Article
Nanoscience & Nanotechnology
Jiaojiao Chen, Yarong Song, Wenqian Yang, Jianhui Guo, Saihui Zhang, Dong Wan, Yonghui Liu, Jie Pan
Summary: In this study, tumor-targeted polymeric micelles were synthesized, and drug release was achieved through extracellular enzyme response and intracellular reduction response, thereby improving the disadvantages of chemotherapy drugs. The experiments demonstrated that this method had good anti-tumor activity in vivo and reduced toxic side effects on normal tissues.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Medicinal
Quanling Guo, Lu Zhang, Mengmeng He, Xiaohua Jiang, Jingrui Tian, Qiurong Li, Zhiwei Liu, Longgang Wang, Haotian Sun
Summary: A method utilizing amphipathic and natural antibacterial peptide daptomycin to stabilize doxorubicin and form zwitterionic nanodrug showed promising targeting and anti-tumor effects in experiments, with higher cytotoxicity and tumor inhibition rate than free doxorubicin. The biocompatible daptomycin-based drug delivery system selectively accumulated at tumor sites in vivo through EPR effect, reducing toxicity and achieving excellent tumor inhibition.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Carolina Henriques Cavalcante, Renata Salgado Fernandes, Juliana de Oliveira Silva, Caroline Mari Ramos Oda, Elaine Amaral Leite, Geovanni Dantas Cassali, Ives Charlie-Silva, Bianca Helena Ventura Fernandes, Lucas Antonio Miranda Ferreira, Andre Luis Branco de Barros
Summary: The developed pH-sensitive micelles encapsulating DOX showed promising results with small diameter, high stability, low toxicity, and significantly better inhibition of tumor growth compared to other forms of DOX.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Irina Negut, Bogdan Bita
Summary: Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The advancement in the field of material science and nanomedicine has led to improved drug delivery systems with proven efficacy and fewer side effects. Various intelligent nanomedicines are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Thorough knowledge of these nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are simple to make and have high solubilization characteristics, making them a promising alternative in nanosystems for cancer treatment.
Review
Chemistry, Multidisciplinary
Balaram Ghosh, Swati Biswas
Summary: Polymeric micelles are extensively used for delivering poorly soluble chemotherapeutic agents in cancer treatment. These micelles can be easily tailored by self-assembly of amphiphilic polymers to optimize drug loading, stability, and delivery to target tissues. The current trend focuses on developing various block polymeric micelles and stimuli-sensitive micelles to enhance therapeutic activity.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Physical
Zhongjie Fei, Mehdi Yoosefian
Summary: This study investigates the assembly mechanism of Ribociclib encapsulated by DPC micelle using all-atom molecular dynamics simulations. The main forces involved in the drug encapsulation process are hydrophobic and van der Waals interactions, with hydrogen bonding and electrostatic interactions also contributing. Solvent accessible surface area and radial distribution function analyses show that DPC micelles can improve the aqueous solubility of hydrophobic drugs, providing a new pathway for designing drug delivery systems with necessary properties.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Pharmacology & Pharmacy
Lyubomira Radeva, Yordan Yordanov, Ivanka Spassova, Daniela Kovacheva, Virginia Tzankova, Krassimira Yoncheva
Summary: This study aimed to improve the safety of the anticancer drug doxorubicin by encapsulating it with the cardioprotective agent resveratrol in Pluronic micelles. The micelles were successfully prepared and characterized by small size and narrow size distribution. In vitro studies showed that the dual-loaded micelles reduced the cytotoxicity of doxorubicin in cardiac cells while enhancing its cytotoxic effect in lymphoma cells.
Review
Polymer Science
Suguna Perumal, Raji Atchudan, Wonmok Lee
Summary: This review discusses the self-assembly of amphiphilic polymers into micelles (polymeric nanoparticles) and their importance in bio-applications. Micelles, with their unique properties, size, shape, and biocompatibility, enhance drug loading and target release, making them a research focus in the field of biomedicine.
Article
Pharmacology & Pharmacy
Mohamad Mahani, Maral Bahmanpouri, Faeze Khakbaz, Faten Divsar
Summary: A pH-tunable on-off module polymeric micelles were synthesized for the delivery and controlled release of drug DOX. Nitrogen-doped carbon quantum dots were used to form micelles with robust fluorescence characteristics, and their properties were verified through various analyses. In vitro experiments showed that the developed nanocarrier exhibited good cytotoxicity against tumor cells, making it a promising approach for drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Instruments & Instrumentation
Rosario Pignatello, Roberta Corsaro, Angela Bonaccorso, Elide Zingale, Claudia Carbone, Teresa Musumeci
Summary: This study characterized Soluplus(R) nanomicelles to enhance the apparent solubility of drugs in BCS class II. The prepared nanomicelles showed small and stable particle size and could be easily filtered. The freeze-dried powder materials maintained the micelle size upon reconstitution. Additionally, the nanomicelles demonstrated potential applications in topical ocular administration.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Jaskiran Kaur, Vijay Mishra, Sachin Kumar Singh, Monica Gulati, Bhupinder Kapoor, Dinesh Kumar Chellappan, Gaurav Gupta, Harish Dureja, Krishnan Anand, Kamal Dua, Gopal L. Khatik, Kuppusamy Gowthamarajan
Summary: Amphiphilic block copolymers are widely used in drug delivery for enhancing bioavailability, molecular targeting, and sustained release. However, challenges such as premature drug release, low drug loading capacity, and poor stability need to be addressed for wider clinical utility. Future studies should focus on exploring their full potential in the treatment and diagnosis of diseases.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Materials Science, Biomaterials
Nannan Lu, Longchang Xi, Zengshi Zha, Yuheng Wang, Xinghua Han, Zhishen Ge
Summary: This study presents a pH-responsive endosomolytic polymeric micelle system for the delivery and activation of an oxidation-activable prodrug in cancer cells, leading to amplification of intracellular oxidative stress and effective tumor growth inhibition. The engineered micelles can release cinnamaldehyde under acidic conditions, promoting endosomal escape and induction of intracellular reactive oxygen species for prodrug activation. The ProCPT-loaded micelles demonstrate efficient tumor accumulation without significant toxic side effects, exerting synergistic therapeutic effects through enhancement of oxidative stress and prodrug activation.
BIOMATERIALS SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Sabna Kotta, Hibah Mubarak Aldawsari, Shaimaa M. Badr-Eldin, Anroop B. Nair, Y. T. Kamal
Summary: Polymeric micelles (PMs) have shown significant progress in drug delivery applications due to their robust core-shell structure and ability to solubilize hydrophobic drugs. This review presents the recent advances and understandings of PMs, including preparation methods, applications, and tumor-targeted delivery.
Article
Environmental Sciences
Muhammad Usman Akram, Naseem Abbas, Muhammad Farman, Suryyia Manzoor, Muhammad Imran Khan, Sameh M. Osman, Rafael Luque, Abdallah Shanableh
Summary: A therapeutic system is designed to release drugs at specific target tissues without damaging healthy cells, by using chitosan-based polymeric nanoparticles containing N-isopropyl acrylamide and 2-(di -isopropyl amino) ethyl methacrylate.
Review
Chemistry, Multidisciplinary
Xue Zheng, Jizhen Xie, Xing Zhang, Weiting Sun, Heyang Zhao, Yantuan Li, Cheng Wang
Summary: Polymeric nanomedicine, especially polymeric micelles (PM) with nanoscale size, shows promising physical and biological advantages such as excellent solubility, pharmacokinetics, efficacy, and lower toxicity. PM has garnered increasing interest in research and clinical applications, with good clinical outcomes but also facing challenges.
CHINESE CHEMICAL LETTERS
(2021)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
