Article
Reproductive Biology
Dongmei Jiang, Yilong Jiang, Shiyun Long, Ziyu Chen, Yanling Li, Guilin Mo, Lin Bai, Xiaoxia Hao, Yanhong Yan, Liang Li, Chunchun Han, Shenqiang Hu, Hua Zhao, Bo Kang
Summary: This study demonstrates for the first time that supraphysiological doses of spermidine cause ovarian oxidative stress and induce granulosa cell apoptosis, potentially through the P53 and/or BCL2-CASPASEs pathway.
Article
Chemistry, Physical
M. Ruan, Y. M. Qiao, Y. Chen, F. Chen, B. S. Wang, L. L. Lu, Z. L. Yu, Z. Sun, C. S. Zhou, J. M. Liu
Summary: Ice formation on high-voltage wire surfaces can cause disaster. Superhydrophobic treatment is a promising strategy to reduce icing adhesion. Molecular dynamics simulations were used to investigate ice pulling and shearing on different surface morphologies and doping, and the results showed that ice stress is anisotropic and related to solvent accessible surface area and non-bonded interaction.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Chemistry, Multidisciplinary
Silvia Diabate, Lucie Armand, Sivakumar Murugadoss, Marco Dilger, Susanne Fritsch-Decker, Christoph Schlager, David Beal, Marie-Edith Arnal, Mathilde Biola-Clier, Selina Ambrose, Sonja Mulhopt, Hanns-Rudolf Paur, Iseult Lynch, Eugenia Valsami-Jones, Marie Carriere, Carsten Weiss
Summary: The study suggests that exposure to MNMs at the ALI is more sensitive than under classical submerged conditions, especially for titania NPs. Titania NPs not only triggered cytotoxicity and inflammatory responses, but also induced genotoxicity. Further development of ALI systems may potentially replace acute pulmonary toxicity studies in animals.
Article
Biochemical Research Methods
Eduard Bezuglov, Oleg Talibov, Artemii Lazarev, Zbigniew Waskiewicz, Sergei Iljukov
Summary: Studies show that the effects of new anti-doping measures on elite athletes' performance are limited. However, the implementation of these measures can lead to a decrease in performance in sports where banned substances are widely used. A study found that the performance of athletes from Country A, which was accused of systematic doping, decreased in 8 out of 10 disciplines after the implementation of new anti-doping methods. In contrast, the performance of athletes from Country B, their competitors, did not significantly change.
DRUG TESTING AND ANALYSIS
(2023)
Article
Thermodynamics
Yu-Kai Weng, Ali Yousefzadi Nobakht, Seungha Shin, Kenneth D. Kihm, Douglas S. Aaron
Summary: The effects of silicon (Si) doping on the thermal transport of graphene were investigated, showing that Si doping suppresses in-plane transport but enhances cross-plane transport due to multiple factors such as phonon scattering and interfacial interactions. This enhanced understanding of doping effects provides insights for effective thermal transport control in various graphene structures.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2021)
Article
Chemistry, Multidisciplinary
Thorren Kirschbaum, Tristan Petit, Joachim Dzubiella, Annika Bande
Summary: Nanodiamonds (NDs) are promising materials used in various applications. This study reveals that the electronic surface properties of NDs, especially in liquid phase, are influenced by their interactions with the environment. The concept of transfer doping is proven to be valid for highly curved NDs, and the electronic properties can be adjusted by the specific properties of NDs. Furthermore, the formation of ND clusters in aqueous dispersions leads to a significant reduction in optical gaps and the cluster's LUMO shapes resemble atom-type orbitals. These findings have important implications for ND applications as photocatalysts or electronic devices.
JOURNAL OF COMPUTATIONAL CHEMISTRY
(2022)
Review
Medicine, General & Internal
Adrian Eugen Rosca, Ana-Maria Vladareanu, Alina Mititelu, Bogdan Ovidiu Popescu, Corin Badiu, Constantin Caruntu, Suzana Elena Voiculescu, Minodora Onisai, Serban Gologan, Radu Mirica, Leon Zagrean
Summary: The abuse of anabolic androgenic steroids in athletes may lead to enhanced platelet activity and a prothrombotic state, increasing the risk of thrombotic events. The thrombogenic potential of exogenous androgens remains a subject of debate, urging for further studies to clarify their effects on hemostasis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Materials Science, Ceramics
Evgeniya A. Syukkalova, Anastasia V. Sadetskaya, Natalya D. Demidova, Natalia P. Bobrysheva, Mikhail G. Osmolowsky, Mikhail A. Voznesenskiy, Olga M. Osmolovskaya
Summary: In this study, calcium phosphate nanoparticles were synthesized using a scalable hydrothermal method with significantly lower holding time. The effects of surfactants and dopants on the nanoparticles formation process were discussed, with the possibility of regulating morphological parameters demonstrated. Additionally, the thermal properties of the nanoparticles were reported, showing the influence of surfactant presence on preventing sintering at high temperatures and shifting decomposition temperature to higher values.
CERAMICS INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Xiao You, Joseph C. Shirley, Euihyun Lee, Carlos R. Baiz
Summary: The study found that crowders introduce disorder within the first two solvation shells but stabilize ice-like order in water >1 nm from the crowder. Considering crowder chemical structure, conformation, and crowder-solvent interactions is a key step toward a complete description of crowded solutions for in vitro biomolecular studies.
CELL REPORTS PHYSICAL SCIENCE
(2021)
Article
Cell Biology
Bassem Refaat, Mohamed El-Boshy
Summary: This study showed that treating VD-replete female rats with supraphysiological VD3 supplements did not lead to hypercalcemia and could potentially enhance ovarian functions by regulating hypothalamic-pituitary-ovarian hormones and ovarian VD-related molecules. Further research is still needed to determine the clinical significance of VD3 in female reproduction.
HISTOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Gabriella Oliveira Lima, Alex Luiz Menezes da Silva, Julianne Elba Cunha Azevedo, Chirlene Pinheiro Nascimento, Luana Rodrigues Vieira, Akira Otake Hamoy, Luan Oliveira Ferreira, Veronica Regina Lobato Oliveira Bahia, Nilton Akio Muto, Dielly Catrina Favacho Lopes, Moises Hamoy
Summary: Low plasma levels of vitamin D can lead to bone mineral changes and worsen certain diseases. Supplementation is necessary, but carries risks of toxicity. This study explores the effects of high doses of vitamin D on the brain and heart, providing valuable parameters for diagnosing symptoms of intoxication.
ENDOCRINE CONNECTIONS
(2022)
Article
Materials Science, Multidisciplinary
Enkhjargal Enkhbayar, Namuundari Otgontamir, Junho Kim
Summary: The garnet Li7La3Zr2O12 (LLZO) is a promising solid electrolyte for all-solid state Li-ion batteries, with the cubic phase offering better ionic conductivity compared to the tetragonal phase. To stabilize the cubic phase and enhance its ionic conductivity, ternary-doped LLZO was synthesized and investigated. The results showed successful incorporation of the ternary-doped elements into the cubic garnet structure without formation of secondary phases, resulting in enhanced microstructure and the highest ionic conductivity achieved.
RESULTS IN PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Sangmin Chae, Tung Nguyen-Dang, Jirat Chatsirisupachai, Ahra Yi, Ricardo Javier Vazquez, Glenn Quek, Vinich Promarak, Hyo Jung Kim, Guillermo C. Bazan, Thuc-Quyen Nguyen
Summary: Organic electrochemical transistors (OECTs) using conjugated polyelectrolytes (CPEs) as active materials have great potential. By tuning the molecular weight of CPE, OECTs with improved performance can be achieved.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Physics, Applied
Jin Yong An, Han Sung Lee, Jihye Kim, Sang-Wan Ryu, Byong Chon Park, Yung Ho Kahng
Summary: In this study, the effects of doping graphene with the n-type dopant polyethylenimine were investigated, leading to improved performance of graphene-based devices. The doping induced a maximum decrease of 63% in the sheet resistance of reduced graphene oxide (RGO) films, and also improved the specific capacitance of RGO-based supercapacitor electrodes by approximately 3%-11%, with a maximum value of 205 +/- 22F/g (or 260 +/- 50 F/cm(2)). These results can aid future research on combining polymers and graphene-based materials for various applications.
JOURNAL OF APPLIED PHYSICS
(2021)
Article
Engineering, Environmental
Baogen Liu, Lingyun Yu, Huijun Wang, Xiancheng Ma, Zheng Zeng, Liqing Li
Summary: This study reveals the influence of oxygen doping on the surface heterogeneity and adsorption performance of volatile organic compounds (VOCs) through adsorption experiments and theoretical calculations. The results show that oxygen doping can significantly change the charge distribution on the carbon surface and enhance the adsorption capacity of methanol and acetone. The study also investigates the synergistic effect of oxygen-containing functional groups and finds no obvious synergistic effect.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Marianna Caterino, Margherita Ruoppolo, Michele Costanzo, Lucia Albano, Daniela Crisci, Giovanni Sotgiu, Laura Saderi, Andrea Montella, Flavia Franconi, Ilaria Campesi
Summary: Prematurity is the leading cause of neonatal deaths and high economic costs, with the metabolome of premature infants being influenced by various factors including gender, gestational age, and pharmacological treatments. Sex-related differences in the metabolome of premature infants were observed, with significant impacts from factors such as gestational age and caffeine treatment. These findings highlight the complex interplay between physiology, health, and treatment strategies in premature infants.
Article
Biochemistry & Molecular Biology
Denise Drongitis, Marianna Caterino, Lucia Verrillo, Pamela Santonicola, Michele Costanzo, Loredana Poeta, Benedetta Attianese, Adriano Barra, Gaetano Terrone, Maria Brigida Lioi, Simona Paladino, Elia Di Schiavi, Valerio Costa, Margherita Ruoppolo, Maria Giuseppina Miano
Summary: This study investigated the effects of mutations in the ARX gene on brain development and identified disrupted pathways related to cytoskeleton, protein synthesis, and splicing control. The study also found allele-dependent differences in neurite network organization, protein expression, and alternative splicing. Abnormal alternative splicing in the Neurexin-1 gene, which is involved in synaptic remodeling, was detected. These findings provide insights into the pathogenic mechanisms of ARX-related disorders and can inform the development of targeted therapies.
HUMAN MOLECULAR GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Alessandro Di Minno, Monica Gelzo, Marianna Caterino, Michele Costanzo, Margherita Ruoppolo, Giuseppe Castaldo
Summary: Metabolomics plays a crucial role in characterizing and refining perturbations of biological pathways. Limitations in implementing metabolomics have been addressed, and potential biomarkers have been discovered. Metabolomics is critical for personalized diagnosis and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Michele Costanzo, Marianna Caterino, Roberta Fedele, Armando Cevenini, Mariarca Pontillo, Lucia Barra, Margherita Ruoppolo
Summary: This review summarizes the diverse knowledge acquired through the application of COVIDomics techniques, focusing on proteomics and metabolomics studies, to identify common dysregulation in proteins, metabolites, and pathways in COVID-19 disease. Exploring the multiomics perspective and data integration may lead to new therapeutic solutions against the COVID-19 pandemic.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Michele Costanzo, Marianna Caterino, Illari Salvatori, Valeria Manganelli, Alberto Ferri, Roberta Misasi, Margherita Ruoppolo
Summary: In this study, the proteome of human neuroblastoma cells overexpressing Neuroglobin (NGB) was analyzed. The results revealed 178 differentially expressed proteins associated with NGB overexpression. These findings provide important insights into the neuroprotective mechanism of NGB.
Article
Environmental Sciences
Annamaria Mancini, Domenico Martone, Daniela Vitucci, Adriano Capobianco, Andreina Alfieri, Pasqualina Buono, Stefania Orru
Summary: This study aimed to assess the physical fitness level of schoolchildren in the Campania Region of Italy using health-related physical fitness components. The results showed that boys engaged in more sports practice than girls, and boys performed better in certain tests while girls performed better in one test. Overweight/obesity negatively affected the muscular strength of lower limbs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Endocrinology & Metabolism
Michele Costanzo, Marianna Caterino, Giovanni Sotgiu, Margherita Ruoppolo, Flavia Franconi, Ilaria Campesi
Summary: This review focused on sex-related metabolic differences by analyzing metabolomics studies on healthy populations, extracting shared and distinct features between males and females in the metabolome of common biological fluids, and considering the influence of age and the interaction between sex and age.
BIOLOGY OF SEX DIFFERENCES
(2022)
Article
Biochemistry & Molecular Biology
Emanuela Marchese, Marianna Caterino, Roberta Fedele, Francesca Pirozzi, Armando Cevenini, Neha Gupta, Diego Ingrosso, Alessandra Perna, Giovambattista Capasso, Margherita Ruoppolo, Miriam Zacchia
Summary: This study provides insights into the mechanisms underlying renal disease in Bardet-Biedl syndrome (BBS) through urine metabolomic and proteomic analyses. The increased urinary excretion of lactate suggests a possible renal-specific defective handling. The BBS10 gene may play a role in renal metabolism, RNA processing, and cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Iolanda Boffa, Elena Polishchuk, Lucia De Stefano, Fabio Dell'Aquila, Edoardo Nusco, Elena Marrocco, Matteo Audano, Silvia Pedretti, Marianna Caterino, Ilaria Bellezza, Margherita Ruoppolo, Nico Mitro, Barbara Cellini, Alberto Auricchio, Nicola Brunetti-Pierri
Summary: GACR is a chorioretinal degeneration caused by pathogenic variants in the gene encoding ornithine aminotransferase (OAT). The current therapies are unsatisfactory and this study investigates the efficacy of liver-directed AAV-mediated gene therapy using an intravenously injected AAV8 vector expressing OAT. The results show that this gene therapy effectively reduces ornithine concentrations and improves retinal function and structure in mouse models of OAT deficiency.
EMBO MOLECULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Marianna Caterino, Roberta Fedele, Vincenzo Carnovale, Alice Castaldo, Monica Gelzo, Paola Iacotucci, Margherita Ruoppolo, Giuseppe Castaldo
Summary: Cystic fibrosis is a hereditary metabolic disorder affecting chloride ions and water transport, resulting in inadequate hydration and dehydrated secretions. Understanding the metabolic alterations associated with the disease can help in developing targeted therapeutic strategies. This study used mass spectrometry analysis to investigate lipid metabolic changes in saliva samples from CF patients, associated with various complications.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Stefania Orru, Esther Imperlini, Daniela Vitucci, Marianna Caterino, Annalisa Mandola, Morten Bredsgaard Randers, Jakob Friis Schmidt, Marie Hagman, Thomas Rostgaard Andersen, Peter Krustrup, Margherita Ruoppolo, Pasqualina Buono, Annamaria Mancini
Summary: Lifelong football training has a positive impact on the oxidative capacity and body composition of elderly individuals, promoting successful aging. Furthermore, polyamines play an important role in muscle growth and hypertrophy.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Ilaria Campesi, Giampiero Capobianco, Antonella Cano, Valeria Lodde, Sara Cruciani, Margherita Maioli, Giovanni Sotgiu, Maria Laura Idda, Mariangela Valentina Puci, Margherita Ruoppolo, Michele Costanzo, Marianna Caterino, Francesca Cambosu, Andrea Montella, Flavia Franconi
Summary: This study found sex-related differences in amniotic fluid and amniotic fluid cells. Inflammation markers and certain metabolites were higher in female amniotic fluid, while other metabolites were higher in male amniotic fluid. Female amniotic fluid cells expressed more estrogen receptors and proteins associated with autophagy, while male amniotic fluid cells expressed more proteins associated with lysosomes.
Article
Sport Sciences
Domenico Martone, Daniela Vitucci, Annamaria Mancini, Georgios Ermidis, Jeppe Panduro, Loretta Francesca Cosco, Morten Bredsgaard Randers, Malte Nejst Larsen, Magni Mohr, Pasqualina Buono, Peter Krustrup
Summary: Lifelong participation in football training improves regional bone mineral density and bone mineral content in the legs, femur, and lumbar spine. It also correlates to a healthier body composition.
Review
Biotechnology & Applied Microbiology
Lucia Santorelli, Marianna Caterino, Michele Costanzo
Summary: The majority of cellular processes are regulated by protein-protein interactions (PPI), and defining the dynamic interactome has great significance in postgenomic era. Cross-linking mass spectrometry (XL-MS) is a powerful tool for PPI discovery, providing insights into the three-dimensional protein complexes in vivo. This review discusses advanced XL-MS approaches and their applications in structural proteomics and systems biology.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2022)
Meeting Abstract
Biotechnology & Applied Microbiology
Iolanda Boffa, Elena Marrocco, Marianna Caterino, Margherita Ruoppolo, Alberto Auricchio, Nicola Brunetti Pierri