Article
Pharmacology & Pharmacy
Yannick Guinet, Laurent Paccou, Alain Hedoux
Summary: This study focuses on the physical stability of amorphous ibuprofen in two types of formulations: terpenes-based deep eutectic solvents (DES) and arginine-based co-amorphous blends. The results show that amorphous ibuprofen is stabilized in thymol:menthol DES but recrystallizes in co-amorphous mixtures obtained by cryo-milling. The mechanism of stabilization is discussed based on the inability to form dimers due to preferential heteromolecular H-bonding.
Review
Chemistry, Analytical
Alex M. Sherman, Nita Takanti, Jiayue Rong, Garth J. Simpson
Summary: This review article highlights the use of nonlinear optical (NLO) interactions to address challenges in formulating stable formulations for the next generation of active pharmaceutical ingredients (APIs). The applications of second harmonic generation (SHG) and coherent anti-Stokes Raman spectroscopy (CARS) provide efficient analysis and precise formulation design.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Karlis Berzins, Sara J. Fraser-Miller, Keith C. Gordon
Summary: Low-frequency Raman (LFR) spectroscopy is a technique that probes vibrational modes related to long-range order and crystallinity in solids, providing unique information about their properties. Recent advancements in instrumentation and data analysis have overcome previous limitations and led to a surge in popularity of LFR spectroscopy with applications in various research areas, particularly pharmaceutical analysis. This mini-review article comprehensively summarizes established and exciting new LFR applications, discussing aspects of theory, instrumentation, and data analysis including the use of chemometric and computational techniques.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Engineering, Chemical
Qiao Chen, Yuanhui Ji
Summary: In this study, the effects of temperature, relative humidity, and polymeric excipients on the phase behavior of amorphous irbesartan and oxaprozin were systematically investigated. It was found that polyvinylpyrrolidone (PVP) can better inhibit the recrystallization of irbesartan, while poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA46) can better maintain the amorphous form of oxaprozin. The molecular interaction mechanism of amorphous solid dispersions (ASDs) was explained through calculations of electrostatic potential and binding energies using density functional theory (DFT).
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Chemistry, Analytical
Chen Liu, Lisa Mueller-Botticher, Chang Liu, Jurgen Popp, Dagmar Fischer, Dana Cialla-May
Summary: A Raman-based label-free analytical method was developed to detect ciprofloxacin in different matrices. The method allows for semiquantification and can overcome interference from excipients and carrier substances. Surface-enhanced Raman spectroscopy is applied for sensitive detection, and the method can also monitor the degradation of ciprofloxacin within pharmaceutical formulations.
Review
Pharmacology & Pharmacy
Luz Maria Martinez, Jorge Cruz-Angeles, Monica Vazquez-Davila, Eduardo Martinez, Paulina Cabada, Columba Navarrete-Bernal, Flor Cortez
Summary: This review summarizes recent research on the preparation of pharmaceutical formulations through ball milling to enhance the physicochemical properties of active pharmaceutical ingredients. The paper discusses the experimental conditions of ball milling, structural modifications, and characterization techniques and results.
Article
Pharmacology & Pharmacy
Khadijah Edueng, Aleksei Kabedev, Alyssa Ekdahl, Denny Mahlin, John Baumann, Deanna Mudie, Christel A. S. Bergstrom
Summary: This study reveals the importance of physical stability and efficient supersaturation of amorphous solid dispersions (ASDs) in vivo, using molecular dynamics simulations and experimental assessments. The effect of drug loading on physical stability and supersaturation potential is specific to the drug. Storage under humid conditions influences crystallization and particle changes, which significantly affect dissolution rate.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Yoshihisa Yamamoto, Mizuho Kajita, Yutaro Hirose, Naoki Shimada, Toshiro Fukami, Tatsuo Koide
Summary: This study evaluated the pharmaceutical properties of levofloxacin (LV) in the form of orally disintegrating tablets (LVODT) using low frequency (LF) Raman spectroscopy. The results showed that LVODT and LV tablets (LVT) contained the active pharmaceutical ingredient (API) in different crystalline forms or environments. Microscopic LF Raman spectroscopy also detected thin layers containing titanium dioxide and a polymer that masked the bitterness of the API on the outer edges of the granules. This study highlights the new applications of LF Raman spectroscopy in pharmaceutical science.
Review
Pharmacology & Pharmacy
Ming Gao, Sibo Liu, Jianan Chen, Keith C. Gordon, Fang Tian, Cushla M. McGoverin
Summary: Drug development is a time-consuming process with high failure rates, where pharmaceutical formulation development plays a crucial role in linking new chemical entities to clinical trials. Artificial intelligence and Raman spectroscopy have the potential to accelerate formulation development and provide new pathways for high-quality data gathering.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Malinda Salim, Sara J. Fraser-Miller, Karlis Berzins, Joshua J. Sutton, Keith C. Gordon, Ben J. Boyd
Summary: Low-frequency Raman spectroscopy (LFRS) is used to detect and track the precipitation of drugs in lipid-based formulations during digestion. Multivariate data analysis and univariate analysis approaches were used to analyze the spectral changes over time and compare the results with small angle X-ray scattering (SAXS) measurements. LFRS was found to be a complementary technique to determine the kinetics of drug precipitation from lipid-based formulations, potentially providing more accessible results than SAXS.
Article
Biochemistry & Molecular Biology
Chao-Yang Zhao, Huimin Sui, Endi Xue, Li Li, Jie Zhang, Tao Xu, Xin Liang, Ying Yang
Summary: A simple, rapid, sensitive, and effective surface-enhanced resonance Raman scattering (SERRS) detection method for benzocaine was developed by coupling it with an azo coupling reaction. The method showed a strong SERRS response with the addition of Ag NPs excited with a 532 nm laser, allowing for quantitative determination of benzocaine concentration. The method had a low limit of detection (LOD) and was superior in simplicity and rapidness compared to previous studies.
Article
Pharmacology & Pharmacy
Dipesh Khanal, Wei-Ren Ke, Hak-Kim Chan
Summary: Raman spectroscopy was used to evaluate the effects of temperature and humidity on the physicochemical stability of inhalable spray-dried powders containing budesonide and crystalline or amorphous lactose. The study found that powders prepared from solution exhibited better stability, while powders prepared from suspension were prone to recrystallization and changes in chemical composition.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Polymer Science
Yoshitomo Furushima, Akihiko Toda, Masaru Nakada, Nobuhiro Hirota, Hideaki Takahashi, Toshiumi Tatsuki, Satoshi Fujiwara, Kazuma Okada, Masatoshi Ohkura
Summary: The study used fast scanning calorimetry and temperature modulated FSC to analyze the enthalpy relaxation behavior of low isotacticity polypropylene amorphous phase, revealing the influence of crystallization. It was found that above the crystallization temperature, the consecutive glass transition of the rigid amorphous phase and the gradual increase in heat capacity of the mobile amorphous phase were experimentally indistinguishable.
Article
Medicine, Research & Experimental
Anas Aljabbari, Shinji Kihara, Thomas Rades, Ben J. Boyd, Karlis Berzins
Summary: The adsorption of gut relevant biomolecules onto particles after oral administration of solid oral dosage forms is expected to form a gastrointestinal corona, which could influence solution-mediated solid-state transformations. This study used low-frequency Raman spectroscopy to investigate the in situ solid-state phase transformations under biorelevant conditions and the presence of biomolecules. The results showed a change in the solid-state transformation pathway from amorphous to crystalline drug and the role of biomolecules in influencing these transformations.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Analytical
Meilan Ge, Yuye Wang, Junfeng Zhu, Bin Wu, Degang Xu, Jianquan Yao
Summary: This paper investigates the low-frequency vibrational properties of carbamazepine co-crystals with nicotinamide and saccharin, and characterizes them using THz spectroscopy and low-wavenumber Raman spectroscopy. The results show that the co-crystals have different absorption peaks and Raman characteristic peaks compared to their individual constituents, and the theoretical calculations agree well with the experimental measurements.
Article
Pharmacology & Pharmacy
Mani Ordoubadi, Florence K. A. Gregson, Hui Wang, Mark Nicholas, Sandra Gracin, David Lechuga-Ballesteros, Jonathan P. Reid, Warren H. Finlay, Reinhard Vehring
Summary: The study extensively investigated the particle formation of L-leucine through three experimental methods and theory, providing insights into predicting the properties of spray-dried particles. The research enhanced the understanding of the particle formation process and proposed a model for predicting the properties of spray-dried particles.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Mellissa Gomez, Joseph McCollum, Hui Wang, Mani Ordoubadi, Chester Jar, Nicholas B. Carrigy, David Barona, Isobel Tetreau, Michelle Archer, Alana Gerhardt, Chris Press, Christopher B. Fox, Ryan M. Kramer, Reinhard Vehring
Summary: This study aimed to develop a stable inhalable dry powder vaccine for respiratory infectious diseases like tuberculosis. Results showed that different additives in the formulations had varying effects on the stability and aerosol performance of the vaccine, providing important insights for vaccine preparation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Engineering, Chemical
Zheng Wang, Mani Ordoubadi, Hui Wang, Reinhard Vehring
Summary: This study aimed to investigate leucine crystallization kinetics and develop multi-orifice plates for increasing the production rate of monodisperse spray drying. Numerical models were used to predict crystallization and drying kinetics for different co-solvent ratios and drying temperatures. Controlling crystal size and particle morphology is important in the design and manufacture of microparticles for desired powder properties.
AEROSOL SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zheng Wang, Hui Wang, Reinhard Vehring
Summary: This study found that a formulation containing 30% leucine maintained the highest emitted dose (90.3 ± 10%) at a 60 L/min flow rate after exposure to high humidity and temperature, demonstrating superior protection against moisture. Further investigations on trehalose/leucine combinations with different compositions revealed that higher leucine concentration generally provided better protection against moisture and maintained higher powder dispersibility.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Mellissa Gomez, Michelle Archer, David Barona, Hui Wang, Mani Ordoubadi, Shabab Bin Karim, Nicholas B. Carrigy, Zheng Wang, Joseph McCollum, Chris Press, Alana Gerhardt, Christopher B. Fox, Ryan M. Kramer, Reinhard Vehring
Summary: The study found that using spray drying technology can successfully encapsulate adjuvanted vaccine in dry powder form, effectively stabilizing it for extended periods. After storage at high temperatures, the spray-dried product demonstrated better antigen heat stability compared to the liquid product.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Respiratory System
Solbee Seo, Conor A. Ruzycki, Bailey Johnson, Hui Wang, Reinhard Vehring, Dan Romanyk, Warren H. Finlay, Andrew R. Martin
Summary: The study showed that moist heat incubation can be used for respirator decontamination without significant decrease in filtration efficiency. The impact of moist heat incubation may vary among different respirator models, hence requiring individual evaluation. Evaluating size-specific filtration efficiency across various particle sizes is crucial in determining the most penetrating particle size for respirators.
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY
(2022)
Article
Chemistry, Multidisciplinary
Mani Ordoubadi, Florence K. A. Gregson, Hui Wang, Nicholas B. Carrigy, Mark Nicholas, Sandra Gracin, David Lechuga-Ballesteros, Jonathan P. Reid, Warren H. Finlay, Reinhard Vehring
Summary: The study investigated the formation of trileucine-containing spray-dried microparticles for pulmonary delivery. It was found that adding a small amount of trileucine could significantly lower particle densities, and particle morphology and surface composition varied with different trileucine concentrations.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Immunology
Mellissa Gomez, Joseph McCollum, Hui Wang, Shital Bachchhav, Isobel Tetreau, Alana Gerhardt, Chris Press, Ryan M. Kramer, Christopher B. Fox, Reinhard Vehring
Summary: Particle engineering via spray drying was utilized to develop a dry powder format of an adjuvanted tuberculosis vaccine candidate, demonstrating excellent stability and inhalable properties at high temperatures, ensuring the efficacy and effectiveness of the vaccine components.
Article
Mathematics, Interdisciplinary Applications
Mohammed A. Boraey
Summary: An analytical model for the filtration efficiency of face masks is developed, considering the effect of gap leakage due to improper fitting and verified using experimental data. The adverse effect of gap leakage depends on the mask characteristics, and wearing multiple masks might not always be beneficial. Recommendations on the best practice for wearing two face masks are provided.
CHAOS SOLITONS & FRACTALS
(2021)
Article
Mechanics
Mohammed A. Boraey, Amr Guaily
Summary: This article presents a mathematical model for the flow of molten salt in a circular pipe, deriving a closed-form approximate solution for specific conditions. The accuracy of this simplified solution is tested against numerical solutions and provides insight into the effects of physical parameters on the flow properties and thermal behavior of molten salt.
Article
Nuclear Science & Technology
Mohammed A. Boraey
Summary: The proposed Energy-Utilization Metric (EUM) is a new metric for quantifying the achieved heat transfer rate per unit consumed mechanical power in heat transfer devices. It helps in selecting designs with superior energy-utilization characteristics and analyzing the impact of different design parameters on power consumption potential. Experimental and numerical data confirm the validity of EUM and show significant differences in energy consumption potential for different designs and operating conditions, with a cubic dependence on the Re number.
PROGRESS IN NUCLEAR ENERGY
(2021)
Article
Pharmacology & Pharmacy
Mellissa Gomez, Mushtaq Ahmed, Shibali Das, Joseph McCollum, Leah Mellett, Rosemary Swanson, Ananya Gupta, Nicholas B. Carrigy, Hui Wang, David Barona, Shital Bachchhav, Alana Gerhardt, Chris Press, Michelle C. Archer, Hong Liang, Emilie Seydoux, Ryan M. Kramer, Philip J. Kuehl, Reinhard Vehring, Shabaana A. Khader, Christopher B. Fox
Summary: Converting vaccines into thermostable dry powders offers advantages in reducing resource burden and providing flexibility in dosage and administration. This study evaluates the immunogenicity and protective efficacy of a promising TB vaccine candidate when administered via different routes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hui Wang, Mani Ordoubadi, Patrick Connaughton, Kellisa Lachacz, Nicholas Carrigy, Scott Tavernini, Andrew R. Martin, Warren H. Finlay, David Lechuga-Ballesteros, Reinhard Vehring
Summary: This study developed a new lipid-based particle formulation platform for respiratory drug delivery applications. Rugose lipid particles were successfully produced using a spray drying method, with good manufacturability and promising aerosol performance. The new technique has the potential to produce rugose particles using various other lipids.
PHARMACEUTICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Hui Wang, Patrick Connaughton, Kellisa Lachacz, Nicholas Carrigy, Mani Ordoubadi, David Lechuga-Ballesteros, Reinhard Vehring
Summary: Administration of biologics via the respiratory route is gaining popularity. A new lipid-based inhalable microparticle platform, manufactured using a simplified spray drying method, ensures both powder dispersibility and physicochemical stability, and shows great potential for efficient drug delivery.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Review
Engineering, Chemical
Mani Ordoubadi, Hui Wang, Reinhard Vehring
Summary: Spray drying is becoming popular in the pharmaceutical industry for producing solid dosage forms. It can create engineered particles with improved efficacy and stability, making it suitable for drugs and formulations including vaccines. The complexity of formulation design based on spray drying requires step-by-step guidance, which includes understanding solute concentration, solidification, and the use of stabilizers to produce stable powders.
KONA POWDER AND PARTICLE JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)