The Influence of Coating Thickness of Polymer on Chiral Discrimination of Cellulose Tris(3,5-Dimethyl Phenylcarbamate) Chiral Stationary Phase

The influence of the coating thickness of the polymer on the chiral discrimination of cellulose tris(3,5-dimethyl phenylcarbamate) (CDMPC) chiral stationary phase (CSP) is investigated. CDMPC-CSPs with different thicknesses of polymer were prepared, and their chromatographic performances were investigated. Thinner coat of polymer will increase the interactions between the samples and the support of CSPs and decrease the selectivity of CSPs. Too thick coat of polymer will not increase the performance of CSPs significantly but will decrease the performance of the column. The suited thickness of polymer is very important for the selectivity of the chiral stationary phase.