Article
Pharmacology & Pharmacy
Marwa H. Shukr, Soha Ismail, Ghada G. El-Hossary, Amany H. El-Shazly
Summary: Travoprost (TRAVO) is a prostaglandin analog used to reduce intraocular pressure in patients with glaucoma and ocular hypertension. This study successfully developed a novel in situ mucoadhesive ocular liposomal gel to enhance the therapeutic efficacy of TRAVO. The selected liposomal formulation showed high drug entrapment efficiency, suitable vesicle size, polydispersibility, and zeta potential, and was further incorporated into an in situ mucoadhesive gel with controlled release and improved bioavailability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Health Care Sciences & Services
Guglielmo Stabile, Roberta Marie Gentile, Stefania Carlucci, Stefano Restaino, Francesco De Seta
Summary: The combination of clotrimazole and Unilen(R) Microbio+ was found to be as effective as azole treatment alone in curing uncomplicated vulvovaginal candidiasis, reducing recurrence rates and improving vaginal flora.
Article
Chemistry, Multidisciplinary
Xue-Liang Liu, Xiao Dong, Si-Cong Yang, Xing Lai, Hai-Jun Liu, Yuhao Gao, Hai-Yi Feng, Mao-Hua Zhu, Yihang Yuan, Qin Lu, Jonathan F. Lovell, Hong-Zhuan Chen, Chao Fang
Summary: Nano-Pt loaded liposomal system enhances photodynamic therapy and chemotherapy in cancer treatment by increasing oxygen supply and releasing nanoparticles for better penetration, leading to inhibited tumor growth and extended survival without toxicity in animal models.
Article
Biochemistry & Molecular Biology
Ahmed Alzainy, Joshua Boateng
Summary: This research aimed to develop, characterize, and optimize freeze-dried wafers loaded with metronidazole (MTz) to treat vaginal bacterial infections. The study improved the physico-chemical properties of the wafer formulations and successfully achieved sustained drug release and antimicrobial activity, demonstrating potential clinical applications.
Article
Engineering, Biomedical
Lingna Sun, Mingrui Fan, Dong Huang, Bingqin Li, Ruoting Xu, Feng Gao, Yanzuo Chen
Summary: A clodronate-loaded liposome and fibroblast-derived exosome hybrid drug delivery system, named EL-CLD, was designed for the treatment of pulmonary fibrosis. This system effectively targeted fibrotic lung tissue by homing to fibroblasts and showed enhanced therapeutic efficacy compared to traditional drug delivery methods. The EL-CLD system acted as an efficient carrier for anti-fibrotic drugs, improving tissue accumulation and delivery while reducing inflammatory responses.
Article
Pharmacology & Pharmacy
Maria Jose De Jesus Valle, Aranzazu Zarzuelo Castaneda, Cristina Maderuelo, Alejandro Cencerrado Trevino, Jorge Loureiro, Paula Coutinho, Amparo Sanchez Navarro
Summary: A pharmaceutical vehicle based on lyophilized liposomes was developed for the buccal administration of drugs aimed at systemic delivery through the sublingual mucosa. The optimized formulation of lyophilized liposomes in unidirectional round tablets showed palatability, small size, comfortability, and buccal retention suitable for sublingual administration. The liposome release rate was slower compared to the permeation efficiency determined using a biomimetic membrane. The proposed liposomal formulation is suitable for systemic drug delivery through the sublingual mucosa.
Article
Pharmacology & Pharmacy
Abdulaziz Mohsen Al-mahallawi, Doaa Ahmed, Mariam Hassan, Doaa Ahmed El-Setouhy
Summary: The study successfully formulated clotrimazole into a chitosan-coated microemulsion system for enhanced ocular delivery, showing promising results in terms of efficacy and safety in animal studies.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Emilia Szymanska, Malgorzata Krzyzowska, Krzysztof Cal, Barbara Mikolaszek, Jakub Tomaszewski, Slawomir Wolczynski, Katarzyna Winnicka
Summary: The study found that chitosan glutamate spray-dried microparticles displayed feasible mucoadhesive and mucoretention characteristics to human vaginal tissue, but did not facilitate drug penetration across the tissue. The obtained antiviral results demonstrated the potential of chitosan glutamate as an antiherpes adjunctive.
Article
Chemistry, Multidisciplinary
Yifei He, Kaiyuan Wang, Yutong Lu, Bingjun Sun, Jin Sun, Wei Liang
Summary: The penetration of antitumor nanomedicines in solid tumors is limited. However, extracellular vesicles (EVs) secreted by tumor cells can facilitate the intercellular transport of drugs in the tumor microenvironment. The inefficient generation of EVs hinders the application of this approach. Therefore, researchers developed a liposome-based nanoplatform containing a stimulant for EV secretion and a therapeutic agent. This endogenous EV-driven nanoplatform enables deep tumor penetration and enhanced phototherapeutic efficacy.
Article
Pharmacology & Pharmacy
Hasan Afzaal, Shahiq-uz-Zaman, Adil Saeed, Syed Damin Abbas Hamdani, Amir Raza, Alvina Gul, Mustafeez Mujtaba Babar, Jayakumar Rajadas
Summary: A mucoadhesive formulation has been developed to improve the absorption of drugs through the intravaginal route, and an efficient assay method has been established for quantification of the drug molecule.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Richard Wibel, Doris E. Braun, Laurenz Haemmerle, Arne M. Joergensen, Patrick Knoll, Willi Salvenmoser, Christian Steinbring, Andreas Bernkop-Schnuerch
Summary: In this study, thiolated chitosan was used as a coating material for solid lipid nanoparticles, with the protection of thiol groups playing a key role in their interaction with mucosa. Different coating materials showed varying effects on mucus interaction and diffusion behavior on intestinal mucosa.
Article
Medicine, Research & Experimental
Maie S. Taha, Shallu Kutlehria, Anisha D'Souza, Benjamin S. Bleier, Mansoor M. Amiji
Summary: Verapamil, a calcium channel blocker, shows potential for treating chronic rhinosinusitis (CRS) with or without nasal polyps. However, its dose is limited by side effects, making localized intranasal administration preferable. The challenge with intranasal administration is mucociliary clearance, which reduces localized drug availability. To overcome this challenge, verapamil was loaded into mucoadhesive cationic polyethylene glycol-modified (PEGylated) liposomes. This formulation increased tissue residence time and nasal tissue accumulation of verapamil, making it a promising intranasal delivery system for CRS therapy.
MOLECULAR PHARMACEUTICS
(2023)
Article
Obstetrics & Gynecology
Manopchai Thamkhantho, Chenchit Chayachinda
Summary: DQC and CT demonstrate comparable clinical response for treating vaginal candidiasis, with CT showing greater improvement in microscopic examination and fungal culture.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Polymer Science
Boglarka Szalai, Orsolya Jojart-Laczkovich, Anita Kovacs, Szilvia Berko, Gyorgy Tibor Balogh, Gabor Katona, Maria Budai-Szucs
Summary: This study aims to develop in situ gelling mucoadhesive ophthalmic preparations that can improve the bioavailability of eye drops. The results show that formulations based on thermosensitive polymers and mucoadhesive polymers can increase the residence time and penetration of the active pharmaceutical ingredient, thereby enhancing the bioavailability of the eye drops.
Article
Engineering, Biomedical
Guowei Li, Kai Lv, Xiangjun Pan, Siting Zhou, Hui Xing, Jun Xu, Dong Ma, Yunfeng Hu, Hao Xu
Summary: In this study, a dynamic delivery system Clo@mPRP/NONOate was developed, which effectively attached to fungal biofilms through electrostatic interaction and enhanced the permeability of nanoparticles to the biofilms by introducing polyrotaxane. This system could inhibit the formation of fungal hyphae and eradicate fungi inside the biofilms by combining nitric oxide and clotrimazole. Additionally, it could safely and effectively eliminate planktonic Candida albicans and treat C. albicans-induced vaginal infection.
ACTA BIOMATERIALIA
(2023)
Article
Pharmacology & Pharmacy
Jorgen Brustugun, Nikolai Notaker, Lasse Holtan Paetz, Ingunn Tho, Kathrin Bjerknes
Summary: This study aimed to investigate the effects of tablet formulation and manipulation technique on dose accuracy and precision when dispersing different aspirin tablets for children. The results showed that only dispersible tablets provided doses within 20% of the intended dose, highlighting the importance of considering tablet formulation and extraction technique in such manipulations.
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2021)
Article
Pharmacology & Pharmacy
Martina M. Tzanova, Ellen Hagesaether, Ingunn Tho
Summary: This study aimed to develop and characterize solid lipid nanoparticle (SLN)-loaded mucoadhesive films for potential drug formulations. The SLNs showed good storage stability, and their incorporation into the film matrix increased thickness and flexibility while slightly decreasing mechanical strength. Additionally, solubilization in SLNs reduced permeation rate and extent of the model drug C6, which was compensated for when incorporated into the mucoadhesive film.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Tina Gulin-Sarfraz, Georgios N. Kalantzopoulos, Marit Kvalvag Pettersen, Anette Wold Asli, Ingunn Tho, Lars Axelsson, Jawad Sarfraz
Summary: The study evaluated the feasibility of porous silica particles and nanoclays as encapsulation matrices for natural antimicrobial substances in food packaging applications. Different carriers showed significant differences in their loading capability and subsequent release of volatile and non-volatile compounds. Selection of the right nanocarrier for a specific food packaging application should be based on the particular characteristics and requirements of the substances being encapsulated.
Article
Chemistry, Medicinal
Lisa Myrseth Hemmingsen, Kjersti Julin, Luqman Ahsan, Purusotam Basnet, Mona Johannessen, Natasa Skalko-Basnet
Summary: In an era of antimicrobial resistance, novel treatment options are urgently needed to improve the prevention and eradication of infectious skin biofilm-producing pathogens, while enhancing wound healing. Tailoring formulations for acute skin injuries is crucial for proper skin retention and release of antimicrobials.
Review
Pharmacology & Pharmacy
Zeljka Vanic, May Wenche Joraholmen, Natas Skalko-Basnet
Summary: There has been a surprising increase in sexually transmitted infections (STIs) in recent years, coupled with the threat of rising antimicrobial resistance (AMR). The use of nano medicine for treating vaginal infections offers advantages such as localized therapy, reducing systemic drug exposure, and minimizing side effects.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Eric Ofosu Kissi, Robin Nilsson, Liebert Parreiras Nogueira, Anette Larsson, Ingunn Tho
Summary: This study investigated the influence of drug load on the printability and physical stability of 3D-printed pharmaceutical products. Adjusting the drug ratio can improve printability without compromising the physical stability of the amorphous solid dispersion.
Article
Pharmacology & Pharmacy
Laura Victoria Schulte-Werning, Anjanah Murugaiah, Bhupender Singh, Mona Johannessen, Rolf Einar Engstad, Natasa Skalko-Basnet, Ann Mari Holsaeter
Summary: The development of multifunctional nanofibrous wound dressings containing chloramphenicol, beta-glucan, and chitosan shows promising anti-inflammatory and antimicrobial properties for the treatment of infected and exuding wounds.
Article
Chemistry, Medicinal
Lisa Myrseth Hemmingsen, Natasa Skalko-Basnet, May Wenche Joraholmen
Summary: This review discusses the potential of chitosan in the field of biomedical applications, with a focus on its use in localized antimicrobial therapy to combat increasing antimicrobial resistance. The review categorizes and evaluates chitosan-based delivery systems, addressing challenges related to different administration sites, especially for skin and vaginal infections. It also provides an overview of chitosan's potential in treating ocular, buccal and dental, and nasal infections, as well as remarks on toxicity issues and remaining challenges.
Article
Pharmacology & Pharmacy
Ivo Laidmae, Andres Meos, Irja Alainezhad Kjaervik, Sveinung G. Ingebrigtsen, Natasa Skalko-Basnet, Kalle Kirsimae, Tavo Romann, Urmas Joost, Vambola Kisand, Karin Kogermann
Summary: The study compared the preparation of drug-loaded liposomes using two methods and found that liposomes prepared by electrospinning were smaller and more homogeneous but contained less drug. Additionally, the electrospinning method was faster for in-situ liposome preparation.
Article
Pharmacology & Pharmacy
May Wenche Joraholmen, Pauliina Damdimopoulou, Ganesh Acharya, Natasa Skalko-Basnet
Summary: A formulation using liposomes loaded with resveratrol (RES) and incorporated into a chitosan hydrogel has been developed for delivering RES to the vaginal site. In vitro experiments showed that this formulation is non-irritant and biocompatible with vaginal tissue at therapeutic concentrations.
Article
Pediatrics
Katerina Nezvalova-Henriksen, Tone Huseby Holm, Niklas Nilsson, Inge Kjonniksen, Ingunn Tho
Summary: The aim of this study was to identify the commonly acquired intravenous drugs in neonatal intensive care units and test their compatibility. The results showed that ampicillin and benzylpenicillin were incompatible with morphine, while flecainide and fluconazole showed no signs of incompatibility with morphine. Co-administration of ampicillin and benzylpenicillin with morphine should be avoided in neonatal intensive care settings, while the combination of morphine, flecainide, and fluconazole was evaluated as safe in neonatal patients.
Article
Pharmacology & Pharmacy
Peter Meiland, Bjarke Strom Larsen, Matthias Manne Knopp, Ingunn Tho, Thomas Rades
Summary: This study proposes a new method for determining the solubility of crystalline drugs in polymers by utilizing annealing of supersaturated amorphous solid dispersions. The method accurately predicts the solubility of problematic drug-polymer systems by measuring the enthalpy of melting and mixing of the recrystallized drug and extrapolating to room temperature using the Flory-Huggins model.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Karin Korelc, Bjarke Strom Larsen, Mirjana Gasperlinb, Ingunn Tho
Summary: Oromucosal films and wafers are convenient solid dosage forms for drug delivery. In this study, prednisolone containing chitosan-based mucoadhesive films and wafers were developed with different chitosan types. The mucoadhesive properties, drug release rate, and permeability of the formulations were evaluated. The results showed that chitosan type, solvent, and preparation method influenced the mucoadhesive properties, drug release rate, and permeability. The mucoadhesive wafers with a slower drug release rate and stronger mucoadhesion were considered promising alternatives to films.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Anesthesiology
Niklas Nilsson, Vivian Nguyen, Katerina Nezvalova-Henriksen, Ingunn Tho
Summary: The study found that precipitation occurs when midazolam and ketamine are mixed with the buffered electrolyte solution, which may pose a safety concern. Conversely, fentanyl and potassium chloride were found to be compatible with the buffered electrolyte solution.
PEDIATRIC ANESTHESIA
(2023)
Article
Pediatrics
Niklas Nilsson, Ingebjorg Storesund, Ingunn Tho, Katerina Nezvalova-Henriksen
Summary: This study provides compatibility data for intravenous therapy in neonatal intensive care unit (NICU) patients. By assessing particle formation and emulsion destabilisation, the study concludes that the drugs dopamine, morphine, and cefotaxime are compatible with the 3-in-1 parenteral nutrition Numeta G13E, ensuring safe co-administration in NICU patients.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)