Review
Pharmacology & Pharmacy
Jeroen Heuts, Wim Jiskoot, Ferry Ossendorp, Koen van der Maaden
Summary: Cationic nanoparticles have shown to be effective in cancer immunotherapy by delivering tumor-associated antigens to dendritic cells and inducing strong antigen-specific cellular immune responses. Lipid- and polymer-based cationic nanoparticles are utilized for different types of cancer vaccines, and their potential in T-cell induction is discussed for therapeutic cancer vaccination.
Article
Pharmacology & Pharmacy
Amanda C. Carita, Jacqueline Resende de Azevedo, Yves Chevalier, Delphine Arquier, Marcus Buri, Karin A. Riske, Gislaine Ricci Leonardi, Marie-Alexandrine Bolzinger
Summary: The study investigates the influence of hydrophilic surfactants on the membrane elasticity of liposomes and their effect on the skin absorption of vitamin C. Encapsulation of vitamin C inside cationic liposomes is aimed at improving its delivery to the skin. Elastic liposomes (ELs) formed by the addition of Polysorbate 80 to conventional liposomes (CLs) were compared. The presence of a positive charge in the liposomal membrane significantly increases the encapsulation efficacy of both CLs and ELs, indicating a potential mechanism involving interactions between cationic lipids and vitamin C during skin diffusion.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Rejhana Kolasinac, Dirk Bier, Laura Schmitt, Andriy Yabluchanskiy, Bernd Neumaier, Rudolf Merkel, Agnes Csiszar
Summary: The study focused on the development of cationic fusogenic liposomes with intercalated radioactive [I-131]I- for potential therapeutic applications. Experiment results showed that these liposomes, with high membrane fusion ability, had a special delivery pathway and exhibited excellent delivery efficiency in in vitro experiments, suitable for invasive cancer cell models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Chengcheng Zhang, Jingru Qin, Lu Yang, Zhiyao Zhu, Jia Yang, Wan Su, Haibin Deng, Zhongqi Wang
Summary: This study reveals that exosomes secreted from pulmonary adenocarcinoma cells enhance osteoclastogenesis and osseous resorption by downregulating neuropilin 2 expression. These findings shed light on the mechanism of osseous metastases in pulmonary carcinoma and provide a potential nanodrug for treating bone metastases.
CELL DEATH DISCOVERY
(2022)
Article
Pharmacology & Pharmacy
Zhimei Xiao, Bo Zhuang, Guoli Zhang, Miao Li, Yiguang Jin
Summary: This study explored the combination of cationic liposomal hydroxycamptothecin (CLH) and 5-aminolevulinic acid (5-ALA) for chemo-sonodynamic therapy (Chemo-SDT) of metastatic lung cancer via intratracheal administration. The results demonstrated that this combination showed higher anticancer efficacy by enhancing cancer cell apoptosis and reactive oxygen species production.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Yaqeen Nadheer Al Badri, Cheng Shu Chaw, Amal Ali Elkordy
Summary: Liposome-based drug delivery systems are nanosized spherical lipid bilayer carriers that can encapsulate a broad range of small and large drug molecules. While there are FDA-approved liposomal-based medicines, including an inhalable therapy, asymmetric liposomes have not yet been approved due to formulation and stability challenges. This review explores the potential of asymmetric liposomes as future carriers for enhancing drug delivery, particularly in pulmonary nanotherapeutics.
Article
Pharmacology & Pharmacy
Cristina Loira-Pastoriza, Kevin Vanvarenberg, Bernard Ucakar, Maria Machado Franco, Aurelie Staub, Muriel Lemaire, Jean-Christophe Renauld, Rita Vanbever
Summary: Immunotherapy using immunostimulatory agents delivered intratumorally has shown promising efficacy in the treatment of lung cancer. Encapsulation of unmethylated oligodeoxynucleotides containing CpG motifs (CpG) and polyinosinic-polycytidylic acid (poly I:C) double-stranded RNA in liposomes can enhance their antitumor activity by increasing uptake by lung phagocytes and activating toll-like receptors. CpG encapsulation in DOTAP/DPPC liposomes significantly enhances its antitumor effects in lung cancer by inducing immune responses and delaying tumor growth.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Cell Biology
Sabreena Aashaq, Asiya Batool, Shabir Ahmad Mir, Mushtaq Ahmad Beigh, Khurshid Iqbal Andrabi, Zaffar Amin Shah
Summary: TGF-beta serves as a dual role in tumor progression, acting both as a tumor suppressor in the early stages and a metastatic promoter in the later stages. The signaling pathways of TGF-beta are complex, involving both SMAD-dependent and SMAD-independent pathways.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Nevena Duskunovic, San Hae Im, Juhee Lee, Hyun Jung Chung
Summary: In this study, cationic nanogels were incorporated into liposomes for stable and enhanced mRNA delivery to cells. The use of DNPR9 with liposomes resulted in enhanced internalization and a 4-fold increase in transfection efficiency compared to control liposomes. The condensation strategy using DNPR9 can be widely applied to enhance the efficacy of various lipid-based formulations.
MOLECULAR PHARMACEUTICS
(2023)
Review
Oncology
Fatema Tuz Zahra, Md. Sanaullah Sajib, Constantinos M. Mikelis
Summary: Anti-angiogenic therapies targeting VEGF signaling have shown temporary benefits in cancer treatment, with resistance often developing due to the upregulation of other growth factors like bFGF. Recent efforts have focused on developing multi-target anti-angiogenic drugs to overcome resistance mechanisms and improve outcomes in clinical practice.
Article
Biochemistry & Molecular Biology
Gen Chen, Ning An, Weijian Ye, Shuai Huang, Yunjie Chen, Zhicheng Hu, Enzhao Shen, Junjie Zhu, Wenjie Gong, Gaozan Tong, Yu Zhu, Lexuan Fang, Chunyuan Cai, Xiaokun Li, Kwonseop Kim, Litai Jin, Jian Xiao, Weitao Cong
Summary: The study demonstrates that bFGF plays a key regulatory role between S-nitrosylation homeostasis and inflammation, alleviating endothelial dysfunction and angiogenic defects in diabetes. Under conditions of hyperglycemia and hyperlipidemia, bFGF was found to suppress inflammation via the S-nitrosylation pathway.
Article
Biochemistry & Molecular Biology
Hyun Hee Jang, Youngsook Son, Gabee Park, Ki-Sook Park
Summary: This study demonstrates that bone marrow-derived mesenchymal stem cells (MSCs) have vasculogenic properties. Different populations of MSCs vary in angiogenic factor expression and vasculogenic properties. The vasculogenic MSCs (vMSCs), distinct from endothelial progenitor cells (EPCs), may contribute to neovascularization and could be a promising cellular therapy for cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Meimei Wu, Yanfang Liang, Xin Zhang
Summary: Breast cancer is the most common malignant disease worldwide, and distant metastasis is the leading cause of death. The lung is a common site for breast cancer metastasis and the alterations in the pulmonary microenvironment play a crucial role in this process.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lutan Zhou, Ronghua Yin, Na Gao, Huifang Sun, Dingyuan Chen, Ying Cai, Lin Ren, Lian Yang, Zhili Zuo, Hongbin Zhang, Jinhua Zhao
Summary: nHG and its derivatives extracted from sea cucumber demonstrate the ability to inhibit heparanase activity and show inhibitory effects on various cancer-related cells and angiogenesis. In addition, they exhibit practical antimetastatic effects in a metastatic mouse model.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Sabna Kotta, Hibah Mubarak Aldawsari, Shaimaa M. Badr-Eldin, Lenah S. Binmahfouz, Rana Bakur Bakhaidar, Nagaraja Sreeharsha, Anroop B. Nair, Chandramouli Ramnarayanan
Summary: Pulmonary fibrosis, caused by excessive tissue remodeling due to myofibroblast proliferation and extracellular matrix deposition, affects lung function. The developed naringin liposomal delivery system shows potential therapeutic effects in both in vitro and in vivo experiments, providing a promising strategy for managing pulmonary fibrosis.
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
