Journal
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
Volume 76, Issue 3, Pages 186-192Publisher
ELSEVIER
DOI: 10.1016/j.ijpsycho.2010.03.013
Keywords
Hemodynamic response; Prefrontal cortex; Mental arithmetic; (De)oxyhemoglobin change; Near-infrared spectroscopy (MRS); Multi-channel NIRS
Funding
- EU [IST-2006-27731]
- Land Steiermark [A3-22. N-13/2009-8]
- Neuro Center Styria (NCS) in Graz, Austria
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Near-infrared spectroscopy (NIRS) is a functional brain imaging method able to study hemodynamic changes during cortical activation. We studied the changes of oxy- and deoxyhemoglobin ([oxy-Hb],[deoxy-Hb]) with a 52-channel NIRS system during simple mental arithmetic in ten healthy volunteers over the prefrontal cortex. We found that eight of the ten subjects showed a relative focal bilateral increase of [oxy-Hb] in the dorsolateral prefrontal cortex (DLPFC) in parallel with a decrease in the medial area of the anterior prefrontal cortex (APFC). The [oxy-Hb] response in left DLPFC and APFC was significant, while the [deoxy-Hb] response was clearly smaller and not significant. These observations were discussed within the context of focal activation/surround deactivation. (C) 2010 Elsevier B.V. All rights reserved.
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