Article
Biophysics
Keyi Luo, Hang Wu, Yongkang Chen, Jinfeng Li, Lingling Zhou, Fan Yang, Mingxian Huang, Xiao An, Shige Wang
Summary: Radiotherapy is a common treatment for cancer, but tumors with a hypoxic environment often show resistance to it, leading to potential recurrence and metastasis. Therefore, strategies to enhance radiotherapy efficiency are crucial for effective cancer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Engineering, Biomedical
Yunyi Liu, Cheng Peng, Hui Zhang, Juan Li, Hailong Ou, Yang Sun, Chaoqi Wen, Dan Qi, Xiaoxiao Hu, Erxi Wu, Weihong Tan
Summary: This study demonstrates that DNA aptamer S11e can accurately recognize fibrosarcoma cells and localize in the mitochondria, promoting cell apoptosis and inhibiting cell migration. Additionally, the study reveals the interaction between S11e and Diablo/SMAC protein, leading to the inhibition of fibrosarcoma cell migration and invasion.
BIOACTIVE MATERIALS
(2022)
Review
Chemistry, Physical
Wenjing Xiao, Lin Zhao, Yang Sun, Xiao Yang, Qinrui Fu
Summary: This review provides a comprehensive overview of the recently reported studies on stimuli-responsive nanomaterials for tumor radio-sensitization, including endogenous and exogenous responses, dual stimuli-response, and multi stimuli-response approaches. It also discusses the challenges and perspectives related to stimuli-responsive nanomaterials for tumor radio-sensitization.
Article
Engineering, Biomedical
Wenxin Zhang, Xiaodie Li, Jialin Zeng, Xin Wen, Chao Zhang, Yinan Zhang, Jian He, Lihua Yang
Summary: This study demonstrated a dual-channel parallel free radicals-amplifying radiation therapy strategy for neuroblastoma. By releasing atovaquone (ATO) and Fe3+ in response to the tumor microenvironment, this strategy improved the effectiveness of radiation therapy by inhibiting tumor cell respiration and consuming tumor-overexpressed GSH.
MATERIALS TODAY BIO
(2023)
Article
Cell Biology
Narisa Dewi Maulany Darwis, Eisuke Horigome, Shan Li, Akiko Adachi, Takahiro Oike, Atsushi Shibata, Yuka Hirota, Tatsuya Ohno
Summary: This study demonstrates the potential radiosensitization effect of LY2874455, a selective pan-FGFR inhibitor, on various cancer cell lines. The combination of LY2874455 and X-rays induces mitotic catastrophe and increases cell death. In vivo experiments also show the inhibitory effect of this combination treatment on tumor growth.
Review
Pharmacology & Pharmacy
Wei Liu, Bo Chen, Haocheng Zheng, Yun Xing, Guiyuan Chen, Peijie Zhou, Liting Qian, Yuanzeng Min
Summary: Nanomedicine has provided effective approaches for improving the efficiency of radiotherapy and reducing its side effects, with metal nanoparticles proving to be ideal radiosensitizers. The use of nanoparticles can help facilitate the delivery of radiosensitizing drugs to tumor sites, enhancing anti-tumor responses.
Review
Polymer Science
Jinfeng Lin, Mingming Yin, Xiaoming Liu, Fanling Meng, Liang Luo
Summary: This review provides an overview of functional polymer-based nanomaterials for radiosensitization in recent years. Different types of polymer nanomaterials, including polymeric micelles, dendrimers, polymeric nanospheres, nanoscale coordination polymers, polymersomes, and nanogels, are discussed in terms of their action mechanisms, drug loading methods, targeting efficiencies, impact on therapeutic effects, and biocompatibility. Polymeric nano-radiosensitizers have the potential to improve the efficacy of radiotherapy and minimize damage to healthy tissues.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Yin Wang, Weiwei Zeng, Huazhen Liang, Xixi Wu, Hanyue Li, Ting Chen, Mi Yang, Xiaoqing Wang, Wen Li, Fan Zhang, Qianqian Li, Feng Ye, Jian Guan, Lin Mei
Summary: In this study, a novel wolfram-doped polypyrrole (WPPy) was intelligently fabricated and further decorated with an active targeted component, enabling hyperthermia-synergized radiotherapy against malignant tumors. The WPPy@SP94 showed good biocompatibility, high radiosensitivity, and the ability to induce DNA damage and ROS generation under X-ray irradiation, effectively inhibiting tumor growth through single drug injection.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Yao Chen, Shuya Liu, Yin Liao, Hanshan Yang, Zhuo Chen, Yuru Hu, Shaozhi Fu, Jingbo Wu
Summary: In this study, albumin-modified gold nanoparticles (Alb-GNPs) were prepared and their radiosensitizing effects and biotoxicity in human non-small-cell lung carcinoma tumor-bearing mice models were observed. The prepared nanoparticles (Alb-GNPs) showed excellent colloidal stability and biocompatibility with a mean size of 205.06 +/- 1.03 nm. Clone formation experiments demonstrated that Alb-GNPs exerted excellent radiosensitization with a higher sensitization enhancement ratio (SER) of 1.432 compared to X-ray alone. Alb-GNPs could accumulate favorably in tumors and their combination with radiotherapy exhibited a greater radiosensitizing effect and anti-tumor activity. Additionally, no toxicity or abnormal irritating response was observed with the application of Alb-GNPs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Nanoscience & Nanotechnology
Anqi Zhang, Lei Gao
Summary: Radiotherapy is an important method for treating malignant tumors. Enhancing its therapeutic gain ratio through physical techniques is the current direction of radiotherapy. The combination of hyperthermia and radiotherapy can improve the radiosensitivity of tumor cells and has significant clinical value. Nanomaterials have attracted widespread attention in tumor hyperthermia research and show great potential. This article summarizes the sensitizing mechanisms and effects of gold nanotechnology and provides an overview of the advancements of other nanoparticles in radiation therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Marika Musielak, Agnieszka Bos-Liedke, Oliwia Piwocka, Katarzyna Kowalska, Roksana Markiewicz, Barbara Szymkowiak, Pawel Bakun, Wiktoria M. Suchorska
Summary: In this study, the role of gold nanoparticles in enhancing the response of breast cancer cells to ionizing radiation was assessed by comparing 2D and 3D models. It was found that the PEG chain plays an important role in the efficiency of gold nanoparticles in sensitizing cells to ionizing radiation, indicating that gold nanoparticles are a promising agent for combined treatment with radiotherapy.
Article
Oncology
Emilie Thivat, Melanie Casile, Juliette Moreau, Ioana Molnar, Sandrine Dufort, Khalide Seddik, Geraldine Le Duc, Olivier De Beaumont, Markus Loeffler, Xavier Durando, Julian Biau
Summary: This study aims to determine the recommended dose of AGuIX as a radiosensitizer in combination with radiotherapy and TMZ, as well as to assess the efficacy of the combination. The study design is a multicenter, randomized, open-label, non-comparative therapeutic trial, expected to recruit 66 patients. Secondary objectives include assessing the pharmacokinetics, distribution of nanoparticles, tolerance of the combination, neurological status, overall survival, response to treatment, and progression-free survival.
Review
Biochemistry & Molecular Biology
Henry Ruiz-Garcia, Cristopher Ramirez-Loera, Timothy D. Malouff, Danushka S. Seneviratne, Joshua D. Palmer, Daniel M. Trifiletti
Summary: Nanomedicine plays a crucial role in the treatment of GBM, with nanoparticles showing promise as radiosensitizers for improved therapeutic outcomes. Researchers are actively exploring novel treatment strategies, such as combining preoperative radiation with nanoradiosensitizers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sung-Won Shin, Kyungmi Yang, Miso Lee, Jiyoung Moon, Arang Son, Yeeun Kim, Suha Choi, Do-hyung Kim, Changhoon Choi, Nohyun Lee, Hee Chul Park
Summary: The study found that MFN may overcome radioresistance by alleviating hypoxia and enhancing antitumor immunity in the tumor microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Ya Wang, Huilin Zhang, Yanyan Liu, Muhsin H. Younis, Weibo Cai, Wenbo Bu
Summary: Radiotherapy is essential in clinical cancer treatment, but its effectiveness is limited. Researchers are currently developing advanced nanomaterials and nanotechnologies to improve the sensitivity of radiotherapy. One promising approach involves utilizing the catalytic activity of nanomaterials triggered by radiation to enhance therapeutic effects.
Article
Biochemistry & Molecular Biology
Arpita Ghosh, Mary Krishna Ekka, Arpita Tawani, Amit Kumar, Debojyoti Chakraborty, Souvik Maiti
Review
Biochemical Research Methods
Harleen Kaur, Sonali R. Bhagwat, Tarun Kumar Sharma, Amit Kumar
Article
Nanoscience & Nanotechnology
Ritu Das, Abhijeet Dhiman, Subodh Kumar Mishra, Sagarika Haldar, Neera Sharma, Anjali Bansal, Yusra Ahmad, Amit Kumar, Jaya Sivaswami Tyagi, Tarun Kumar Sharma
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Arun Kumar Verma, Eshan Khan, Subodh Kumar Mishra, Neha Jain, Amit Kumar
ACS CHEMICAL NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Richa Agrawal, Venuka Durani Goyal, Ashwani Kumar, Neeraj K. Gaur, Sahayog N. Jamdar, Amit Kumar, Ravindra D. Makde
JOURNAL OF STRUCTURAL BIOLOGY
(2019)
Article
Medicine, Research & Experimental
Subodh Kumar Mishra, Uma Shankar, Neha Jain, Kriti Sikri, Jaya Sivaswami Tyagi, Tarun Kumar Sharma, Jean-Louis Mergny, Amit Kumar
MOLECULAR THERAPY-NUCLEIC ACIDS
(2019)
Article
Biochemistry & Molecular Biology
Eshan Khan, Soumen Biswas, Subodh Kumar Mishra, Ribhav Mishra, Sampak Samanta, Amit Mishra, Arpita Tawani, Amit Kumar
Article
Neurosciences
Arun Kumar Verma, Eshan Khan, Sonali R. Bhagwat, Amit Kumar
MOLECULAR NEUROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Sonali R. Bhagwat, Krishnan Hajela, Sumit Bhutada, Kornai Choudhary, Mritunjay Saxena, Sadhana Sharma, Amit Kumar
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Biochemistry & Molecular Biology
Richa Agrawal, Venuka Durani Goyal, Rahul Singh, Ashwani Kumar, Sahayog N. Jamdar, Amit Kumar, Ravindra D. Makde
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Biochemistry & Molecular Biology
Prativa Majee, Neha Jain, Amit Kumar
Summary: The Nipah virus, known for high fatality rates, is listed as an urgent priority for research and development. A stable multivalent vaccine has been designed to induce immune responses in humans, showing potential as a prophylactic solution. Molecular dynamic analysis and cloning experiments support the stability and feasibility of the vaccine.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Multidisciplinary Sciences
Prativa Majee, Subodh Kumar Mishra, Nirali Pandya, Uma Shankar, Sanjeev Pasadi, K. Muniyappa, Debasis Nayak, Amit Kumar
SCIENTIFIC REPORTS
(2020)
Article
Medicine, Research & Experimental
Abhijeet Dhiman, Chanchal Kumar, Subodh Kumar Mishra, Kriti Sikri, Ishara Datta, Pradeep Sharma, Tej P. Singh, Sagarika Haldar, Neera Sharma, Anjali Bansal, Yusra Ahmad, Amit Kumar, Tarun Kumar Sharma, Jaya Sivaswami Tyagi
MOLECULAR THERAPY-NUCLEIC ACIDS
(2019)
Article
Neurosciences
Arun Kumar Verma, Eshan Khan, Subodh Kumar Mishra, Amit Mishra, Nicolas Charlet-Berguerand, Amit Kumar
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Pharmacology & Pharmacy
Bhavana Joshi, Jaspreet Kaur, Eshan Khan, Amit Kumar, Abhijeet Joshi
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)