4.7 Article

Detailed modeling and process design of an advanced continuous powder mixer

Journal

INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 552, Issue 1-2, Pages 288-300

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2018.09.032

Keywords

Continuous manufacturing; Continuous mixing technology; Discrete element method; Cohesive contact model; Residence time distribution; Operating space; Process modeling

Funding

  1. Austrian COMET Program under the Austrian Federal Ministry of Transport, Innovation and Technology (bmvit)
  2. Austrian Federal Ministry of Economy, Family and Youth (bmwfj)
  3. State of Styria (Styrian Funding Agency SFG)

Ask authors/readers for more resources

A vertical in-line continuous powder mixing device (CMT - Continuous Mixing Technology) has been modelled with the discrete element method (DEM) utilizing a calibrated cohesive contact model. The vertical design of the mixing device allows independent control of mean residence time (MRT) and shear rate. The hold-up mass and outlet flow are controlled by an exit valve, located at the bottom of the in-line mixer. A virtual design of experiments (DoE) of DEM simulations has been performed and parameters such as particle velocities, powder bed shape, residence time distribution (RTD), travel distance, and mixing quality are evaluated for the complete operating space. The RTD of the DEM model has been validated with tracer experiments. The resulting RTD has been fitted with an analytical form (generalized cascade of n continuous stirred tank reactors) and utilized to study the downstream response of the continuous mixing device to upstream fluctuations in the inlet material stream. The results indicate a high mixing quality and good filtering properties across the operating space. However, the combination of low hold-up mass and high impeller speeds leads to a reduced filtering capability and wider exit valve openings, indicating a less desirable operating point.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available