Article
Medicine, General & Internal
Yedda Nunes Reis, Jonathan Yugo Maesaka, Carlos Shimizu, Jose Maria Soares-Junior, Edmund Chada Baracat, Jose Roberto Filassi
Summary: The study found that fibroepithelial lesions of the breast larger than 3 cm are more likely to be phyllodes tumors.
Review
Oncology
Miguel Esperanca-Martins, Cecilia Melo-Alvim, Sara Damaso, Raquel Lopes-Bras, Tania Peniche, Goncalo Nogueira-Costa, Catarina Abreu, Helena Luna Pais, Rita Teixeira de Sousa, Sofia Torres, Lina Marcela Gallego-Paez, Marta Martins, Leonor Ribeiro, Luis Costa
Summary: Breast sarcomas, phyllodes tumors, and desmoid tumors are rare and poorly characterized entities. This article aims to provide new data for researchers and a decision-making tool for clinicians when treating patients with these tumors.
Review
Cell Biology
Eunah Shin, Ja Seung Koo
Summary: This review discusses clinicopathological factors, immunohistochemical markers, and molecular factors that have been investigated in previous studies to have an impact on the clinical prognosis of Phyllodes tumor.
HISTOLOGY AND HISTOPATHOLOGY
(2023)
Article
Surgery
Yashuang Ji, Yuting Zhong, Yanjun Zhang, Huayu Hu, Ningning Min, Yufan Wei, Rui Geng, Chenyan Hong, Qingyu Guan, Jie Li, Zhili Wang, Xiru Li, Yanju Zhang
Summary: The study found no association between surgical modalities and the local recurrence rate of benign phyllodes tumors (BPT). A "wait-and-watch" policy is recommended for patients with unexpected benign subtypes to avoid unnecessary re-excision. For borderline/malignant tumors, wide local excision or even mastectomy should be performed for large masses.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mitsuteru Tsuchiya, Takayuki Masui, Kazuma Terauchi, Takahiro Yamada, Motoyuki Katyayama, Shintaro Ichikawa, Yoshifumi Noda, Satoshi Goshima
Summary: The radiomics analysis based on MRI shows promise for discriminating between phyllodes tumors and fibroadenomas, with significantly improved performance compared to the conventional radiological model. The combined model incorporating radiomics and radiological features had the highest AUC value among the models tested in the validation set.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Lily Gutnik, Yi Ren, Samantha M. Thomas, Jennifer K. Plichta, Rachel A. Greenup, Oluwadamilola M. Fayanju, E. Shelley Hwang, Laura H. Rosenberger
Summary: Malignant phyllodes and primary breast sarcomas have different survival rates, with surgery being the mainstay of treatment and lumpectomy potentially being a reasonable option for some patients.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaowen Ma, Jing Gong, Feixiang Hu, Wei Tang, Yajia Gu, Weijun Peng
Summary: The study developed and validated a clinical-radiomics model based on multiparametric MRI and clinical information for the pretreatment differential diagnosis of breast phyllodes tumors (PTs). The model showed excellent diagnostic efficiency in both the training and validation cohorts, suggesting its potential as a noninvasive tool for assessing PTs grades.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Oncology
Jessica Bogach, Apishanthi C. Sriskandarajah, Frances Wright, Nicole Look Hong
Summary: National consensus statements were developed to guide the management of phyllodes tumors based on literature review and expert opinions. One hundred approved statements and two tables on locoregional management were established. The findings provide guidance for clinical practice and future research.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Samir Patel, Jennifer Vogel, Kristin Bradley, Paul J. Chuba, Jeffrey Buchsbaum, Matthew J. Krasin
Summary: The role of surgery, chemotherapy, and radiation therapy for retinoblastoma has evolved, with proton therapy potentially reducing the risk of secondary malignancies; pediatric nasopharyngeal carcinoma is treated with induction chemotherapy followed by chemoradiation therapy, and for adrenocortical carcinoma, surgery and chemotherapy are the mainstay with the role of radiation therapy yet to be defined.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
Juergen Hench, Tatjana Vlajnic, Savas Deniz Soysal, Ellen C. Obermann, Stephan Frank, Simone Muenst
Summary: This study explores the use of combined DNA methylation and copy number variant profiling to classify fibroepithelial breast tumors. The results show that these tumors can be divided into distinct categories based on their DNA methylation and copy number variation patterns. This classification has diagnostic and prognostic implications and may aid in therapeutic decision-making.
Article
Chemistry, Analytical
Zhaoting Shi, Yebo Ma, Xiaowen Ma, Anqi Jin, Jin Zhou, Na Li, Danli Sheng, Cai Chang, Jiangang Chen, Jiawei Li
Summary: AI-assisted diagnosis shows superior performance in differentiating breast phyllodes tumors from fibroadenomas, compared to experienced ultrasound physicians.
Article
Oncology
Keyu Chen, Jiaojiao Xu, Wei Wang, Ruiyuan Jiang, Huanping Zhang, Xiaojia Wang, Jun Cao, Meiyu Fang
Summary: Phyllodes tumors (PTs) are rare neoplasms with a risk of recurrence and/or metastasis. There is a lack of high-quality clinical studies and unified guidelines for treatment. A retrospective study was conducted on 82 patients diagnosed with malignant and recurrence/metastasis PTs. Surgical treatment was the main approach, and factors such as surgical methods, tumor size, and biological behavior were associated with the survival of PTs. Borderline PTs rarely metastasized, and surgical resection led to long-term survival. In metastatic PTs, systemic therapy was ineffective, but antiangiogenic drugs showed potential benefits. Lactate dehydrogenase (LDH) was identified as an independent prognostic factor for malignant PTs.
Article
Medicine, General & Internal
Ying Jin, Lirong Bi, Ruming Yang, Tinghan Jiang, Xiaoxiao Zhang, Sijie Li
Summary: Malignant phyllodes tumors with osteosarcomatous transformation are extremely rare and require a high level of suspicion for diagnosis. Awareness by both surgeons and pathologists, as well as consideration of medical history and imaging findings, is essential for accurate diagnosis and proper treatment to prevent negative outcomes.
Article
Pathology
Amelie Wabik, Mieke R. Van Bockstal, Martine Berliere, Christine Galant
Summary: Periductal stromal tumors (PSTs) of the breast, a rare subtype of phyllodes tumors, display biphasic morphology, surrounded by cellular stroma. Contrary to phyllodes tumors, PSTs lack leaflike architecture, making biopsy diagnosis challenging. Both entities share similarities and differences, with potential pitfalls in respective biopsies due to the existence of hybrid lesions.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Medicine, General & Internal
Atif A. Hashmi, Bakhtawar Allauddin Mallick, Khushbakht Rashid, Sumbal Zafar, Shamail Zia, Umair Arshad Malik, Fnu Sapna, Fnu Anjali, Fnu Vishal, Muhammad Irfan
Summary: This study evaluated the clinicopathological features associated with malignancy in breast Phyllodes tumors (PTs) and found a significant association among patient age, tumor size, and PT subtype.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Urology & Nephrology
Thi Oanh Bui, Van Tu Dao, Van Tai Nguyen, Jean-Paul Feugeas, Frederic Pamoukdjian, Guilhem Bousquet
Summary: Genetic tumor heterogeneity is a major cause of resistance in metastatic renal cell carcinoma patients. A meta-analysis of genomic data from 14,696 patients revealed a higher level of mutations in metastases compared to primary tumors, emphasizing the importance of biopsies on metastases in guiding treatment strategies.
Review
Oncology
Van Tai Nguyen, Sabine Winterman, Margot Playe, Amelie Benbara, Laurent Zelek, Frederic Pamoukdjian, Guilhem Bousquet
Summary: This article used a meta-analysis to study the effectiveness of dose-intense cisplatin-based neoadjuvant chemotherapy in the treatment of locally advanced cervical cancer. The results showed that this treatment could improve overall survival and open up new possibilities for clinical trials in cases where local treatment is suboptimal.
Review
Oncology
Tsvetalina Tankova, Elzbieta Senkus, Maria Beloyartseva, Simona Borstnar, Doina Catrinoiu, Mona Frolova, Alinta Hegmane, Andrej Janez, Mladen Krnic, Zoltan Lengyel, Yiola Marcou, Laura Mazilu, Bela Mrinakova, Ruth Percik, Katarina Petrakova, Gabor Rubovszky, Margarita Tokar, Eduard Vrdoljak
Summary: Alpelisib is a drug used to treat a specific type of breast cancer. One of its side effects is an increase in blood glucose levels, which needs to be managed.
Article
Environmental Sciences
Christopher F. Sharpley, David R. H. Christie, Vicki Bitsika
Summary: This study aimed to investigate the moderating effect of psychological resilience on sleep-deterioration-related depression among patients with prostate cancer. The findings showed that psychological resilience moderated the depressive effect of sleep deterioration reported by patients, but its effectiveness was conditional upon the severity of sleep difficulties and the strength of psychological resilience.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Editorial Material
Rheumatology
Eurydice Angeli, Alexander Ariel Padron Gonzalez, Diaddin Hamdan, Gabriel Pop, Geraldine Falgarone, Guilhem Bousquet
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Medicine, General & Internal
Liam King, Nijole Bernaitis, David Christie, Russ Chess-Williams, Donna Sellers, Catherine McDermott, Wendy Dare, Shailendra Anoopkumar-Dukie
Summary: Prostate cancer is the second most commonly diagnosed cancer worldwide, and the development of radioresistance is a major challenge in treatment. Understanding the biological mechanisms behind radioresistance is crucial for developing effective therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Burak Gonullu, Eurydice Angeli, Frederic Pamoukdjian, Guilhem Bousquet
Summary: Anti-HER2 therapies greatly improve the prognosis of HER2-overexpressing cancers, but the relationship between HER2 copy number and response rate to treatment is unclear. A meta-analysis was performed on 9 studies, involving 11,238 women with breast cancer, to study the association between HER2 amplification level and pathological complete response (pCR). The analysis showed that higher HER2/CEP17 ratio was associated with higher pCR rates, confirming the potential therapeutic value of considering HER2 amplification level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anna Lawless, Andrew Kneebone, Shreya Armstrong, Sarat Chander, David Christie, Renee Finnigan, Amy Hayden, Braden Higgs, Matthew Knox, Giuseppe Sasso, Mark Sidhom, Thomas P. Shakespeare, Tanya Holt
Summary: This study examines the practices of radiation oncologists (ROs) and urologists in Australia and New Zealand regarding post-prostatectomy radiation therapy (RT). The survey found significant differences in practice between ROs and urologists, and even within the radiation oncology community. The results highlight the need for updated guidelines in the management of prostate cancer relapse post-prostatectomy.
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2023)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Gerald B. Fogarty, Elizabeth J. Paton, David Schlect, David Christie, Tuan Ha, Evan Ng, Brad Wong, Andrew Potter
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2023)
Article
Surgery
Sammi Zerrouk, Paolo Casoni, Edoardo Cervi, Rafik Amirat, Guilhem Bousquet, Christophe Leboeuf, Anne Janin, Frederic Pamoukdjian
Summary: This study aimed to compare ultrasound and histological approaches for patients with chronic venous disease (CVD). The results showed that ultrasound assessment of vein wall thickness (VWT) could be a non-invasive tool for diagnosis and follow-up in CVD, and could help optimize treatment plans.
Article
Oncology
Thuy Thi Nguyen, Diaddin Hamdan, Eurydice Angeli, Jean-Paul Feugeas, Quang Van Le, Frederic Pamoukdjian, Guilhem Bousquet
Summary: Breast cancer brain metastases are a challenging daily practice. This study performed a meta-analysis on genomic data to identify gene alterations associated with metastatic processes in the brain. Six genes with a higher mutation prevalence in brain metastases than in extracerebral metastases were identified, indicating their potential therapeutic implications.
Editorial Material
Oncology
Eurydice Angeli, Guilhem Bousquet
Letter
Oncology
Thi Oanh Bui, Eurydice Angeli, Morad El Bouchtaoui, Guillaume Gapihan, Van Tu Dao, Justine Paris, Christophe Leboeuf, Michael Soussan, Patrick Villarese, Marianne Ziol, Emmanuel Van Glabeke, Thi Huong Le, Jean-Paul Feugeas, Anne Janin, Guilhem Bousquet
Summary: This study identified a frequent pL1575P NOTCH1 mutation as a new biomarker for ccRCC metastases and predictive of response to the CB103 NOTCH1-intracellular domain inhibitor.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Review
Oncology
Malwina Stanowicka-Grada, Elzbieta Senkus
Summary: Approximately 15-20% of breast cancers demonstrate HER2 overexpression/gene amplification. Anti-HER2 agents have significantly improved the prognosis and survival of patients with HER2-positive breast cancer. New anti-HER2 therapies have been developed, providing additional treatment options for advanced HER2-positive breast cancer. Current worldwide treatment options for metastatic breast cancer include different HER2 pathway blocking drugs at different stages. Clinical trials are ongoing to evaluate HER2 pathway blocking drugs in advanced disease settings. New data challenge current treatment standards, raising questions about the optimal sequence and combination of anti-HER2 targeted therapies, as well as treatment for special patient populations.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Grazyna Suchodolska, Anna Koelmer, Monika Puchowska, Elzbieta Senkus
Summary: This study aims to explore the use of an in-app electronic questionnaire to assess and monitor chemotherapy-related symptoms in early breast cancer patients. The acceptance of the study was higher among younger women and patients from rural areas. However, the usage of the electronic questionnaire decreased substantially after the period of active encouragement during the study enrolment. The study concludes that patients' age should be carefully considered when introducing app-based interventions into usual cancer care and additional support is suggested for older patients to improve their awareness and participation in eHealth interventions.
