4.2 Article

THE RELATIONSHIP BETWEEN PSYCHOLOGICAL FACTORS, INFLAMMATION, AND NUTRITION IN PATIENTS WITH CHRONIC RENAL FAILURE UNDERGOING HEMODIALYSIS

Journal

INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
Volume 44, Issue 2, Pages 105-118

Publisher

SAGE PUBLICATIONS INC
DOI: 10.2190/PM.44.2.b

Keywords

cytokine; albumin; emotion; renal disease; structural equation modeling

Categories

Funding

  1. National Science Council, Taiwan [NSC 96-2314-B-182A-090-MY2]

Ask authors/readers for more resources

Objective: Hemodialysis has an adverse impact on the immunological, nutritional, and emotional status of patients. The biochemical markers of inflammation and nutrition were studied as well as the relationship of these factors to emotional symptoms. Method: One hundred and ninety-five patients undergoing hemodialysis were enrolled. The mean age was 58.5 years. Emotional symptoms were assessed using the Mini International Neuropsychiatric Interview, Hospital Anxiety and Depression Scale, Chalder Fatigue Scale, and Short-form Health-related Quality of Life. Venus blood was collected for laboratory assessment of serum hemoglobin, albumin, ferritin, C-reactive protein, interleukin (IL) 1 beta), IL-6, and tumor necrosis factor alpha. Results: Among the 195 subjects (92 men and 103 women), 47 (24.1%) fulfilled the criteria for a major depressive disorder (MDD). The IL-6 level in patients with a MDD was significantly higher than in the patients without a MDD. Significant correlation was observed among the following factors: IL-6, fatigue, and quality of life for both physical and mental components. The albumin levels showed a significant correlation with the IL-6 and depression scores. Conclusions: These results show that the serum levels of albumin and IL-6 might be laboratory markers associated with the expression of emotional symptoms in patients undergoing hemodialysis. Prospective studies are needed to determine the causal relationships among these variables. (Int'l J. Psychiatry in Medicine 2012;44:105-118)

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.2
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Psychology, Developmental

Interrelationships among growth hormone, thyroid function, and endocrine-disrupting chemicals on the susceptibility to attention-deficit/hyperactivity disorder

Liang-Jen Wang, Ying-Hua Huang, Wen-Jiun Chou, Sheng-Yu Lee, Hsin-Yu Chang, Chih-Cheng Chen, How-Ran Chao

Summary: Abnormal growth hormones and thyroid function may contribute to the pathophysiology of ADHD. Endocrine-disrupting chemicals (EDCs) such as phthalates and bisphenol-A (BPA) may affect the endocrine system. This study found that ADHD patients had lower levels of IGF-1 and higher levels of certain EDCs compared to healthy controls. The findings suggest that MEHP exposure may be associated with decreased IGF-1 levels and increased risk of ADHD.

EUROPEAN CHILD & ADOLESCENT PSYCHIATRY (2023)

Article Psychology, Developmental

Incremental Validity of Multi-Method and Multi-Informant Evaluations in the Clinical Diagnosis of Preschool ADHD

I-Chun Chen, Pai-Wei Lee, Liang-Jen Wang, Chih-Hao Chang, Cheng-Hsiu Lin, Li-Wei Ko

Summary: This study investigated the discriminative validity of various single or combined measurements of EEG data, K-CPT, and DBDRS to differentiate preschool children with ADHD from those with TD. The combination of DBDRS, K-CPT, and specific EEG data provided the best probability scores and discriminative validity to identify preschool children with ADHD. Multi-method and multi-informant evaluations should be emphasized in clinical diagnosis of preschool ADHD.

JOURNAL OF ATTENTION DISORDERS (2022)

Article Psychiatry

BST-1 as a serum protein biomarker involved in neutrophil infiltration in schizophrenia

Liang-Jen Wang, Yu-Chi Huang, Pao-Yen Lin, Yu Lee, Chi-Fa Hung, Su-Ting Hsu, Lien-Hung Huang, Sung-Chou Li

Summary: This study identified four novel protein markers (BST1, ITIH5, SDPR, and OSCAR) of schizophrenia, with BST-1 serving as a serum protein biomarker involved in neutrophil infiltration. The anti-inflammation nature of BST1 was highlighted, showing its potential significance in schizophrenia research. The machine learning algorithm combining BST1, ITIH5, and OSCAR levels developed a prediction model of schizophrenia with an auROC value of 0.78.

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY (2022)

Letter Endocrinology & Metabolism

Discovery of a Biomarker Signature That Reveals a Molecular Mechanism Underlying Diabetic Kidney Disease via Organ Cross Talk

I-Wen Wu, Tsung-Hsien Tsai, Chi-Jen Lo, Yi-Ju Chou, Chi-Hsiao Yeh, Mei-Ling Cheng, Chi-Chun Lai, Huey-Kang Sytwu, Ting-Fen Tsai

DIABETES CARE (2022)

Article Education & Educational Research

Effectiveness of end-stage renal disease communication skills training for healthcare personnel: a single-center, single-blind, randomized study

Ji-Tseng Fang, Shih-Ying Chen, Ya-Chung Tian, Chien-Hung Lee, I-Wen Wu, Chen-Yi Kao, Chung-Chih Lin, Woung-Ru Tang

Summary: This study demonstrated that online ESRD communication skills training can enhance the truth-telling confidence of healthcare personnel, though it is unclear whether this improvement is due to the content of the training or its online delivery. While face-to-face training may be unsuitable during pandemics, online training remains an indispensable tool. Future intervention studies should focus on designing interactive modules and controlling for instructional methods.

BMC MEDICAL EDUCATION (2022)

Article Public, Environmental & Occupational Health

Relationships Between Metabolic Body Composition Status and Rapid Kidney Function Decline in a Community-Based Population: A Prospective Observational Study

Shao-Chi Chu, Po-Hsi Wang, Kuan-Ying Lu, Chia-Chun Ko, Yun-Hsuan She, Chin-Chan Lee, I-Wen Wu, Chiao-Yin Sun, Heng-Jung Hsu, Heng-Chih Pan

Summary: Obesity and metabolic syndrome are risk factors for chronic kidney disease. This study found that the combination of obesity and metabolic syndrome, known as metabolic body composition status (MBCS), is associated with rapid kidney function decline (RKFD), particularly in older adults. Metabolically unhealthy normal weight and metabolically unhealthy overweight were identified as risk factors for RKFD.

FRONTIERS IN PUBLIC HEALTH (2022)

Article Psychology, Developmental

Gut mycobiome dysbiosis and its impact on intestinal permeability in attention-deficit/hyperactivity disorder

Liang-Jen Wang, Sung-Chou Li, Yuan-Ming Yeh, Sheng-Yu Lee, Ho-Chang Kuo, Chia-Yu Yang

Summary: This study used high-throughput sequencing to explore the dysbiosis of the gut mycobiome in children with ADHD. The results showed that ADHD patients had abnormal fungal community composition and increased abundance of Candida, especially Candida albicans. The in vitro cell assay also demonstrated that C. albicans secretions enhanced intestinal permeability.

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY (2023)

Article Immunology

Medical outcomes of children with neurodevelopmental disorders after SARS-CoV-2 vaccination: A six-month follow-up study

Liang-Jen Wang, Ching-Shu Tsai, Wen-Jiun Chou, Chia-Jung Li, Sheng-Yu Lee, Yi-Chun Chen, I. -Chun Lin

Summary: This longitudinal study compared adverse outcomes after SARS-CoV-2 vaccination in children with neurodevelopmental disorders (ND) and healthy control children. The results showed that children with ND had a higher likelihood of subsequent outpatient department or emergency department visits, especially pediatric neurology visits, after the first dose of vaccination compared to the control group. However, only a small proportion of children visited the outpatient department or emergency department due to adverse vaccination-related effects. Overall, the study concluded that specific ND diagnosis or medication use did not significantly increase the risk of adverse effects of SARS-CoV-2 vaccination, and children with ND can be reassured that the vaccination is safe.

VACCINE (2023)

Article Food Science & Technology

Sex differences in vitamin D and behavioral profiles among children with allergic diseases

Chia-Jung Li, Ling-Sai Chang, Mindy Ming-Huey Guo, Liang-Jen Wang, Ho-Chang Kuo

Summary: This study aimed to investigate the role of vitamin D in children with coexisting allergic diseases, particularly in terms of sex differences, and to explore the behavioral profiles of these patients. The study found that males with two or more allergic diseases had significantly lower levels of vitamin D, while the levels of IgE were negatively correlated with vitamin D in females. Additionally, serum IgE was significantly correlated with children's adaptive skills, and different sexes were associated with different aspects of adaptive skills. Therefore, vitamin D has a protective role in the development of one allergic disease against the coexistence of allergic diseases in males, and the study extends the evidence for sex differences in immunity.

FOOD SCIENCE & NUTRITION (2023)

Article Pediatrics

Gut Leakage Markers and Cognitive Functions in Patients with Attention-Deficit/Hyperactivity Disorder

Sheng-Yu Lee, Sung-Chou Li, Chia-Yu Yang, Ho-Chang Kuo, Wen-Jiun Chou, Liang-Jen Wang

Summary: This study investigated the role of gut leakage biomarkers in the susceptibility of ADHD. The results showed that DEFA1 levels were significantly lower in ADHD group compared to the healthy control group. There was no significant difference in serum levels of zonulin and occludin. DEFA1 levels were negatively correlated with inattention scores, while occludin levels were positively correlated with detectability subtest scores. This study provides new insights into the relationship between gut leakage markers and cognition, advancing research on the pathophysiology of ADHD.

CHILDREN-BASEL (2023)

Article Neurosciences

The Outcome of Antipsychotics-induced Tardive Syndromes: A Ten-year Follow-up Study

Pei-Chien Chou, Yu Lee, Yung-Yee Chang, Pao-Yen Lin, Liang-Jen Wang

Summary: This study investigated the prevalence, incidence, remission rate, and factors associated with remission of tardive syndrome (TS) in patients using antipsychotics. The findings suggest that TS may be a treatable condition, and early detection and prompt intervention, including closely monitoring antipsychotics-related TS symptoms and using antioxidants, are key to achieving better outcomes.

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE (2023)

Article Clinical Neurology

The Morbidity and Associated Factors of Depression in Caregivers of Patients with Depressive Disorder

Yu Lee, Pao-Yen Lin, Nien-Mu Chiu, Chi-Fa Hung, Liang-Jen Wang

Summary: Depressive disorder has a significant impact on patients' daily activities and quality of life, as well as on caregivers who may experience psychological distress. This study aimed to evaluate the prevalence and associated factors of depression in caregivers of patients with depressive disorder. The results showed that depression was the most common psychiatric diagnosis among caregivers, highlighting the importance of early psychiatric diagnosis and appropriate support for improving caregivers' quality of life.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2023)

Review Medicine, General & Internal

Urinary microRNA in Diabetic Kidney Disease: A Literature Review

Chin-Chan Lee, Chia-Chun Chen, Cheng-Kai Hsu, Yih-Ting Chen, Chun-Yu Chen, Kai-Jie Yang, Ming-Jui Hung, I-Wen Wu

Summary: Diabetic kidney disease is a common primary disease of end-stage kidney disease, but there is currently no sensitive and accurate biomarker to predict it. microRNAs, which are noncoding RNAs, have been reported to play a potential role in the pathophysiology of diabetic kidney disease. Urinary microRNAs have emerged as a novel, non-invasive liquid biopsy for disease diagnosis. This review discusses the experimental and clinical evidence of urinary microRNA in the context of diabetic kidney disease and explores its future application in routine practice.

MEDICINA-LITHUANIA (2023)

Article Health Care Sciences & Services

Prevalence and Risk Factors of Depression between Patients with Parkinson's Disease and Their Caregivers: A One-Year Prospective Study

Yu Lee, Yung-Yee Chang, Ying-Fa Chen, Tsu-Kung Lin, Chi-Fa Hung, Yu-Jie Chiou, Liang-Jen Wang

Summary: This study aimed to compare the prevalence and risk factors of depression between patients with Parkinson's disease (PD) and their caregivers. The findings showed that depressive disorders were common in both PD patients and their caregivers, and were associated with factors such as fatigue, suicide risk, pain, and anxiety. These findings provide references for early detection and treatment of depressive disorders in PD patients and their caregivers.

HEALTHCARE (2022)

Article Pharmacology & Pharmacy

The comparative effectiveness of antidepressants for youths with major depressive disorder: a nationwide population-based study in Taiwan

Sheng-Yu Lee, Liang-Jen Wang, Yao-Hsu Yang, Chih-Wei Hsu

Summary: This study compared the effectiveness of different antidepressants in treating youths with major depressive disorder (MDD). The findings suggest that bupropion may be more effective than fluoxetine in preventing hospitalization and maintaining drug therapy, while mirtazapine users have a higher risk of hospitalization.

THERAPEUTIC ADVANCES IN CHRONIC DISEASE (2022)

No Data Available