Journal
MOLECULAR BIOLOGY AND EVOLUTION
Volume 32, Issue 4, Pages 1091-1096Publisher
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msu399
Keywords
positive selection; simian primates; host-virus arms race; host-virus coevolution; HIV
Funding
- National Institutes of Health [R01-GM-093086]
- National Science Foundation
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Over evolutionary time, both host- and virus-encoded genes have been continually selected to modify their interactions with one another. This has resulted in the rapid evolution of the specific codons that govern the physical interactions between host and virus proteins. Virologists have discovered that these evolutionary signatures, acquired in nature, can provide a shortcut in the functional dissection of host-virus interactions in the laboratory. However, the use of evolution studies in this way is complicated by the fact that many nonhuman primate species are endangered, and biomaterials are often difficult to acquire. Here, we assess how the species representation in primate gene data sets affects the detection of positive natural selection. Our results demonstrate how targeted primate sequencing projects could greatly enhance research in immunology, virology, and beyond.
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