Orchestration of ErbB3 signaling through heterointeractions and homointeractions

Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer

(2015) Christopher C. Valley et al.   MOLECULAR BIOLOGY OF THE CELL

Role of erbB3 receptors in cancer therapeutic resistance

(2014) Y. Lee et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Identification of Druggable Cancer Driver Genes Amplified across TCGA Datasets

(2014) Ying Chen et al.   PLoS One

Dynamic Transition States of ErbB1 Phosphorylation Predicted by Spatial Stochastic Modeling

(2013) Meghan McCabe Pryor et al.   BIOPHYSICAL JOURNAL

Oncogenic ERBB3 Mutations in Human Cancers

(2013) Bijay S. Jaiswal et al.   CANCER CELL

Heregulin induces resistance to lapatinib-mediated growth inhibition of HER2-amplified cancer cells

(2013) Yuji Sato et al.   CANCER SCIENCE

Dynamic conformational transitions of the EGF receptor in living mammalian cells determined by FRET and fluorescence lifetime imaging microscopy

(2013) Iwona Ziomkiewicz et al.   CYTOMETRY PART A

erbB3 Is an Active Tyrosine Kinase Capable of Homo- and Heterointeractions

(2013) M. P. Steinkamp et al.   MOLECULAR AND CELLULAR BIOLOGY

Exploring higher-order EGFR oligomerisation and phosphorylation—a combined experimental and theoretical approach

(2013) Noga Kozer et al.   Molecular BioSystems

An ERBB3/ERBB2 oncogenic unit plays a key role in NRG1 signaling and melanoma cell growth and survival

(2013) Keman Zhang et al.   Pigment Cell & Melanoma Research

Mechanism for activation of mutated epidermal growth factor receptors in lung cancer

(2013) M. Red Brewer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Model-Based Analysis of HER Activation in Cells Co-Expressing EGFR, HER2 and HER3

(2013) Harish Shankaran et al.   PLoS Computational Biology

Insights into Cell Membrane Microdomain Organization from Live Cell Single Particle Tracking of the IgE High Affinity Receptor FcϵRI of Mast Cells

(2012) Flor A. Espinoza et al.   BULLETIN OF MATHEMATICAL BIOLOGY

HER3 Is Required for HER2-Induced Preneoplastic Changes to the Breast Epithelium and Tumor Formation

(2012) D. B. Vaught et al.   CANCER RESEARCH

Simulation of homology models for the extracellular domains (ECD) of ErbB3, ErbB4 and the ErbB2–ErbB3 complex in their active conformations

(2012) Juan Felipe Franco-Gonzalez et al.   JOURNAL OF MOLECULAR MODELING

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Functional isolation of activated and unilaterally phosphorylated heterodimers of ERBB2 and ERBB3 as scaffolds in ligand-dependent signaling

(2012) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional reconstructions of Arp2/3 complex with bound nucleation promoting factors

(2011) Xiao-Ping Xu et al.   EMBO JOURNAL

A multiscale modeling approach to investigate molecular mechanisms of pseudokinase activation and drug resistance in the HER3/ErbB3 receptor tyrosine kinase signaling network

(2011) Shannon E. Telesco et al.   Molecular BioSystems

Rapid Phospho-Turnover by Receptor Tyrosine Kinases Impacts Downstream Signaling and Drug Binding

(2011) Laura B. Kleiman et al.   MOLECULAR CELL

Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor

(2011) Li-Zhi Mi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand binding

(2011) Shalini T Low-Nam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanics of EGF Receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging

(2011) J. L. Macdonald-Obermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

AZD8931, an Equipotent, Reversible Inhibitor of Signaling by Epidermal Growth Factor Receptor, ERBB2 (HER2), and ERBB3: A Unique Agent for Simultaneous ERBB Receptor Blockade in Cancer

(2010) D. M. Hickinson et al.   CLINICAL CANCER RESEARCH

Fast, single-molecule localization that achieves theoretically minimum uncertainty

(2010) Carlas S Smith et al.   NATURE METHODS

Signalling ballet in space and time

(2010) Boris N. Kholodenko et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

(2010) Fumin Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distribution of resting and ligand-bound ErbB1 and ErbB2 receptor tyrosine kinases in living cells using number and brightness analysis

(2010) P. Nagy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells

(2009) Yi Zhang et al.   BMC CELL BIOLOGY

Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment

(2009) Natalia Jura et al.   CELL

ErbB receptors and signaling pathways in cancer

(2009) Nancy E Hynes et al.   CURRENT OPINION IN CELL BIOLOGY

Her4 and Her2/neu Tyrosine Kinase Domains Dimerize and Activate in a Reconstitutedin VitroSystem

(2009) John Monsey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional and Structural Stability of the Epidermal Growth Factor Receptor in Detergent Micelles and Phospholipid Nanodiscs†

(2008) Li-Zhi Mi et al.   BIOCHEMISTRY

Stochastic simulations of ErbB homo and heterodimerisation: potential impacts of receptor conformational state and spatial segregation

(2008) M.-Y. Hsieh et al.   IET Systems Biology