plans, but the IMRT plan showed superior HI and CI values compared to VMAT and 3D-CRT plans. The D-mean of the liver was also significantly lower in the IMRT and VMAT plans compared to 3D-CRT plan.
ANTICANCER RESEARCH
(2021)
Article
Biology
Duong Thanh Tai, Luong Thi Oanh, Pham Hoai Phuong, Abdelmoneim Sulieman, Fouad A. Abolaban, Hiba Omer, James C. L. Chow
Summary: Comparing the Jaws-only Intensity-modulated radiotherapy (JO-IMRT) technique with 3D conformal radiation therapy (3D-CRT) for head and neck treatment, it was found that JO-IMRT can improve dose coverage to the target, enhance conformity index (CI) and homogeneity index (HI), and reduce doses to the parotid glands.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yeongdon Ju, Young Mi Seol, Jungho Kim, Hyunwoo Jin, Go-Eun Choi, Aelee Jang
Summary: This study aimed to identify factors significant for neurological adverse events in gastric cancer patients receiving XELOX chemotherapy. The results show that XELOX chemotherapy induces changes in the expression of several miRNAs, and hsa-miR-378f was significantly downregulated in CIPN. Furthermore, potential target genes related to these miRNAs were predicted, and their enrichment in specific signaling pathways was identified.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yutian Zhao, Jiahao Zhu, Xiaojun Zhang, Gang Wu, Yu Xu, Peipei Shen, Xianding Wei, Dong Kong, Shengjun Ji, Bo Yang
Summary: The study evaluated the efficacy of two radiotherapy techniques for post-mastectomy breast cancer patients. It found that intensity-modulated radiotherapy using whole planning target volume for chest wall and regional nodes reduced recurrence rate with tolerable toxicities.
Article
Multidisciplinary Sciences
Atefeh Talebi, Carlos A. Celis-Morales, Nasrin Borumandnia, Somayeh Abbasi, Mohamad Amin Pourhoseingholi, Abolfazl Akbari, Javad Yousefi
Summary: This study aims to develop predictive models using different machine learning classifiers based on demographic and clinical variables to predict the metastasis status of gastric cancer patients. By training and testing the data of 733 gastric cancer patients, it was found that Support Vector Machine and Neural Network are two better predictive models among the applied machine learning algorithms.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Jun-Bing Chen, Zi-Ning Liu, Yin-Kui Wang, Fei Shan, Shuang-Xi Li, Yong-Ning Jia, Kan Xue, Ru-Lin Miao, Zhe-Min Li, Zhou-Qiao Wu, Xiang-Ji Ying, Yan Zhang, Zi-Yu Li, Jia-Fu Ji
Summary: This study investigated the impact of time interval between multimodality therapies on survival for locally advanced gastric cancer patients. The results showed that prolonging the time from neoadjuvant chemotherapy to surgery and from surgery to adjuvant chemotherapy had a negative correlation with patient survival. A nomogram model was also developed to predict patient survival probability.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Shan Xu, Rezarta Frakulli, Yilan Lin
Summary: This study explored the effectiveness of various modern radiotherapy strategies in treating newly diagnosed glioblastoma patients. The findings highlighted the significant benefits of proton therapy in terms of survival outcomes.
Article
Gastroenterology & Hepatology
Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, Kyu-Won Jung, Kui Son Choi
Summary: This study investigates the impact of a cancer screening program on the long-term survival of gastric cancer patients in Korea. The results show that screened patients have a higher survival rate compared to never-screened patients. Specifically, patients who underwent upper endoscopy had a lower risk of gastric cancer-specific mortality compared to those who underwent upper gastrointestinal series. Furthermore, patients who were screened within 2 years before diagnosis had a 35% reduction in gastric cancer death risk.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Na Wang, Xia Zhang, Shuwen Xu, Xuehui Li, Yali Meng, Zhixiang Dou
Summary: The study showed that pelvic IMRT combined with chemotherapy is effective and safe for high-risk endometrial cancer, with YKL-40, HE4, and PRL being effective indicators for predicting chemotherapy efficacy.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Article
Microbiology
Baptiste Oosterlinck, Hannah Ceuleers, Wout Arras, Joris G. De Man, Karen Geboes, Heiko De Schepper, Marc Peeters, Sarah Lebeer, Jurgita Skieceviciene, Georgina L. Hold, Juozas Kupcinskas, Alexander Link, Benedicte Y. De Winter, Annemieke Smet
Summary: This study identified the mucin-microbiome signatures in gastric adenocarcinomas and their impact on clinical outcomes. The findings showed that intestinal mucin phenotype and high-level MUC13 expression were associated with poor survival, while gastric MUC5AC or MUC6 abundance was associated with a more favorable outcome. Furthermore, oral bacteria such as Neisseria, Prevotella, and Veillonella were found to play a potential role in MUC13 signaling and were associated with intestinal and mixed mucin phenotype tumors.
Article
Oncology
F. Guillemin, L. Berger, M. Lapeyre, A. Belliere-Calandry
Summary: IMRT improves target volume coverage compared to 3D-CRT in the treatment of NSCLC, without increasing doses to organs at risk and reducing dysphagia.
CANCER RADIOTHERAPIE
(2021)
Review
Medicine, General & Internal
Lucian Mocan
Summary: Gastric cancer is the fifth most common cancer worldwide, with surgery being the only curative treatment. Early detection and screening combined with neoadjuvant therapy can reduce the incidence of gastric cancer, but patients are often diagnosed at an advanced stage.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fuli Wang, Aizhong Qu, Yinping Sun, Jifeng Zhang, Benzun Wei, Yong Cui, Xiao Liu, Wei Tian, Yan Li
Summary: NACRT combined with postoperative adjuvant XELOX chemotherapy can improve R0 resection rate, reduce loco-regional recurrence, prolong PFS and FFLP without increasing the incidence of postoperative complications in patients with LAGC. Compared with postoperative adjuvant chemotherapy, locally advanced gastric cancer patients may benefit from neoadjuvant chemoradiotherapy, and toxicity associated with chemoradiotherapy was tolerant and manageable.
BRITISH JOURNAL OF RADIOLOGY
(2021)
Article
Oncology
Gage Redler, Erik Pearson, Xinmin Liu, Inna Gertsenshteyn, Boris Epel, Charles Pelizzari, Bulent Aydogan, Ralph Weichselbaum, Howard J. Halpern, Rodney D. Wiersma
Summary: The study demonstrates the efficacy of using 3D-printed compensators for small-animal IMRT treatment plans and shows that the preclinical data provided can be translated into clinical practice. Compensators of varied thickness provide the desired attenuation, with spatial resolution capabilities investigated using 3D printing. The methodology was ultimately validated for accuracy and precision.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Letter
Dermatology
C. Chello, S. Ciardo, J. Chester, M. Guanti, F. Farnetani, S. Guida, A. Sticchi, P. Giacobazzi, B. Meduri, F. Lohr, G. Pellacani, M. Manfredini
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Review
Oncology
Alessia Di Rito, Francesco Fiorica, Roberta Carbonara, Francesca Di Pressa, Federica Bertolini, Francesco Mannavola, Frank Lohr, Angela Sardaro, Elisa D'Angelo
Summary: Oral cavity carcinoma (OCC) is a common malignant tumor with high risk of recurrence. The efficacy of postoperative chemotherapy in addition to radiotherapy (POCRT) for OCC with minor risk factors is controversial. A systematic review and meta-analysis were conducted, revealing that POCRT showed improved overall survival (OS) but inconclusive disease-free survival (DFS) and local-recurrence-free survival (LRFS). Further analysis is warranted.
Article
Chemistry, Multidisciplinary
Hannes Berg, Maria A. Wirtz Martin, Nadide Altincekic, Islam Alshamleh, Jasleen Kaur Bains, Julius Blechar, Betul Ceylan, Vanessa de Jesus, Karthikeyan Dhamotharan, Christin Fuks, Santosh L. Gande, Bruno Hargittay, Katharina F. Hohmann, Marie T. Hutchison, Sophie Marianne Korn, Robin Krishnathas, Felicitas Kutz, Verena Linhard, Tobias Matzel, Nathalie Meiser, Anna Niesteruk, Dennis J. Pyper, Linda Schulte, Sven Trucks, Kamal Azzaoui, Marcel J. J. Blommers, Yojana Gadiya, Reagon Karki, Andrea Zaliani, Philip Gribbon, Marcius da Silva Almeida, Cristiane Dinis Anobom, Anna L. Bula, Matthias Butikofer, Icaro Putinhon Caruso, Isabella Caterina Felli, Andrea T. Da Poian, Gisele Cardoso de Amorim, Nikolaos K. Fourkiotis, Angelo Gallo, Dhiman Ghosh, Francisco Gomes-Neto, Oksana Gorbatyuk, Bing Hao, Vilius Kurauskas, Lauriane Lecoq, Yunfeng Li, Nathane Cunha Mebus-Antunes, Miguel Mompean, Thais Cristtina Neves-Martins, Marti Ninot-Pedrosa, Anderson S. Pinheiro, Letizia Pontoriero, Yulia Pustovalova, Roland Riek, Angus J. Robertson, Marie Jose Abi Saad, Miguel A. Trevino, Aikaterini C. Tsika, Fabio C. L. Almeida, Ad Bax, Katherine Henzler-Wildman, Jeffrey C. Hoch, Kristaps Jaudzems, Douglas Laurents, Julien Orts, Roberta Pierattelli, Georgios A. Spyroulias, Elke Duchardt-Ferner, Jan Ferner, Boris Furtig, Martin Hengesbach, Frank Lohr, Nusrat Qureshi, Christian Richter, Krishna Saxena, Andreas Schlundt, Sridhar Sreeramulu, Anna Wacker, Julia E. Weigand, Julia Wirmer-Bartoschek, Jens Wohnert, Harald Schwalbe
Summary: This study explores novel drug design against SARS-CoV-2 through NMR screening and computational mapping. They identified multiple molecules that bind to SARS-CoV-2 proteins and studied their structural and chemical properties, providing new insights for drug development.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Medicine, General & Internal
Vincenzo Livio Malavasi, Jacopo Francesco Imberti, Alberto Tosetti, Giulio Francesco Romiti, Marco Vitolo, Massimo Zecchin, Ercole Mazzeo, De Marco Giuseppina, Frank Lohr, Teresa Lopez-Fernandez, Giuseppe Boriani
Summary: The prevalence of radiotherapy-induced CIEDs malfunctions ranges from 4% to 20%. The use of neutron-producing energies and more complex devices (ICD/CRT-D) are associated with a higher risk of device malfunction, while the radiation dose at CIED does not significantly impact the risk unless higher doses (>10 Gy) are used.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Letter
Oncology
Rudiger Hehlmann, Michael Lauseker, Astghik Voskanyan, Alice Fabarius, Claudia Haferlach, Andreas Hochhaus, Susanne Saussele
Article
Hematology
Jochen J. Frietsch, Sarah Flossdorf, James F. Beck, Nicolaus Kroeger, Katharina Fleischhauer, Peter Dreger, Johannes Schetelig, Martin Bornhaeuser, Andreas Hochhaus, Inken Hilgendorf
Summary: This retrospective analysis examined the outcomes of young adults who underwent allogeneic haematopoietic stem cell transplantation (HSCT) in Germany. The study found that the outcomes of young adults after HSCT improved over time and were influenced by factors such as underlying disease, age at disease onset, stem cell source, and donor type. However, the survival rate of HSCT recipients after 10 years was significantly lower compared to the general population of young adults.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Andreas Hochhaus, Delphine Rea, Carla Boquimpani, Yosuke Minami, Jorge E. Cortes, Timothy P. Hughes, Jane F. Apperley, Elza Lomaia, Sergey Voloshin, Anna Turkina, Dong-Wook Kim, Andre Abdo, Laura Maria Fogliatto, Philipp le Coutre, Koji Sasaki, Dennis Dong Hwan Kim, Susanne Saussele, Mario Annunziata, Naeem Chaudhri, Lynette Chee, Valentin Garcia-Gutierrez, Shruti Kapoor, Alex Allepuz, Sara Quenet, Veronique Bedoucha, Michael J. Mauro
Summary: Asciminib, a BCR-ABL1 inhibitor that targets the ABL Myristoyl Pocket (STAMP), is approved worldwide for the treatment of adults with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase (CML-CP) who have been previously treated with at least 2 tyrosine kinase inhibitors (TKIs). In the ASCEMBL study, asciminib demonstrated superior efficacy and better safety and tolerability compared to bosutinib in patients with CML-CP who had received at least 2 prior TKIs. The major molecular response rate at week 96 was significantly higher with asciminib than with bosutinib, and fewer adverse events and treatment discontinuations were observed with asciminib.
Article
Oncology
Annamaria Brioli, Laura Gengenbach, Katia Mancuso, Mascha Binder, Thomas Ernst, Florian H. Heidel, Thomas Stauch, Elena Zamagni, Inken Hilgendorf, Andreas Hochhaus, Monika Engelhardt, Marie von Lilienfeld-Toal
Summary: This study investigates the role of pomalidomide combinations in daratumumab-refractory multiple myeloma (MM) patients. The results show that pomalidomide-based combinations can be effective and safe for daratumumab-refractory patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Letter
Oncology
Yulin Chen, Susanne Moebius, Konstantin Riege, Steve Hoffmann, Andreas Hochhaus, Thomas Ernst, Karl Lenhard Rudolph
Article
Oncology
Michael J. Mauro, Timothy P. Hughes, Dong-Wook Kim, Delphine Rea, Jorge E. Cortes, Andreas Hochhaus, Koji Sasaki, Massimo Breccia, Moshe Talpaz, Oliver Ottmann, Hironobu Minami, Yeow Tee Goh, Daniel J. DeAngelo, Michael C. Heinrich, Valle Gomez-Garcia de Soria, Philipp le Coutre, Francois-Xavier Mahon, Jeroen J. W. M. Janssen, Michael Deininger, Naranie Shanmuganathan, Mark B. Geyer, Silvia Cacciatore, Fotis Polydoros, Nithya Agrawal, Matthias Hoch, Fabian Lang
Summary: Asciminib has been approved for patients with Philadelphia chromosome-positive chronic-phase chronic myeloid leukemia (CML-CP) who have received >= 2 prior tyrosine kinase inhibitors or have the T315I mutation. A phase 1 trial evaluated the safety and efficacy of asciminib monotherapy in 115 CML-CP patients without T315I. After a median exposure of approximately 4 years, most patients remained on asciminib and achieved significant molecular responses.
Article
Oncology
Michael Lauseker, Ruediger Hehlmann, Andreas Hochhaus, Susanne Saussele
Summary: The therapy after failing response milestones in CML is controversial, and there is a lack of information on the long-term survival of these patients. A study on patients from CML-study IV showed that the survival rate of patients who failed the failure milestones was approximately 10% lower than those who reached the milestones, suggesting a need for revising these milestones.
Review
Biochemistry & Molecular Biology
Alessio Bruni, Federica Bertolini, Elisa D'Angelo, Giorgia Guaitoli, Jessica Imbrescia, Anna Cappelli, Gabriele Guidi, Alessandro Stefani, Massimo Dominici, Frank Lohr
Summary: Locally advanced non-small-cell lung cancer poses challenges in treatment choice and outcomes. Different treatments such as chemo-radiotherapy followed by immunotherapy or surgery followed by adjuvant therapies may yield similar results. We present a case of successful treatment for mediastinal nodal recurrence after thoracic surgery using sequential chemo-radiotherapy-immunotherapy. The patient also received stereotactic ablative radiotherapy for a single brain lesion. Comprehensive clinical data are needed to determine the role of combining systemic and local treatments in managing relapse after chemo-radiotherapy and immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Oncology
G. M. Mistretta, F. Itta, P. Ceroni, M. V. Gutierrez, N. Maffei, F. Campanaro, A. Bernabei, F. Marino, F. Lohr, G. Guidi
RADIOTHERAPY AND ONCOLOGY
(2022)
Meeting Abstract
Oncology
C. Dreher, P. Wojtal, H. Oppitz, L. Kaestner, K. Siebenlist, M. Eckl, D. Buergy, J. Fleckenstein, F. Lohr, M. Ehmann, J. Boda-Heggemann
STRAHLENTHERAPIE UND ONKOLOGIE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Giulio Francolini, Barbara Alicja Jereczek-Fossa, Vanessa Di Cataldo, Gabriele Simontacchi, Giulia Marvaso, Sara Gandini, Federica Corso, Lucia Pia Ciccone, Maria Alessia Zerella, Piercarlo Gentile, Federico Bianciardi, Sara Allegretta, Beatrice Detti, Isacco Desideri, Rolando Maria D'Angelillo, Laura Masi, Gianluca Ingrosso, Mario Di Staso, Ercole Mazzeo, Fabio Trippa, Frank Lohr, Alessio Bruni, Lorenzo Livi
Summary: This study compared the outcomes of salvage radiation therapy (SRT) with curative intent and stereotactic radiotherapy (SSRT) for macroscopic prostate recurrence after radical prostatectomy. The results showed no significant differences in terms of biochemical recurrence-free survival and progression-free survival between the two treatment groups. The matched cohort analysis revealed lower rates of toxicity for patients undergoing SSRT.