Replication stress in early S phase generates apparent micronuclei and chromosome rearrangement in fission yeast

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Deciphering the Evolutionary History of Open and Closed Mitosis

(2014) Shelley Sazer et al.   CURRENT BIOLOGY

The Interaction between Checkpoint Kinase 1 (Chk1) and the Minichromosome Maintenance (MCM) Complex Is Required for DNA Damage-induced Chk1 Phosphorylation

(2014) Xiangzi Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

(2013) Luis Ignacio Toledo et al.   CELL

Centromere fragmentation is a common mitotic defect of S and G2checkpoint override

(2013) Neil Beeharry et al.   CELL CYCLE

Chromothripsis: Breakage-fusion-bridge over and over again

(2013) Carlos Oscar Sánchez Solorzano et al.   CELL CYCLE

Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements

(2013) C.-Z. Zhang et al.   GENES & DEVELOPMENT

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

ERCC1 and MUS81–EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis

(2013) Valeria Naim et al.   NATURE CELL BIOLOGY

Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage

(2013) Irene Saugar et al.   NUCLEIC ACIDS RESEARCH

Replication Fork Stability Is Essential for the Maintenance of Centromere Integrity in the Absence of Heterochromatin

(2013) Pao-Chen Li et al.   Cell Reports

Chromothripsis and Focal Copy Number Alterations Determine Poor Outcome in Malignant Melanoma

(2012) D. Hirsch et al.   CANCER RESEARCH

Forkhead Transcription Factors Establish Origin Timing and Long-Range Clustering in S. cerevisiae

(2012) Simon R.V. Knott et al.   CELL

A Mammalian-Like DNA Damage Response of Fission Yeast to Nucleoside Analogs

(2012) S. A. Sabatinos et al.   GENETICS

Brc1-dependent recovery from replication stress

(2012) K. L. Bass et al.   JOURNAL OF CELL SCIENCE

MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans

(2012) Claire R. Hughes et al.   JOURNAL OF CLINICAL INVESTIGATION

Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency

(2012) Laure Gineau et al.   JOURNAL OF CLINICAL INVESTIGATION

Recessive mutations inMCM4/PRKDCcause a novel syndrome involving a primary immunodeficiency and a disorder of DNA repair

(2012) Jillian P Casey et al.   JOURNAL OF MEDICAL GENETICS

Continued DNA Synthesis in Replication Checkpoint Mutants Leads to Fork Collapse

(2012) S. A. Sabatinos et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements

(2012) Andrew J Holland et al.   NATURE MEDICINE

Dormant Origins, the Licensing Checkpoint, and the Response to Replicative Stresses

(2012) D. McIntosh et al.   Cold Spring Harbor Perspectives in Biology

A Dominantly Acting Murine Allele of Mcm4 Causes Chromosomal Abnormalities and Promotes Tumorigenesis

(2012) Bruce N. Bagley et al.   PLoS Genetics

The Rad4TopBP1 ATR-Activation Domain Functions in G1/S Phase in a Chromatin-Dependent Manner

(2012) Su-Jiun Lin et al.   PLoS Genetics

Centromere fission, not telomere erosion, triggers chromosomal instability in human carcinomas

(2011) C. Martinez-A et al.   CARCINOGENESIS

On the origins of ultra-fine anaphase bridges

(2011) Kok Lung Chan et al.   CELL CYCLE

Overexpression of MCM2 in myelodysplastic syndromes: Association with bone marrow cell apoptosis and peripheral cytopenia

(2011) Shiho Suzuki et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Stalled Fork Rescue via Dormant Replication Origins in Unchallenged S Phase Promotes Proper Chromosome Segregation and Tumor Suppression

(2011) Tsuyoshi Kawabata et al.   MOLECULAR CELL

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier

(2011) Sevil Sofueva et al.   NUCLEIC ACIDS RESEARCH

Common fragile sites: mechanisms of instability revisited

(2011) Michelle Debatisse et al.   TRENDS IN GENETICS

Regulation of Minichromosome Maintenance Gene Family by MicroRNA-1296 and Genistein in Prostate Cancer

(2010) Shahana Majid et al.   CANCER RESEARCH

DDK Phosphorylates Checkpoint Clamp Component Rad9 and Promotes Its Release from Damaged Chromatin

(2010) Kanji Furuya et al.   MOLECULAR CELL

Homologous Recombination Restarts Blocked Replication Forks at the Expense of Genome Rearrangements by Template Exchange

(2010) Sarah Lambert et al.   MOLECULAR CELL

Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

(2010) M. Fenech et al.   MUTAGENESIS

Telomeres avoid end detection by severing the checkpoint signal transduction pathway

(2010) Tiago Carneiro et al.   NATURE

Minichromosome maintenance proteins 2, 3 and 7 in medulloblastoma: overexpression and involvement in regulation of cell migration and invasion

(2010) K-M Lau et al.   ONCOGENE

Emergence of Micronuclei and Their Effects on the Fate of Cells under Replication Stress

(2010) Koh-ichi Utani et al.   PLoS One

Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle

(2010) A. A. Guerrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smc5/6 maintains stalled replication forks in a recombination-competent conformation

(2009) Anja Irmisch et al.   EMBO JOURNAL

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

(2009) Valeria Naim et al.   NATURE CELL BIOLOGY

Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe

(2008) Ken-ichi Nakamura et al.   EMBO JOURNAL

Subunit Organization of Mcm2-7 and the Unequal Role of Active Sites in ATP Hydrolysis and Viability

(2008) M. L. Bochman et al.   MOLECULAR AND CELLULAR BIOLOGY

Minichromosome Maintenance Proteins Interact with Checkpoint and Recombination Proteins To Promote S-Phase Genome Stability

(2008) J. M. Bailis et al.   MOLECULAR AND CELLULAR BIOLOGY

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE

Cleavage of Stalled Forks by Fission Yeast Mus81/Eme1 in Absence of DNA Replication Checkpoint

(2007) Benoît Froget et al.   MOLECULAR BIOLOGY OF THE CELL