Article
Oncology
Minsi Zhang, Aimee Crago, Sam S. Yoon, Samuel Singer, Kaled Alektiar
Summary: In patients with borderline-resectable primary nonmetastatic retroperitoneal sarcoma, preoperative dose-painting IMRT rendered 67% of patients resectable, provided a 5-year local control rate of 57%, which is similar to those with resectable disease, and had an acceptable morbidity profile.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Fady Samir, Talaat M. Meaz, Fathi AEl Hussiny, Ahmed A. Ahmed, Amr A. Mahmoud, Tamer Refaat, Ahmed Gawish, Mohamed Abouegylah
Summary: The study compared four techniques in prostate treatment to find the preferred technique. Plans were created for 30 prostate cancer patients using different techniques, and the quality of the plans was assessed by comparing target coverage, organs at risk, monitor units, homogeneity, and conformity among the techniques.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Daniela Alterio, Simona Marani, Valeria Zurlo, Stefano Filippo Zorzi, Annamaria Ferrari, Stefania Volpe, Francesco Bandi, Sabrina Vigorito, Maria Giulia Vincini, Sara Gandini, Aurora Gaeta, Cristiana Iuliana Fodor, Alessia Casbarra, Mattia Zaffaroni, Anna Starzynska, Liliana Belgioia, Mohssen Ansarin, Cynthia Aristei, Barbara Alicja Jereczek-Fossa
Summary: The study compared the toxicity profiles of patients treated with intensity-modulated radiotherapy (IMRT) and 3D conformal radiotherapy (3D-CRT) for tumors of the supraglottic regions, finding that IMRT had lower toxicity rates and better treatment outcomes, especially in preserving long-term laryngeal and swallowing functions for patients.
Article
Medicine, General & Internal
Irini Youssef, Jennifer Yoon, Nader Mohamed, Kaveh Zakeri, Robert H. Press, Linda Chen, Daphna Y. Gelblum, Sean M. McBride, Chiaojung Jillian Tsai, Nadeem Riaz, Yao Yu, Marc A. Cohen, Lara Ann Dunn, Alan L. Ho, Richard J. Wong, Loren S. Michel, Jay O. Boyle, Bhuvanesh Singh, Anuja Kriplani, Ian Ganly, Eric J. Sherman, David G. Pfister, James Fetten, Nancy Y. Lee
Summary: This study compared the toxic effects and oncologic outcomes of patients with newly diagnosed nonmetastatic oropharyngeal carcinoma (OPC) treated with intensity-modulated proton therapy (IMPT) or intensity-modulated radiation therapy (IMRT). The results showed that IMPT treatment was associated with reduced acute toxicity and favorable oncologic outcomes compared to IMRT.
Review
Oncology
Won Il Jang, Sunmi Jo, Ji Eun Moon, Sun Hyun Bae, Hee Chul Park
Summary: This study is the first systematic review and meta-analysis on the advantages of IMRT for hepatocellular carcinoma. Despite most patients being in advanced stages and using combined treatment, IMRT for HCC showed similar survival rates to existing radiotherapy modalities and relatively low toxicity.
Article
Oncology
Sota Nakahara, Takayuki Ohguri, Sho Kakinouchi, Hirohide Itamura, Takahiro Morisaki, Subaru Tani, Katuya Yahara, Naohiro Fujimoto
Summary: This study retrospectively analyzed the efficacy and toxicity of adding regional hyperthermia to intensity-modulated radiotherapy (IMRT) plus neoadjuvant androgen deprivation therapy (ADT) for high-risk localized prostate carcinoma. The results showed that adding hyperthermia improved clinical relapse-free survival and higher thermal dose predicted improved biochemical disease-free survival.
Article
Oncology
Guanzhu Shen, Yinglin Peng, Jian Li, Haijun Wu, Guangshun Zhang, Chong Zhao, Xiaowu Deng
Summary: This study evaluated the incidence of hypothyroidism in patients with nasopharyngeal carcinoma after IMRT, finding that 34.8% of patients developed hypothyroidism 12 months after radiotherapy. The average thyroid dose and thyroid volume were identified as key factors affecting hypothyroidism, with an NTCP model constructed based on these factors showing good fit.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yi-Jun Hua, Yan-Feng Ou-Yang, Xiong Zou, Le Xia, Dong-Hua Luo, Ming-Yuan Chen
Summary: Radiotherapy is crucial for nasopharyngeal carcinoma patients, with a typical treatment duration of six to six and a half weeks. Prolonged radiotherapy duration is associated with higher risk of distant metastasis and death, highlighting the importance of avoiding prolonged treatment to improve outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Fen Xue, Xiaoshuang Niu, Chaosu Hu, Xiayun He
Summary: This study aimed to determine the long-term risk of second primary lung adenocarcinoma (SPLAC) in nasopharyngeal cancer (NPC) patients after intensity-modulated radiotherapy (IMRT). The results showed that the incidence of SPLAC in NPC patients after IMRT was similar to that of the normal population, and most cases were detected in early stages during follow-up, with good surgical efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Zheng Lao, Fan Bi, Wenhui Fan, Xuanli Xu, Wenyong Tu, Huifeng Shi
Summary: This study compared coplanar and noncoplanar intensity-modulated radiation therapy (IMRT) treatment planning for tongue cancer patients. Non-coplanar field radiotherapy was found to effectively reduce exposure dose to the lip and buccal mucosa, leading to significantly better results in terms of radiation-related toxicity of the lip and cheek membrane. Such application of noncoplanar treatment plans demonstrates good clinical significance and should be promoted.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Oncology
Serra Kamer, Sunde Yilmaz Susluer, Tugce Balci Okcanoglu, Cagla Kayabasi, Besra Ozmen Yelken, Sinan Hoca, Emin Tavlayan, Nezahat Olacak, Yavuz Anacak, Murat Olukman, Cumhur Gunduz
Summary: This study investigated the impact of intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) on cellular response in head and neck cancer and melanoma models. The results showed that different tumor cell types were influenced differently by dose rate, IMRT, and VMAT in terms of biological processes. Therefore, careful consideration should be given to the selection of appropriate techniques.
Article
Oncology
Juliane Hoerner-Rieber, Tobias Forster, Adriane Hommertgen, Matthias F. Haefner, Nathalie Arians, Laila Konig, Semi B. Harrabi, Ingmar Schlampp, Fabian Weykamp, Jonathan W. Lischalk, Vanessa Heinrich, Nicola Weidner, Johannes Huesing, Christof Sohn, Joerrg Heil, Holger Hof, David Krug, Juergen Debus
Summary: In adjuvant breast radiation therapy after breast conservation surgery, conventional fractionated intensity modulated radiation therapy with simultaneous integrated boost (IMRT-SIB) was found to be noninferior to 3-D conformal radiation therapy with sequential boost (3-D-CRT-seqB) in terms of local control rates and cosmetic results at 2 years.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Katharina Seidensaal, Matthias Dostal, Andreas Kudak, Cornelia Jaekel, Eva Meixner, Jakob Liermann, Fabian Weykamp, Philipp Hoegen, Gunhild Mechtersheimer, Franziska Willis, Martin Schneider, Juergen Debus
Summary: Retroperitoneal sarcomas are rare and commonly recur locally, even at high-volume centers. The role of radiotherapy in retroperitoneal sarcoma is not established, and the study aimed to report the results of a trial on dose-escalated intensity-modulated radiotherapy with an intraoperative boost. The primary endpoint of 5-year local control was not met, but promising results were seen in patients who received a higher dose and intraoperative boost.
Article
Oncology
Livia Marrazzo, Icro Meattini, Gabriele Simontacchi, Lorenzo Livi, Stefania Pallotta
Summary: Multiple phase 3 trials have shown that partial breast irradiation is not inferior to whole breast irradiation in terms of local control and has similar or reduced toxicity. The 5-fraction regimen has gained interest, especially during the COVID-19 pandemic. The APBI-IMRT-Florence trial schedule of 30 Gy in 5 fractions appears to be a safe and effective option for patients with early breast cancer.
PRACTICAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Nicolette Taku, Gregory Chronowski, G. Brandon Gunn, William H. Morrison, Neil D. Gross, Amy C. Moreno, Renata Ferrarotto, Steven J. Frank, C. David Fuller, Ryan P. Goepfert, Jack Phan, Stephen Y. Lai, Jay P. Reddy, David Rosenthal, Adam S. Garden
Summary: This study aimed to evaluate disease, survival, and toxic effects after unilateral radiation therapy for tonsillar cancer. The results showed favorable disease outcomes, high survival rates, and relatively low toxicity profiles in patients who received unilateral radiation therapy for well-lateralized tonsillar tumors with no contralateral neck involvement.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Otorhinolaryngology
Sajid S. Qureshi, Monica Bhagat, Nitin Singhal, Nitin Tathe, Seema Kembhavi, Siddharth Laskar, Mukta Ramadwar, Prabha Yadav
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2016)
Article
Dentistry, Oral Surgery & Medicine
S. S. Qureshi, M. Bhagat, S. Laskar, S. Kembhavi, T. Vora, M. Ramadwar, G. Chinnaswamy, M. Prasad, N. Khanna, S. Shah, S. Talole
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2016)
Article
Pediatrics
Sajid S. Qureshi, Aruna Prabhu, Monica Bhagat, Seema Kembhavi, Tushar Vora, Girish Chinnaswamy, Mukta Ramadwar, Siddharth Laskar, Sanjay Talole
JOURNAL OF PEDIATRIC SURGERY
(2017)
Article
Pediatrics
Sajid S. Qureshi, Praveen Kammar, Seema Kembhavi
JOURNAL OF PEDIATRIC SURGERY
(2017)
Editorial Material
Pediatrics
Sajid S. Qureshi, Bharat Rekhi, Seema Kembhavi
JOURNAL OF PEDIATRICS
(2017)
Article
Oncology
Sajid S. Qureshi, Seema A. Kembhavi, Monica Bhagat, Tejas Kapadia, Maya Prasad, Tushar Vora, Girish Chinnaswamy, Mukta Ramadwar, Siddhartha Laskar, Nehal Khanna, Akshay Baheti, Sneha Shah, Purna Kurkure, Sanjay Talole
PEDIATRIC BLOOD & CANCER
(2019)
Article
Pediatrics
Sajid S. Qureshi, Seema A. Kembhavi, Mufaddal Kazi, Vasundhara Smriti, Akshay Baheti, Tushar Vora, Girish Chinnaswamy, Maya Prasad, Nayana Amin, Mukta Ramadwar, Nehal Khanna, Sidharth Laskar
Summary: Nonanatomic resections (NAR) for hepatoblastoma are feasible in carefully selected patients, with lower blood loss and operative times compared to anatomic resections (AR). Postoperative complications and oncologic outcomes are similar between the two groups, with NAR not inferior to AR.
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Oncology
Badira Cheriyalinkal Parambil, Tushar Vora, Hari Sankaran, Maya Prasad, Asish Bakshi, Ajay Puri, Ashish Gulia, Sajid Qureshi, Siddhartha Laskar, Nehal Khanna, Sneha Shah, Mukta Ramadwar, Seema Kembhavi, Girish Chinnaswamy, Shripad Banavali
PEDIATRIC BLOOD & CANCER
(2020)
Review
Oncology
Mufaddal Kazi, Sajid S. Qureshi
Summary: Pediatric primary peritoneal embryonal rhabdomyosarcoma is a rare entity with majority of cases being inadequately treated and having poor outcomes. However, in certain cases, aggressive treatment through cytoreductive surgery and hyperthermic intraperitoneal chemotherapy can lead to favorable outcomes.
INDIAN JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Subramaniam Ramanathan, Maya Prasad, Tushar Vora, Badira C. Parambil, Seema Kembhavi, Mukta Ramadwar, Nehal Khanna, Siddhartha Laskar, Purna Kurkure, Sajid Qureshi, Shripad Banavali, Girish Chinnaswamy
Summary: This study aimed to analyze the outcomes of extracranial germ cell tumors (GCTs) in children. The results showed that low-risk and intermediate-risk GCTs had excellent outcomes, while for high-risk GCTs, intensifying therapies must be balanced against the risk of cumulative toxicity.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Oncology
Subramaniam Ramanathan, Maya Prasad, Tushar Vora, Cheriyalinkal Parambil Badira, Seema Kembhavi, Mukta Ramadwar, Nehal Khanna, Siddhartha Laskar, Mary Ann Muckaden, Sajid Qureshi, Shripad Banavali, Girish Chinnaswamy
Summary: This study examines the remission rates and outcomes of relapsed/refractory germ cell tumors (rel/ref-GCTs) in children treated with conventional salvage chemotherapy (SC) regimens. The results show that patients with high-risk tumors and resistance to platinum analogs have lower survival rates, while testicular GCTs have the best chance of salvage.
PEDIATRIC BLOOD & CANCER
(2023)
Editorial Material
Gastroenterology & Hepatology
Kaustubha S. Gour, Shraddha Patkar, Sajid S. Qureshi
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Oncology
Vasundhara Smriti, Akshay D. Baheti, Sneha Shah, Sajid S. Qureshi, Nanadan Shetty, Kunal Gala, Suyash Kulkarni, Abhijit Raut, Veenita Kamble, Girish Chinnaswamy, Maya Prasad, C. P. Badira, Mukta Ramadwar, Suryaveer Singh, Anuradha Shukla, Hirenkumar Panwala, Arpita Sahu, Laskar Siddharth, Tejas Kapadia
Summary: Paediatric extra-cranial solid tumours are a common cause of paediatric malignancies. Lack of appropriate imaging techniques for diagnosis, staging, and follow-up poses a major challenge. We have reviewed the imaging protocols for paediatric solid tumours suggested by major oncological societies/groups worldwide (SIOP - Society International Pediatric Oncology and COG - Children's Oncology Group), and adapted some of them to develop imaging recommendations based on Indian treatment protocols.
INDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGY
(2023)
Article
Oncology
Sajid S. Qureshi, Mufaddal Kazi, Jarin Noronha, Vasundhara Smriti, Sandeep Basu, Sneha Shah, Sanjay Talole
Summary: Pediatric differentiated thyroid cancer has a high incidence of lymph node metastasis, with extrathyroid extension being the most important predictor of nodal disease. The ATA pediatric risk stratification is valuable in predicting clinical outcomes.
INDIAN JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Shivpal Saini, Mufaddal Kazi, Sajid S. Qureshi
INDIAN JOURNAL OF SURGICAL ONCOLOGY
(2020)