Article
Biochemistry & Molecular Biology
Derya Burcu Hazer Rosberg, Baki Hazer, Lena Stenberg, Lars B. Dahlin
Summary: The study showed that conduits modified with gold and cobalt-oxide nanoparticles improved axonal outgrowth and decreased the number of apoptotic Schwann cells, leading to enhanced nerve regeneration after reconstruction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Tabinda Riaz, Nafisa Gull, Atif Islam, Muhammad Rizwan Dilshad, Leonard Ionut Atanase, Christelle Delaite
Summary: Summary: A novel bilayer structure of PCL nanofibers deposited on a hydrogel layer of GE and HA was prepared using needleless electrospinning for drug delivery. IBU was successfully loaded into the nanofibrous structure, and the GH hydrogel films showed good mechanical strength and hydrophilicity. The IBU-loaded bilayer films demonstrated controlled drug release, with 45% release of IBU in 48 hours. The antibacterial analysis showed mild inhibition against E. coli in the case of IBU-loaded nanofibers, suggesting their potential as effective wound dressings.
Article
Polymer Science
Balakondareddy Sana, Nancy Ferrentino, Taha Behroozi Kohlan, Yaqun Liu, Valdas Pasiskevicius, Anna Finne-Wistrand, Daniela Pappalardo
Summary: We have designed a light-sensitive polymer material that self-assembles into core-shell nanoparticles and releases encapsulated fluorescent dye upon light irradiation.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Yuandou Wang, Shuxin Wang, Wenju Hu, Feng Su, Fusheng Liu, Suming Li
Summary: Amphiphilic block copolymers were synthesized and photo-crosslinked hydrogels were prepared. The hydrogels exhibited high swelling and excellent biocompatibility. Drug loading efficiency and release rate were dependent on the hydrogel properties. Hydrogels with higher drug concentration and shorter hydrophobic block length showed higher anti-cancer activity. Therefore, these hydrogels have great potential for long-term local cancer therapy.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Polymer Science
Muhammad Suhail, Yi-Han Hsieh, Arshad Khan, Muhammad Usman Minhas, Pao-Chu Wu
Summary: A new type of aspartic acid/alginic acid-co-poly(acrylic acid) hydrogels was developed for the controlled delivery of ibuprofen, exhibiting pH-dependent swelling and drug release properties. Various analytical techniques confirmed the structural properties and stability of the hydrogels.
Article
Materials Science, Multidisciplinary
Hongwen Sun, Jiachun Feng
Summary: The study investigated the nucleation effect of the synthesized nucleating agent Ca-HHPA on PCL by different thermal treatments. The results showed that Ca-HHPA80-200 had a significantly improved nucleation efficiency compared to Ca-HHPA80 under similar dosages.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Engineering, Chemical
Keziban Huner
Summary: Conductive polymers (P3ANA and PEDOT:PSS) were mixed with biocompatible and biodegradable PCL to prepare electrospun nanofibers. The nanofibers containing 10% P3ANA showed the highest antioxidant activity and were non-toxic to cells. The nanofiber with the highest amount of P3ANA also had a higher anodic current value than other P3ANA nanofibers.
POLYMER ENGINEERING AND SCIENCE
(2023)
Article
Polymer Science
Victoria J. Barber, Meredith A. Borden, Jill W. Alty, Ly D. Tran, Hilmar Koerner, Luke A. Baldwin, Erik J. Alexanian, Frank A. Leibfarth
Summary: There is an increasing demand for degradable polymers in sustainable plastics and medical implants. To improve their usability, it is necessary to have a better understanding of degradation factors and develop new tools for modulation. In this study, poly(caprolactone) was modified through C-H xanthylation, resulting in changes in material properties and slower degradation. The interplay between molecular and materials characteristics was found to impact the degradation rate.
Article
Agricultural Engineering
Weijun Yang, Yanlin Zhu, Yongbin He, Liqiang Xiao, Pengwu Xu, Debora Puglia, Piming Ma
Summary: In this study, nanocomposites of PLLA-PCL-lignin were prepared to improve the mechanical and thermal properties of PLA. The results showed that the nanocomposites had increased impact strength and UV-B resistance. Additionally, annealing treatment improved the storage modulus of the nanocomposites.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Engineering, Environmental
Matias Menossi, Florencia Salcedo, Nazarena Rivilli, Andres Torres Nicolini, Vera A. Alvarez, Leandro N. Luduena
Summary: Novel formulations based on corn starch, thermoplastic starch, poly (lactic acid), and poly (epsilon-caprolactone) were developed for agricultural mulch films. The addition of poly (epsilon-caprolactone) had slight effects on the properties of PLA/CS and PLA/TPS blends. Bioassays showed that the use of these biodegradable mulch films based on PLA/CS and PLA/TPS had positive effects on the growth of tomato plants, comparable to low-density polyethylene.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Ekkachai Martwong, Yvette Tran
Summary: The study reports on the synthesis and temperature-responsive properties of poly(PEGMA) hydrogel thin films. Surface-attached poly(PEGMA) hydrogel films were synthesized using a simple, versatile, and well-controlled thiol-ene click reaction method, with the transition temperature finely tunable by adjusting the number of PEG units. The LCST properties of the hydrogel films are not sensitive to salt, holding promise for applications in biology such as injectable hydrogels, drug delivery systems, microfluidic valves, and flow switches for biotechnologies.
Article
Materials Science, Paper & Wood
Melika Sharahi, Ahmad Hivechi, S. Hajir Bahrami, Nahid Hemmatinejad, Peiman B. Milan
Summary: This study produced nanoparticles from walnut shells and co-electrospun them with polycaprolactone and gelatin to create nanofibers with excellent mechanical properties. The nanofiber scaffolds showed excellent viability, growth, and proliferation of adipose-derived mesenchymal stem cells.
Article
Polymer Science
Prasong Srihanam, Yaowalak Srisuwan, Theeraphol Phromsopha, Apirada Manphae, Yodthong Baimark
Summary: In this study, the phase compatibility and mechanical properties of flexible poly(L-lactide)-b-poly(ethylene glycol)-b-poly(L-lactide) (PLLA-PEG-PLLA)/thermoplastic starch (TPS) blends were improved by adding citric acid (CA) as a compatibilizer. The crystallinity of PLLA-PEG-PLLA matrix was suppressed and the thermal stability was enhanced by CA modification of TPS. The compatibility between TPS and PLLA-PEG-PLLA phases was improved, and the blends exhibited increased tensile strength, elongation at break, and Young's modulus with higher CA content.
Article
Polymer Science
Wasana Nonkrathok, Tatiya Trongsatitkul, Nitinat Suppakarn
Summary: In this study, the shape memory properties of poly(lactic acid) (PLA)/poly(ethylene glycol) (PEG) blends were improved by adding maleic anhydride-grafted poly(lactic acid) (PLA-g-MA) as a compatibilizer. The PLA-g-MA improved interfacial adhesion between phases and promoted chain entanglement, leading to enhanced mechanical properties and shape fixity performance. The compatibilized blend containing 2 wt% PLA-g-MA exhibited the best shape fixity and recovery performance.
Article
Polymer Science
Wei-Chi Lai, Li-Jie Liu
Summary: Polylactic acid (PLA) bioplastics have garnered attention due to their biomass-derived nature and low toxicity. However, the slow crystallization of PLA limits its commercial applications. This study developed a simple and cost-effective approach using eco-friendly low molecular weight poly(ethylene glycol) (PEG) as a green solvent to enhance the PLA crystallization process.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Biophysics
Jiraphong Suksiriworapong, Vincenzo Taresco, Delyan P. Ivanov, Ioanna D. Styliari, Krisada Sakchaisri, Varaporn Buraphacheep Junyaprasert, Martin C. Garnett
COLLOIDS AND SURFACES B-BIOINTERFACES
(2018)
Article
Chemistry, Applied
Boontida Morakul, Veerawat Teeranachaideekul, Varaporn Buraphacheep Junyaprasert
JOURNAL OF MICROENCAPSULATION
(2019)
Article
Plant Sciences
Pornpatsorn Lertphadungkit, Jiraphong Suksiriworapong, Veena Satitpatipan, Supaart Sirikantaramas, Amaraporn Wongrakpanich, Somnuk Bunsupa
Article
Pharmacology & Pharmacy
Parichart Thummarati, Jiraphong Suksiriworapong, Krisada Sakchaisri, Varaporn Buraphacheep Junyaprasert
Summary: Chemical linkers play a crucial role in determining the physicochemical properties, stability and cytotoxic activities of CUR-HA conjugate nanoparticles. The nanoparticles with pH-sensitive linkers demonstrated better stability, lower drug release at physiological pH, and higher release in acidic cancer cell environments, showing potential for cancer therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Parichart Thummarati, Jiraphong Suksiriworapong, Krisada Sakchaisri, Thomas Nawroth, Peter Langguth, Benjamaporn Roongsawang, Varaporn Buraphacheep Junyaprasert
Summary: Dual-delivery nanoparticles of GEM and CUR conjugated on HA were developed for targeted cancer therapy. The nanoparticles showed pH-dependent drug release and exhibited superior characteristics in terms of particle size, size distribution, and critical aggregation concentration. In vitro studies demonstrated enhanced cellular uptake and cytotoxicity in cancer cell lines compared to conventional drug delivery methods.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Veerawat Teeranachaideekul, Putita Boribalnukul, Boontida Morakul, Varaporn Buraphacheep Junyaprasert
Summary: The study revealed that different types and content of oil had an impact on the chemical stability and release of lutein, with NLC and NE prepared from coconut oil showing higher release but those prepared from rice bran oil exhibiting better penetration through the skin.
Article
Chemistry, Multidisciplinary
Sumet Chongruchiroj, Jaturong Pratuangdejkul, Kittisak Sripha, Brompoj Prutthiwanasan
Summary: A lecithin molecularly imprinted polymer (LEC-MIP) for endotoxin removal was developed and synthesized under specific conditions, showing the optimal binding performance with up to 47% endotoxin removal rate.
Article
Polymer Science
Amaraporn Wongrakpanich, Nichakan Khunkitchai, Yanisa Achayawat, Jiraphong Suksiriworapong
Summary: This study developed ketorolac microparticles using hyaluronic acid stabilized poly(lactide-co-glycolide) (PLGA), poly(lactide) (PLA), and their blend for osteoarthritis treatment. Different emulsification techniques and polymer compositions influenced the microparticle characteristics, with probe sonication resulting in smaller size and broader size distribution than high-speed stirring. The microparticles showed biphasic drug release over 35 days and demonstrated potential for treating osteoarthritis.
Article
Pharmacology & Pharmacy
Boontida Morakul, Varaporn Buraphacheep Junyaprasert, Krisada Sakchaisri, Veerawat Teeranachaideekul
Summary: The aim of this study was to improve the stability and anti-inflammatory activity of cannabidiol (CBD) for dermal delivery by encapsulating it in nanostructured lipid carriers (NLCs). CBD-NLCs were prepared using different oils and surfactants, and showed successful encapsulation with small particle sizes. The CBD-NLCs exhibited enhanced chemical stability and slower release of CBD, as well as reduced cytotoxicity and increased anti-inflammatory activity compared to the CBD extract alone.
Article
Pharmacology & Pharmacy
Jiraporn Leanpolchareanchai, Patamaporn Tangteerakoon, Patcharin Supapsophon, Somsiri Sukavatcharin, Pornchai Simaroj, Jiraphong Suksiriworapong
Summary: This study aimed to prepare extemporaneous 20 mg/mL ganciclovir in artificial tears and compare its stability with that of ganciclovir in sterile water for ophthalmic administration. The results showed that ganciclovir/0.1% HYA eyedrops had good stability at different temperatures and could be used as home medications for the treatment of ophthalmic viral infections.
Article
Pharmacology & Pharmacy
Jiraphong Suksiriworapong, Nutthachai Pongprasert, Somnuk Bunsupa, Vincenzo Taresco, Valentina Cuzzucoli Crucitti, Thitapa Janurai, Pornpoj Phruttiwanichakun, Krisada Sakchaisri, Amaraporn Wongrakpanich
Summary: This study aimed to enhance the anticancer effect of Cordyceps militaris herbal extract (CME) on breast cancer cells by using hyaluronic acid (HYA) surface-decorated lipid polymer hybrid nanoparticles (LPNPs), and evaluate the feasibility of using a synthesized poly(glycerol adipate) (PGA) polymer for LPNP preparation. The results showed that the synthesized polymers could successfully encapsulate CME in LPNPs. The HYA-decorated PGA-based LPNPs significantly improved the anticancer effect of CME against breast cancer cells by enhancing cellular uptake through CD44 receptor-mediated endocytosis.
Article
Chemistry, Medicinal
Somjate Laivut, Primchanien Moongkarndi, Worawan Kitphati, Pattarawit Rukthong, Korbtham Sathirakul, Kittisak Sripha
Summary: In this study, several phenoxyindole derivatives were synthesized and tested for their neuroprotective effects on SK-N-SH cells. The compounds showed potential in protecting the cells against A beta-induced cell death and having anti-A beta aggregation and antioxidant activities. Compound 5 exhibited the strongest effects in both anti-A beta aggregation and antioxidant assays, while compound 8 showed the highest cell viability. These compounds have the potential to be novel therapeutic approaches for Alzheimer's disease.
Article
Pharmacology & Pharmacy
Jiraphong Suksiriworapong, Chittin Achayawat, Phutthikom Juangrattanakamjorn, Vincenzo Taresco, Valentina Cuzzucoli Crucitti, Krisada Sakchaisri, Somnuk Bunsupa
Summary: This study aimed to fabricate new variations of glycerol-based polyesters by grafting poly(glycerol adipate) (PGA) with hydrophobic bioactive moieties, tocopherol (TOC), and cholesterol (CHO). Their effects on nanoparticle (NP) formation, drug release, and cellular responses in cancer and normal cells were evaluated. The results showed that both PGA-TOC NPs and PGA-CHO NPs could be used as delivery systems for anticancer drugs, with different characteristics and effects on cancer and normal cells.
Review
Pharmacology & Pharmacy
Varaporn Buraphacheep Junyaprasert, Parichart Thummarati
Summary: Polymer-drug conjugates (PDCs) have emerged as a versatile and effective approach to enhance cancer therapy. This review provides an overview of recent advancements in PDCs, including the choice of polymers, strategies for drug-polymer conjugation, and the importance of tumor-targeting ligands.
Article
Chemistry, Medicinal
M. Kawami, Y. Yamada, O. Issarachot, V. B. Junyaprasert, R. Yumoto, M. Takano
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
