Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 391, Issue 1-2, Pages 197-202Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2010.03.007
Keywords
Fluoroquinolone; Salts; Polymorphism; Solid-state characterization
Categories
Funding
- CONICET
- SeCyT-UNC
- MinCyT Cordoba
- ANPCyT-FONCyT. Dra.
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A new polymorphic form of ciprofloxacin saccharinate (CIP-SAC II) is presented, and compared with CIP-SAC I, a different polymorph which we had previously reported. The characterization techniques used were single crystal and powder X-ray diffraction, differential scanning calorimetry, thermogravimetry analysis and infrared and C-13 solid-state nuclear magnetic resonance spectroscopy. The results obtained from these techniques are consistent. Differential scanning calorimetry and thermogravimetric analysis showed that the reaction between the precursors is completed and the crystalline forms of both salts obtained (land II) are highly pure. Infrared spectroscopy gave clear evidence of a salt formation. Solidstate nuclear magnetic resonance spectroscopy would indicate some degree of qualitative similarity in the intermolecular interaction scheme in both polymorphs, while thermal analysis data might indicate a difference in quantitative terms. A thorough single crystal structure determination of the new form CIP-SAC II allowed disclosing the most important inter- and intramolecular interactions. (C) 2010 Elsevier B.V. All rights reserved.
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