Review
Chemistry, Multidisciplinary
Suliman Khan, Anwarul Hasan, Farnoosh Attar, Mohammad Mahdi Nejadi Babadaei, Hojjat Alizadeh Zeinabad, Majid Salehi, Morteza Alizadeh, Mahbub Hassan, Hossein Derakhshankhah, Michael R. Hamblin, Qian Bai, Majid Sharifi, Mojtaba Falahati, Timo L. M. ten Hagen
Summary: Microneedle arrays have attracted attention as cancer detection and treatment platforms, delivering active molecules through the skin and improving patient health. They enable controlled release of multiple drugs, optimizing treatment and preventing drug interactions.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Physical
Gabriela Mojeiko, Alexsandra Conceica Apolinario, Giovanna Cassone Salata, Marlus Chorilli, Luciana B. Lopes
Summary: In this study, an innovative nanoemulsified system was proposed for the local-transdermal co-delivery of celecoxib and endoxifen as a potential strategy for breast cancer prevention. The system showed enhanced penetration of the drugs into the skin and demonstrated synergistic anticancer effects in cell experiments.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Review
Biochemistry & Molecular Biology
Moong Yan Leong, Yeo Lee Kong, Kevin Burgess, Won Fen Wong, Gautam Sethi, Chung Yeng Looi
Summary: Nano-engineered medical products have emerged in the past decade. Current research focuses on developing safe drugs with minimal adverse effects. Transdermal drug delivery offers convenience, local targeting, and reduced toxicity. Nanomaterials provide alternatives to conventional methods and this article reviews the recent research and emphasizes the mechanisms and nano-formulations in use.
Article
Biochemistry & Molecular Biology
Madhu Sharma, Naresh Mittapelly, Venkatesh Teja Banala, Sandeep Urandur, Shalini Gautam, Disha Marwaha, Nikhil Rai, Neha Singh, Ashutosh Gupta, Kalyan Mitra, Prabhat Ranjan Mishra
Summary: HR+/HER2- metastatic breast cancer is a common and dangerous condition in women. A novel MN system using HA-PVA-PVP microneedle array is developed to deliver RB for breast cancer treatment, reducing toxicity and improving efficacy.
Review
Biochemistry & Molecular Biology
Zhiguo Li, Xuexun Fang, Dahai Yu
Summary: Transdermal drug delivery (TDD) has emerged as an effective alternative to traditional oral and injection administration, with potential for enhanced anti-obesity drug delivery. Obesity is a global epidemic with significant health threats, requiring more effective drug delivery strategies. Despite most studies being in the animal stage, the application of TDD in anti-obesity drugs could bring safe and effective therapies to obese patients in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Vivek Phatale, Klaudi K. Vaiphei, Shikha Jha, Dnyaneshwar Patil, Mukta Agrawal, Amit Alexander
Summary: Transdermal drug delivery system (TDDS) is a potential approach for effective drug delivery, with advantages such as easy administration, controlled release, and prolonged therapeutic effect. Poor skin permeability is a primary challenge, but can be overcome through fusion with other methods. This article summarizes the fundamental features, components, and design of TDDS, as well as methods for assessing skin permeability. It also explores the application of active methods and passive methods in transdermal drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Pharmacology & Pharmacy
Rong-Ping Chen, Vivek P. Chavda, Aayushi B. Patel, Zhe-Sheng Chen
Summary: Transdermal drug delivery is a safe and effective method of administering drugs through the skin. Transferosomes, flexible vesicles with better skin penetration properties, have been discovered as a promising carrier for transdermal drug delivery. By attaching specific herbal extracts to phosphatidylcholine, phytosomes (Transferosomes) improve drug solubility and absorption. This review highlights the potential of nanotechnology, particularly phytosomes, as lipid-based nanocarriers for transdermal drug delivery.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Polymer Science
Dong-Jin Lim, Hong-Jun Kim
Summary: This review provides an overview of advanced fabrication techniques for microneedles and discusses various drug coating and drug elution strategies. It also explores the potential of microneedle technologies in improving the clinical efficacy of treating skin diseases.
Article
Chemistry, Multidisciplinary
Song Li, Dengning Xia, Mark R. Prausnitz
Summary: The study introduces biphasic dissolvable microneedle patches which enhance efficient drug delivery to the skin, reducing drug residue and waste.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Tidayu Saramas, Phimchanok Sakunpongpitiporn, Kornkanok Rotjanasuworapong, Rawita Morarad, Sumonman Niamlang, Anuvat Sirivat
Summary: Transdermal drug delivery system using kappa-Carrageenan as the matrix material showed potential for controlled release of Metformin for abdominal obesity and diabetes. The porous matrices demonstrated varying pore sizes and drug release properties were influenced by the concentration of kappa-Carrageenan and applied electric strength.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
J. J. Zhu, C. H. Tang, F. C. Luo, S. W. Yin, X. Q. Yang
Summary: This study developed novel nanoparticles for the topical delivery of curcumin to treat atopic dermatitis. The nanoparticles showed enhanced penetration into the dermis and exhibited anti-inflammatory effects. The findings suggest a promising strategy for effective topical delivery systems.
MATERIALS TODAY CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Tao Sheng, Bowen Luo, Wentao Zhang, Xinyang Ge, Jicheng Yu, Yuqi Zhang, Zhen Gu
Summary: The application of microneedles for vaccine delivery has gained widespread interests due to its high compliance, minimal invasiveness, and convenience. Recent advances in the development and application of microneedles for vaccination based on different delivery strategies have been introduced. The prospects for its application including opportunities and challenges are further discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Biophysics
Zehua Li, Ranran Wu, Ke Chen, Wei Gu, Yi-Heng PJ. Zhang, Zhiguang Zhu
Summary: Recent advancements in enzymatic biofuel cells (EBFCs) have shown great potential in health monitoring and powering medical applications such as drug delivery. In this study, an EBFC was combined with a facial mask to enhance the transdermal permeability of target molecules using microcurrents. The results demonstrated a significant increase in drug permeation compared to non-iontophoretic transdermal drug delivery.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Chemistry, Analytical
Muhammet Avcil, Ayhan Celik
Summary: The innovative transdermal delivery technology of microneedle patch has great potential for various applications, but also faces limitations that need to be addressed for further improvements. Scientists and technologists should be aware of these concerns and allocate resources wisely.
Review
Veterinary Sciences
Jaskaran Bains, Scott Carver, Susan Hua
Summary: Sarcoptic mange is a serious parasitic infection in wombats that can potentially be treated through transdermal drug delivery. This review discusses the physiological impact of sarcoptic mange on wombats, the commonly used antiparasitic drugs, and the prospects for improving drug absorption.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Plant Sciences
Jiaojiao Cong, Yiling Ruan, Qinglin Lyu, Xiaohui Qin, Xinming Qi, Wenyuan Liu, Lifeng Kang, Junying Zhang, Chunyong Wu
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Seng Han Lim, Himanshu Kathuria, Muhd Hafiz Bin Amir, Xiyuan Zhang, Hien T. T. Duong, Paul Chi-Lui Ho, Lifeng Kang
Summary: By investigating the ratio of two liquid monomers, a suitable resin for 3D printing was developed and successfully loaded with AHP-3 for the fabrication of personalized MN patches. The experimental results demonstrated that the patch had good drug penetration and biocompatibility, providing a new approach for effective wrinkle management.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Justin J. Y. Tan, Duc-Viet Nguyen, John E. Common, Chunyong Wu, Paul C. L. Ho, Lifeng Kang
Summary: Hair follicle morphogenesis relies on the interaction between epidermal stem cells and specialized mesenchymal cells. Previous studies have shown that co-culture with keratinocytes can maintain the characteristics of the dermal papilla, but challenges exist due to poor intercellular adherence. Developing long-term 3D co-culture models is difficult because of keratinocytes' exfoliative behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Seng Han Lim, Sol Park, Chun Chuan Lee, Paul Chi Lui Ho, Philip Chi Lip Kwok, Lifeng Kang
Summary: An in vitro human upper respiratory tract model was fabricated and tested for drug deposition patterns, showing promising correlation with in vivo studies. This model could potentially open up opportunities for personalized medicine in specific populations or disease states.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Medicine, Research & Experimental
Yiling Ruan, Xinran Li, Linjun You, Jungen Chen, Yueyue Shen, Junying Zhang, Yaozuo Yuan, Lifeng Kang, Chao Qin, Chunyong Wu
Summary: This study demonstrates that certain pharmaceutical excipients can impact the intestinal absorption of metformin by affecting various transporters. Understanding the interaction between excipients and cation-selective transporters may enhance the formulation design and clinical application of cationic drugs.
MOLECULAR PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Wenting Liao, Qiwen Jin, Junning Liu, Yiling Ruan, Xinran Li, Yueyue Shen, Zhicheng Zhang, Yong Wang, Shengming Wu, Junying Zhang, Lifeng Kang, Chunyong Wu
Summary: This study investigated the protective effect of Mahuang decoction (MHD) against acute liver failure (ALF), demonstrating that MHD alleviated liver damage in an ALF mouse model by modulating the tricarboxylic acid cycle and amino acid metabolism.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jungen Chen, Junxing Bian, Basil M. Hantash, Lamyaa Albakr, David E. Hibbs, Xiaoqiang Xiang, Peng Xie, Chunyong Wu, Lifeng Kang
Summary: A novel peptide called Decapeptide-12 was modified by adding a palmitate chain to enhance its transcutaneous penetration, and the modified palm-peptide showed improved skin retention due to increased lipophilicity. The combinatory approach of molecular modification, chemical penetration enhancers, and microneedle patch proved to be effective in enhancing skin permeation of the peptides, potentially offering a promising solution for treating hyperpigmentation without the adverse effects associated with traditional treatments like hydroquinone.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Himanshu Kathuria, Harish K. Handral, Saera Cha, Diep T. P. Nguyen, Junyu Cai, Tong Cao, Chunyong Wu, Lifeng Kang
Summary: The study aimed to investigate the role of propylene glycol-based liposomes named 'proposomes' in enhancing skin permeation of drugs with different physicochemical properties. The results showed that proposomes significantly enhanced drug permeation through the skin, with enhancement ratio linearly correlated to drug's logP, molecular weight, and melting point. Confocal imaging demonstrated higher skin permeation of drugs in proposomes compared to solution, with proposomes found safe for skin application. The entrapment efficiency of drugs in proposomes was positively correlated with drug's logP, leading to high drug absorption.
Review
Pharmacology & Pharmacy
Ahmad Fahmi bin Anwar-Fadzil, Yunong Yuan, Lingxin Wang, Jaspreet S. Kochhar, Nezamoddin N. Kachouie, Lifeng Kang
Summary: This review summarises the recent development of 3D-printed dosage forms, including their applications, active pharmaceutical ingredients, printers and materials used, and discussions on topics such as personalised dosing, drug combinations, and compounding pharmacies. 3D printing is expected to become a common tool for personalised medications and revolutionise the future of pharmacy practice.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Si Kei Vong, Lifeng Kang, Stephen R. Carter
Summary: This study developed and validated a self-report measure, the FD-NPM scale, to evaluate the extent to which consumers follow directions when using non-prescription medicines (NPMs). The findings showed that less than 20% of participants always or often followed the dosage, frequency, and duration instructions. Consumers with high-risk perception towards NPMs, younger individuals, and those with higher education were more likely to not follow the directions.
RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY
(2022)
Article
Nanoscience & Nanotechnology
Junying Zhang, Yiwen Zhang, Hufang Wang, Wenlin Chen, Aiyu Lu, Hailiang Li, Lifeng Kang, Chunyong Wu
Summary: This study prepared a solid dispersion of CUR in Mogroside V (Mog-V), a non-nutritive natural sweetener, which can self-assemble into micelles in water and effectively improve the water solubility and oral absorption of CUR. The results showed that compared with pure CUR crystals, the solid dispersion increased the solubility of CUR by nearly 6000 times and the oral absorption of CUR by 29 folds in rats.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Klaudia Englezos, Lingxin Wang, Edwin C. K. Tan, Lifeng Kang
Summary: The healthcare dynamic has shifted to patient-centred care, requiring more individualised therapies. However, the pharmaceutical industry has not fully adapted to this shift, preventing pharmacists from providing completely personalised medicine to patients. This article reviews the limitations of current pharmaceutical manufacturing methods, discusses the benefits of 3D printing for personalised medicine, and explores the implications for pharmacy practice and policy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biotechnology & Applied Microbiology
Yunong Yuan, Yiting Han, Chun Wei Yap, Jaspreet S. S. Kochhar, Hairui Li, Xiaoqiang Xiang, Lifeng Kang
Summary: Stratum corneum as the outermost layer of the skin prevents external substances from entering the human body. Microneedles can facilitate drug permeation through the skin by penetrating the stratum corneum. Machine learning methods are employed to predict drug permeation through the skin, eliminating the need for costly and time-consuming experiments.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Chemistry, Inorganic & Nuclear
Seoyoon Song, Deborah Lee, Lucia C. Dalle Ore, Sungjun Kwak, Lifeng Kang, Hyung Kyo Kim, Noah Malmstadt, Sun Min Kim, Tae-Joon Jeon
Summary: This paper introduces the latest advancements in photoactivable liposomes in drug delivery, highlighting their advantages in precise control over drug release and targeted delivery, as well as the fine control over release kinetics achieved through the manipulation of light-responsive components. Additionally, the paper emphasizes the design considerations of physicochemical properties and light-related constituents.
COORDINATION CHEMISTRY REVIEWS
(2024)
Article
Polymer Science
Sol Park, Naomi W. Y. Huang, Cheryl X. Y. Wong, Jing Pan, Lamyaa Albakr, Jing Gu, Lifeng Kang
Summary: Tooth loss can impact quality of life and psychological health, leading to increased interest in bioengineering of teeth. By using MeHA hydrogel microwell scaffolds, interactions between epithelial and mesenchymal cells can be facilitated, showing promise for in vitro bioengineering of human tooth germs.
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
