Article
Multidisciplinary Sciences
Simon Mylius Rasmussen, Thomas Nielsen, Sofie Hody, Henrik Hager, Lars Peter Schousboe
Summary: This study introduces a video processing algorithm designed to identify cancer suspicious skin areas, based on remote photoplethysmography signal differences between squamous cell carcinoma and healthy skin. The research shows significant temporal signal changes in cancer areas versus healthy areas, providing valuable insights for further investigation on detailed disease boundary recognition.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Jennifer Hazel Elizabeth Baker, Firas Moosvi, Alastair Hugh Kyle, Judit Puspoky Banath, Katayoun Saatchi, Urs Otto Haefeli, Stefan Alexander Reinsberg, Andrew Ivor Minchinton
Summary: There is a need for a widely available, translatable, sensitive and non-invasive imaging biomarker for tumor hypoxia in radiation oncology. This study investigates the utility of dOE-MRI, a previously validated imaging approach, to detect VEGF-ablation treatment-induced changes in tumor oxygenation that result in radiosensitization. The results illustrate the effectiveness of dOE-MRI as a non-invasive biomarker for treatment response and tumor sensitivity during cancer interventions.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Alberto Sanchez-Aguilera, Mariam Masmudi-Martin, Andrea Navas-Olive, Patricia Baena, Carolina Hernandez-Oliver, Neibla Priego, Lluis Cordon-Barris, Laura Alvaro-Espinosa, Santiago Garcia, Sonia Martinez, Miguel Lafarga, Michael Z. Lin Renacer, Fatima Al-Shahrour, Liset Menendez de la Prida, Manuel Valiente
Summary: This article investigates the impact of brain metastases on neuronal circuit function and explores the underlying molecular mechanisms. By testing different models of brain metastasis, the researchers identified various changes in brain activity that could help predict the presence and subtype of metastases.
Article
Health Care Sciences & Services
Igor Maiborodin, Alfija Mansurova, Alexander Chernyavskiy, Alexander Romanov, Vladimir Voitcitctkii, Anna Kedrova, Alexander Tarkhov, Alena Chernyshova, Sergey Krasil'nikov
Summary: Based on recent scientific literature on neovascularization and angiogenesis in malignant neoplasms, it is concluded that there are numerous studies on tumor angiogenesis and vascularization. The formation of blood vessels in tumors and the prognostic value of vascularization severity in almost all cancer forms are discussed. Angiogenesis in tumors of the female reproductive system is given special attention. A high number of vessels in tumors often indicates a poor prognosis. Extensive research is being conducted on the influence of various factors on angiogenesis initiation and the possibility of suppressing angiogenesis signals to slow down tumor growth. Pharmacological suppression of tumor vessel formation shows promising clinical outcomes but is accompanied by severe side effects. The significant amount of research on tumor vascularization highlights the increasing importance of this area in oncology. However, there is still limited research on the differences in angiogenesis and vessel number between different parts of tumors, as well as between primary tumor nodes and metastases. Further refinement of the results is needed. It has been noted that the expression of proangiogenic factors is usually higher in metastases than in the primary source, and higher in lymphogenous metastases compared to hematogenous ones.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Jiun-Lin Yan, Cheng-Hong Toh, Li Ko, Kuo-Chen Wei, Pin-Yuan Chen
Summary: The study utilized multimodal MRI, machine learning, and neural network analysis to predict progression patterns of GBM. Different progression phenotypes were found to be clinically significant, affecting treatment and prognosis. Results showed neural network models can efficiently predict tumor progression patterns, highlighting the importance of these patterns as prognostic factors.
Article
Chemistry, Multidisciplinary
Ying Chen, Yong Liu, Peipei Kuang, Chunmei Guo, Jiahui Zan, Chen Xie, Chao Yin, Quli Fan
Summary: This study demonstrates a nanoenzyme-based photothermal agent that can achieve both photothermal conversion and MRI signal amplification in the tumor microenvironment.
CHEMICAL COMMUNICATIONS
(2022)
Article
Oncology
C. Zhou, J. O'Connor, A. Backen, J. W. Valle, J. Bridgewater, C. Dive, G. C. Jayson
Summary: In this study, it was found that plasma Tie2 (pTie2) can serve as a response biomarker for vascular endothelial growth factor inhibitors (VEGFi) treatment, predicting treatment response and disease progression. By integrating data from different types of cancer, it was demonstrated that pTie2 can guide the optimal use of VEGFi in clinical practice.
Article
Medicine, Research & Experimental
Xiao-Fang Yi, Ruo-Lin Gao, Li Sun, Zhi-Xuan Wu, Shu-Ling Zhang, Le-Tian Huang, Cheng-Bo Han, Jie-Tao Ma
Summary: PARP inhibitors exert antitumor effects through synthetic lethality and PARP trapping, and modulate the tumor microenvironment to impact the antitumor immune response. They have dual properties of promoting and inhibiting the antitumor immune response. This review summarizes the dual immunomodulatory effects and possible underlying mechanisms of PARP inhibitors, providing a basis for the design of combination regimens for clinical treatment and the identification of populations who may benefit from these therapies.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Katarzyna Staszak, Karolina Wieszczycka, Anna Bajek, Maciej Staszak, Bartosz Tylkowski, Krzysztof Roszkowski
Summary: According to the World Health Organization (WHO), cancer is the second leading cause of death globally. This review focuses on recent developments of chemical compounds in cancer angiogenesis imaging and monitoring, providing insights into active agents structures involved in various imaging techniques. The aim is to provide the journal audience with a comprehensive understanding of chemistry policy in tumor angiogenesis imaging.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Medicine, Research & Experimental
Deyana Nasri, Rayyan Manwar, Ajeet Kaushik, Ekrem Emrah Er, Kamran Avanaki
Summary: Hypoxia leads to the expression of signaling molecules that regulate cell division, promote angiogenesis, increase resistance to chemotherapy and radiotherapy, and induce metastasis in the tumor microenvironment. Photoacoustic imaging (PAI) utilizes the unique absorption characteristics of chromophores in tissues to construct high-resolution images. This review discusses the physiological characteristics of tumor hypoxia and the current applications of PAI using both label-free and exogenous contrast agents. It analyzes the efficacy of various methods in determining physiological and proteomic phenomena. The review demonstrates that PAI has the potential to understand tumor growth and metastasis development by measuring regulatory molecule concentrations, oxygen gradients, and vascular distribution.
Article
Medicine, General & Internal
David A. A. Paul, Emma Strawderman, Alejandra Rodriguez, Ricky Hoang, Colleen L. Schneider, Sam Haber, Benjamin L. Chernoff, Ismat Shafiq, Zoe R. Williams, G. Edward Vates, Bradford Z. Z. Mahon
Summary: This study demonstrated the sensitivity of diffusion MRI in detecting rapid changes in white matter integrity related to alterations in serum prolactin levels. Stopping or resuming cabergoline treatment led to changes in white matter structure and visual function measurements in a patient with a prolactinoma.
FRONTIERS IN MEDICINE
(2021)
Article
Physiology
Kathleen Cantow, Thomas Gladytz, Jason M. Millward, Sonia Waiczies, Thoralf Niendorf, Erdmann Seeliger
Summary: This study used dynamic MRI to monitor kidney size and provided physiological interpretation of changes in renal oxygenation. The results showed correlations between changes in kidney size and T-2* and T-2. Monitoring kidney size allows for a better understanding of renal pathophysiology.
Article
Endocrinology & Metabolism
Jesus M. Pradillo, Macarena Hernandez-Jimenez, Maria E. Fernandez-Valle, Violeta Medina, Juan E. Ortuno, Stuart M. Allan, Spencer D. Proctor, Juan M. Garcia-Segura, Maria J. Ledesma-Carbayo, Andres Santos, Maria A. Moro, Ignacio Lizasoain
Summary: The study found that stroke outcomes and angiogenesis/vasculogenesis in old rats are negatively affected by the co-morbidities present in the corpulent genotype. DCE-MRI may be a useful technique for non-invasive evaluation of vascular function and angiogenesis processes.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Immunology
Raefa Abou Khouzam, Klaudia Brodaczewska, Aleksandra Filipiak, Nagwa Ahmed Zeinelabdin, Stephanie Buart, Cezary Szczylik, Claudine Kieda, Salem Chouaib
Summary: The environmental and metabolic pressures in the tumor microenvironment have a significant impact on tumor development, especially hypoxia-triggered events that promote growth, enhance resistance to the immune response, and stimulate angiogenesis. Normalizing tumor vasculature can restore integrity, increase perfusion, alleviate hypoxia, and reshape anti-tumor immunity, offering potential in achieving stable vascular normalization for mature and functional blood vessels.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Nehad M. Ayoub, Sara K. Jaradat, Kamal M. Al-Shami, Amer E. Alkhalifa
Summary: Angiogenesis plays a vital role in the growth and spread of solid cancers, but breast cancer has shown poor response to anti-angiogenic drugs. Assessing the angiogenic signaling mechanisms in breast cancer, exploring new drug targets, and improving treatment outcomes through vascular normalization and nanotechnology are important areas of research.
FRONTIERS IN PHARMACOLOGY
(2022)