Single-cell phenomics in budding yeast

Compartmentalization of a Bistable Switch Enables Memory to Cross a Feedback-Driven Transition

(2015) Andreas Doncic et al.   CELL

Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis

(2015) Yolanda T. Chong et al.   CELL

Essential gene disruptions reveal complex relationships between phenotypic robustness, pleiotropy, and fitness

(2015) C. R. Bauer et al.   Molecular Systems Biology

Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion

(2015) Christof Osman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unveiling nonessential gene deletions that confer significant morphological phenotypes beyond natural yeast strains

(2014) Ming Yang et al.   BMC GENOMICS

Organelle-Based Aggregation and Retention of Damaged Proteins in Asymmetrically Dividing Cells

(2014) Chuankai Zhou et al.   CELL

The mystery of aging and rejuvenation—a budding topic

(2014) Thomas Nyström et al.   CURRENT OPINION IN MICROBIOLOGY

Systematic identification of cell size regulators in budding yeast

(2014) I. Soifer et al.   Molecular Systems Biology

Single-cell and multivariate approaches in genetic perturbation screens

(2014) Prisca Liberali et al.   NATURE REVIEWS GENETICS

Three Dimensional Fluorescence Imaging Using Multiple Light-Sheet Microscopy

(2014) Kavya Mohan et al.   PLoS One

Single-cell phenomics reveals intra-species variation of phenotypic noise in yeast

(2013) Gaël Yvert et al.   BMC Systems Biology

Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast

(2013) D. A. Skelly et al.   GENOME RESEARCH

Distinct roles of cell wall biogenesis in yeast morphogenesis as revealed by multivariate analysis of high-dimensional morphometric data

(2013) Hiroki Okada et al.   MOLECULAR BIOLOGY OF THE CELL

Vanillin Inhibits Translation and Induces Messenger Ribonucleoprotein (mRNP) Granule Formation in Saccharomyces cerevisiae: Application and Validation of High-Content, Image-Based Profiling

(2013) Aya Iwaki et al.   PLoS One

High-throughput hyperdimensional vertebrate phenotyping

(2013) Carlos Pardo-Martin et al.   Nature Communications

Unsupervised Clustering of Subcellular Protein Expression Patterns in High-Throughput Microscopy Images Reveals Protein Complexes and Functional Relationships between Proteins

(2013) Louis-François Handfield et al.   PLoS Computational Biology

Negative Feedback Enhances Robustness in the Yeast Polarity Establishment Circuit

(2012) Audrey S. Howell et al.   CELL

Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress

(2012) Johnny M. Tkach et al.   NATURE CELL BIOLOGY

Mitochondrial Network Size Scaling in Budding Yeast

(2012) S. M. Rafelski et al.   SCIENCE

A role for seipin in lipid droplet dynamics and inheritance in yeast

(2011) H. Wolinski et al.   JOURNAL OF CELL SCIENCE

Getting the whole picture: combining throughput with content in microscopy

(2011) N. Rimon et al.   JOURNAL OF CELL SCIENCE

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

(2011) Zhijian Li et al.   NATURE BIOTECHNOLOGY

High-throughput phenotyping of multicellular organisms: finding the link between genotype and phenotype

(2011) Rosangela Sozzani et al.   GENOME BIOLOGY

Multiple Functional Domains of the Yeast l,3- -Glucan Synthase Subunit Fks1p Revealed by Quantitative Phenotypic Analysis of Temperature-Sensitive Mutants

(2010) H. Okada et al.   GENETICS

Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis

(2010) Franco J. Vizeacoumar et al.   JOURNAL OF CELL BIOLOGY

Systems survey of endocytosis by multiparametric image analysis

(2010) Claudio Collinet et al.   NATURE

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes

(2010) Beate Neumann et al.   NATURE

High-Content, Image-Based Screening for Drug Targets in Yeast

(2010) Shinsuke Ohnuki et al.   PLoS One

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

Multidimensional quantification of subcellular morphology of Saccharomyces cerevisiae using CalMorph, the high-throughput image-processing program

(2009) Takahiro Negishi et al.   JOURNAL OF BIOTECHNOLOGY

Dynamic analysis of MAPK signaling using a high-throughput microfluidic single-cell imaging platform

(2009) R. J. Taylor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Forced periodic expression of G1 cyclins phase-locks the budding yeast cell cycle

(2009) G. Charvin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum

(2009) M. C. Jonikas et al.   SCIENCE

Network Hubs Buffer Environmental Variation in Saccharomyces cerevisiae

(2008) Sasha F Levy et al.   PLOS BIOLOGY