Article
Cardiac & Cardiovascular Systems
Ruijiao Liu, Tengfei Duan, Li Yu, Yongzhong Tang, Shikun Liu, Chunjiang Wang, Wei-Jin Fang
Summary: This study found that high-fat diet leads to activation of cardiomyocyte ASMase, which increases NOX4 expression and thereby increases oxidative stress and apoptosis, ultimately causing metabolic cardiomyopathy.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Oncology
Anet Valdes Zayas, Neeraj Kumari, Kevin Liu, Denae Neill, Abagail Delahoussaye, Patrik Goncalves Jorge, Reiner Geyer, Steven H. Lin, Claude Bailat, Francois Bochud, Raphael Moeckli, Albert C. Koong, Jean Bourhis, Cullen M. Taniguchi, Fernanda G. Herrera, Emil Schuler
Summary: Ultra-high dose rate FLASH radiation therapy has the potential to revolutionize cancer treatment by reducing normal tissue toxicity while maintaining tumor response. However, the robustness and reproducibility of the FLASH effect have been questioned due to variations between treatment centers. This study demonstrates that a consistent and reproducible FLASH effect can be achieved when similar irradiation beam parameter settings are used.
Article
Multidisciplinary Sciences
Michele Dei Cas, Sara Ottolenghi, Camillo Morano, Rocco Rinaldo, Gabriella Roda, Davide Chiumello, Stefano Centanni, Michele Samaja, Rita Paroni
Summary: The serum lipidome of COVID-19 patients shows significant and unique dyslipidemia related to factors such as inflammation, hypoxia, coagulation state, kidney function, and age, indicating reduced defense against oxidative stress. A particular lipidome signature was identified in patients with different outcomes after 7 days, with an increase in specific lipid species like ceramides and sulfatides, potentially serving as biomarkers for disease progression and severity.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Yangyang Zhang, Wenjing Wu, Junjie Zhang, Zhao Li, Huimin Ma, Zhenwen Zhao
Summary: A sphingomyelin-based ratiometric FEN probe was developed for detecting acid SMase activity, showing high selectivity and sensitivity with a detection limit of 4.8 x 10(-4) U/mL. The probe has been successfully applied to analyzing acid SMase activity in cells and urine samples. This method is biocompatible and simpler than existing ones, potentially providing new strategies for developing methods for other important esterases.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Kan Yang, Keyi Nong, Fei Xu, Yu Chen, Jinying Yu, Lizhi Lin, Xiao Hu, Youzhi Wang, Ting Li, Jibin Dong, Jinxin Wang
Summary: In this study, a series of benzene-heterocyclic-based ASM inhibitors were designed, synthesized, and screened, and some compounds showed favorable inhibitory activity against recombinant human ASM. Compound 4i exhibited good pharmacokinetic properties and in vivo inhibitory activity against ASM, reducing the level of ceramide in mice plasma and liver. Moreover, 4i was found to decrease lipid plaques, plasma ceramide concentration, and Ox-LDL levels, and to regulate cell inflammation induced by LPS and Ox-LDL by modulating the levels of ceramide and sphingomyelin. Overall, this study demonstrates the potential of ASM as an effective target for treating atherosclerosis.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Irina Petrache, Elisabet Pujadas, Aditya Ganju, Karina A. Serban, Alexander Borowiec, Beatrice Babbs, Irina A. Bronova, Nicholas Egersdorf, Patrick S. Hume, Khushboo Goel, William J. Janssen, Evgeny Berdyshev, Carlos Cordon-Cardo, Richard Kolesnick
Summary: The concentration of C16:0-ceramide in the plasma of COVID-19 patients was significantly increased compared to healthy individuals. Autopsied lungs of individuals with COVID-ARDS showed a massive elevation of C16:0-ceramide and exhibited a previously unrecognized microvascular ceramide-staining pattern and increased apoptosis. C16:0-ceramide may be implicated in the vascular injury associated with COVID-19.
Article
Food Science & Technology
Qian Liu, Chao Fu, Hai Yang, Chuanshe Zhou, Jinhe Kang, Liang Chen, Zhiwei Kong, Zhiliang Tan, Shaoxun Tang
Summary: The study found that substituting alfalfa with ramie has an impact on the expression of apoptotic genes in the gastrointestinal tract of goats, especially when ramie substitution reaches 100%, which may have a strong antinutritional effect and promote apoptosis in goat intestines, affecting their growth and development.
FOOD SCIENCE & NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Fahadul Islam, Saikat Mitra, Talha Bin Emran, Zidan Khan, Nikhil Nath, Rajib Das, Rohit Sharma, Ahmed Abdullah Al Awadh, Moon Nyeo Park, Bonglee Kim
Summary: Gastric cancer is common and challenging to treat, with chemotherapy as a last resort. Research focus is on natural small molecules for better therapeutics.
Article
Pharmacology & Pharmacy
Susan J. Keam
Summary: This article summarizes the milestones in the development of olipudase alfa leading to its first approval for the treatment of patients with ASMD, including the drug's mechanism of action, approval status, and ongoing regulatory review.
Review
Biochemistry & Molecular Biology
Elissa Elia, David Brownell, Stephane Chabaud, Stephane Bolduc
Summary: This passage discusses the similarities between the gastrointestinal and genitourinary tracts, which both consist of hollow structures that rely on muscle contractions to facilitate the flow of materials. It describes the anatomy, pathologies, and treatments of these organs, with a particular emphasis on tissue engineering strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Carolina Pinto, Diana Sousa, Vladimir Ghilas, Andrea Dardis, Maurizio Scarpa, Maria Fatima Macedo
Summary: ASMD is a lysosomal storage disease caused by deficient ASM enzyme activity, leading to various clinical features. ASM enzyme replacement therapy is currently in clinical trial to address the underlying pathology of the disease. It is critical to better understand ASMD for improved diagnosis and monitoring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Wusun Li, Yingying Lin, Yujia Luo, Yuqi Wang, Yao Lu, Yixuan Li, Huiyuan Guo
Summary: Vitamin D mediated through VDR protects against IR-induced intestinal injury by inhibiting apoptosis of crypt stem/progenitor cells. VDR deficiency may lead to more severe DNA damage and apoptosis, impairing intestinal regeneration and survival time. Targeting VDR could be an effective strategy for treatment of gastrointestinal syndrome in clinical radiation therapy.
Article
Oncology
Daniel Lin, Shalini Moningi, Joseph Abi Jaoude, Ben S. Singh, Irina M. Cazacu, Ramez Kouzy, Graciela M. Nogueras Gonzalez, Phonthep Angsuwatcharakon, Joseph M. Herman, Manoop S. Bhutani, Cullen M. Taniguchi
Summary: The study aimed to develop an objective toxicity scoring system to directly assess changes in upper gastrointestinal (GI) toxicity during pancreatic cancer radiation treatment. Evaluation of 19 patients undergoing SBRT showed a mild increase in toxicity in the stomach and duodenum, with no severe toxicity observed. The developed toxicity scoring system was reliable with good interobserver agreement for pre- and post-treatment scores, indicating its potential usefulness in assessing GI toxicity during pancreatic cancer treatment and research trials.
Article
Chemistry, Multidisciplinary
Peng Shan, Jing Liao, Jiayi Li, Chengyan Wang, Jie Zhou, Linqiang Mei, Yunlu Dai, Qiang Wang, Wenyan Yin
Summary: This study reports an oral radioprotectant Gel@GYY that combines a gelatin-based hydrogel and a pH-responsive hydrogen sulfide donor. Gel@GYY has excellent adhesion and sustained release properties, allowing it to release H2S in the gastrointestinal tract and effectively scavenge free radicals induced by radiation. It also reduces inflammation and has biodegradable properties.
CHINESE CHEMICAL LETTERS
(2024)
Article
Biology
Kelvin W. Pond, Julia M. Morris, Olga Alkhimenok, Reeba P. Varghese, Carly R. Cabel, Nathan A. Ellis, Jayati Chakrabarti, Yana Zavros, Juanita L. Merchant, Curtis A. Thorne, Andrew L. Paek
Summary: The establishment and maintenance of different cellular compartments in tissues is crucial for all metazoans, especially in the human colon. This study reveals the critical role of wave-like ERK signaling induced by apoptotic cells in maintaining tissue patterning and homeostasis.
Article
Engineering, Biomedical
Amey Bandekar, Shrirang Karve, Min-Yuan Chang, Qingshan Mu, Jimmy Rotolo, Stavroula Sofou
Article
Biology
Kamal Datta, Shubhankar Suman, Daniela Trani, Kathryn Doiron, Jimmy A. Rotolo, Bhaskar V. S. Kallakury, Richard Kolesnick, Michael F. Cole, Albert J. Fornace
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2012)
Article
Medicine, Research & Experimental
Jimmy Rotolo, Branka Stancevic, Jianjun Zhang, Guoqiang Hua, John Fuller, Xianglei Yin, Adriana Haimovitz-Friedman, Kisu Kim, Ming Qian, Marina Cardo-Vila, Zvi Fuks, Renata Pasqualini, Wadih Arap, Richard Kolesnick
JOURNAL OF CLINICAL INVESTIGATION
(2012)
Article
Immunology
Raymond Schuch, Han M. Lee, Brent C. Schneider, Karen L. Sauve, Christina Law, Babar K. Khan, Jimmy A. Rotolo, Yuki Horiuchi, Daniel E. Couto, Assaf Raz, Vincent A. Fischetti, David B. Huang, Robert C. Nowinski, Michael Wittekind
JOURNAL OF INFECTIOUS DISEASES
(2014)
Article
Multidisciplinary Sciences
Hyunmi Lee, Jimmy A. Rotolo, Judith Mesicek, Tuula Penate-Medina, Andreas Rimner, Wen-Chieh Liao, Xianglei Yin, Govind Ragupathi, Desiree Ehleiter, Erich Gulbins, Dayong Zhai, John C. Reed, Adriana Haimovitz-Friedman, Zvi Fuks, Richard Kolesnick
Article
Multidisciplinary Sciences
Sydney X. Lu, Lucy W. Kappel, Anne-Marie Charbonneau-Allard, Renee Atallah, Amanda M. Holland, Claire Turbide, Vanessa M. Hubbard, Jimmy A. Rotolo, Marsinay Smith, David Suh, Christopher King, Uttam K. Rao, Nury Yim, Johanne L. Bautista, Robert R. Jenq, Olaf Penack, Il-Kang Na, Chen Liu, George Murphy, Onder Alpdogan, Richard S. Blumberg, Fernando Macian, Kathryn V. Holmes, Nicole Beauchemin, Marcel R. M. van den Brink
Article
Multidisciplinary Sciences
Branka Stancevic, Nira Varda-Bloom, Jin Cheng, John D. Fuller, Jimmy A. Rotolo, Monica Garcia-Barros, Regina Feldman, Shyam Rao, Ralph R. Weichselbaum, Dror Harats, Adriana Haimovitz-Friedman, Zvi Fuks, Michel Sadelain, Richard Kolesnick
Correction
Multidisciplinary Sciences
Hyunmi Lee, Jimmy A. Rotolo, Judith Mesicek, Tuula Penate-Medina, Andreas Rimner, Wen-Chieh Liao, Xianglei Yin, Govind Ragupathi, Desiree Ehleiter, Erich Gulbins, Dayong Zhai, John C. Reed, Adriana Haimovitz-Friedman, Zvi Fuks, Richard Kolesnick
Article
Oncology
Maria Laura Martin, Mohammad Adileh, Kuo-Shun Hsu, Guoqiang Hua, Sang Gyu Lee, Christy Li, John D. Fuller, Jimmy A. Rotolo, Sahra Bodo, Stefan Klingler, Adriana Haimovitz-Friedman, Joseph O. Deasy, Zvi Fuks, Philip B. Paty, Richard N. Kolesnick
Article
Cell Biology
Charles S. Ferranti, Jin Cheng, Chris Thompson, Jianjun Zhang, Jimmy A. Rotolo, Saha Buddaseth, Zvi Fuks, Richard N. Kolesnick
JOURNAL OF CELL BIOLOGY
(2020)
Article
Medicine, Research & Experimental
Jimmy A. Rotolo, Chii Shyang Fong, Sahra Bodo, Prashanth Kb Nagesh, John Fuller, Thivashnee Sharma, Alessandra Piersigilli, Zhigang Zhang, Zvi Fuks, Vijay K. Singh, Richard Kolesnick
Summary: This study identified an anti-ceramide 6B5 single-chain variable fragment (scFv) that mitigated mouse lethality after nuclear attack, initiating tissue repair and promoting survival. Successful preclinical development may lead to inclusion of anticeramide 6B5 scFv in the Strategic National Stockpile for distribution after radiation catastrophe.
Article
Oncology
Emad Darvishi, Lila Ghamsari, Siok F. Leong, Ricardo Ramirez, Mark Koester, Erin Gallagher, Miao Yu, Jody M. Mason, Gene Merutka, Barry J. Kappel, Jim A. Rotolo
Summary: The study reveals the mechanism of action and antitumor activity of ST101, a novel peptide antagonist of C/EBP beta. ST101 inhibits dimerization of C/EBP beta and enhances its degradation, resulting in attenuation of transcription of C/EBP beta target genes and potent tumor-specific cytotoxic activity in various cancer cell lines. In mouse xenograft models, ST101 shows strong inhibition or regression of tumor growth, both as a single agent and in combination studies.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Miao Yu, Lila Ghamsari, Jim A. Rotolo, Barry J. Kappel, Jody M. Mason
Summary: The study focused on developing an antagonist selective for the Fra1 oncogenic transcriptional regulator using library design, computational screening, and intracellular screening. By reducing the library size and enriching for binders with specific criteria, the researchers identified a peptide (Fra1W) that exhibited specificity through a combination of hydrophobic and electrostatic contacts, showing high Fra1 affinity and selective binding. The multidisciplinary approach demonstrated a robust screening pipeline for generating target-specific hits and provided new insights into rational peptide design for novel bZIP family inhibitors.
RSC CHEMICAL BIOLOGY
(2021)
Article
Microbiology
Raymond Schuch, Babar K. Khan, Assaf Raz, Jimmy A. Rotolo, Michael Wittekind
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2017)
Article
Cell Biology
Jeanna Jacobi, Monica Garcia-Barros, Shyam Rao, Jimmy A. Rotolo, Chris Thompson, Aviram Mizrachi, Regina Feldman, Katia Manova, Alicja Bielawska, Jacek Bielawska, Zvi Fuks, Richard Kolesnick, Adriana Haimovitz-Friedman
CELLULAR SIGNALLING
(2017)