Article
Biochemistry & Molecular Biology
Ewa Trybus, Teodora Krol, Wojciech Trybus
Summary: The study investigates the mechanisms of action of azelastine hydrochloride in cancer treatment. The results demonstrate that azelastine can induce degradation processes, increase autophagy activity, and activate apoptosis, leading to anti-proliferative, cytotoxic, autophagic, and apoptotic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Orawan Waenphimai, Panupong Mahalapbutr, Kulthida Vaeteewoottacharn, Sopit Wongkham, Kanlayanee Sawanyawisuth
Summary: The potent inhibitor NMS-P715 showed multiple anti-cancer effects in human CCA cell lines, including inhibiting cell proliferation and colony formation, inducing G2/M arrest, mitotic catastrophe, caspase-dependent apoptosis, autophagosome formation, and suppressing cell migration and invasion. The study suggests that NMS-P715 may have potential for further development in clinical studies as a promising candidate for combating CCA.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Dinesh Kumar Tiwari, Ricarda Hannen, Kristian Unger, Sibylla Kohl, Julia Hess, Kirsten Lauber, Florentine S. B. Subtil, Ekkehard Dikomey, Rita Engenhart-Cabillic, Ulrike Schoetz
Summary: In this study, the effects of photon and C-12-ion irradiation on HPV-negative HNSCC cells were investigated. C-12-ion irradiation showed higher cell killing and residual DSBs compared to photon irradiation, and also induced more senescence. The expression of SASP-related genes and the IL1 pathway were strongly induced by both types of irradiation and correlated with radioresistance and senescence. However, knockdown of IL1A and IL1B revealed that the IL1 pathway is not functionally involved in radioresistance, DSB repair, or induction of senescence.
FRONTIERS IN ONCOLOGY
(2022)
Article
Toxicology
Eduardo Cremonese Filippi-Chiela, Jose Eduardo Vargas, Mardja Manssur Bueno E. Silva, Marcos Paulo Thome, Guido Lenz
Summary: This study investigated the effects of Vincristine (VCR) on glioblastoma cells, finding strong negative correlations between cell number, nuclear irregularities, senescence, or apoptosis depending on genetic makeup and treatment regimen. Topological network analysis revealed the importance of P53 in all analyzed processes. Despite acute sensitivity, both cell lines regrew in the long term after a single VCR treatment, especially in populations with high levels of autophagy.
TOXICOLOGY IN VITRO
(2022)
Article
Toxicology
Momoka Ota, Takeshi Funakoshi, Toshihiko Aki, Kana Unuma, Koichi Uemura
Summary: Oxcarbazepine, a derivative of carbamazepine, induces G2/M cell cycle arrest in renal proximal tubular cells by inhibiting centrosome separation, leading to mitotic catastrophe and apoptosis.
TOXICOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Charlotte Dubois, Kateryna Kondratska, Artem Kondratskyi, Angela Morabito, Lina Mesilmany, Valerio Farfariello, Robert-Alain Toillon, Nathalie Ziental Gelus, Emilie Laurenge, Fabien Vanden Abeele, Loic Lemonnier, Natalia Prevarskaya
Summary: Changes in cytosolic free Ca2+ concentration play a central role in cellular processes. ORAI3 channels are expressed in both normal and pancreatic ductal adenocarcinoma cell lines, affecting store-operated calcium entry (SOCE). Silencing ORAI3 increases SOCE in PDAC cell lines and decreases SOCE in normal pancreatic cell line, impacting proliferation, cell cycle, viability, mitotic catastrophe, and cell death.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Shuang Zhao, Yufei Tang, Ruohan Wang, Masoud Najafi
Summary: This article focuses on the cell death mechanisms induced by paclitaxel, a chemotherapy drug, in cancer treatment and the resistance of cancer cells to paclitaxel. The study found that paclitaxel can induce apoptosis and mitotic catastrophe, as well as other cell death mechanisms, and it can also lead to drug resistance. The article also discusses the use of combination therapies to overcome drug resistance.
Article
Pathology
Handy Riantana, Orawan Waenphimai, Panupong Mahalapbutr, Kun Karnchanapandh, Kulthida Vaeteewoottacharn, Sopit Wongkham, Kanlayanee Sawanyawisuth
Summary: PLK1 is an essential mitotic checkpoint protein that plays a key role in cell cycle division and its overexpression is associated with poor prognosis in various cancers. In this study, the PLK1 inhibitors BI6727 and GSK461364A effectively suppressed cholangiocarcinoma cell proliferation, induced G2/M arrest, and triggered mitotic catastrophe and cell apoptosis, suggesting that they could be potential drugs for cholangiocarcinoma therapy at the clinical level.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Xiao Fu, Mu Li, Cuilian Tang, Zezhi Huang, Masoud Najafi
Summary: Increasing apoptosis, mitotic catastrophe, senescence, and necrosis can help overcome tumor resistance to therapy. Stimulation of autophagy cell death may also be useful for cancer therapy. Resveratrol has potential to affect various signaling pathways related to cell death and modulate cancer cell death mechanisms.
Review
Chemistry, Medicinal
Peyman Amini, Reza Moazamiyanfar, Mohammad Sedigh Dakkali, Emad Jafarzadeh, Maryam Ganjizadeh, Nima Rastegar-Pouyani, Kave Moloudi, Ehsan Khodamoradi, Shahram Taeb, Masoud Najafi
Summary: Inducing cell death and inhibiting cell proliferation in cancer is important in anti-tumor therapy. Apigenin, a nature-derived and herbal agent, has shown anticancer properties by directly inducing cell death and enhancing the induction of cell death through other anti-tumor modalities. It can induce various types of cell death, such as apoptosis, autophagic cell death, senescence, anoikis, necroptosis, and ferroptosis. The modulatory actions of apigenin enhance anticancer effects and may be dependent on the type of cancer. Overall rating: 8/10.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Review
Oncology
Zicheng Wang, Yanqing Liu, Ahmed Eleojo Musa
Summary: Cancer therapy is aimed at killing cancer cells using various therapeutic agents. Melatonin, a circadian regulator hormone, has the potential to activate tumor suppressor genes and attenuate the expression of survival genes in cancer cells. Modulating disrupted or overexpressed cell death or survival genes in cancer cells can improve cancer therapy.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Terumitsu Miura, Katsuhiko Fujii, Koji Fukuya, Masahiro Kawakubo
Summary: This study irradiated carbon steels and model alloys under different radiation conditions to investigate the changes in microstructure and hardness, identifying radiation hardening factors and elucidating the effects of material composition and irradiation conditions on radiation-induced microstructure and hardness changes.
JOURNAL OF NUCLEAR MATERIALS
(2021)
Article
Environmental Sciences
Dylan J. Buglewicz, Cathy Su, Austin B. Banks, Jazmine Stenger-Smith, Suad Elmegerhi, Hirokazu Hirakawa, Akira Fujimori, Takamitsu A. Kato
Summary: Cu2+ and Co2+ metals can increase DNA damage in the presence of hydrogen peroxide. Cu2+ is more efficient than Co2+ at inducing both DNA single-strand and double-strand breaks. The effect of radiation and chemical treatments on Cu2+ and Co2+ varies, with positive correlation for single-strand break formation and negative correlation for double-strand break formation.
Article
Biochemistry & Molecular Biology
Jenna M. Len, Noor Hussein, Saloni Malla, Kyle Mcintosh, Rahul Patidar, Manivannan Elangovan, Karthikeyan Chandrabose, N. S. Hari Narayana Moorthy, Manoj Pandey, Dayanidhi Raman, Piyush Trivedi, Amit K. Tiwari
Summary: The novel compound DML6 showed selective and significant anti-proliferative effects on cervical cancer cells, inducing apoptosis. It arrested cell cycle at G2 phase, increased reactive oxygen species level, and disrupted mitochondrial membrane potential. DML6 also modulated the expression of apoptotic proteins and activated caspases, leading to cancer cell death. Further evaluation of DML6 as a potential treatment for cervical cancer is warranted.
Article
Biochemistry & Molecular Biology
Marilena Taggi, Andjela Kovacevic, Chiara Capponi, Marta Falcinelli, Veronica Cacciamani, Elena Vicini, Rita Canipari, Ada Maria Tata
Summary: This study investigates the expression characteristics of muscarinic receptors (mAChRs) in ovarian cancer cell lines and ovarian surface epithelium cell lines. It is found that the M2 receptor is downregulated in cancer cells and its inhibition leads to decreased cell proliferation and increased cell death. Arecaidine propargyl ester hydrobromide (APE), an M2 agonist, is shown to inhibit cell growth and induce abnormal mitosis.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Oncology
Alexander Helm, Walter Tinganelli, Palma Simoniello, Fuki Kurosawa, Claudia Fournier, Takashi Shimokawa, Marco Durante
Summary: A combination of high-energy carbon ion radiation therapy and checkpoint inhibitors shows significant effectiveness in reducing the growth of abscopal tumors in a murine model, with carbon ions being more efficient in reducing lung metastases compared to x-rays. The infiltration of immune cells in the abscopal tumors increased in animals treated with the combination therapy, suggesting a potential for effective treatment of advanced tumors with this approach.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Review
Biochemistry & Molecular Biology
Andreas Maier, Julia Wiedemann, Felicitas Rapp, Franziska Papenfuss, Franz Roedel, Stephanie Hehlgans, Udo S. Gaipl, Gerhard Kraft, Claudia Fournier, Benjamin Frey
Summary: Radon, an imperceptible natural occurring radioactive noble gas, is a major contributor to radiation exposure from natural sources. It is both a concern for radiation protection and a therapy for inflammatory and degenerative diseases. The effects of radon on organisms involve various levels of interaction from physical diffusion to biological response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Floriane Poignant, Caterina Monini, Etienne Testa, Michael Beuve
Summary: In this study, a new quantity called the probability enhancement ratio (PER) was introduced to estimate the probability of imparting specific energy to nanotargets. The results showed that the PER varied significantly with various factors, and the highest enhancement could lead to severe damages for biological nanotargets located near gold nanoparticles.
Article
Chemistry, Physical
Floriane Poignant, Hela Charfi, Chen-Hui Chan, Elise Dumont, David Loffreda, Benoit Gervais, Michael Beuve
Summary: Gold nanoparticles (GNPs) have been investigated as a radiosensitizing agent for radiation therapy for the past two decades. Monte Carlo simulations were conducted to study the production of radiolysis chemical products following ionization events induced by 20-90 keV photons in nanoparticles (NPs). It was found that GNPs produced an excess of chemical species compared to reference water nanoparticles (WNPs) in the micrometer range, due to differences in dominant processes of photon interaction.
RADIATION PHYSICS AND CHEMISTRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
H. Rabus, W. B. Li, C. Villagrasa, J. Schuemann, P. A. Hepperle, L. de la Fuente Rosales, M. Beuve, S. Di Maria, A. P. Klapproth, C. Y. Li, F. Poignant, B. Rudek, H. Nettelbeck
Summary: The study compared dose enhancement ratios (DERs) for simulations of gold nanoparticles irradiated by X-rays using Monte Carlo codes, finding that DER values with realistic radiation field extensions and presence of secondary particle equilibrium (SPE) were much smaller than those for narrow-beam irradiation.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2021)
Article
Physics, Multidisciplinary
R. Ramos, F. Poignant, C. -H. Chan, A. Ipatov, B. Gervais, E. Dumont, D. Loffreda, M. Beuve
Summary: This paper focuses on improving the cross sections for a Monte Carlo simulation of electron transport in solid gold, by predicting the mesoscopic potential and evaluating its impact on electron emission yields. The results showed a decrease in the inverse mean free path for plasmon excitations and an increase in secondary electron yields depending on the primary beam energy and gold foil thickness.
EUROPEAN PHYSICAL JOURNAL PLUS
(2021)
Article
Engineering, Biomedical
Hamid Ladjal, Michael Beuve, Philippe Giraud, Behzad Shariat
Summary: This paper aims to calculate complex internal respiratory and tumoral movements by measuring air flows and thorax movements. It presents a new lung tumor tracking approach using a patient-specific biomechanical model, which considers respiratory motion physiology. The model, evaluated on public datasets, predicts lung tumor motion with an average error of 2.0 +/- 1.3 mm and shows potential for 4D dose computation and removal of breathing motion artifacts in medical imaging.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Veronica Belen Tessaro, Benoit Gervais, Floriane Poignant, Michael Beuve, Mariel Elisa Galassi
Summary: The study aimed to develop a particle transport code calculating w-values and stopping power of swift ions in liquid water and gases for reference dosimetry in hadron therapy. It analyzed the relevance of inelastic and post-collisional processes and highlighted the importance of excitation cross sections in Monte Carlo codes for the computation of w-values. The results showed a strong dependence of w-values on electronic excitation cross sections and Auger electron emission, with good agreement in calculations among different Monte Carlo codes.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2021)
Article
Nuclear Science & Technology
H. Rabus, W. B. Li, H. Nettelbeck, J. Schuemann, C. Villagrasa, M. Beuve, S. Di Maria, B. Heide, A. P. Klapproth, F. Poignant, R. Qiu, B. Rudek
Summary: Organized by EURADOS, a Monte Carlo code intercomparison exercise was conducted to simulate emitted electron spectra and energy deposition around a single GNP irradiated by X-rays. Participants evaluated energy imparted in concentric spherical shells around a spherical volume filled with gold or water, as well as the spectral distribution of electrons leaving the GNP. The results showed that the consistency of the data can be cross-validated through the redundancy under different conditions.
RADIATION MEASUREMENTS
(2021)
Article
Oncology
Anne-Sophie Wozny, Arnaud Gauthier, Gersende Alphonse, Celine Malesys, Virginie Varoclier, Michael Beuve, Delphine Brichart-Vernos, Nicolas Magne, Nicolas Vial, Dominique Ardail, Tetsuo Nakajima, Claire Rodriguez-Lafrasse
Summary: Hypoxia-Inducible Factor 1 alpha (HIF-1 alpha), the main regulator of oxygen homeostasis, promotes cancer cell survival and plays a role in the detection, signaling, and repair of DNA Double-Strand-Breaks (DSBs). Silencing HIF-1 alpha under hypoxia leads to radiosensitization of Head-and-Neck Squamous Cell Carcinoma (HNSCC) cells, indicating its potential as a therapeutic target in combination with radiation therapy against radioresistant tumor cells. The study confirms the involvement of HIF-1 alpha in DSB repair pathways, highlighting its importance in targeting cancer stem cells (CSCs) in hypoxic tumor niches.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yasmine Ali, Lucas Auzel, Caterina Monini, Kateryna Kriachok, Jean Michel Letang, Etienne Testa, Lydia Maigne, Michael Beuve
Summary: This study benchmarked two Monte Carlo track structure codes, Geant4-DNA and LPCHEM, for estimating the biological effects of ions during radiation therapy treatments. The results showed that the specific energy spectra and chemical yields obtained by the two codes were in good agreement, with LPCHEM being faster and having slightly faster recombination than Geant4-DNA.
Article
Oncology
Yasmine Ali, Caterina Monini, Etienne Russeil, Jean Michel Letang, Etienne Testa, Lydia Maigne, Michael Beuve
Summary: The study utilized Monte Carlo toolkits and biophysical models to predict biological effects, calculate biological dose and cell survival data, and compare with literature. Satisfactory results were obtained through testing the tool for irradiation results of human salivary gland cell line.
Article
Physics, Multidisciplinary
Mario Alcocer-Avila, Caterina Monini, Micaela Cunha, Etienne Testa, Michael Beuve
Summary: Biophysical models are useful in optimizing radiation absorbed dose in particle therapy, and NanOx model is specifically developed for predicting cell survival fractions in radiotherapy. This study demonstrates the applicability of NanOx in hadrontherapy and validates its predictions against experimental data.
FRONTIERS IN PHYSICS
(2022)
Article
Physics, Multidisciplinary
Mario Alcocer-Avila, Caterina Monini, Micaela Cunha, Etienne Testa, Michael Beuve
Summary: NanOx is a theoretical framework that predicts cell survival to ionizing radiation in radiotherapy. It considers the stochastic nature of radiation at different spatial scales and extends concepts from microdosimetry to nanodosimetry. The model also takes into account the primary oxidative stress.
FRONTIERS IN PHYSICS
(2023)
Article
Optics
M. E. Galassi, V. B. Tessaro, B. Gervais, M. Beuve
Summary: This paper presents a simple theoretical model for calculating the multiple-ionization cross sections of Ne and Ne-like molecules for proton and light-ion impact. The model takes into account both direct and postcollisional emissions and provides results in close agreement with experimental data.