Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 461, Issue 1-2, Pages 157-162Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2013.11.046
Keywords
Simvastatin; PLGA microspheres; Bone substitutions; Critical sized defect
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Funding
- Grants-in-Aid for Scientific Research [24792014] Funding Source: KAKEN
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The present study describes the development of a microsphere capsule based on polylactide-co-glycolide (PLGA) loaded with simvastatin that was subsequently incorporated into synthetic bone cement. The osteogenic effect of simvastatin-loaded bone cement was in a critical sized defect in vivo to test the hypothesis the biologic response would be different depending on the dosage of simvastatin applied to bone cement. Our results showed that simvastatin loaded PLGA microspheres can be successfully obtained through 01W emulsion/solvent evaporation method with appropriate morphologic characteristics and high encapsulation efficiency for incorporation in bone cements. The biodegradable characteristic of the microspheres successfully presented a slow release and the duration of the release lasted for more than 1 month. The in vivo experiment revealed that the microspheres containing simvastatin significantly enhanced bone formation in the rabbit calvaria critical size defect. (C) 2013 Elsevier B.V. All rights reserved.
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