Article
Materials Science, Multidisciplinary
Jeffrey Watchorn, Samantha Stuart, Darcy C. Burns, Frank X. Gu
Summary: Optimizing delivery vehicle properties is crucial for improving the delivery of pharmaceuticals. Mucoadhesion, a designed property that enhances the interaction between polymers and mucins, is an effective approach to increase drug residence times and uptake efficiency. Using nuclear magnetic resonance, this study investigated the influence of polymer design parameters on mucoadhesion and uncovered key findings on the polymer-mucin interaction at the atomic level. The results provide insights into the importance of polymer design and mucoadhesive functional groups for drug delivery.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Computer Science, Interdisciplinary Applications
Davide Candoli, Ilija K. Nikolov, Lucas Z. Brito, Stephen Carr, Samuele Sanna, Vesna F. Mitrovic
Summary: This open-source software simulates observables in magnetic resonance experiments, such as NMR/NQR and ESR. It aims to assist experimental research in the design of new strategies for investigating quantum properties of materials. The software can simulate standard NMR spectroscopic observables and the time-evolution of interacting single-spin systems subject to complex pulse sequences.
COMPUTER PHYSICS COMMUNICATIONS
(2023)
Article
Chemistry, Medicinal
Hristo L. Svilenov, Katharina T. Kopp, Alexander P. Golovanov, Gerhard Winter, Matja Zalar
Summary: This study demonstrates the application of saturation transfer difference (STD) nuclear magnetic resonance (NMR) spectroscopy in detecting protein-surfactant interactions. It was found that polysorbate 20 binds with interferon alpha, with stronger binding at pH closer to the protein's iso-electric point. In contrast, no interactions were detected between poloxamer 407 and interferon alpha. This research highlights the potential of STD-NMR for quickly assessing surfactant-protein interactions and aiding in surfactant selection for protein formulation.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Florence Franconi, Laurent Lemaire, Jean-Christophe Gimel, Samuel Bonnet, Patrick Saulnier
Summary: NMR-based diffusion methods are valuable tools for nanomedicine characterization and understanding interactions with the biological environment. They provide insights into diffusion phenomena and measurement of self-diffusion and mutual diffusion coefficients. NMR diffusometry spectroscopic and imaging methods have broad applications in nanomedicine, aiding in elucidating important issues.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Applied
Stephanie P. Bull, Vitaliy V. Khutoryanskiy, Jane K. Parker, Marianthi Faka, Lisa Methven
Summary: This study found that heated whey protein concentrate has a longer retention time in the oral cavity compared to unheated WPC, causing structural changes, increased free thiol concentration, and exposure of hydrophobic regions. These factors contribute to increased mucoadhesive strength and mouthdrying perception.
Article
Physics, Multidisciplinary
Ainitze Biteri-Uribarren, Pol Alsina-Bolivar, Carlos Munuera-Javaloy, Ricardo Puebla, Jorge Casanova
Summary: This study tackles the detection of individual molecules by combining a hybrid sensor-a nitrogen vacancy center (NV) and a dangling bond on the diamond surface-with a multi-tone dynamical decoupling sequence. Via numerical simulations, the authors prove that the sequence minimizes the impact of decoherence, which allows using the dangling-bond as a signal amplifier.
COMMUNICATIONS PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Yanan Fu, Jin Li, Fang Feng, Lihui Yin
Summary: This study prepared and validated the chemical structures of cefotaxime dimer and trimer impurities obtained from the pharmaceutical industry. The impurities were separated and purified using RP-HPLC, and their structures were characterized using various spectroscopic techniques. The study confirmed the structure of the dimer and validated the polymerization sites and stereochemical configuration of the trimer.
FRONTIERS IN CHEMISTRY
(2022)
Article
Quantum Science & Technology
Soham Pal, Priya Batra, Tanjung Krisnanda, Tomasz Paterek, T. S. Mahesh
Summary: Quantum entanglement is a unique form of correlation between quantum particles that cannot be increased through local operations and classical communication. The presence of entanglement gain between detectors interacting through a classical mediator suggests non-classical characteristics of the mediator. Research indicates the significance of the initial state in determining the entanglement gain between detectors.
Article
Physics, Multidisciplinary
Wentian Zheng, Ke Bian, Xiakun Chen, Yang Shen, Shichen Zhang, Rainer Stohr, Andrej Denisenko, Jorg Wrachtrup, Sen Yang, Ying Jiang
Summary: An efficient method was developed to engineer the electrostatic environment of near-surface nitrogen vacancy center qubits, increasing their coherence and sensitivity.
Article
Soil Science
K. A. Williams, S. A. Ruiz, C. Petroselli, N. Walker, D. M. McKay Fletcher, G. Pileio, T. Roose
Summary: This study investigated the physical behavior of mucilage at the pore scale, validating a polymer-based multi-phase model that accurately characterizes gel-water-air interactions. Results showed that mucilage buckled under drying but maintained connection between surfaces, in contrast to pure water bridges which ruptured. Higher concentrations of mucilage exhibited earlier phase transitions, potentially explaining the greater drought tolerance of plant roots and increased soil water holding capacity. The model may have applications in describing the impacts of microbial biofilms and soil fauna on soil structure and physical functions.
SOIL BIOLOGY & BIOCHEMISTRY
(2021)
Article
Chemistry, Analytical
Lihua Xu, Biling Huang, Zhiying Hou, Shaohua Huang, Yufen Zhao
Summary: This study demonstrates the simultaneous analysis of a complex mixture using solvent effects by F-19 NMR spectroscopy, which enables the identification and quantification of multiple amino acids. This method has important implications for human health and disease diagnosis.
ANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Hsueh-Ying Chen, C. Blake Wilson, Robert Tycko
Summary: The spatial resolution of MRI is limited by signal detection sensitivity, but can be improved by performing measurements at low temperature and using dynamic nuclear polarization (DNP) technique. This allows for higher resolution and shorter data acquisition times, offering a promising direction for high-resolution MRI studies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Polymer Science
Khalid A. Rabaeh, Rawan E. Al-Tarawneh, Molham M. Eyadeh, Issra' M. E. Hammoudeh, Moneeb T. M. Shatnawi
Summary: This article studies the impact of calcium chloride on the performance of NHMA polymer gel dosimeter. The results show that the dose response increases with increasing calcium chloride concentration, but dose-rates and radiation energies have no significant effect on the gel samples. Additionally, the irradiated gel dosimeters exhibit good stability and accuracy.
Article
Environmental Sciences
Kathryn E. Anderssen, Geir Wing Gabrielsen, Mathias Kranz, France Collard
Summary: Monitoring plastic ingestion by marine wildlife is crucial for understanding the extent of plastic pollution and its impact on species and ecosystems. Current detection methods are slow and invasive, limiting the number of animals that can be screened. This study explores the use of MRI as a rapid and non-invasive method to detect plastic ingestion. The results show that MRI and NMR can directly or indirectly detect plastic in the digestive system of animals, with distinctive NMR signal characteristics for each type of plastic. While commercial MRI technology is not suitable for field use, existing single-sided MRI research systems could be adapted for monitoring wildlife outside the laboratory.
MARINE POLLUTION BULLETIN
(2022)
Article
Engineering, Electrical & Electronic
Feifei Ge, Bing Chen, Yangpeng Wang, Feifei Zhou, Renfei Zheng, Xiaofan Yang, Peng Qian, Nanyang Xu
Summary: We present a wideband balun-based microwave device for quantum manipulation of nitrogen-vacancy centers in diamond. The device has a large bandwidth and excellent magnetic field homogeneity, making it suitable for solid-state quantum information processing.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Gloria Uccello Barretta, Alessandro Mandoli, Federica Balzano, Federica Aiello, Beatrice De Nicola, Alessandro Del Grande
Article
Chemistry, Analytical
Gloria Uccello-Barretta, Federica Balzano, Federica Aiello, Niccolo Falugiani, Ielizza Desideri
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2015)
Article
Chemistry, Multidisciplinary
Sofia Masi, Aurora Rizzo, Federica Aiello, Federica Balzano, Gloria Uccello-Barretta, Andrea Listorti, Giuseppe Gigli, Silvia Colella
Article
Chemistry, Organic
Gloria Uccello-Barretta, Federica Balzano, Federica Aiello, Letizia Vanni, Mattia Mori, Sergio Menta, Andrea Calcaterra, Bruno Botta
ORGANIC & BIOMOLECULAR CHEMISTRY
(2015)
Article
Chemistry, Multidisciplinary
Gloria Uccello Barretta, Federica Balzano, Federica Aiello, Francesca Nardelli, Alessia Ciogli, Andrea Calcaterra, Bruno Botta
SUPRAMOLECULAR CHEMISTRY
(2016)
Article
Chemistry, Organic
Valeria Di Bussolo, Ileana Frau, Lucilla Favero, Gloria Uccello-Barretta, Federica Balzano, Paolo Crotti
Article
Chemistry, Organic
Federica Aiello, Federica Balzano, Francesca Ghirga, Ilaria D'Acquarica, Bruno Botta, Gloria Uccello-Barretta, Deborah Quaglio
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2017)
Article
Pharmacology & Pharmacy
Angela Fabiano, Anna Maria Piras, Gloria Uccello-Barretta, Federica Balzano, Andrea Cesari, Lara Testai, Valentina Citi, Ylenia Zambito
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2018)
Article
Chemistry, Multidisciplinary
Sofia Masi, Federica Aiello, Andrea Listorti, Federica Balzano, Davide Altamura, Cinzia Giannini, Rocco Caliandro, Gloria Uccello-Barretta, Aurora Rizzo, Silvia Colella
Article
Chemistry, Applied
Gloria Uccello-Barretta, Federica Balzano, Letizia Vanni, Marco Sanso
CARBOHYDRATE POLYMERS
(2013)
Article
Chemistry, Medicinal
Ilaria D'Acquarica, Andrea Calcaterra, Fabiola Sacco, Federica Balzano, Federica Aiello, Andrea Tafi, Nicolo Pesci, Gloria Uccello-Barretta, Bruno Botta
Article
Chemistry, Medicinal
Gloria Uccello-Barretta, Volker Schurig, Federica Balzano, Letizia Vanni, Federica Aiello, Mattia Mori, Francesca Ghirga
Article
Pharmacology & Pharmacy
Gloria Uccello-Barretta, Federica Balzano, Federica Aiello, Alessandro Senatore, Angela Fabiano, Ylenia Zambito
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2014)
Article
Pharmacology & Pharmacy
Yun Yu, Yu Lu, Ruonan Bo, Yee Huang, Yuanliang Hu, Jiaguo Liu, Yi Wu, Yang Tao, Deyun Wang
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2014)
Article
Chemistry, Organic
Valeria Di Bussolo, Ileana Frau, Stefano Crotti, Gloria Uccello-Barretta, Federica Balzano, Mauro Pineschi, Paolo Crotti
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
