Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 385, Issue 1-2, Pages 73-78Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2009.10.032
Keywords
Sodium carboxymethylcellulose; HFA-134a; pMDI; Protein; Spray-drying
Categories
Funding
- EPSRC [EP/C003020/1]
- Pfizer Global Research and Development, Sandwich, UK
Ask authors/readers for more resources
In this paper, we demonstrate that co-spray-drying a model protein with sodium carboxymethylcellulose (NaCMC) protects protein integrity during spray-drying, and that the resultant spray-dried powders can be successfully dispersed in hydrofluoroalkane (HFA) propellant to prepare pressurised metered dose (pMDI) formulations that exhibit high respirable fractions. The spray-dried powders were formulated as HFA-134a pMDI suspensions in the absence of any other excipients (e.g. surfactants) or co-solvents (e.g ethanol). The in vitro aerosolisation profile of these systems was assessed using the twin stage impinger, fine particle fractions (FPF) >= 50% of the recovered dose were obtained. Following storage for five months, the aerosolisation performance was reassessed; the NaCMC-free formulation demonstrated a significant decrease in FPF, whereas the performance of the NaCMC-modified formulations was statistically equivalent to their initial performance. Thus, formulation of pMDI suspensions using NaCMC-based spray-dried powders is a promising approach for the pulmonary delivery of proteins and peptides. (C) 2009 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available