Article
Nutrition & Dietetics
Qilyu Zhou, Ruyang Yu, Tianlong Liu, Yeye Li, Jia Zhong, Tao Zhang, Zhongjie Liu, Yusheng Hu
Summary: Coix seed, a functional food in the Chinese diet, has the ability to alleviate ulcerative colitis. This study found that Coix seed feed can alleviate colitis symptoms, maintain a normal blood count, reduce pathological damage, suppress inflammatory cytokine secretion, and relieve oxidative stress. The network pharmacology analysis suggests that T-cell regulation may be one of the mechanisms of action. Experimental evidence supports this finding in the T-lymphocyte subset and innate immune cell distribution of colon tissue.
Article
Environmental Sciences
Mai M. Eissa, Mohamed M. Ahmed, Mabrouk A. Abd Eldaim, Ahmed A. Mousa, Ahmed F. Elkirdasy, Mostafa A. Mohamed, Sahar H. Orabi
Summary: Chlorella vulgaris extract ameliorates sodium nitrite-induced hepatotoxicity in rats by modulating inflammation, oxidative stress, and hepatic tissue function and architecture.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Plant Sciences
Yu Zhang, Guangyao Ye, Yuebo Chen, Chaoxu Sheng, Jianlin Wang, Lingsi Kong, Liyong Yuan, Chunyan Lin
Summary: Veratramine may alleviate pain symptoms in rats with diabetic peripheral neuropathy by inhibiting activation of the SIGMAR1-NMDAR pathway.
PHARMACEUTICAL BIOLOGY
(2022)
Review
Immunology
Matteo Bronzini, Alessandro Maglione, Rachele Rosso, Manuela Matta, Federica Masuzzo, Simona Rolla, Marinella Clerico
Summary: Multiple sclerosis (MS) is a neurological disease characterized by chronic inflammation and immune-driven demyelination of the central nervous system. Changes in gut microbiome driven by dietary habits may contribute to the increase in MS cases. This review explores the impact of diet on the development and course of MS by feeding the gut microbiome, discussing the role of nutrition, gut microbiota, and potential microbiome-targeted therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Tong Wu, Qinhui Liu, Yanping Li, Hong Li, Lei Chen, Xuping Yang, Qin Tang, Shiyun Pu, Jiangying Kuang, Rui Li, Ya Huang, Jinhang Zhang, Zijing Zhang, Jian Zhou, Cuiyuan Huang, Guorong Zhang, Yingnan Zhao, Min Zou, Wei Jiang, Li Mo, Jinhan He
Summary: Liver-specific overexpression of Manf promotes browning of white adipocytes and protects against obesity, insulin resistance, and hepatic steatosis. Mechanistically, Manf can directly promote browning of white adipocytes via the p38 MAPK pathway. Moreover, circulating levels of Manf are positively correlated with BMI in humans.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Shao-Jung Hsu, Chihao Zhang, Jain Jeong, Seong-il Lee, Matthew McConnell, Teruo Utsumi, Yasuko Iwakiri
Summary: This study demonstrated that enhancing meningeal lymphatic drainage can reduce neuroinflammation and ameliorate hepatic encephalopathy, suggesting a new therapeutic strategy for the treatment of HE.
Article
Plant Sciences
Xin Han, Shaoqi Hu, Qiao Yang, Xianan Sang, Dongxin Tang, Gang Cao
Summary: This study found that TGP and PF can improve lung injury in a mouse model of asthma by inhibiting inflammation, regulating immune response, reducing oxidative stress and inhibiting autophagy.
Article
Chemistry, Medicinal
Chia-Chen Hsu, Yingxiao Li, Chao-Tien Hsu, Juei-Tang Cheng, Mang-Hung Lin, Kai-Chun Cheng, Shang-Wen Chen
Summary: Diet-induced obesity is a major risk factor for cardiovascular diseases, and increases in TNF-alpha is associated with this condition. Etanercept, a TNF-alpha inhibitor, has been shown to alleviate cardiac hypertrophy and fibrosis by reducing STAT3 activation in HFD-fed rats and H9c2 cells.
Article
Environmental Sciences
Abeer A. Aljehani, Nawal A. Albadr, Mohammed Z. Nasrullah, Thikryat Neamatallah, Basma G. Eid, Ashraf B. Abdel-Naim
Summary: The study showed that ICA can effectively improve MetS-induced BPH through its antiproliferative, proapoptotic, antioxidant, and anti-inflammatory activities as well as the activation of AMPK.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Dalia O. Saleh, Maha Nasr, Azza Hassan, Sally A. El-Awdan, Gehad A. Abdel Jaleel
Summary: The aim of this study was to investigate the therapeutic effects of curcumin nanoemulsion (NC) on cerebral damage in diabetic rats. The results showed that NC treatment reduced neurological deficit and redox imbalance, decreased inflammation and apoptosis, and restored glucose transporter 1 expression in the brain.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Neurosciences
Meng-Tong Xue, Wen-Jie Sheng, Xue Song, Yu-Jiao Shi, Zhi-Jun Geng, Lin Shen, Rui Wang, He-Zuo Lu, Jian-Guo Hu
Summary: ATL-III improves spinal cord injury by modulating microglial/macrophage polarization, and it possesses anti-inflammatory and neuroprotective effects.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Food Science & Technology
Hatice Ozcaliskan Ilkay, Derya Karabulut, Gonca Kamaci Ozocak, Ecmel Mehmetbeyoglu, Emin Kaymak, Betul Kisioglu, Betul Cicek, Asli Akyol
Summary: The study aimed to investigate the protective effects of quinoa in glucose homeostasis in a model of cafeteria diet-induced obesity. Results showed that quinoa lowered body weight, blood glucose, and insulin levels, increased liver IRS-1 and AMPK gene expressions, and enhanced pancreatic beta-cell insulin immunoreactivity. Quinoa may be useful in preventing obesity and associated metabolic disorders.
FOOD SCIENCE & NUTRITION
(2023)
Article
Anatomy & Morphology
C. V. Haritha, Madhu Cholenahalli Lingaraju, Karikalan Mathesh, Sunil E. Jadhav, T. S. Shyamkumar, V. A. Aneesha, Subhashree Parida, Thakur Uttam Singh, Dinesh Kumar
Summary: PRE-084 has been shown to partly ameliorate renal dysfunction and exhibit anti-fibrotic potential in the kidney of adenine fed rats.
Article
Urology & Nephrology
Dongsheng Cheng, Rulian Liang, Baorui Huang, Jiasheng Hou, Jianyong Yin, Ting Zhao, Lu Zhou, Rui Wu, Youcun Qian, Feng Wang
Summary: This study demonstrated that TNF-alpha inhibition can reduce tubular injury in diabetic rats by suppressing the expression of the NLRP3 inflammasome, offering potential protective effects against tubulointerstitial injury in diabetic nephropathy.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Mervat E. Askar, Sousou I. Ali, Nahla N. Younis, Mohamed A. Shaheen, Mahmoud E. Zaher
Summary: In this study, the researchers found that orally administered raspberry ketone (RK) could ameliorate nonalcoholic fatty liver disease (NAFLD) induced by high-fat high-fructose diet (HFFD) in rats. RK effectively attenuated NAFLD by upregulating the expression of phosphorylated AMP-activated protein kinase and fatty acid oxidation factors, and downregulating lipogenic factors. It also improved lipid profile parameters and liver enzymes.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Ali Emre Atici, Sevil Arabaci Tamer, Hilal Nisva Levent, Irem Peker Eyuboglu, Feriha Ercan, Mustafa Akkiprik, Berrak C. Yegen
Summary: NPW has a beneficial effect against oxidative damage and inflammation induced by sepsis, with notable protection on renal and hepatic function. NPW treatment reduced levels of inflammatory markers, alleviated tissue damage, and improved antioxidant status.
Article
Medicine, Research & Experimental
Sevil Arabaci Tamer, Turkan Koyuncuoglu, Ayca Karagoz Koroglu, Dilek Akakin, Meral Yuksel, Berrak C. Yegen
Summary: This study found that Nesfatin-1 has neuroprotective effects and can alleviate oxidative damage and memory dysfunction caused by epilepsy. It acts by inhibiting reactive nitrogen species and increasing antioxidant capacity.
Article
Transplantation
Neslihan Tezcan, Zarife Nigar Ozdemir-Kumral, Naziye Ozkan Yenal, Ozlem T. Cilingir-Kaya, Aysin Tulunay Virlan, Dilek Ozbeyli, Sule Cetinel, Berrak C. Yegen, Mehmet Koc
Summary: The study demonstrates that NES-1 has renoprotective effects and can ameliorate renal fibrosis induced by unilateral ureteral obstruction. The mechanism may involve inhibition of neutrophil infiltration, reduction of oxidative stress, and inflammation. These findings suggest that NES-1 may play a regulatory role in protecting the kidneys against obstruction-induced renal injury.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Cell Biology
Sevil Arabaci Tamer, Tulin Altinoluk, Miray Emran, Seda Korkmaz, Rozerin Goze Yuksel, Zeynep Baykal, Zehra Sena Dur, Hilal Nisva Levent, Muruvvet Abbak Ural, Meral Yuksel, Ozge Cevik, Feriha Ercan, Alper Yildirim, Berrak C. Yegen
Summary: This study aimed to evaluate the effects of hormone replacement, melatonin, exercise, or their combination on oxidative damage and functional status of ovariectomized rats, and to determine whether the SIRT1 signaling pathway is involved. The results showed that melatonin treatment, either alone or in combination with hormone replacement therapy, upregulated SIRT1 expression and alleviated oxidative injury and inflammation in the hearts and aortas of ovariectomized rats.
Article
Pharmacology & Pharmacy
Ayca Yildiz Pekoz, Ozlem Akbal Dagistan, Hanan Fael, Meltem Culha, Aybige Erturk, Nur Sena Basarir, Gokben Sahin, Muge Serhatli, Gamze Cakirca, Saban Tekin, Leyla Semiha Sen, Mustafa Sevim, Lutfiye Mulazimoglu Durmusoglu, Berrak C. Yegen
Summary: This study developed and characterized an inhalation solution of favipiravir at a concentration of 2 mg/mL for the treatment of patients with COVID-19. The solution showed superior stability in phosphate buffer saline (PBS) and demonstrated minimum toxicity and sufficient antiviral activity at a concentration of 2 mg/mL. The study suggests that the favipiravir solution prepared with PBS could be a suitable and promising inhalation formulation for pulmonary delivery in the treatment of COVID-19 patients.
Article
Gastroenterology & Hepatology
Sevil Arabaci Tamer, Selin Akbulut, Oemer Erdogan, Oezge Cevik, Feriha Ercan, Berrak C. Yegen
Summary: This study suggests that the novel peptide neuropeptide W (NPW) has potential preventive and therapeutic effects on colitis-associated oxidative injury. It achieves its effects by upregulating colonic blood flow, inhibiting COX-2 protein expression, and suppressing pro-inflammatory cytokine production.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Critical Care Medicine
Pinar Kuru Bektasoglu, Turkan Koyuncuoglu, Dilan Ozaydin, Cansu Kandemir, Dilek Akakin, Meral Yuksel, Bora Gurer, Erhan Celikoglu, Berrak C. Yegen
Summary: This study aimed to investigate the antioxidant and neuroprotective effects of Dexpanthenol in traumatic brain injury (TBI). The results showed that Dexpanthenol reduced oxidative damage, suppressed apoptosis by stimulating antioxidant systems, and alleviated brain damage caused by TBI.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Neurosciences
Sevil Arabaci Tamer, Berrak C. Yegen
Summary: The study investigated the role of peripherally administered neuropeptide W (NPW) in the modulation of gastric emptying. It was found that NPW delayed liquid emptying from the stomach, and this effect was reversed by CCK receptor antagonists or denervation of small diameter afferents. Moreover, NPW inhibited antrum contractility in the organ bath. These findings suggest that peripherally administered NPW regulates gastric motility through small diameter afferent neurons and CCK receptors, contributing to its central regulatory role in food intake and energy balance.
NEUROSCIENCE LETTERS
(2023)
Article
Oncology
Bahattin Tanrikulu, Ahmet Harun Yasar, Cengiz Canpolat, Funda corapcioglu, Evrim Tezcanli, Ufuk Abacioglu, Ayca Ersen Danyeli, M. Memet Ozek
Summary: This study aimed to evaluate the effectiveness of German-sourced ONC201 for the treatment of pediatric H3K27 altered pDMGs. The results showed that patients receiving ONC201 had longer overall survival and fewer side effects compared to other chemotherapy protocols. However, further randomized clinical studies are needed to confirm these findings due to the retrospective design and biases.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Meeting Abstract
Physiology
Z. N. Ozdemir-Kumral, T. Akgun, C. Hasim, E. Ulusoy, F. Yuksel, M. K. Kalpakcioglu, T. Okumus, Z. Uslu, D. Akakin, Z. Goren, M. Yuksel, A. Yildirim, B. Yegen
Article
Medicine, General & Internal
Selcuk Akturan, Mustafa Sevim, Can Erzik, Berrak Yegen, Mehrnet Ali Gulpinar
Summary: This study aimed to investigate the perceptions, attitudes, and behavior of medical students and lecturers towards lectures and their impact on learning behavior. The findings revealed that lectures had negative effects on students and lecturers, resulting in unfavorable attitudes and behavior. It is recommended to focus on interactive lectures to develop reasoning, decision-making, and evaluation competencies.
MARMARA MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Sevil Arabaci -Tamer, Ozlem Tugce Cilingir-Kaya, Meral Yuksel, Alper Yildirim, Berrak C. Yegen
Summary: This study found that exercising prior to seizure can reduce oxidative damage in the brain and skeletal muscle caused by epileptic seizures, suggesting a protective effect against seizure-induced injury.
MARMARA MEDICAL JOURNAL
(2022)
Meeting Abstract
Physiology
Zarife Nigar Ozdemir Kumral, Leyla Semiha Sen, Cigdem Cantali Ozturk, Tevfik Kivilcim Uprak, Berrak C. Yegen
Meeting Abstract
Physiology
Leyla Semiha Sen, Tulin Altinoluk, Betul Esra Ipek, Selin Akbulut, Ozlem Tugce Cilingir, Feriha Ercan, Cumhur Yegen, Berrak Caglayan Yegen
Meeting Abstract
Physiology
Leyla Semiha Sen, Sevil Arabaci Tamer, Fatma Kanpalta, Feriha Ercan, Cumhur Yegen, Berrak Caglayan Yegen