Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 382, Issue 1-2, Pages 160-164Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2009.08.026
Keywords
Remote controlled capsule; Site-specific drug delivery; Regional drug absorption; MEMS; Micro-thruster
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Funding
- Chinese National Natural Science Foundation [30700160]
- Natural Science Foundation [2006BA5005]
- China Postdoctoral Science Foundation [20070420718]
- SRFDP [20070611045]
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Remote controlled capsule (RCC) has been extensively used in the field of site-specific drug delivery. It is a potent tool to study the regional drug absorption of the gastrointestinal (GI) tract that provides pharmaceutical scientists with significant pharmacokinetics data for oral drug formulation development. In present investigations, a patented novel RCC has been devised based on micro-electronic mechanical system (MEMS) technology. Micro-thrusters were for the first time exploited as drug release actuators of RCCs. As the micro-thruster is ignited by a radio frequency (RF) signal, the thrust force generated by the propellants pushes the piston forward and leads to a rapid and complete expulsion of therapeutic agents from the capsule. The micro-thruster merely consumes 120 mW for ignition and the duration time of drug release is decreased to less than 1 s. The feasibility of the novel RCC was evaluated through animal experiments in beagles using aminophylline as the model drug. The novel RCC developed is a promising alternative for site-specific drug delivery in human GI tract. (C) 2009 Elsevier B.V. All rights reserved.
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