Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Volume 47, Issue 3, Pages 149-155Publisher
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmu133
Keywords
ubiquitin modification; pattern-recognition receptor; cellular innate antiviral signaling
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Funding
- Ministry of Science and Technology of China [2014CB540600]
- National Natural Science Foundation of China [31371427]
- Ministry of Education of China
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Host pattern-recognition receptors (PRRs) recognize pathogen-associated molecular patterns generated by invading viruses and initiate a series of signaling cascades that lead to the activation of interferon-regulatory factor 3 (IRF3) and nuclear factor-kappa B (NF-kappa B) and subsequent induction of type I interferons (IFNs). Posttranslational modification of proteins by ubiquitin plays an essential role in mediating or regulating the virus-triggered PRRs-mediated signaling. Deubiquitination is the reversible process of ubiquitination and its role in regulating PRRs-mediated signaling has recently been explored. In this review, we first summarize the ubiquitination events in PRRs-mediated signaling that is triggered by viral nucleic acid and then focus on host and viral deubiquitinating enzymes-mediated regulation of virus-triggered signaling that modulates the activation of IRF3 and NF-kappa B and subsequent induction of type I IFNs.
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