Article
Plant Sciences
Xiuhuan Wang, Ying Dong, Ruolan Song, Axiang Yu, Jing Wei, Qiqi Fan, Jianling Yao, Dongjie Shan, Xiangjian Zhong, Fang Lv, Gaimei She
Summary: This study investigated the intestinal metabolism, absorption properties, and mechanism of the anti-rheumatic arthritis fraction (ARF) extracted from Dianbaizhu in vitro and in situ models. The results showed that the absorption of ARF in the small intestine was significantly stronger than in the colon, with the best absorption sites identified as duodenum and ileum in normal and model rats, respectively. Additionally, it was found that MSTG-B, MSTG-A, and Gaultherin were likely to be substrates of P-glycoprotein, while other ingredients were not.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Melissa Metry, James E. Polli
Summary: This review article summarizes literature data on the potential effects of excipients on intestinal drug permeability and transit. Excipients have been used in drug products for many years, but there is ongoing research to evaluate their impact on drug bioavailability. Regulatory agencies have established in vivo bioequivalence standards and may waive in vivo testing for certain oral products through biowaivers. Biowaiver acceptance criteria are based on in vitro characterization using the Biopharmaceutics Classification System. Recent FDA guidance has become more restrictive, particularly regarding the risk of excipients such as sugar alcohols.
Article
Entomology
Chiyoko Miyata, Yoshihide Matoba, Makiko Mukumoto, Yoshiaki Nakagawa, Hisashi Miyagawa
Summary: The ability to predict the environmental behavior of chemicals is crucial for better regulation. This study evaluated the bioaccumulation of different chemicals in fish using a specific method, and found that the same criteria could be used to predict low bioaccumulation through both the gill membrane and the intestinal tract.
JOURNAL OF PESTICIDE SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Xi Tang, Hui Feng, Jie Gao, Ruohong Bi, Lin Pan, Yi Shi, Yunfeng Han, Xianrong Lai
Summary: This study investigated the intestinal absorption characteristics of berberine hydrochloride (BBH) under different perfusion conditions in rats. The results showed that BBH is absorbed through passive diffusion in a neutral environment of pH 7.4, and the jejunum is the most efficient segment for absorption.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Cheng-Qi Jia, Shu-Yan Wang, Ye Yuan, Yu-Qing Wu, Yan Cai, Jun-Wei Liu, Hai-Qiu Ma
Summary: Vitamin B12 is a vital micronutrient that cannot be synthesized by the human body and needs to be obtained from the diet. Its absorption in the gastrointestinal tract is mediated by intrinsic factor. The present study aims to increase VB12 intestinal absorption using cost-effective excipients and formulations.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Biology
Weiyin Huang, Shuang Chen, Lin Sun, Hubin Wwang, Hongqun Qiao
Summary: The study investigated the intestinal permeability of lamivudine using Caco-2 cells monolayer and single-pass intestinal perfusion, revealing a passive diffusion absorption mechanism possibly related to efflux transporters. Lamivudine was classified as a moderate-permeability drug in the Biopharmaceutics Classification System.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Gerwin Louis T. Dela Torre, Alice Alma C. Bungay
Summary: This study investigated the effect of probiotic Lactobacillus acidophilus on the transepithelial mucosal-to-serosal transport of colchicine. The results showed that Lactobacillus acidophilus BIOTECH 1900 reduced the transport of colchicine, suggesting a potential induction of P-gp.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
Article
Multidisciplinary Sciences
Aditi Jangid, Shinji Fukuda, Masahide Seki, Yutaka Suzuki, Todd D. Taylor, Hiroshi Ohno, Tulika Prakash
Summary: The interaction between gut microbiota and intestinal epithelium plays a crucial role in intestinal immune homeostasis and barrier function. This study found that knockout of the Piga gene in mice resulted in reduced microbiota diversity, increased presence of pathogenic bacteria, and decreased beneficial capabilities.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Sage E. Foley, Christine Tuohy, Merran Dunford, Michael J. Grey, Heidi De Luca, Caitlin Cawley, Rose L. Szabady, Ana Maldonado-Contreras, Jean Marie Houghton, Doyle Ward, Randall J. Mrsny, Beth A. McCormick
Summary: The study finds that specific genera within the Clostridia and Bacilli classes of the intestinal microbiome are essential for inducing P-glycoprotein (P-gp) expression in the intestinal epithelium. Metabolites produced by these microbial communities, such as short-chain fatty acids and secondary bile acids, positively associate with P-gp expression and synergistically upregulate P-gp function. In patients with ulcerative colitis, reduced P-gp expression is linked to a decrease in anti-inflammatory endocannabinoids and luminal content that can induce P-gp expression, highlighting the important role of the microbiome in regulating intestinal inflammation.
Article
Pharmacology & Pharmacy
Xiao-Hang Liu, Xin-Rong Li, Xiao-Ming Gao, Mei Wang, Zhan-Ying Chang, Xiao-Li Gao
Summary: The study investigated the permeability of Conjugated Estrogens (CEs) as a potential drug using rat intestinal perfusion and cell monolayer models. The results showed that CEs had similar permeability to a reference drug and that their permeability was time- and concentration-dependent. P-gp was found to be involved in the transport of CEs. Overall, CEs can be considered as a drug with moderate permeability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mrunal Pradeep Desai, Prajakta Harish Patil, Sai Krishna Anand Vullendula, Sumit Birangal, G. Gautham Shenoy, Mahadev Rao, Swapnil Jayant Dengale, Krishnamurthy Bhat, Jagadish Puralae Channabasavaiah
Summary: Molecular docking and ex vivo gut sac model were used to investigate the inhibitory effect of proton pump inhibitors on P-glycoprotein mediated efflux of palbociclib and ribociclib. The study found that proton pump inhibitors bind to the ATP binding site, inhibiting the efflux of palbociclib and ribociclib mediated by P-glycoprotein.
CURRENT DRUG METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Zhixiang Liu, Tong An, Rui Yuan, Maoxiong Tian, Linlin Yuan, Tong Zhang, Gang Cheng
Summary: This study investigated the applicability of mPEG-PR as a novel non-absorbable indicator in the in situ single-pass intestinal perfusion (SPIP) experiment. The results showed that mPEG-PR was a stable and accurate method for correcting water flux and predicting the fraction dose absorbed in human.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yuan Chen, Xiaowei Jin, Yanhui Kuang, Sisi Zhang, Chuanping Zhang, Chuyuan Li, Bohong Guo
Summary: The objective of this study was to develop a new method for delivering oral borneol (BN) drug that improves stability. The researchers achieved this by microencapsulation using HiCap (R) 100 and maltodextrin (MD), resulting in HiCap (R) 100/MD/BN microcapsules (MCs). The MCs showed improved stability, drug release behavior, and intestinal permeability in rat models.
Article
Pharmacology & Pharmacy
Olfa Ben Hadj Ayed, Mohamed Ali Lassoued, Badr Bahloul, Souad Sfar
Summary: The study focused on developing a new QTF-loaded SEDDS to improve the dissolution and absorption of the drug. The optimized formulation showed enhanced dissolution rate and permeability compared to the free drug, suggesting a new way to improve the drug's bioavailability.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Tingting Yao, Lili Zhu, Jiajia Wang, Chunxia Lu, Yuan Su, Haiming Fang, Lijiu Zhang
Summary: This study aimed to evaluate the hepatic and intestinal first-pass effect of S-adenosylmethionine (SAMe) in rats and explore its potential mechanism. The results showed that SAMe exhibited dose-dependent pharmacokinetic characteristics when administered via different routes, with higher extraction in the intestine than in the liver. Intestinal CYP3A4 and P-glycoprotein may be involved in the intestinal first-pass extraction of SAMe. Inhibition of intestinal CYP3A4 and P-glycoprotein activity may be an effective approach to improve the bioavailability of SAMe.
ACTA POLONIAE PHARMACEUTICA
(2022)
Article
Biochemical Research Methods
Yeli Guan, Qiao Deng, Gao Li, Luqin Si, Lihong Long, Mohammadali Soleimani Damaneh, Jiangeng Huang
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Ajaz Ahmad, Saeed Alqahtani, Basit Latief Jan, Mohammad Raish, Abdullah K. Rabba, Khalid M. Alkharfy
SAUDI PHARMACEUTICAL JOURNAL
(2020)
Article
Medicine, Research & Experimental
Wan-yu Liu, Cong-ming Zou, Jian-hua Hu, Zi-jun Xu, Lu-qin Si, Jun-jun Liu, Jian-geng Huang
CURRENT MEDICAL SCIENCE
(2020)
Article
Biotechnology & Applied Microbiology
Abdullah K. Rabba, Ayeshe M. Abu Hussein, Bayan K. Abu Sbeih, Somaya Nasser
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Medicine, Research & Experimental
Ying Zhang, Minghui Sun, Shuxin Jian, Jiangeng Huang, Chuyao Xiao, Xiangyu Zhang, Ruhao Hu, Luqin Si
Summary: This study demonstrates that amphiphilic polymer micelles can inhibit the transport function of OCTs, indicating a potential risk of drug-drug interactions during concurrent medication of nanomedicine with organic cationic drugs.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Meng-Meng Pan, Yu Ouyang, Yong-Li Song, Lu-Qin Si, Ming Jiang, Xu Yu, Li Xu, Itamar Willner
Summary: In this study, the synthesis and characterization of Au3+-modified UiO-67 metal-organic framework nanoparticles were described. The Au3+-NMOFs showed dual oxidase-like and peroxidase-like activities, and acted as an effective catalyst for the generation of ROS agents for antibacterial and wound healing applications.
Article
Pharmacology & Pharmacy
Li Kang, Dan Li, Xin Jiang, Yao Zhang, Minhong Pan, Yixin Hu, Luqin Si, Yongjun Zhang, Jiangeng Huang
Summary: This study demonstrates for the first time that Polygoni Multiflori Radix (PMR) and its major anthraquinones have hepatotoxic effects in mice by altering bile acid homeostasis through the regulation of bile acid efflux transporters. These findings provide a theoretical basis for the quality control and safe use of PMR in clinical practice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Yixin Hu, Jianyuan Wu, Xin Jiang, Guiying Chen, Yang Zhang, Luqin Si, Hongliang Jiang, Jiangeng Huang, Jianying Huang
Summary: A rapid, simple and sensitive LC-MS/MS method was developed and validated to quantify abiraterone and its metabolites in human plasma. The method showed good accuracy, precision and stability, making it suitable for pharmacokinetic studies.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Pharmacology & Pharmacy
Hani Naseef, Yousef Sahoury, Mohammad Farraj, Moammal Qurt, Abdallah D. Abukhalil, Nidal Jaradat, Israr Sabri, Abdullah K. Rabba, Mahmmoud Sbeih
Summary: This study aimed to develop and evaluate a cream formulation containing fusidic acid and natural products for eradicating fusidic-acid-resistant microorganisms in skin infections. The study found that the cream had stable physical and chemical properties, and demonstrated better antimicrobial activity than the marketed product.
Article
Chemistry, Multidisciplinary
Naseef Hani, Nawaf Al-Maharik, Abdullah K. Rabba, Majid Sharifi-Rad, Mohammed Hawash, Nidal Jaradat
Summary: This study identified the chemical constituents of Lavandula coronopifolia (LC) aerial parts volatile oil (VO) from Palestine and demonstrated its potent bactericidal, anti-inflammatory, and cytotoxic effects. The results suggest that LC-VO is a promising alternative for treating various infectious diseases, cancer, and chronic inflammation.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Medicine, General & Internal
Hani Naseef, Dana Joza', Ahlam Awawdeh, Alaa Hasan, Abdallah Damin Abukhalil, Ni'meh Al-Shami, Abdullah Rabba
Summary: The study in Palestine found that around 50% of patients engaged in self-medication with antibiotics, with primary access through community pharmacies. Despite varying levels of awareness about antibiotics, educating patients about the risks of inappropriate antibiotic use is crucial for reducing demand.
PATIENT PREFERENCE AND ADHERENCE
(2022)
Article
Medicine, General & Internal
Abdallah Damin Abukhalil, Hiba Falana, Rawan Hamayel, Fatima Yasser, Aleen Nasser, Hani Naseef, Ni'meh Al-Shami, Abdullah Rabba
Summary: This study investigated the prevalence of vitamin D deficiency and its associated comorbidities in Palestine, revealing a high and alarming prevalence of vitamin D deficiency as well as significant associations with symptoms such as back pain, arthritis, and hypothyroidism. Health initiative programs are needed to increase awareness and further research should be conducted to confirm the relationship between vitamin D supplementation and the reduced risk of comorbid diseases.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Medicine, General & Internal
Abdallah Damin Abukhalil, Ola Ali, Asmaa Saad, Hiba Falana, Ni'meh Al-Shami, Hani A. Naseef, Abdullah Rabba
Summary: This study aimed to assess the appropriate utilization of PPIs in terms of indication, dose, frequency, and route of administration. The study found that most patients received appropriate PPI treatment, but there was a high prevalence of inappropriate IV pantoprazole administration, resulting in the highest costs, highlighting the importance of correctly ordering IV medications.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Medicine, General & Internal
Abdullah K. Rabba, Waffa O. Atta, Aseel N. Naser, Aya A. Injas, Hani A. Naseef, Abdallah D. Abukhalil
Summary: This study aimed to assess the prevalence and risk factors associated with drug-drug interactions among patients admitted to internal medicine departments in Palestinian hospitals. A high prevalence of potential drug-drug interactions was found, which was associated with polypharmacy, increased age, and increased length of hospitalization.
SAGE OPEN MEDICINE
(2022)
Article
Plant Sciences
Dan Wang, Minghui Sun, Ying Zhang, Zehong Chen, Shuya Zang, Genyun Li, Gao Li, Andrew R. Clark, Jiangeng Huang, Luqin Si
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)