Article
Medicine, General & Internal
Miguel German Borda, Kolbjorn Kallesten Bronnick, Elkin Garcia-Cifuentes, Alberto Jaramillo-Jimenez, Carlos Reyes-Ortiz, Jonathan Patricio-Baldera, Hogne Soennesyn, Mario Ulises Perez-Zepeda, Audun Osland Vik-Mo, Dag Aarsland
Summary: Specific NPS show distinct associations with longitudinal trajectories of functional decline in AD and LBD, underscoring the importance of early detection and intervention to improve functional prognosis in individuals living with dementia.
FRONTIERS IN MEDICINE
(2023)
Article
Clinical Neurology
Lucy L. Gibson, Lea T. Grinberg, Dominic Ffytche, Renata E. P. Leite, Roberta D. Rodriguez, Renata E. L. Ferretti-Rebustini, Carlos A. Pasqualucci, Ricardo Nitrini, Wilson Jacob-Filho, Dag Aarsland, Claudia K. Suemoto
Summary: In a post mortem study on LBD, hallucinations were found to be associated with higher LB Braak stages, while higher NFT Braak staging was associated with depression, agitation, and greater number of symptoms. Patients with dual AD+LBD pathology had the highest risk of hallucinations, agitation, apathy, and total symptoms.
ALZHEIMERS & DEMENTIA
(2023)
Article
Psychology, Clinical
Hamish Naismith, Robert Howard, Robert Stewart, Alexandra Pitman, Christoph Mueller
Summary: This study examines factors associated with suicidal ideation around the time of dementia diagnosis. The findings suggest that depression, dementia with Lewy bodies, impaired activities of daily living, and vascular dementia are associated with a higher risk of suicidal ideation. The study highlights the importance of identifying and treating depressive symptoms in individuals with dementia and encourages further research on under-researched dementia subtypes.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Clinical Neurology
Jeremy C. S. Johnson, Charles R. Marshall, Rimona S. Weil, Doris-Eva Bamiou, Chris J. D. Hardy, Jason D. Warren
Summary: The association between hearing impairment and dementia poses a significant public health challenge, with potential for earlier diagnosis and prevention. Neurodegenerative pathologies are predicted to target the auditory brain and damage hearing function early. It is important to reconsider the role of auditory cognitive function in dementia and develop new auditory tests for early diagnosis.
Article
Clinical Neurology
Jeremy C. S. Johnson, Charles R. Marshall, Rimona S. Weil, Doris-Eva Bamiou, Chris J. D. Hardy, Jason D. Warren
Summary: The relationship between hearing impairment and dementia highlights the crucial role of the auditory brain in cognitive function, suggesting potential opportunities for early diagnosis and management strategies. Research emphasizes the importance of auditory cognitive function in neurodegenerative dementias, calling for the development of novel auditory testing methods and early diagnosis strategies.
Article
Clinical Neurology
Laura M. Wright, Paul C. Donaghy, David J. Burn, John -Paul Taylor, John T. O'Brien, Alison J. Yarnall, Fiona E. Matthews, Michael J. Firbank, Alan J. Thomas, Rachael A. Lawson
Summary: There is a limited longitudinal relationship between neuropsychiatric symptoms (NPS) and cognitive decline in prodromal Lewy body dementias (LBD). Core neuropsychiatric symptoms are not strongly associated with cognition, suggesting different underlying neuropathological mechanisms.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Geriatrics & Gerontology
Emmanuel Cognat, Severine Sabia, Alexandra Fayel, Matthieu Lilamand, Ron Handels, Sara Fascendini, Sverre Bergh, Giovanni B. Frisoni, Andrea Fabbo, Magdalina Tsolaki, Lutz Frolich, Oliver Peters, Paola Merlo, Alfonso Ciccone, Patrizia Mecocci, Julien Dumurgier, Carlo A. Defanti, Jacques Hugon, Claire Paquet
Summary: A study found that the profiles of behavioral and psychological symptoms of dementia (BPSD) vary depending on etiology in patients with mild-to-moderate BPSD. However, it is not known if similar differences exist in patients with severe BPSD.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Clinical Neurology
Alberto Jaramillo-Jimenez, Lasse M. Giil, Diego A. Tovar-Rios, Miguel German Borda, Daniel Ferreira, Kolbjorn Bronnick, Ketil Oppedal, Dag Aarsland
Summary: The study found that larger amygdala volume in patients with mild dementia is associated with an increased likelihood of developing depression symptoms, a decreased likelihood of agitation/aggression, and a slower rate of cognitive decline over a 5-year period.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Benedikt Romer, Ingvild Dalen, Clive Ballard, Dag Aarsland
Summary: This study found that depressive symptoms increased continuously in patients with DLB, whereas patients with AD showed a delayed increase. The increase in depressive symptoms in DLB was mainly driven by anhedonia and retardation. Proximity to death and risk factors for depression and dementia also played a role in the course of depressive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Geriatrics & Gerontology
Jeffrey Cummings
Summary: Neuropsychiatric syndromes and symptoms are playing increasingly important roles in research diagnostic criteria for neurodegenerative disorders. They are often core diagnostic criteria, and the relationships between neuropsychiatric symptoms and cognitive, motor, and autonomic symptoms are being studied and better understood.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Neurosciences
Fabricio Ferreira de Oliveira, Marjorie Camara Miraldo, Eduardo Ferreira de Castro-Neto, Sandro Soares de Almeida, Sandro Luiz de Andrade Matas, Paulo Henrique Ferreira Bertolucci, Maria da Graca Naffah-Mazzacoratti
Summary: Behavioral features may predict proteinopathies in neurodegenerative diseases, study examined associations of CSF biomarkers with neuropsychiatric features in DLB compared with AD and controls. DLB patients showed more intense behavioral burden, biomarker ratios were similar to AD, and APOE epsilon 4 status influenced amyloidogenesis and tau pathology differently in DLB and AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Multidisciplinary Sciences
Dorit Trudler, Kristopher L. Nazor, Yvonne S. Eisele, Titas Grabauskas, Nima Dolatabadi, James Parker, Abdullah Sultan, Zhenyu Zhong, Marshall S. Goodwin, Yona Levites, Todd E. Golde, Jeffery W. Kelly, Michael R. Sierks, Nicholas J. Schork, Michael Karin, Rajesh Ambasudhan, Stuart A. Lipton
Summary: Parkinson's disease is associated with the accumulation of alpha-synuclein and activation of microglia, potentially leading to neuronal death. This study shows that alpha-synuclein can activate NLRP3 inflammasome in human microglia and that alpha-synuclein-antibody complexes can exacerbate inflammation in a human context.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Clinical Neurology
Leonidas Chouliaras, Alan Thomas, Maura Malpetti, Paul Donaghy, Joseph Kane, Elijah Mak, George Savulich, Maria A. Prats-Sedano, Amanda J. Heslegrave, Henrik Zetterberg, Li Su, James Benedict Rowe, John Tiernan O'Brien
Summary: This study compared plasma biomarkers for neurodegenerative diseases in different patient groups and found that p-tau181 was elevated in MCI+AD patients with high accuracy in differentiating between different types of dementia. NfL was elevated in all dementia groups, while GFAP was elevated in MCI+AD and LBD.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Georges Naasan, Suzanne M. Shdo, Estrella Morenas Rodriguez, Salvatore Spina, Lea Grinberg, Lucia Lopez, Anna Karydas, William W. Seeley, Bruce L. Miller, Katherine P. Rankin
Summary: This study compared the rates and content of psychosis in patients with different neurodegenerative diseases. It found that patients with Lewy body disease/Alzheimer's disease pathology were more likely to have hallucinations, while patients with FTLD-TDP were more likely to have delusions. The data suggests that the nature and content of psychosis can provide valuable information about underlying neurodegenerative pathology.
Article
Clinical Neurology
Amalia Perna, Kathleen S. Montine, Lon R. White, Thomas J. Montine, Brenna A. Cholerton
Summary: Neurodegenerative dementia arises from various abnormalities and the co-occurrence of multiple processes complicates identifying effective treatment targets. Current treatments mainly focus on symptoms and recently approved drugs for disease structures only have moderate benefit on symptom progression. Ongoing trials explore cognition enhancers, new drug combinations, less toxic prodrugs, and drugs targeting neuroinflammation or microbiome. A paradigm shift towards individualized and multimodal treatments is necessary to advance dementia therapeutics effectively.
Article
Psychiatry
Marcelo B. Generoso, Ivan Taiar, Quirino Cordeiro, Pedro Shiozawa, Siegfried Kasper
Summary: Early treatment of psychotic illness is important for better outcomes, and cariprazine, a promising antipsychotic drug, may be beneficial in treating psychosis regardless of the diagnosis of schizophrenia or bipolar disorder.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Daniele Altomare, Lyduine Collij, Camilla Caprioglio, Philip Scheltens, Bart N. M. van Berckel, Isadora Lopes Alves, Johannes Berkhof, Yvonne de Gier, Valentina Garibotto, Christian Moro, Lea Poitrine, Julien Delrieu, Pierre Payoux, Laure Saint-Aubert, Jose Luis Molinuevo, Oriol Grau-Rivera, Juan-Domingo Gispert, Carolina Minguillon, Karine Fauria, Marta Felez Sanchez, Andreea Radoi, Alexander Drzezga, Frank Jessen, Claus Escher, Philip Zeyen, Agneta Nordberg, Irina Savitcheva, Vesna Jelic, Zuzana Walker, Ho-Yun Lee, Lean Lee, Jean-Francois Demonet, Sonia Plaza Wuthrich, Rossella Gismondi, Gill Farrar, Frederik Barkhof, Andrew W. Stephens, Giovanni B. Frisoni
Summary: The AMYPAD Diagnostic and Patient Management Study aims to investigate the clinical utility and cost-effectiveness of amyloid-PET in Europe. Participants with subjective cognitive decline, mild cognitive impairment, or dementia were recruited in eight European memory clinics and randomized into three study arms. The baseline features of the participants were representative of a memory clinic population, ensuring the generalizability of the study results.
ALZHEIMERS & DEMENTIA
(2023)
Letter
Clinical Neurology
Hans Foerstl
Review
Geriatrics & Gerontology
Lutz Froelich, Christine von Arnim, Jens Bohlken, Johannes Pantel, Oliver Peters, Hans Foerstl
Summary: This article aims to provide practical recommendations to help physicians identify cognitive deficits in geriatric patients at an early stage and provide high-quality care focusing on counseling, treatment, and comorbidity management.
ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE
(2023)
Article
Clinical Neurology
Oliver Goldhardt, Robert Freiberger, Tobias Dreyer, Luisa Willner, Igor Yakushev, Marion Ortner, Hans Foerstl, Janine Diehl-Schmid, Esther Milz, Josef Priller, Alfredo Ramirez, Viktor Magdolen, Markus Thaler, Timo Grimmer
Summary: This study investigated the association between HSV infection and AD biomarkers. The results suggest that in HSV1-seropositive AD patients, there is a significant predictive effect of AI-IgG(HSV1/2) and Aβ(42)/Aβ(40) ratio on pTau.
ALZHEIMERS & DEMENTIA
(2023)
Biographical-Item
Clinical Neurology
Hans Foerstl
Article
Neurosciences
Maria Galuszko-Wegielnik, Zuzanna Chmielewska, Katarzyna Jakuszkowiak-Wojten, Mariusz S. Wiglusz, Wieslaw J. Cubala
Summary: Psychotic treatment-resistant depression is a challenging manifestation of mood disorders in clinical settings, often underdiagnosed and undertreated. This study aimed to assess the usage of ketamine as an add-on treatment for major depressive disorder with psychotic features, and the results suggest its potential benefits for individuals with treatment-resistant depression.
Article
Chemistry, Medicinal
Adam Wlodarczyk, Alicja Dywel, Wieslaw Jerzy Cubala
Summary: This study investigates the safety of intravenous ketamine treatment for treatment-resistant depression and finds a significant association between epilepsy and elevated BPRS scores.
Article
Psychiatry
Hans Foerstl
Summary: Richard Semon, a biologist, studied various animals such as sea urchins, starfish, chicken, and lung fish. He developed the theory of "mneme" and expanded it to the inheritance of acquired characteristics. After being forced to leave Germany, he continued his philosophical research in biology in Munich. In 1918, he tragically took his own life due to various reasons.
Review
Biochemistry & Molecular Biology
Luiza Marek-Jozefowicz, Boguslaw Nedoszytko, Malgorzata Grochocka, Michal A. Zmijewski, Rafal Czajkowski, Wieslaw J. Cubala, Andrzej T. Slominski
Summary: Neurogenic inflammation is the result of nerve endings and mediators' activity in the skin, leading to inflammatory reactions. TRPV-ion channels' activation increases the release of inflammatory mediators and contributes to the maintenance of cutaneous neurogenic inflammation. Understanding the molecular mechanisms of neuropeptide and neurotransmitter receptors in cutaneous cells can aid in developing effective treatments for inflammatory skin disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Lluis Niell Galmes, Elmars Rancans
Summary: Real-world evidence provides valuable data on the effectiveness and tolerability of cariprazine in patients with schizophrenia or schizoaffective disorder. This study conducted in a Spanish hospital collected data on the demographic characteristics, disorder history, and treatment details of 14 patients. The results showed significant improvement in symptoms and a high tolerability of cariprazine even at high doses.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Krista Mieze, Anda Kivite-Urtane, Daiga Grinberga, Biruta Velika, Iveta Pudule, Elmars Rancans
Summary: This study aimed to assess the prevalence of different types of self-reported suicidal behaviors in Latvia and determine the associated sociodemographic and health-related factors. The findings showed that 15.6% of the respondents reported some type of suicidal behavior, and factors such as age, education, nationality, and mental state were associated with different types of suicidal behavior.
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2023)
Letter
Dermatology
E. Serkies-Minuth, P. Glasner, K. Michalska-Malecka, W. Baranska-Rybak
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Clinical Neurology
Milena Shrashimirova, Ivan Tyanev, Wieslaw J. Cubala, Adam Wichniak, Claudia Vodickova-Borzova, Alessandro Ruggieri, Annalisa Bonelli, Paola Lipone, Alessandro Comandini, Agnese Cattaneo
Summary: This study aims to describe the clinical response, functional impairment, and quality of life (QoL) of patients with major depressive disorder (MDD) treated with Trazodone Once-A-Day (TzOAD) monotherapy over a 24-week period. The results demonstrate the safety, tolerability, and effectiveness of TzOAD in improving depressive symptoms, QoL, sleep quality, and overall functioning.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)